Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation
Relaxation tests are often used in the pharmaceutical field to assess the strain rate sensitivity of pharmaceutical powders and tablets. These tests involve applying a constant strain to the powder in the die and then monitoring the stress evolution over time. Interpreting these tests is complicated because different physical phenomena, mainly…
EudraGMDP – Database
15. January 2017 EudraGMDP is the name for the Union database referred to in article 111(6) of Directive 2001/83/EC and article 80(6) of Directive 2001/82/EC. It contains…
Engineering hot-melt extruded solid dispersion for controlled release of hydrophilic drugs
Abstract
It is often challenging to precisely manipulate the release behavior of hydrophilic drugs that is believed to be crucial for a satisfactory therapeutic outcome. The aim of this work was to regulate the dissolution of…
Continuous direct compression as manufacturing platform for sustained release tablets
13. January 2017 Abstract This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging…
Microencapsulation Improved Probiotics Survival During Gastric Transit
13. January 2017 Abstract Several studies have demonstrated differences among strains of probiotic bacteria with regard to their survival in acid environment. Probiotics…
Polymer Nanoparticles for Nanomedicines
12. January 2017 "The book edited by Drs. Vauthier and Ponchel, Polymer Nanoparticles for Nanomedicines: A Guide for their Design, Preparation and Development, represents a…
Poorly Soluble Drugs: Dissolution and Drug Release
12. January 2017 Summary This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release…
Abuse-Deterrent Technologies: One Step in the Opioid Epidemic but, How to we Evaluate Them?
12. January 2017
Abuse-Deterrent Technologies: One Step in the Opioid Epidemic but, How to we Evaluate Them?
Over the past two decades, the increased use of opioids for legitimate medical purposes has been…
An innovative polysaccharide nanobased nail formulation for improvement of onychomycosis treatment
11. January 2017 Abstract Tioconazole-loaded nanocapsule suspensions and its coating with a cationic polymer were developed for nail drug delivery. The colloidal systems…
Influence of HPMC K100LV and Compritol® HD5 ATO on Drug Release and Rheological Behavior of HPMC K4M…
11. January 2017 Purpose The objectives of this study were to develop once-a-day oral controlled-release tablets of quetiapine fumarate (QF) and to determine the effect…
Estimation of the critical quality attributes for hydroxypropyl methylcellulose with near-infrared…
11. January 2017 Abstract With the implementation of quality by design (QbD), critical attributes of raw material (drug substance and excipients) are of significantly…
VWR’S OHIO SITES RECEIVE EXCiPACT GMP & GDPCERTIFICATION AS PHARMACEUTICAL EXCIPIENT SUPPLIERS
11. January 2017 VWR’S OHIO SITES RECEIVE EXCiPACT GMP & GDPCERTIFICATION AS PHARMACEUTICAL EXCIPIENT SUPPLIERS EXCiPACT asbl is delighted to announce that…
8th Global Drug Delivery & Formulation Summit
11. January 2017 8th Global Drug Delivery & Formulation Summit 8th Global Drug Delivery & Formulation Summit 27 – 29 March | Berlin…
Effective Management of Rheumatoid Arthritis: An Approach for Bioavailability Enhancement of…
10. January 2017 Objective: Present study aimed towards the development of a novel delivery system for pain management of rheumatic disorders. Materials and methods: An…
A Rational Approach towards Development of Amorphous Solid Dispersions: Experimental and…
10. January 2017 Abstract The purpose of this study was to determine the drug-polymer miscibility of GENE-A, a Genentech molecule, and Hydroxypropyl…
Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug…
10. January 2017
Abstract: A double layer-coated colon-specific drug delivery system (DL-CDDS) was developed, which consisted of chitosan (CTN) based polymeric subcoating of the core tablet containing citric acid for…
25thAnniversary IPEC Europe
10. January 2017
25thAnniversary IPEC Europe
2 February 2017 in Monte-Carlo
For this special occasion, we have put together one of our most exciting programmes yet. Check it out here!.
So, don't delay…
New: weekly blog article summary on pharma-excipients!
09. January 2017 Up from today you can subscribe to get the all articles on a weekly basis via email. A summary of all published news and articles on products, suppliers,…
Physical, Chemical, and Performance Assessment of Amorphous Solid Dispersions of Ritonavir Prepared…
09. January 2017 Abstract The purpose of this study was to compare the chemical and physical stability of amorphous solid dispersions of Ritonavir formulated with either…
Novel Co-processed Spray Dried Super Disintegrants Designing of Fast Dissolving Tablets Using
08. January 2017 ABSTRACT: In the present study, novel co-processed superdisintegrants were developed by spray drying method using microcrystalline cellulose and mannitol in…
Hibiscus sabdariffa Mucilage as a Disintegrant in Formulating Fast Dissolving Tablets
08. January 2017
ABSTRACT: The aim of the present work was to prepare and evaluate fast dissolving tablets of nebivolol with a view to enhance patient compliance and minimize the side effects. In this study, fast dissolving…
Simultaneous Formulation Development, Evaluation and Estimation of Innovative Controlled Release…
07. January 2017 ABSTRACT: Bosentan is an endothelial receptor antagonist (ERA) indicated for the treatment of Pulmonary arterial hypertension (PAH). The aim of the…
FORMULATION AND IN VITRO EVALUATION OF METFORMIN HYDROCHLORIDE DIRECT COMPRESSIBLE TABLET USING BY…
06. January 2017 ABSTRACT Metformin hydrochloride is generally used to regulate blood glucose level; It is mainly used for Insulin- dependent mellitus or Type II…
Physicochemical Parameter of Microcrystalline Cellulose and the Most Acceptability in Pharmaceutical…
06. January 2017 Abstract Microcrystalline cellulose (MCC) HiCelTM is native from cellulose, which is manufactured from wood pulp. Microcrystalline cellulose is made…
LIPID BASED FORMULATIONS OF BIOPHARMACEUTICS CLASSIFICATION SYSTEM (BCS) CLASS II DRUGS: STRATEGY,…
04. January 2017 Active ingredients in pharmaceuticals di er by their physico-chemical properties and their bioavailabil- ity therefore varies. e most frequently used and…
Hydrophilic drug encapsulation in shell-core microcarriers by two stage polyelectrolyte complexation…
04. January 2017 Abstract In this study a protocol exploiting the combination of the ultrasonic atomization and the complexation between polyelectrolytes was developed to…
Formulation and Optimization of Multiparticulate Drug Delivery System Approach for High Drug Loading
04. January 2017 The aim of the present work was to develop and optimize multiparticulate formulation viz. pellets of naproxen by employing QbD and risk assessment approach.…
Development and characterization of anti-inflammatory activity of curcumin-loaded biodegradable…
04. January 2017 Abstract This research addresses the development and in vitro evaluation of a microparticulate system intended for intestine-targeted delivery of…
Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability of…
03. January 2017
Abstract
Aspirin is apt to hydrolyze. In order to improve its stability, a new method has been developed involving the application of hot-melt sub- and outercoating combined with enteric aqueous coating.…
Influence of Particle Properties on Powder Bulk Behaviour and Processability
03. January 2017 Abstract Understanding interparticle interactions in powder systems is crucial to pharmaceutical powder processing. Nevertheless, there remains a great…
A systematic review of the use of dosage form manipulation to obtain required doses to inform use of…
03. January 2017 Abstract This study sought to determine whether there is an evidence base for drug manipulation to obtain the required dose, a common feature of…
Efavirenz dissolution enhancement III: Colloid milling, pharmacokinetics and electronic tongue…
03. January 2017
Abstract
Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), is part of first-line therapy for the treatment of human immunodeficiency virus type 1 infection (HIV-1/AIDS). This drug…
Efavirenz Dissolution Enhancement I: Co-Micronization
03. January 2017 Abstract AIDS constitutes one of the most serious infectious diseases, representing a major public health priority. Efavirenz (EFV), one of the most…
EFAVIRENZ DISSOLUTION ENHANCEMENT II: AQUEOUS CO-SPRAY-DRYING
03. January 2017 ABSTRACT: Efavirenz is a crystalline lipophilic solid with a low aqueous solubility and intrinsic dissolution rate. It is classified in class II of the…
What Is Continuous Manufacturing, Anyway? Agreeing On A (Proper) Definition
02. January 2017 In the past 10 years, continuous manufacturing (CM) has gone from theoretical discussion to manufacturing reality. However, the pharmaceutical industry has…