Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation
Relaxation tests are often used in the pharmaceutical field to assess the strain rate sensitivity of pharmaceutical powders and tablets. These tests involve applying a constant strain to the powder in the die and then monitoring the stress evolution over time. Interpreting these tests is complicated because different physical phenomena, mainly…
Excipient GMP Compliance Workshop for Auditors and Audits – IPEC Workshop
18. February 2017 Excipient GMP Compliance Workshop for Auditors and Audits - IPEC Workshop April 4-6, 2017 Hosted by Baxter Healthcare Corporation…
Excipient GMP Compliance Workshop for Auditors and Auditees – IPEC Workshop
18. February 2017 October 17-19, 2017 Hosted by VWR Radnor, PA. More Information & Registration
Nano carrier mediated co-delivery of dapsone and clofazimine for improved therapeutic efficacy…
17. February 2017
Abstract
Dapsone and clofazimine is a known therapeutically effective combination against various Mycobacterium species. However, anti-tubercular effect of this combination is limited due to…
Webinar: Hot Melt Extrusion with Polyvinyl Alcohol:Overcoming Challenges in API Solubility and…
17. February 2017 Thursday, March 2, 2017 More Information & Registration
Continuous manufacture of polymeric cellular dosage forms
16. February 2017 Abstract The most prevalent pharmaceutical dosage forms at present are granular solids in the form of oral tablets and capsules. While effective in…
Prosopis juli ora (mesquite) gum exudate as a potential excipient
16. February 2017 Introduction Prosopis juli ora(Sw.) DC, an invasive weed in India has been highlighted for its bioreme- diation and bioeconomic potentials (1). Prosopis…
Fast disintegrating tablets of amiodarone for intra-oral administration
16. February 2017 ABSTRACT Amiodarone is antihypertensive drug with variable bioavailability following oral administration due to poor solubility and pre-systemic…
The Impact of Granule Density on Tabletting and Pharmaceutical Product Performance
16. February 2017 Purpose The impact of granule densification in high-shear wet granulation on tabletting and product performance was investigated, at pharmaceutical…
Superdisintegrants:introduction to chemistry and Performance – DFE Pharma
16. February 2017
Superdisintegrants: Introduction to chemistry and Performance - DFE Pharma
Summary
The superdisintegrants Primojel® (sodium starch glycolate) and Primellose® (croscarmellose sodium) are…
Functional Assessment of Four Types of Disintegrants and their Effect on the Spironolactone Release…
16. February 2017
Abstract
Spironolactone is a drug derived from sterols that exhibits an incomplete oral absorption due to its low water solubility and slow dissolution rate. In this study, formulations of…
Stabilizing two IgG1 monoclonal antibodies by surfactants: Balance between aggregation prevention…
15. February 2017 Abstract Surfactants are widely used as stabilizers in the biopharmaceutical formulations to minimize protein aggregation. Under a fixed stress…
Physicochemical Characterization of Physical Mixture and Solid Dispersion of Diclofenac Potassium…
15. February 2017
Diclofenac potassium is an anti-inflammatory agent classified as a class II drug as per the biopharmaceutical classification system (BCS). The poor dissolution rate of water-insoluble drugs is still a major…
Solid dispersion of berberine hydrochlorid and Eudragit® S100:Formulation, physicochemical…
15. February 2017 Abstract The purpose of this study was to develop and evaluate the berberine hydrochloride (HB) - Eudragit S100 solid dispersion to prolong the drug…
ENHANCING THE SOLUBILITY OF IBUPROFEN USING BIOPOLYMERS-BASED NANOENCAPSULATION
15. February 2017 The clinical use of poorly water-soluble drugs has become a big challenge in pharmaceutical development due to the compromised bioavailability of the drugs…
Mesalamine-loaded alginate microspheres filled in enteric coated HPMC capsules for local treatment…
15. February 2017 Abstract An attempt was made to formulate mesalamine-loaded alginate microspheres by emulsion cross linking method for local treatment of ulcerative…
Continuous Manufacturing in Pharma – 16 hours hands-on seminar
15. February 2017
First Practival Pharma workshop on Continuous Wet Granulation and Direct Compression process lines
04 – 06 APRIL 2017 in Binzen, Germany
Effects of moisture content and compression pressure of various deforming granules on the physical…
14. January 2017
Abstract
The main purpose of this study was to investigate the effects of moisture content (MC) of different deformation granules (brittle, plastic, and elastic) and compression pressure (CP) on the…
Compacted Multiparticulate Systems for Colon-Specific Delivery of Ketoprofen
14. January 2017 Pellet-containing tablets for colon-specific drug delivery present higher targeting efficiency and lower costs when compared with monolithic tablets and…
More Efficient Compliance with EMA and FDA Regulations for Pediatric Oncology Drug Development:…
14. February 2017 Abstract 5w?>The morbidity and mortality toll of pediatric cancer affects the public health of children worldwide, but despite the gains in the fight…
Effect of roll compaction on granule size distribution of microcrystalline cellulose–mannitol…
14. February 2017
Abstract
Dry granulation using roll compaction is a typical unit operation for producing solid dosage forms in the pharmaceutical industry. Dry granulation is commonly used if the powder…
Characterisation of aggregates of cyclodextrin-drug complexes using Taylor Dispersion Analysis
14. February 2017 Abstract There is a need to understand the nature of aggregation of cyclodextrins (CDs) with guest molecules in increasingly complex formulation…
Fabrication of letrozole formulation using chitosan nanoparticles through ionic gelation method
14. February 2017 Abstract In this study, the anticancer drug letrozole (LTZ) was formulated using chitosan nanoparticles (CS-NPs) with the crosslinking agent sodium…
Pharmaceutical applications of native starch in conventional drug delivery : Starch
14. February 2017
Abstract
Starch is a naturally occurring polymer that is present in many green plants. Its nontoxic and nonirritant properties, as well as low cost, ease of modification, and versatility in…
Kinetic study of type SBA-15 materials functionalized with chitosan
14. February 2017 Abstract Amino-functionalized SBA-15 was prepared using 1.0 and 2.5% chitosan solutions and a wet impregnation method. The adsorbents were characterized…
Nano-suspension coating as a technique to modulate the drug release from controlled porosity osmotic…
14. February 2017 Abstract In controlled porosity osmotic pumps (CPOP), usually finding a single solvent with a capability to dissolve both film former (hydrophobic) and…
Dissolution and dissolution/permeation experiments for predicting systemic exposure following oral…
13. February 2017 Abstract In order to save time and resources in early drug development, in vitro methods that correctly predict the formulation effect on oral drug…
Extrusion based 3D printing as a novel technique for fabrication of oral solid dosage forms
13. February 2017 Abstract Extrusion based three dimensional (3D) printing is defined as a process used to make a 3D object layer by layer directly from a computer aided…
Humidity Induced Phase Transformation of Poloxamer 188 and Its Effect on Physical Stability of…
13. February 2017
Abstract
Poloxamer 188, a commonly used emulsifying and solubilizing agent, was found to be the cause of crystallization of an investigational drug, AMG 579, from its amorphous solid…
Dissolution enhancement of leflunomide incorporating self emulsifying drug delivery systems and…
13. February 2017 Abstract The objective of this study is to enhance the dissolution properties of leflunomide, a class BCS-II drug by incorporating the self emulsifying…
Co-amorphous drug systems of carbamazepine: intrinsic dissolution rate improvements
12. February 2017 Abstract Co-amorphous systems is one of the attractive strategies used to enhance the dissolution rates of poorly soluble drugs. This strategy has an…
Microwave processed solid dispersions for enhanced dissolution of gemfibrozil using non-ordered…
12. February 2017 Abstract This study describes the application of three non-ordered mesoporous silicas (Syloid AL-1, Syloid 72 and Syloid 244) in improving the…
Submicrometric hypromellose acetate succinate particles as carrier for soy isoflavones extract with…
12. February 2017 Abstract In this study, hypromellose acetate succinate (HPMCAS) stable submicronic particles loaded with a soy isoflavones extract, have been obtained…
Ashland Specialties France site in Alizay receives EXCiPACT certficate
10. February 2017
EXCiPACT asbl is delighted to announce that Ashland Specialties France has recently been awarded an EXCiPACT Certificate from SGS, one of EXCIPACT’s internationally-recognised Certification Bodies.
The…
Impact of dissolution rate on bioequivalence: Comparative human in-vivo…
10. February 2017 Impact of dissolution rate on bioequivalence: Comparative human in-vivo study of animmediate release tablet over-encapsulatedb Introduction Rapid…