Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Preparation and Characterization of Prednisolone Acetate Microemulsion for Ophthalmic Use
Abstract
Background: Prednisolone acetate is an ester form of prednisolone. It is used topically as an ophthalmic suspension to treat many inflammatory ocular conditions, where its absorption from suspension is highly variable and has poor…
Selective anomer crystallization from aqueous solution: Monitoring lactose recovery under…
Lactose is typically produced via cooling crystallization either from whey(-permeate) (edible-grade) or from aqueous solution (pharmaceutical-grade). While in solution, lactose is present in 2 anomeric forms, α- and β-lactose. During…
Formulation and In Vitro Evaluation of Taste- Masked Prednisolone Orodispersible Tablets
Abstract
Background: Prednisolone is a corticosteroid with a very bitter taste acts as anti- anti-inflammatory and immune suppressant drug and it is used at any age.
Objective: To improve patient compliance by masking the bitter taste…
Polyenylphosphatidylcholines as bioactive excipient in tablets for the treatment of liver fibrosis
Liver fibrosis is a condition characterized by the accumulation of extracellular matrix (ECM) arising from the myofibroblastic transdifferentiation of hepatic stellate cells (HSCs) occurring as the natural response to liver damage. To date,…
Enhanced Anti-Herpetic Activity of Valacyclovir Loaded in Sulfobutyl-ether-β-cyclodextrin-decorated…
Valacyclovir (VACV) was developed as a prodrug of the most common anti-herpetic drug Acyclovir (ACV), aiming to enhance its bioavailability. Nevertheless, prolonged VACV oral treatment may lead to the development of important side effects.…
Revisiting the Landscape of Potential Small and Drug Substance Related Nitrosamines in…
N-Nitrosamines are a class of indirect acting mutagens, as their metabolic degradation leads to the formation of the DNA-alkylating diazonium ion. Following up on the in-silico identification of thousands of nitrosamines that can…
Shell Formulation in Soft Gelatin Capsules: Design and Characterization
Soft gelatin capsules are the most widely used pharmaceutical form after tablets. The active components, active pharmaceutical ingredients or nutrients are dissolved or suspended in a liquid or semi-solid fill, which is covered with a…
A coronavirus-mimic mesoporous silica nanosystem enables efficient targeted delivery of siRNA for…
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a threat to human beings' health. However, there is still a lack of effective specific antiviral drugs for SARS-CoV-2 at present, which calls for the…
Recent Progress in Diatom Biosilica: A Natural Nanoporous Silica Material as Sustained Release…
Abstract
A drug delivery system (DDS) is a useful technology that efficiently delivers a target drug to a patient’s specific diseased tissue with minimal side effects. DDS is a convergence of several areas of study, comprising pharmacy,…
How a suction cup delivers medications to the bloodstream
Researchers at ETH Zurich have developed a suction cup that allows medications to be absorbed through the mucosal lining of the cheeks. This new approach could spare millions of patients the pain and fear associated with injections.
Many…
Influence of Poloxamer 188 on Anti-Inflammatory and Analgesic Effects of Diclofenac-loaded…
Abstract
In this study, a polymer-stabilized nanoemulsion (PNE) was developed to improve the inflammatory and analgesic activities of diclofenac (DA). DA-PNEs were prepared from sesame oil and poloxamer 188 (P188), polysorbate 80, and span…
Niosomes for nose-to-brain delivery: A non-invasive versatile carrier system for drug delivery in…
Neurodegenerative diseases (NDDs) significantly contribute to morbidity and mortality worldwide. The suboptimal effect of currently used therapeutic approaches administered via oral and parenteral routes for treatment of NDDs is mainly due…
Biocompatible hydroxy double salt tablet formulations
Generally, commercial extended release tablets are core-based, which can cause problems for certain patients if they split them prior to ingestion. There is a need to develop non-core-based extended release tablets. We have previously…
Nitrosamine acceptable intakes should consider variation in molecular weight: The implication of…
N-nitrosamines (NAs) are a class of compounds of which many, especially of the small dialkyl type, are indirect acting DNA alkylating mutagens. Their presence in pharmaceuticals is subject to very strict acceptable daily intake (AI) limits,…
Study of Microcrystalline Cellulose as a Substitute of Magnesium Stearate Towards Functionality of…
Abstract
In pharmaceutical industries, magnesium stearate is used as a lubricating agent. It is frequently used in the solid dosage forms. In solid dosage forms generally it is used in the concentration of 0.2 % to 2.0%. However, it…
Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies
Abstract
The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist, they come with challenges such as a heavy pill…
Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and…
Monoclonal antibodies (mAbs) hold promise for treating Parkinson's disease (PD), but their therapeutic use is hindered by poor delivery to the brain. In this study, we demonstrate that brain-targeted liposomes (BTL) enhance the delivery of…
Controlled release mechanism of thymol loaded into mesoporous silica nanoparticles for active…
In order to overcome the poor water solubility and instability of thymol to enhance its bioavailability, mesoporous silica nanoparticles (MSNPs: SBA-15, SBA-16 and MCM-41) with different pore structures were developed using solution-gel…
Challenges in Permeability Assessment for Oral Drug Product Development
Drug permeation across the intestinal epithelium is a prerequisite for successful oral drug delivery. The increased interest in oral administration of peptides, as well as poorly soluble and poorly permeable compounds such as drugs for…
Permeation-Enhancing Strategies for Transdermal Delivery of Cannabinoids
Introduction:
This review aims to provide an overview of the advancements and status of clinical studies and potential permeation-enhancing strategies in the transdermal delivery of cannabinoids.
Methods:
A systematic and comprehensive…
Preparation and formula optimization of cephalexin loaded transferosomal gel by QbD to enhance the…
Most antibiotics used in topical formulations are not absorbed by deeper skin layers and subdermal tissues. Hence the skin infections are treated with large doses of oral or parenteral antibiotics which lead to unpleasant side effects with…
Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical…
Abstract
Introduction
Tablets are commonly produced by internally adding particulate lubricants, which are known to possibly lower the mechanical strength of tablets. This reduction is caused by the coverage of matrix forming components…
Optimization of radial extrusion and pellet coating processes using pat approaches
FDA's initiative Pharmaceutical CGMPs for the 21st century opened the door for introduction of several risk based approaches in pharmaceutical industry. One significant advancement that has emerged is the implementation of process…
Nagase/Hayashibara will be attending the AAPS 2023 PharmSci 360 in Orlando
Press release
Nagase/Hayashibara will be attending the AAPS 2023 PharmSci 360 in Orlando, FL, USA.
AAPS 2023 PharmSci 360 in Orlando, FL, Orange County Convention Center
Nagase/Hayashibara Booth #3046
Poster Session M0930-04-23,…
Revolutionizing Drug Formulation Development: The Increasing Impact of Machine Learning
Abstract
Over the past few years, the adoption of machine learning (ML) techniques has rapidly expanded across many fields of research including formulation science. At the same time, the use of lipid nanoparticles to enable the successful…
Structural modifications for the conversion of proteins and peptides into stable dried powder…
The drying of biomolecules into powdered formulations has become the main form of long-term product stabilisation, allowing for the delivery of safe and efficient medicines. Stability of proteins and peptides during the drying process is…
Lactalis Ingredients Pharma enters the excipients market with reliable pharmaceutical grade lactose
PRESS RELEASE
Our Story and Mission
Lactalis Ingredients was born with the certitude that every drop of milk is a source of innovation and inspiration. As an expert in high-value dairy ingredients with an experience of over 50 years, we…
Quantification of Soluplus® and copovidone polymers in dissolution media: Critical systematic review
Polymer-based solid dispersions including amorphous solid dispersions (ASD) are viable strategies to enhance the release of poorly soluble drugs. The concurrency of the drug and polymer release and the concentration of polymer in…
USP-NF: Proposed Revisions to Polyethylene Glycol Monograph and Call for Stakeholder Feedback
The United States Pharmacopeial Convention (USP) develops and regularly updates USP–NF (United States Pharmacopeia and the National Formular) standards via a distinctive collaborative process that engages pharmaceutical scientists from…
Flow behavior under shear cell analysis of two HMPC grades
Abstract
A comparative analysis was conducted to examine the flow characteristics of two HPMC grades and their fractions. Excipients processing contains critical steps in the manufacturing of solid dosage forms and therefore it is…
Immediate-release dosage form; focus on disintegrants use as a promising excipient
Disintegrants are materials or mixtures of substances added in the drug formulations, which make easier dispersion or breakup of tablets and ingredients of capsules in small-scale particles for fast dissolution then it comes in contact with…
Boosting systemic absorption of peptides with a bioinspired buccal-stretching patch
Biopharmaceuticals, including proteins and peptides, have revolutionized the treatment of a wide range of diseases, from diabetes and cardiovascular disorders to virus infections and cancer. Despite their efficacy, most of these…
Microneedle-based biosensing
Microneedles (MNs) are microscopic needles that are applied to the skin in a minimally invasive way to facilitate transdermal drug delivery and/or uptake of interstitial fluid from the skin, which contains a variety of metabolites that can…
The influence of hydrogen bonding between different crystallization tendency drugs and PVPVA on the…
Abstract
Amorphous solid dispersion (ASD) is one of the formulation strategies for drugs displaying low solubility and low oral bioavailability. In this study, high drug-loaded ASDs of drugs with different crystallization tendencies were…