Virtual screening of drug materials for pharmaceutical tablet manufacturability with reference to sticking
Abstract
The manufacturing of pharmaceutical solid dosage forms, such as tablets involves a large number of successive processing operations including crystallisation of the drug substance, granulation, drying, milling, mixing of the formulation, and compaction. Each step is fraught with manufacturing problems. Undesired adhesion of powders to…
Defining Patient Centric Pharmaceutical Drug Product Design
24. June 2016 Abstract The term “patient centered,” “patient centric,” or “patient centricity” is increasingly used in the scientific literature in a wide variety of…
Development and In Vitro Evaluation of Zeta Potential Changing Self-Emulsifying Drug Delivery…
24. June 2016 Abstract The aim of this study was the development of zeta potential changing self-emulsifying drug delivery systems (SEDDS). Various cationic surfactants…
Development and Evaluation of Matrix Tablet by Taking New Chemicals Combination of Chitosan and…
24. June 2016 ABSTRACT Objective: The objective of this study is to develop extended release matrix tablet by taking mixture of chitosan and anionic polymers and then to…
Charge changing phosphorylated polymers: Proof of in situ mucoadhesive properties
23. June 2016 Abstract The objective of this study was to design a novel polyethylene glycol (PEG) derivative exhibiting mucus permeating and mucoadhesive properties.…
Intestinal permeation enhancers for oral peptide delivery
23. June 2016
Abstract
Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation enhancement action…
Preparation of an oral acetaminophen film that is expected to improve medication administration:…
22. June 2016 Summary This study investigated the effect of polyvinylpyrrolidone (PVP) on a film containing carboxymethyl cellulose sodium (CMC) as a matrix to improve…
Bioavailability Improvement Strategies for Poorly Water-Soluble Drugs Based on the Supersaturation…
22. June 2016 Bioavailability Improvement Strategies for Poorly Water-Soluble Drugs Based on the Supersaturation Mechanism: An Update ABSTRACT - The formulation…
Influences of copolymers (Copovidone, Eudragit® RL PO and Kollicoat® MAE 30 DP) on stability and…
21. June 2016 Abstract Protein stability is the most crucial factor in protein pharmaceutical preparations. Various techniques were applied for producing stable protein…
Can dosage form-dependent food effects be predicted using biorelevant dissolution tests? Case…
21. June 2016 Aims Food intake is known to have various effects on gastrointestinal luminal conditions in terms of transit times, hydrodynamic forces and/or luminal…
Mucoadhesive microparticles for local treatment of gastrointestinal diseases
21. June 2016 Abstract Mucoadhesive microparticles formulated in a capsule and delivered to the gastrointestinal tract might be useful for local drug delivery. However,…
The application of povidone in the preparation of modified release tablets
21. June 2016 Abstract The aim of the study was to investigate the modified release of a model substance, of tablets containing different types of Kollidon and particular…
“Back to the Future”: A New Look at Hydroxypropyl Beta-Cyclodextrins
20. June 2016 Abstract Since the discovery about 30 years ago (2-hydroxypropyl) beta-cyclodextrin, a highly soluble derivative of beta-cyclodextrin, has become an…
Totally S-protected hyaluronic acid: evaluation of stability and mucoadhesive properties as liquid…
20. June 2016 AIM It is the aim of this study to synthesize hyaluronic acid (HA) derivatives bearing mucoadhesive properties and showing prolonged stability at pH 7.4 and…
Formulation and evaluation of bioadhesive drug delivery system
20. June 2016 ABSTRACT Objective: The objective of the work is to formulate gliclazide bioadhesive tablets that will significantly improve the availability of the drug…
Design of binary polymeric platforms containing ɩ-carrageenan and hydroxypropylcellulose for use in…
20. June 2016 Highlights • Ophthalmic viscoelastic devices (OVDs) were designed composed of HPC and ɩ-carrageenan (Carr). • The rheological and compressional…
Pulsatile drug delivery system using core-in-cup approach: a review
20. June 2016
Abstract
Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the obvious advantages of oral route of drug administration. Such systems release the…
Buccal Dosage Forms: General Considerations for Pediatric Patients
20. June 2016 ABSTRACT The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution…
Spray-dried amorphous isomalt and melibiose, two potential protein-stabilizing excipients
20. June 2016
Abstract
The possibility of producing amorphous isomalt and melibiose by spray drying was studied. The impact of process parameters on yield and solid-state stability was compared to sucrose and trehalose. All…
Robust Tableting Excipient: Starch-Lactose Compound
17. June 2016
A robust excipient, STARLAC® could be considered as perfect filler binder for direct compression applications, combining fast tablet disintegration with easy tableting.
The co-processed starch-lactose…
Water mediated solid statetransformations of a polymorphic drug –effect on pharmaceutical…
17. June 2016 Water mediated solid statetransformations of a polymorphic drug –effect on pharmaceutical productperformance 1. INTRODUCTION Many drugs can exist in…
“COMPARATIVE STUDY OF THREE GRANULATION TECHNIQUES: MOISTURE ASSISTED GRANULATION TECHNIQUE, ROLLER…
17. June 2016 Abstract Three granulation processing methods; Hot melt extrusion (HME), Roller compaction Dry granulation (RCDG) and Moisture assisted dry granulation…
Application of freeze-drying in the development of oral drug delivery systems
17. June 2016 Introduction: With continual focus on oral drug delivery systems (ODDS), the role of freeze-drying becomes increasingly valuable. While freeze-drying is…
Recent Advances in Drug Delivery and Solubility Enhancement Based on Cellulosic Polymers –…
17. June 2016
Recent Advances in Drug Delivery and Solubility Enhancement Based on Cellulosic Polymers - Second Scientific Seminar in North America
Recent Advances in Drug Delivery and Solubility Enhancement Based…
The use of captisol (SBE7-β-CD) in oral solubility-enabling formulations: Comparison to HPβCD and…
16. June 2016 Abstract The aim of this research was to study the interaction of sulfobutyl ether7 β-cyclodextrin (captisol) and 2-hydroxypropyl-β-cyclodextrin (HPβCD)…
Multipoint Spectroscopy and Stereoscopic Imagingof Pharmaceutical Particles
16. June 2016 Multipoint Spectroscopy and Stereoscopic Imagingof Pharmaceutical Particles Abstract Particle and granule properties play a key role in the final product…
Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet…
15. June 2016 Context: The negative impact of magnesium stearate on the hardness of tablets is a well-known phenomenon, but the influence of paddle movement in the forced…
Captisol 20g free sample – Captisol a uniquely modified cyclodextrin
15. June 2016 Captisol 20g free sample - Captisol a uniquely modified cyclodextrin Greetings, We are offering a free 20g starter kit of Captisol. To receive…
Recent advances in abuse-deterrent technologies for the delivery of opioids
15. June 2016 Abstract Over the past decade, the abuse of prescription opioid drugs has become a national health crisis in the United States. Pharmaceutical companies,…
Terahertz study on porosity and mass fraction of active pharmaceutical ingredient of pharmaceutical…
15. June 2016 Abstract In this study, terahertz time-domain spectroscopic (THz-TDS) technique has been used to ascertain the change in the optical properties, as a…
Initial Drug Dissolution from Amorphous Solid Dispersions Controlled by Polymer Dissolution and…
15. June 2016 Purpose To identify the key formulation factors controlling the initial drug and polymer dissolution rates from an amorphous solid dispersion (ASD).…
Thin films as an emerging platform for drug delivery
13. June 2016 Pharmaceutical scientists throughout the world are trying to explore thin films as a novel drug delivery tool. Thin films have been identified as an…
Dissolution enhancement of tadalafil by liquisolid technique
13. June 2016
This study aimed to enhance the dissolution of tadalafil, a poorly water-soluble drug by applying liquisolid technique. The effects of two critical formulation variables, namely drug concentration (17.5% and…
Pore blocking: An innovative formulation strategy for the design of alcohol resistant…
13. June 2016 In this work calcium stearate (CaSt) multi-particulates loaded with codeine phosphate (COP) were developed in an attempt to provide extended release (ER)…
Nordic Life Science Days 2016
13. June 2016 14-15 September 2016 Stockholm Waterfront Information & Registration