Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation
Relaxation tests are often used in the pharmaceutical field to assess the strain rate sensitivity of pharmaceutical powders and tablets. These tests involve applying a constant strain to the powder in the die and then monitoring the stress evolution over time. Interpreting these tests is complicated because different physical phenomena, mainly…
Thermal Processing of PVP- and HPMC-Based Amorphous Solid Dispersions
Abstract
Thermal processing technologies continue to gain interest in pharmaceutical manufacturing. However, the types and grades of polymers that can be utilized in common thermal processing technologies, such as hot-melt…
Impact of Various Polymeric Matrices on the Dissolution of Itraconazole from Surfactant-Sugar-Free …
31. December 2016 Impact of Various Polymeric Matrices on the Dissolution of Itraconazole from Surfactant-Sugar-Free Nanocomposite Microparticles Bioavailability of a…
Investigating Blend Uniformity of API/Excipient Mixtures via Surface Energy Distribution …
31. December 2016 Investigating Blend Uniformity of API/Excipient Mixtures via Surface Energy Distribution Measurements The powder blending process is often identified…
In Vitro and Ex Vivo Evaluation of Novel Curcumin-Loaded Excipient for Buccal Delivery
31. December 2016 Abstract This study aimed to develop a mucoadhesive polymeric excipient comprising curcumin for buccal delivery. Curcumin encompasses broad range of…
Supercritical fluid coating of API on excipient enhances drug release
29. December 2016 Abstract A process to coat particles of active pharmaceutical ingredient (API) onto microcrystalline cellulose (MCC) excipient shows promise as a new…
Natural Material Source of Bagasse Cellulose and Their Application to Hydrogel Films
29. December 2016 Abstract Among all biomass sources, cellulose is the most diverse material sourced from plants and is abundant in nature. It possesses some promising…
Formulation design and optimization of novel fast dissolving tablet of chlorpheniramine maleate by…
29. December 2016 Abstract Fast dissolving tablets (FDTs) have received more interest in the pharmaceutical industry for those categories of drug which show slow…
Formulation and Evaluation of Low Floating Lag Time Metformin Hydrochloride 500 mg Sustained Release…
28. December 2016 Introduction: Diabetes mellitus (DM) is a worldwide disease with high mortality rate. Metformin hydrochloride has been used as the first-line drug for the…
Development and Characterization of Press Coated Tablet of Flurbiprofen: A Chronotherapeutic…
28. December 2016 Development and Characterization of Press Coated Tablet of Flurbiprofen: A Chronotherapeutic Approach Aim: The main objective of the present…
PAT-Based Control of Fluid Bed Coating Process Using NIR Spectroscopy to Monitor the Cellulose…
28. December 2016 Abstract Current endeavor was aimed towards monitoring percent weight build-up during functional coating process on drug-layered pellets. Near-infrared…
Denatured Whey Protein Powder as a New Matrix Excipient: Design and Evaluation of Mucoadhesive…
27. December 2016 Purpose In earlier study, we proposed denatured whey protein (DWP) powder obtained by atomization as a new excipient to promote oral drug delivery. In…
Influence of Several Excipients on Drug Release of Tablets Containing Resveratrol
For pharmaceutical tablet production, there are lots of commercial excipients available. All these excipients influence the drug release of tablet cores in different ways. In this project the influence of Carbopol 71G®, Carbopol 971P®, …
Biophysical evaluation of aminoclay as an effective protectant for protein stabilization during…
27. December 2016 Abstract This study aimed to evaluate aminoclay (3-aminopropyl-functionalized magnesium phyllosilicate) as an effective protectant for the stabilization…
Transient supersaturation supports drug absorption from lipid-based formulations for short periods…
27. December 2016 The current studies sought to explore the impact of drug supersaturation and precipitation during the dispersion and digestion of lipid-based formulations…
Physical characterization and kinetic modelling of matrix tablets of ketorolac tromethamol…
27. December 2016
Abstract
Purpose: To design controlled release ketorolac tromethamol (KT) matrix tablets for increased drug bioavailability.
Methods: Waxes (Compritol® ATO 888, Precirol® ATO 5 and stearic acid - SA) and…
Hydrophilic-hydrophobic polymer blend for modulationof crystalline changes and molecular…
23. December 2016 Hydrophilic-hydrophobic polymer blend for modulationof crystalline changes and molecular interactions in soliddispersion Abstract This research study…
Modelling and synthesis of pharmaceutical processes: moving from batch tocontinuous
23. December 2016 Modelling and synthesis of pharmaceutical processes: moving from batch tocontinuous ABSTRACT Research in pharmaceutical process development has gained a…
Seasons Greetings from pharma-excipients!
22. December 2016 Dear pharma-excipients supporters Another year is soon over and I would like to thank you for your loyalty and interest in the activities of…
Synergetic Role of Hypromellose and Methacrylic Acid Copolymer in the Dissolution Improvement of…
21. December 2016 Abstract Synergetic role of polymer blending on dissolution of amorphous solid dispersion was investigated. Dissolution rates of hypromellose (HPMC) and…
Development of predictive tools for amorphous solid dosage forms
21. December 2016 Background Since the introduction of modern medicine in the 19th century, oral delivery has remained the preferred route for drug administration due to…
Development of a Novel Formulation that Improves Pre-clinical Bioavailability of Tenofovir…
20. December 2016 Abstract Tenofovir disoproxil fumarate (TDF), the bisphosphonate ester prodrug of tenofovir (TFV), has poor bioavailability due to intestinal…
Difference in the Dissolution Behaviors of Tablets Containing Polyvinylpolypyrrolidone (PVPP)…
20. December 2016 Difference in the Dissolution Behaviors of Tablets ContainingPolyvinylpolypyrrolidone (PVPP) Depending on PharmaceuticalFormulation After Storage Under High T…
Crystalline solid dispersion-a strategy to slowdown salt disproportionation in solid state…
20. December 2016 Abstract Salt disproportionation (a conversion from the ionized to the neutral state) in solid formulations is a potential concern during manufacturing…
Encapsulating darunavir nanocrystals within Eudragit L100 using coaxial electrospraying
20. December 2016 Abstract Electrospraying is renowned for its simplicity and versatility, and which can effectively produce particles with well-controlled size, size…
Cellulose Nanocrystal Membranes as Excipients for Drug Delivery Systems
19. December 2016 Abstract: In this work, cellulose nanocrystals (CNCs) were obtained from flax fibers by an acid hydrolysis assisted by sonochemistry in order to reduce…
Diminished segregation in continuous powder mixing
19. December 2016 Abstract Binary powder mixtures with variable segregation tendencies were “mixed” in a tumbling batch blender and in a continuous convective tubular…
Managing Risk in Raw Material Sourcing
19. December 2016 Vendor selection and materials testing are complex enough, but in today’s volatile environment, risk mapping and monitoring are also crucial. Choosing…
Small-Scale Modeling of Pharmaceutical Powder Compression from Tap Density Testers, to Roller…
16. December 2016 Introduction Roller compaction is commonly used in the pharmaceutical industry to improve powder flow and compositional uniformity. The process produces…
Use of Spray-Dried Dispersions in Early Pharmaceutical Development: Theoretical and Practical…
16. December 2016 Abstract Spray-dried dispersions (SDDs) have become an important formulation technology for the pharmaceutical product development of poorly…
Systematic reviews on therapeutic efficacy and safety of Cannabis (including extracts and tinctures)…
16. December 2016 Abstract Cannabis is a generic term used for drugs produced from plants and tinctures belonging to the genus Cannabis and it is the most widely used…
AAPS 2016 Posters by Colorcon
16. December 2016
Utilization of a Moisture Barrier Film Coating to Enhance In-Use Tablet Stability
Plinio Sandoval, David Ferrizzi, Jason Teckoe, Charles Cunningham and Ali Rajabi-Siahboomi
Examination of…
Simulating Different Dosing Scenarios for a Child-Appropriate Valproate ER Formulation in a New…
15. December 2016 Abstract Predictive in vitro test methods addressing the parameters relevant to drug release in the pediatric gastrointestinal tract could be an…
EVALUATION OF CAPRIC GLYCERIDES AS ANTI-TACK AGENT IN COATING FORMULATIONS
15. December 2016 Introduction Talc has been traditionally used as an anti-tack agent in various immediate release and enteric coating formulations. However, it is…
Effects of frequently used pharmaceutical excipients on the organic cation transporters 1–3 and…
15. December 2016 Abstract There is ample evidence that pharmaceutical excipients, which are supposed to be pharmacologically inactive, have an impact on drug metabolism…