Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Extemporaneous preparation of paediatric oral formulations with sildenafil citrate
The paediatric population is composed of several very diferent subgroups, each with its own specifc characteristics. For this reason, children cannot be considered “small adults”. The development of formulations suitable for children is a…
The era of digital pharmacy. 3D printing – realities and perspectives
3D printing is an innovative technology for building three-dimensional objects by laying down successive layers of material under the control of a computer software. It is entering pharmacy mainly because of its revolutionary potential to…
Anti-Melanoma Activity of Single Intratumoral Injection of ZnPc Micelles Mixed With in situ Gel in…
Photodynamic therapy (PDT) is a potential treatment strategy for melanoma. As a second-generation photosensitizer, Zinc phthalocyanine (ZnPc) has many advantages for anti-tumor PDTs, such as strong absorption in the red and near infrared…
Use of Excipients in Downstream Processing to Improve Protein Purification
Excipients are used to improve the stability of protein-based therapeutics by protecting the protein against a range of stress conditions such as temperature changes, pH changes, or agitation. Similar stresses are applied to proteins during…
QbD-driven development of phospholipid-embedded lipidic nanocarriers of raloxifene: extensive in…
Raloxifene (RLX) is popularly indicated in treatment of osteoporosis and prevention of breast cancer. Owing to its poor aqueous solubility, high pre-systemic metabolism, intestinal glucuronidation, and P-glycoprotein (P-gp) efflux, however,…
Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery:…
Abstract
Oral delivery of peptides and biological molecules promises significant benefits to patients as an alternative to daily injections, but the development of these formulations is challenging due to their low bioavailability and high…
Neusilin Redefining Silica´s Potential in Solid Oral Dosage Forms
Neusilin
WHAT IS IT?
Neusilin® UFL2 is an ultra fine powder of magnesium aluminometasilicate and is widely accepted as a problem solving excipient for oral solid dosage forms.
Make harder tablets and protect it from…
Molecular insights into the aggregation and solubilizing behavior of biocompatible amphiphiles…
A comparative analysis of the micellar and solubilizing properties of two polyethylene glycol (PEG)-based amphiphilic biocompatible excipients: Gelucire® 48/16 (Ge 48/16) and Tetronics® 1304 (T1304), in the presence and absence of salt, was…
SIGACHI Mena FZCO and Saudi National Projects Investment LTD (SNP) Forms Joint Venture to Enter…
Press Release
We are pleased to inform you that Sigachi MENA FZCO, a wholly owned subsidiary of the company, incorporated in Dubai, has announced formation of a Joint Venture (JV), “Sigachi Arabia”, with Saudi National Projects…
Challenges in the Transfer and Scale-Up of Mini-Tableting: Case Study with Losartan Potassium
Mini-tablets (MTs) with losartan potassium were developed to treat the rare disease Epidermolysis Bullosa. The focus was placed on transfer and scale-up of a direct compressible formulation from the compaction simulator STYL’One Evo (CS) to…
Comparative Evaluation of Particle Size Reduction, Salt Formation, and Amorphous Formulation on the…
Various approaches have been developed to enhance the solubility or dissolution rate for the delivery of poorly water-soluble molecules. In this work, guided by an in silico solubility sensitivity analysis for oral absorption, a comparative…
Formulation and in vitro evaluation of pramipexole orally disintegrating tablets for pediatric…
Abstract
In this study, orally disintegrating tablets (ODT) of pramipexole dihydrochloride monohydrate (PPX) was developed with direct compression method by using ready-to-use excipients Parteck® ODT, Pharmaburst® 500, Ludiflash®, F Melt®,…
The influence of directly compressible fillers/diluents on selected compact properties and drug…
Introduction
Direct compression represents a favorable tablet manufacturing method. However, obtaining satisfactory mechanical properties of the compacts and drug dissolution remains a challenge in formulation development, particularly in…
Amorphous solid dispersions: Stability mechanism, design strategy and key production technique of…
Abstract
Solid dispersion (SD) system has been used as an effective formulation strategy to increase in vitro and in vivo performances of poorly water-soluble drugs, such as solubility/dissolution, stability and bioavailability. This…
Fabrication of TPGS decorated Etravirine loaded lipid nanocarriers as a neoteric oral…
Etravirine (ERVN) is a potential NNRTI (non-nucleoside reverse transcriptase inhibitor) in treating HIV infection. It possesses extremely low oral bioavailability. The present research aims to optimize the formulation and characterization…
Development of concentration prediction models for personalized tablet manufacturing using…
Abstract
In this work, concentration prediction models applicable to a very wide range of concentrations for personalized tablet manufacturing were developed using near-infrared (NIR) spectroscopy. Tablet manufacturing experiments were…
Preparation of Sustained Release Formulation of Verapamil Hydrochloride Using Ion Exchange Resins
The purpose of this investigation was to formulate and evaluate the interaction between cation exchange resins and verapamil hydrochloride. The uptake studies were conducted using the rotating bottle apparatus. The Langmuir-like equation…
The synthesis of certain fatty acid ester derivatives of trehalose and an investigation of their…
Bio-based surfactants exerting both functional and nutritional properties are needed in the food industry. This study reports the one-pot synthesis, using a Novozym 435-catalyzed trans-esterification protocol, of a new family of such…
Febuxostat solubilization and stabilization approach using solid dispersion method: Synergistic…
Drug solubilization studies are continuously being conducted. Febuxostat (FBX) has a low solubility in water. This study aims to develop a stable FBX-solid dispersion (SD) formulation using a solvent evaporation method. The solubilization …
Silica nanoparticles: A review of their safety and current strategies to overcome biological…
Abstract
Silica nanoparticles (SNP) have gained tremendous attention in the recent decades. They have been used in many different biomedical fields including diagnosis, biosensing and drug delivery. Medical uses of SNP for anti-cancer,…
A novel cationic arginine-modified Self-Nanoemulsifying drug delivery system (SNEDDS) for improved…
Abstract
Naringin (NRG) is a flavonoid derived from citrus fruits. Despite its pharmacological significance, NRG's therapeutic effectiveness is constrained by its unusual physicochemical characteristics, such as its lower aqueous…
Aptamer-modified chitosan-capped Mesoporous silica nanoparticles for co-delivery of cytarabine and…
Abstract
In this study, surface modified mesoporous silica nanoparticles (MSNs) were prepared for the targeted delivery of the anticancer agents, daunorubicin (DNR) and cytarabine (CTR), against K562 leukemia cancer cell lines. The MSNs…
Development of an Image-based Method for Tablet Microstructure Description and Its Correlation with…
The performance of a pharmaceutical formulation, such as the drug (API) release rate, is significantly influenced by the properties of the materials used, the composition of the final product and the tablet compression process parameters.…
Comparative Study of Isomalt and Co-processed Isomalt
ABSTRACT
Objective: The study aims to compare the tableting qualities of isomalt and co-processed isomalt.
Methodology: Co-processed isomalt prepared by melt granulation method evaluated for flow property, dilution potential, Kawakita…
Evonik launches EUDRACAP® preclinic functional oral capsule for preclinical trials
PRESS RELEASE
Health Care Essen, Germany, October 18, 2023
Expands EUDRACAP® brand with globally available size 9h enteric-coated capsule
Seamless transition from preclinical to first-in-human trials with EUDRACAP® platform…
Solid dispersion technology with porous material – Telmisartan
1. Introduction
Solid dispersion is one of the most effective technologies to improve API characteristics such as solubility, stability, and compressibility. Recently developed small molecule APIs with the aim to higher therapeutic…
Carrageenan tethered ion sensitive smart nanogel containing oleophytocubosomes for improved ocular…
Ophthalmic delivery of luteolin (LU) was studied after formulating a carrageenan-based novel ion-sensitive in situ gel (ISG) incorporating oleophytocubosomes for prolonged ocular residence time and improved ocular bioavailability of the…
The Preparation and Evaluation of Cyanocobalamin Mucoadhesive Sublingual Tablets
Cobalamin (vitamin B12), an essential vitamin with low oral bioavailability, plays a vital role in cellular functions. This research aimed to enhance the absorption of vitamin B12 using sublingual mucoadhesive tablets by increasing the…
Transform Liquid-form Active Ingredient into Powder form with High Performance Liquid Carrier
Introduction
Several major active ingredients for human health, such as vitamin A/D/E/K, DHA/EPA, and natural herbal
extracts are supplied in liquid form. Emulsified powder and microencapsulation were previously known as the
major ways…
Review of the efficacy of nanoparticle-based drug delivery systems for cancer treatment
This review evaluates the literature on nanoparticle-based drug delivery systems for cancer treatment and assesses their efficacy. Nanoparticles have shown potential for improving anticancer agent delivery, reducing systemic toxicity, and…
Strategies to Enhance the Solubility and Bioavailability of Tocotrienols Using Self-Emulsifying Drug…
Abstract
Tocotrienols have higher medicinal value, with multiple sources of evidence showing their biological properties as antioxidant, anti-inflammatory, and osteoprotective compounds. However, tocotrienol bioavailability presents an…
Film Coatings Based on Aqueous Shellac Ammonium Salt “Swanlac® ASL 10” and Inulin for Colon…
Over the past decades, increasing interests took place in the realm of drug delivery systems. Beyond treating intestinal diseases such as inflammatory bowel disease, colon targeting can provide possible applications for oral administration…
Bacteriophage entrapped chitosan microgel for biofilm-mediated poly bacterial infection in burn…
Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) bacteria are most commonly present in burn wound infections. Multidrug resistance (MDR) and biofilm formation make it difficult to treat these infections.…
Comparison of Preservatives Used in Various Therapeutic Applications
CONSIDERATIONS FOR USE OF PRESERVATIVES IN TOPICAL, ORAL, OPHTHALMIC, TRANSMUCOSAL, INJECTABLE, INHALATION, AND OTIC APPLICATIONS
A variety of preservatives can be used in therapeutic applications such as topical, oral, transmucosal,…