Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation
Relaxation tests are often used in the pharmaceutical field to assess the strain rate sensitivity of pharmaceutical powders and tablets. These tests involve applying a constant strain to the powder in the die and then monitoring the stress evolution over time. Interpreting these tests is complicated because different physical phenomena, mainly…
Excipient database: all systems go as US FDA clears backlog
18. November 2016 The US FDA has almost cleared a backlog of 4000 excipient formulations in its Inactive Ingredient Database (IID) and wants drugmakers to help ensure…
Ideal Cures Pvt. Ltd.: Ideal Cures Announces a New Manufacturing Location at Sikkim
17. November 2016 MUMBAI, India--(BUSINESS WIRE)--Ideal Cures Private Limited is pleased to announce the addition of a fourth manufacturing location at Sikkim in India for…
The guiding role of fluidized and spouted bed technologies in the particle building process
17. November 2016
Whitepaper Enhancing Ingredients
Owing to their product-enhancing functions and wide range of application possibilities, fluidized and spouted bed technologies have become established as…
Biopharmaceutical aspects and implications of excipient variability in drug product performance
17. November 2016 Abstract Implementation of Quality by Design approaches in pharmaceutical industry requires a sound understanding of the parameters triggering final…
Solid cellulose nanofiber based foams – Towards facile design of sustained drug delivery systems
17. November 2016 Abstract Control of drug action through formulation is a vital and very challenging topic within pharmaceutical sciences. Cellulose nanofibers (CNF) are…
Ocular Bioadhesives and Their Applications in Ophthalmic Drug Delivery
17. November 2016 Abstract Most ophthalmic illnesses are treated by topical administration of drug in the form of conventional dosage forms (solutions, suspensions, or…
Spray freeze drying as an alternative technique for lyophilization of polymeric and lipid-based…
17. November 2016 Abstract The use of nanoparticles for drug delivery is still restricted by their limited stability when stored in an aqueous medium. Freeze drying is…
Application of ICH Q9 Quality Risk Management Tools for Advanced Development of Hot Melt Coated…
17. November 2016 Abstract This study aimed to apply quality risk management based on the The International Conference on Harmonisation guideline Q9 for the early…
Instantaneous coprecipitation of polymer/drug microparticles using the supercritical assisted…
17. November 2016 Abstract In this work, the supercritical assisted injection in a liquid antisolvent (SAILA) has been proposed as a new technique to produce composite…
Preparation and tableting of long-term stable amorphous rutin using porous silica
17. November 2016
Abstract
Amorphous state of drugs increases the oral bioavailability, but typically faces physical stability problems. Amorphous rutin was generated and physically stabilized by encapsulating inside…
Formulation and Taste Masking of Ranitidine Orally Disintegrating Tablet
17. November 2016 Abstract Orally Disintegrating Tablets (ODT) have the advantages of both solid dosage form specially the stability and ease of handling and liquid…
Formulation and Taste Masking of Ranitidine Orally Disintegrating Tablet
16. November 2016 Orally Disintegrating Tablets (ODT) have the advantages of both solid dosage form specially the stability and ease of handling and liquid dosage forms…
Novel anti-inflammatory liposomal formulation for the pre-ocular tear film: In vitro and ex vivo…
16. November 2016 Abstract In ocular surface inflammatory diseases, such as dry eye disease, long-term symptom relief requires targeting the inflammation itself rather…
Evaluation of glibenclamide microspheres for sustained release
16. November 2016 Context: Sustained release drug delivery systems are more preferred than the conventional drug delivery systems due to its enhanced bioavailability and…
Total Excipient Control (TEC) – IPEC Webinar Dec 14, 2016
15. November 2016
Excipient regulations, guides, position papers, white papers – here’s how it all fits together! Total Excipient Control (TEC) is the culmination of three decades of IPEC efforts - a…
Continuous Manufacturing & Advanced PAT Systems – Dec 13, 2016 in Barcelona
15. November 2016 Continuous Manufacturing & Advanced PAT Systems - Dec 13, 2016 in Barcelona Industrial Workshop at University of Barcelona…
Sodium Stearyl Fumarate (SSF) – alternative high quality source
15. November 2016 Are you interested in an alternative source complying with EP/USP-NF/JP monographs, US FDA DMF, CEP from a cGMP facility? Get in touch with:…
Utilization of Quality by Design Principles to Define Formulation Best Practices for a Direct…
14. November 2016 Introduction: Quality by Design (QbD) initiatives enable pharmaceutical manufacturers to proactively design quality and performance into drug products,…
Prediction of Tablet Dissolution from API and Excipient Polymer Properties
14. November 2016 Purpose: Modified-release (MR) matrix tablets are typically produced using hydroxypropyl methylcellulose (HPMC) as rate-modifying polymer. HPMC…
Current Trends in the Development of Technologies for Matrix Formulations with Modified Release…
13. November 2016 Current aspects of the technology used to create matrix formulations ar presented. The main types of matrix are described depending on their behavior in…
Microcrystalline Cellulose – Does Wood Pulp Source Impact the Direct Compression Performace of This…
13. November 2016 INTRODUCTION In a quality by design (QbD) environment knowledge and understanding of raw material critical quality attributes (CQAs) are essential .…
Celanese Presents Cutting-edge Pharmaceutical Copolymer at 2016 AAPS Annual Meeting &…
11. November 2016
Celanese Presents Cutting-edge Pharmaceutical Copolymer at 2016 AAPS Annual Meeting & Convention
DALLAS and DENVER (November 11, 2016) – Celanese Corporation (NYSE: CE), a global technology…
Formulation development of Glipizide matrix tablet using different proportion of natural and semi…
10. November 2016 Abstract: Increased complications and costs of marketing of innovative drugs focused greater attention to the development of sustained release (SR) or…
Novel Nanoprinting for Oral Delivery of Poorly Soluble Drugs
10. November 2016 Abstract Many of the newly developed drugs for cancer, and some of those for cardiovascular disease, are poorly soluble in water and cannot be taken…
Global experts discuss new approaches and innovations in ocular drug delivery systems
09. November 2016 A special issue on ocular drug delivery just published in the journal Drug Delivery and Translational Research The estimated number of…
POTENTIAL USE OF ETHYLENE VINYL ACETATE COPOLYMER EXCIPIENT IN ORAL CONTROLLED RELEASE APPLICATIONS:…
09. November 2016
Ethylene vinyl acetate (EVA) copolymer has a record of successfully serving the pharmaceutical industry as a controlled release excipient. EVA has shown excellent stability, processability and…
A New Chapter in Pharmaceutical Technology: 3D Printing for Solid Oral Dosage Forms
09. November 2016
A New Chapter in Pharmaceutical Technology: 3D Printing for Solid Oral Dosage Forms
Current developments in technology allow manufacturing of dosage forms by printing. Printing technologies have…
Complication with Order: Understanding the Structure-Property Relationship of Polymers for their…
09. November 2016
Complication with Order: Understanding the Structure-Property Relationship of Polymers for their Application in Drug Delivery
In modern pharmaceutical dosage form design, excipients play a central…
Toxicological assessment of Anionic Methacrylate Copolymer: I. Characterization, bioavailability and…
08. November 2016
Abstract
Anionic Methacrylate Copolymer (AMC) is a fully polymerized copolymer used in the pharmaceutical industry as an enteric/delayed-release coating to permit the pH-dependent release of active…
Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine
08. November 2016 More than 6 million children and adolescents in the United States have migraines.1-3 The majority continue to have headaches into adulthood, taking a toll…
Poly vinyl acetate and ammonio methacrylate copolymer as unconventional polymer blends increase the…
08. November 2016 Abstract The objective was to investigate poly vinyl acetate (Kollicoat® SR 30 D) and ammonio methacrylate copolymer (Eudragit® RL 30 D) blends as…
Correlation between the Viscoelastic Properties of the Gel Layer of Swollen HPMC Matrix Tablets and…
08. November 2016 Abstract Drug release from hydroxypropyl methylcellulose (HPMC) hydrophilic matrix tablets is controlled by drug diffusion through the gel layer of…
Controlled-release oral dosage forms containing nimodipine solid dispersion and hydrophilic carriers
08. November 2016 Abstract The aim of this study was to prepare solid dispersion of nimodipine (NMD) by solvent evaporation method to overcome the poor water solubility…
Solid State Interactions Between Ketoprofen and Excipients in Solid Dosage Forms
08. November 2016
This study assesses the solid-solid interactions between the commercial form of Ketoprofen (KET), a non- steroidal anti-inflammatory drug of the propionic acid class, and several widely used pharmaceutical…