Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation
Relaxation tests are often used in the pharmaceutical field to assess the strain rate sensitivity of pharmaceutical powders and tablets. These tests involve applying a constant strain to the powder in the die and then monitoring the stress evolution over time. Interpreting these tests is complicated because different physical phenomena, mainly…
First study of the evolution of the SeDeM expert system parameters based on percolation theory:…
03. February 2017 Abstract The deep understanding of products and processes has become a requirement for pharmaceutical industries to follow the Quality by Design…
Nanostructured lipid carriers for transdermal delivery of acid labile lansoprazole
03. February 2017 Abstract The aim of this study was to develop nanostructured lipid carriers (NLCs) for transdermal delivery of acid-labile lansoprazole (LPZ). The drug…
Process and Development of Co-Processed Excipient Silicified Microcrystalline Cellulose…
03. February 2017 Process and Development of Co-Processed Excipient Silicified Microcrystalline Cellulose andManufacture Paracetamol Tablet by Direct Compression ABSTRACT…
In vitro dissolution models for the prediction of in vivo performance of an oral mesoporous silica…
02. February 2017 Abstract Drug release from mesoporous silica systems has been widely investigated in vitro using USP Type II (paddle) dissolution apparatus. However, it…
Stabilization and Amorphization of Lovastatin Using Different Types of Silica
02. February 2017 Abstract Lovastatin (LOV), an antihyperlipidimic agent, is characterized by low solubility/poor dissolution and, thus, low bioavailability (<5%). A…
The Utilization of Surface Free Energy for Predicting Flowability of Filler-Lubricant or…
31. January 2017
The aim of this study was to apply the knowledge of surface free energy for the flowability prediction of pharmaceutical excipients. In order to predict the flowability, the spreading coefficient was…
Impact of Polymer Excipient Molar Mass and End Groups on Hydrophobic Drug Solubility Enhancement
31. January 2017 Solubility-enhancing amorphous solid dispersions are used in the oral delivery of hydrophobic, crystallizable drugs. Effective solid dispersion excipients…
Adsorption behavior of some metal ions on nanoparticles used in pharmaceutical matrices: Application…
31. January 2017 Abstract The adsorption behavior of some metal ions (Pb, Mn, Mg, Zn and Ca) was studied on silicon dioxide nanoparticles, SiO2 NP, alone and its mixture…
Fabrication of electrospun antioxidant nanofibers by rutin-pluronic solid dispersions for enhanced…
31. January 2017 In this study, solid dispersions (SDs) and electrospinning combined methods were used to increase the bioavailability and solubility of a water insoluble…
Achieving immediate release dosage formsusing DoE and Injection Moulding – Poster
31. January 2017 Achieving immediate release dosage formsusing DoE and Injection Moulding - Poster Achieving…
Relationship between Surface Properties and In Vitro Drug Release from Compressed Matrix Containing…
30. January 2017 Abstract: This work is the continuation of a study focused on establishing relations between surface thermodynamic properties and in vitro release…
Application of Pharmacokinetics and Pharmacodynamics in Product Life Cycle Management. A Case Study…
30. January 2017 Abstract Increasing costs in discovering and developing new molecular entities and the continuing debate on limited company pipelines mean that…
Rationalising polymer selection for supersaturated film forming systems produced by an aerosol spray…
29. January 2017 Abstract Film forming systems offer a number of advantages for topical and transdermal drug delivery, in particular enabling production of a…
Viscosity-Reducing Bulky-Salt Excipients Prevent Gelation of Protein, but Not Carbohydrate,…
29. January 2017 Abstract The problem of gelation of concentrated protein solutions, which poses challenges for both downstream protein processing and liquid formulations…
Can pharmaceutical co-crystals provide an opportunity to modify the biological properties of drugs?
29. January 2017 Poorly soluble and/or permeable molecules jeopardize the discovery and development of innovative medicines. Pharmaceutical co-crystals, formed by an active…
Optimizing drug delivery in COPD: The role of inhaler devices
29. January 2017 Background Inhaled medication is the cornerstone of the pharmacological treatment for patients with asthma and chronic obstructive pulmonary disease…
Self-assembled Nanomaterials for Chemotherapeutic Applications
29. January 2017
Abstract
The self-assembly of short designed peptides into functional nanostructures is becoming a growing interest in a wide range of fields from optoelectronic devices to nanobiotechnology. In the…
Gelatin and pregelatinized starch orally disintegrating films: Properties and stability of vitamin C
29. January 2017
ABSTRACT
The administration of active compounds by the oral mucosa is an efficient method for the delivery of drugs and nutrients. This work aimed to develop and characterize orally…
Investigation of the potential application of sodium bentonite as an excipient in formulation of…
28. January 2017 Abstract In this study, the application of sodium bentonite (SB) in formulation of tablets prepared by direct compression for oral administration was…
Use of mixture design in drug-excipient compatibility determinations: Thymol nanoparticles case…
28. January 2017 Abstract The objective of this work was to access thymol-excipient compatibility using an alternative protocol of mixture design subsidizing the…
Formulating a poorly water soluble drug into an oral solution suitable for paediatric patients;…
28. January 2017 Introduction Many drugs are unavailable in suitable oral paediatric dosage forms, and pharmacists often have to compound drugs to provide paediatric…
Interaction of pharmaceutical excipients with organic cation transporters
28. January 2017 Abstract Increasing evidences have shown that many pharmaceutical excipients are not pharmacologically inert but instead have effects on several…
Estimated generic prices of cancer medicines deemed cost-ineffective in England: a cost estimation…
26. January 2017 Objectives The aim of this study was to estimate lowest possible treatment costs for four novel cancer drugs, hypothesising that generic manufacturing could…
Analytical Strategies to Determine ArtificialSweeteners by Liquid Chromatography-Mass Spectrometry
26. January 2017 Analytical Strategies to Determine ArtificialSweeteners by Liquid Chromatography-Mass Spectrometry Abstract The interest of consumers and government…
The effect of the antioxidant on the properties of thiolated poly(aspartic acid) polymers in aqueous…
26. January 2017 Abstract Thiolated polymers are a promising new group of excipients, but their stability against atmospheric oxidation has not been investigated in…
Impact of food, alcohol and pH on modified-release hydrocortisone developed to treat congenital…
25. January 2017
Abstract
Background: We developed a modified-release hydrocortisone, Chronocort®, to replace the cortisol rhythm in patients with congenital adrenal hyperplasia. Food, alcohol and pH affect drug…
A quality by design (QbD) study on enoxaparin sodium loaded polymeric microspheres for…
25. January 2017 Abstract The aim of this study was to apply quality by design (QbD) for pharmaceutical development of enoxaparin sodium microspheres for colon-specific…
DEVELOPMENT OF PAEDIATRIC DOSAGE FORMS OF FUROSEMIDE USING THE PROBLEM STRUCTURING METHOD OF…
24. January 2017 ABSTRACT The lack of age-appropriate (paediatric) authorised medicines is a long-standing problem amongst regulatory authorities, patients, parents and…
An overview of intestinal wafers for oral drug delivery
24. January 2017 Introduction For drug delivery, oral intake is the most common and widely accepted procedure. However, many active pharmaceutical ingredients (API) for…
Study on the pulmonary delivery system of apigenin loaded albumin nanocarriers with antioxidant…
24. January 2017 Abstract Background: Respiratory diseases are mainly derived from acute and chronic inflammation of the alveoli and bronchi. The pathophysiological…
Formulation, swelling and dissolution kinetics study of zein based matrix tablets
Abstract
This study has investigated the potential use of zein protein from corn as a pharmaceutical excipient for formulation of oral controlled-release matrices. SMCC (silicified microcrystalline cellulose)-Prosolv®…
In vitro gastric survival of commercially available probiotic strains and oral dosage forms
23. January 2017 Abstract Although the intestinal microbial community is still incompletely understood, there is strong evidence of the benefits of using probiotics to…
Implantable Drug-Eluting Devices: A Novel Approach to Patient Care
23. January 2017
Implantable Drug-Eluting Devices: A Novel Approach to Patient Care
Implantable drug-eluting devices (also referred to as implantable drug delivery systems) offer several unique advantages over…
Nanocarriers protecting toward an intestinal pre-uptake metabolism
23. January 2017 Pre-uptake metabolism within the GI tract is responsible for the poor oral bioavailability of numerous drugs. As nanocarriers function as a ‘shield’,…