Virtual screening of drug materials for pharmaceutical tablet manufacturability with reference to sticking
Abstract
The manufacturing of pharmaceutical solid dosage forms, such as tablets involves a large number of successive processing operations including crystallisation of the drug substance, granulation, drying, milling, mixing of the formulation, and compaction. Each step is fraught with manufacturing problems. Undesired adhesion of powders to…
Formulation and evaluation studies of BSA loaded chitosan nanoparticles by polymerization technique
17. July 2016 Abstract Aim: To prepare BSA loaded chitosan nanoparticles by polymerization technique and to study the effect of initiator concentration upon particle…
Electrospun fibers as potential carrier systems for enhanced drug release of perphenazine
17. July 2016
Abstract
Solubility represents an important challenge for formulation of drugs, because the therapeutic efficacy of a drug depends on the bioavailability and ultimately on its solubility. Low aqueous…
Crush resistance and insufflation potential of poly(ethylene oxide)-based abuse deterrent…
17. July 2016 Abstract Objectives: This study was conducted to evaluate suitable methods of testing crush-resistant tablets composed largely of thermoplastic polymers.…
Join The Dialogue: Do We Need an Excipient Classification System Based on Their Traditional and…
17. July 2016
The currently available list of excipients in the market is unending. They include diverse classes of small molecules and macromolecules of natural or semi-synthetic origin, and they represent all states of…
PAT – THE KEY TO A BETTER PROCESS
15. July 2016
Process analysis technology permeates every aspect of pharmaceutical production - Improved process understanding, higher process reliability, and fewer rejects: PAT techniques can achieve all this and…
Design and evaluation of buccal films as paediatric dosage form for transmucosal delivery of…
14. June 2016 In the process of implementation and innovation of paediatric dosage forms, buccal films for transmucosal administration of drug represent one of the most…
Heat sealing property of starch based self-supporting edible films
14. June 2016 Heat sealing property of self-supporting edible films based on corn starch and a functional polysaccharide, such as amylose (AM), methylcellulose (MC) or…
Adsorption and release studies of cefuroxime sodium from acrylic ion exchange resin microparticles…
14. June 2016 Two types of microparticles based on acrylic ion exchange resin were prepared and used as macro-molecular supports for the adsorption of an antibiotic…
Lubricant-Induced Crystallization of Itraconazole From Tablets Made of Electrospun Amorphous Solid…
14. June 2016
Abstract
Investigation of downstream processing of nanofibrous amorphous solid dispersions to generate tablet formulation is in a quite early phase. Development of high speed electrospinning…
Preparation of Enteric Coated Pellets Containing Lansoprazole Using Extrusion/Spheronization…
14. June 2016 Preparation of Enteric Coated Pellets Containing Lansoprazole Using Extrusion/Spheronization Technique Abstract Lansoprazole degrades rapidly in an…
9. Swiss Pharma Science Day 2016
14. June 2016 Wednesday August 31, 2016 Inselspital-University Hospital Bern Keynote Lecture Prof. Dr. Johannes Khinast, Graz University of…
Ideal Cures Pvt. Ltd.: Mike Easterbrook joins Ideal Cures Private Limited as the Chief Technical…
14. June 2016 June 14, 2016 09:04 AM Eastern Daylight Time MUMBAI, India--(BUSINESS WIRE)--Ideal Cures Private Limited, announces the appointment of Mr. Mike Easterbrook…
Bringing Poorly Soluble Molecules to Market with Bioavailability Enhancement Technologies
14. July 2016 According to the popularly cited study from Tufts Center for the Study of Drug Development, it costs $2.6 billion to receive a drug approval.1 Despite the…
Meggle Excipients: A maximum of functionality by an optimized and broad product portfolio
14. July 2016 An Interview With... Dr. Egmont G. Pfeifer and Dr. Albrecht Krämer of MEGGLE Group What are the most important features of a “successful…
Merck Expands Excipients Portfolio, Adding Polymers for Sustained Release Injectables
Darmstadt, Germany, July 12, 2016 — Merck, a leading science and technology company, has entered into an agreement with PCAS S.A. (Longjumeau, France) to expand Merck’s excipients portfolio. Under the agreement, Merck will be the exclusive,…
Preparation, Optimization and Characterization of Eudragit Coated Chitosan Piroxicam Microspheres…
14. July 2016 Preparation, Optimization and Characterization of Eudragit Coated ChitosanPiroxicam Microspheres Intended for the Treatment of Rheumatoid Arthritis As a novel…
Rational excipient selection for co-amorphous formulations
12. June 2016 Introduction: For almost two decades there has been intense debate about whether the amorphous solid state form could resolve the solubility problems and…
Huber Announces New Innovative Packaging Launch For Precipitated Amorphous Silica
12. July 2016 ATLANTA, GA, July 12, 2016 – Huber Engineered Materials, a division of J.M. Huber Corporation, announces the launch of a new packaging concept implemented at…
Taking On Mission Insoluble with Polymers
12. July 2016 Industry experts explain why polymer structures and functionalities are important considerations in formulation development. Poor solubility is one of the…
The importance of lipid screening in the development of lipid-based formulations
12. July 2016 Lipid-based drug delivery is increasingly being used to tackle oral bioavailability challenges resulting from poor solubility. This type of formulation…
Customizing HPMC to Minimize Drug Variability
12. July 2016 The authors evaluated the performance and robustness of controlled-release tablets made with HPMC blends of unimodal and bimodal molecular weight distribution.…
The Medicine Maker – Colorcon: Formulatingfor the PerfectTablet Finish
11. July 2016 The Medicine Maker - Colorcon: Formulatingfor the PerfectTablet Finish When it comes to film coating, there’s more than meets the eye. Is the…
New aspects of developing a dry powder inhalation formulation applying the quality-by-design…
10. July 2016 Abstract The current work outlines the application of an up-to-date and regulatory-based pharmaceutical quality management method, applied as a new…
Ginger Orally Disintegrating Tablets to Improve Swallowing in Older People
10. July 2016 We previously prepared and pharmaceutically evaluated ginger orally disintegrating (OD) tablets, opti- mized the base formulation, and carried out a clinical…
Development of cationic nanocrystals for ocular delivery
10. July 2016 A cationic nanocrystal formulation containing dexamethasone acetate nanocrystals (0.05%) and polymyxin B (0.10%) for ophthalmic application was produced using…
A novel ph–enzyme-dependent melamine colon-specific delivery system
10. July 2016 Abstract: The aim of the present study was to design a new pH–enzyme double-dependent mesalamine colon-specific delivery system. The drug release behaviors in…
Formulation and Evaluation of Fast Dissolving Oral Films of Diazepam
08. July 2016 Ali MS, Vijendar C, Sudheer Kumar D and Krishnaveni J*Department of…
HEAT ACTIVATED DRY GRANULATION WITHIN THE TWIN SCREW GRANULATOR
08. July 2016 Abstract This paper highlights preliminary results related to a new dry granulation process that is run in a twin-screw extruder. This heat-activated dry…
When it Comes to Dietary Supplements, it’s Buyer Beware
08. July 2018 The dietary supplements industry is one of the largest direct-to-consumer health products industry in the country. A 2017 survey commissioned by the Council…
Evaluation of the Impact of Excipients and an Albendazole Salt on Albendazole Concentrations in…
07. July 2016 Abstract An in vitro biorelevant gastrointestinal transfer (BioGIT) system was assessed for its ability to mimic recently reported albendazole…
Evaluation of a film-coating system for heat sensitive products
07. July 2016 Evaluation of a film-coating system for heat sensitive products Evaluation of a…
Ph. Eur. Commission adopts revised general chapter on monocyte activation test to facilitate…
07. July 2016 During its 155th Session, held in Strasbourg on 21-22 June 2016, the European Pharmacopoeia Commission adopted a revision of the general chapter…
New Vice-chairs of the European Pharmacopoeia Commission elected
07. July 2016 During its 155th session, which took place on 21-22 June, the European Pharmacopoeia (Ph. Eur.) Commission elected Prof. Torbjörn Arvidsson (Sweden) and Dr…
Application of water-insoluble polymers to orally disintegrating tablets treated by high-pressure…
06. July 2016 Abstract The phase transition of pharmaceutical excipients that can be induced by humidifying or heating is well-known to increase the hardness of orally…