Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation
Relaxation tests are often used in the pharmaceutical field to assess the strain rate sensitivity of pharmaceutical powders and tablets. These tests involve applying a constant strain to the powder in the die and then monitoring the stress evolution over time. Interpreting these tests is complicated because different physical phenomena, mainly…
Effect of ionization of drug on drug solubilization in SMEDDS prepared using capmul MCM and Caprylic…
08. November 2016 Abstract The purpose of this study was to investigate the effect of ionization of drug on drug solubilization in SMEDDS (self-microemulsifying drug…
How Deformation Behavior Controls Product Performance After Twin Screw Granulation With High Drug…
08. November 2016 Abstract This study addresses the quantitative influence of 12 different materials (active pharmaceutical ingredients and excipients as surrogate active…
Investigation on drying kinetics and tribocharging behaviour of pharmaceutical granules in a…
08. November 2016 Abstract Among various methods for drying of pharmaceutical granules in the pharmaceutical industry, fluidized bed drying is a frequently used method…
SELF-ASSEMBLED NANOGELS OF HYDROPHOBIZED METHYLCELLULOSE
08. November 2016 ABSTRACT Topical administration is the most common method to deliver ocular therapeutics. However, the eye is highly resistant to foreign…
Pharmacokinetic analysis of modified-release metoprolol formulations: An interspecies comparison
08. November 2016 Abstract In the current study, we investigated the metoprolol absorption kinetics of an in-house produced oral sustained-release formulation, matrices…
Impact of Quality by Design on Topical Product Excipient Suppliers, Part II: Reasonable Expectations
07. November 2016 Abstract Quality by design (QbD) is a scientific and risk-based approach to product development that begins at the product concept stage. This…
Promising transport molecule for steroid medications discovered
07. November 2016 When the word steroids comes up, a lot of people think of doping. It is much less well known that steroids are used in the treatment of many diseases, such…
Can a Flavored Spray (Pill Glide) Help Children Swallow Their Medicines? A Pilot Study
06. November 2016 Abstract Pediatric pharmacists are constantly faced with the challenges of supporting children and caregivers for whom the difficulties of swallowing…
The effect of a lipid composition and a surfactant on the characteristics of the solid lipid…
Abstract
Solid lipid microparticles (SLM) were produced by produced by a two-step process that, firstly, involved the emulsification of the molten lipid phase in a heated aqueous phase and, secondly, the system…
A comprehensive insight on ocular pharmacokinetics
06. November 2016 Abstract The eye is a distinctive organ with protective anatomy and physiology. Several pharmacokinetics compartment models of ocular drug delivery have…
Development of oral site-specific pellets containing flavonoid extract with antioxidant activity
06. November 2016 Abstract Herbal medicines are recognized as an effective treatment of common diseases, mainly associated with oxidative stress. Therefore developing…
Swellable Hydrogel-based Systems for Controlled Drug Delivery
06. November 2016 Abstract The controlled delivery of drugs can be effectively obtained using systems based on hydrogels. Tablets, to be orally administered, represent…
Design and Evaluation of Novel Solid Self-Nanodispersion Delivery System for Andrographolide
05. November 2016 Abstract Poorly water-soluble drugs offer challenges in developing a formulation product with adequate bioavailability. This study took advantage of the…
Dry Powder Inhalers: A Focus on Advancements inNovel Drug Delivery Systems
05. November 2016 Dry Powder Inhalers: A Focus on Advancements inNovel Drug Delivery Systems Administration of drug molecules by inhalation route for treatment of respiratory…
Lipid-based nanocarriers for the oral administration of biopharmaceutics
05. November 2016 Biopharmaceutics have been recognized as the drugs of choice for the treatment of several diseases, mainly due to their high selectivity and potent action.…
THE APPLICATION OF SEMI-SYNTHETIC BIOPOLYMER NANO-CARRIER COMPLEXES FOR DRUGS WITH LOW ORAL…
05. November 2016 THE APPLICATION OF SEMI-SYNTHETIC BIOPOLYMER NANO-CARRIER COMPLEXES FOR DRUGS WITH LOW ORAL BIOAVAILABILITY The major challenge in pharmaceutical…
Current Status and New Perspectives on Chitin and Chitosan as Functional Biopolymers
05. November 2016 Abstract The natural biopolymer chitin and its deacetylated product chitosan are found abundantly in nature as structural building blocks and are used…
The Future of 3D Printing in Pharma, Medical Devices
05. November 2016 The concept seems like magic—a few strokes of a printer and a prescription medication or a customized medical device is available at your fingertips. Yet…
Modified biomolecule as potential vehicle for buccal delivery of doxepin
04. November 2016 Aim: Doxepin is a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa. Doxepin is one…
γ-Cyclodextrin
04. November 2016 γ-Cyclodextrin (γCD) is a cyclic oligosaccharide formed by bacterial digestion of starch and used as solubilizing agent and stabilizer in a variety of…
Printed Drug-Delivery Systems for Improved Patient Treatment
04. November 2016 The use of various types of printing technologies offer potential solutions for personalized medicine and tailored dosage forms to meet the needs of…
Formulation and evaluation of chitosan/polyethylene oxide nanofibers loaded with metronidazole for…
04. November 2016 Abstract Nanofibers combined with an antimicrobial represent a powerful strategy for treatment of various infections. Local infections usually have a…
Utilization of chitosan-caged liposomes to push the boundaries of therapeutic delivery
30. October 2016 Abstract Liposomes are self-assembled bilayer vesicles which have attracted a great deal of interest as potential carriers for a wide range of…
Gellan Gum Fluid Gels for Topical Administration of Diclofenac
30. October 2016
Abstract
Diclofenac topical formulations are often preferred for drug administration to patients who experience serious GIT problems. Absorption of the drug through the skin, however, can be challenging…
Formulation, functional evaluation and ex vivo performance of thermoresponsive soluble gels
27. October 2016 Formulation, functional evaluation and ex vivo performance of thermoresponsive soluble gels - A platform for therapeutic delivery to mucosal sinus tissue…
Accelerated oral nanomedicine discovery from miniaturized screening to clinical production…
27. October 2016 Considerable scope exists to vary the physical and chemical properties of nanoparticles, with subsequent impact on biological interactions; however, no…
A top coating strategy with highly bonding polymers to enable direct tableting of multiple unit…
27. October 2016 Abstract Multiple unit pellet system(s), MUPS, is one of the most commonly used means for achieving modified drug release through oral administration.…
Materials and methods for delivery of biological drugs
27. October 2016 Biological drugs generated via recombinant techniques are uniquely positioned due to their high potency and high selectivity of action. The major drawback…
Control of Globular Protein Thermal Stability in Aqueous Formulations by the Positively Charged…
27. October 2016 Abstract The positively charged amino acids are commonly used excipients in biopharmaceutical formulations for stabilization of therapeutic proteins, yet…
Excipients for Formulation Success
27. October 2016 Excipients play a crucial role in the manufacturing of solid-dosage forms and the performance of the finished drug product. Excipients are typically the…
Parenteral preparations, challenges in formulations
The article describes the main challenges encountered during the formulation of parenteral preparations, as well as Roquette’s solutions meeting the formulator’s needs.
Author: Dr Elham Blouet, Global market manager…
CFDA Order 134 – Quite a Bundle for Excipient Makers Selling into China
26. October 2016 Chinese FDA (CFDA) Order 134 "Matters Concerning Bundling Review and Approval of Pharmaceutical Packaging Materials, Pharmaceutical Excipients and Drugs"…
Drug Product Development for Older Adults—Multiparticulate Formulations
26. October 2016 Abstract The multiparticulate drug product concept covering micropellets, pellets, and mini-tablets is presented as a highly feasible approach to present…
Ashland opens Nanjing excipient plant citing growing local demand in light of new quality…
25. October 2016
Ashland has opened a pharmaceutical excipients plant in Nanjing, China in a bid to capture growing local demand for modern formulation technologies.
Read more here: …