Virtual screening of drug materials for pharmaceutical tablet manufacturability with reference to sticking
Abstract
The manufacturing of pharmaceutical solid dosage forms, such as tablets involves a large number of successive processing operations including crystallisation of the drug substance, granulation, drying, milling, mixing of the formulation, and compaction. Each step is fraught with manufacturing problems. Undesired adhesion of powders to…
Influence of relative humidity during coating on polymer deposition and film formation
13. June 2016 The influence of relative humidity in the pan during coating on polymer deposition and film formation was investigated. Four tablet substrates, differing in…
Phosphated crosslinked pectin as a potential excipient for specific drug delivery: preparation and…
13. June 2016 Pectin was chemically modified with different amounts of trisodium trimetaphosphate (STMP) in aqueous solution (pH = 12), thereby giving a material with…
The role of the carrier in the formulation of pharmaceutical solid dispersions. Part II: amorphous…
12. June 2016 Introduction: Amorphous solid dispersions are considered as one of the most powerful strategies to formulate poorly soluble drugs. They are made up of an…
From Single Excipients to Dual Excipient Platforms in Dry Powder Inhaler Products
09. June 2016 Recent years have seen a marked diversification of excipient based formulation strategies used for the development and commercialisation of dry powder inhaler…
Preactivated thiolated pullulan as a versatile excipient for mucosal drug targeting
09. June 2016 Aim The purpose of the present study was to generate a novel mucoadhesive thiolated pullulan with protected thiol moieties and to evaluate its suitability…
Hollow mesoporous silica as a high drug loading carrier for regulation insoluble drug release
09. June 2016 Highlights Hollow mesoporous silica was synthesized using hard template phenolic resin nanoparticles with the aid of cetyltrimethyl ammonium bromide…
Encapsulation of active ingredients in polysaccharide-protein complex coacervates
09. June 2016 Polysaccharide-protein complex coacervates are amongst the leading pair of biopolymer systems that has been used over the past decades for encapsulation of…
Beyond Keeping Up Appearances – Film coatings
09. June 2016 You have the perfect drug and the right packaging to protect it. All is well until the medication reaches the patient, who habitually pops the tablets into…
Essential medicines containing ethanol elevate blood acetaldehyde concentrations in neonates
08. June 2016 Essential medicines containing ethanol elevate blood acetaldehyde concentrations in neonates Abstract Neonates administered ethanol-containing…
Transparent computational intelligence models for pharmaceutical tableting process
08. June 2016 Purpose: Pharmaceutical industry is tightly regulated owing to health concerns. Over the years, the use of computational intelligence (CI) tools has…
Novel isotretinoin microemulsion-based gel for targeted topicaltherapy of acne: formulation…
08. June 2016 Isotretinoin was formulated in novel micro emulsion based gel formulation with the aim of improving its solubility, skin tolerability, therapeutic…
Enhancement of dissolution rate and intestinal stability of candesartan cilexitil
08. June 2016 The objective of this work was to improve the dissolution rate of candesartan cilexitil, a poorly water soluble prodrug and to reduce its premature degradation…
Identification of Protein–Excipient Interaction Hotspots Using Computational Approaches
08. June 2016 Identification of Protein–Excipient Interaction Hotspots Using Computational Approaches Abstract: Protein formulation development relies on the selection…
Solid Dispersion of Curcumin as Polymeric Films for Bioenhancement and Improved Therapy of…
04. June 2016 Purpose The aim of our study was development of advanced third generation Curcumin self microemulsifying composition solid dispersion (Cur SMEC-SD) with…
Differential Effects of Commercial-Grade and Purified Poloxamer 188 on Renal Function
07. June 2016 Abstract Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer with hemorheologic, antithrombotic, anti-inflammatory, and cytoprotective…
Solvent-Free Melting Techniques for the Preparationof Lipid-Based Solid Oral Formulations
07. June 2016 ABSTRACT Lipid excipients are applied for numerous purposes such as taste masking, controlled release, improvement of swallowability and moisture…
The Effect of Excipients on the Permeability of BCS Class III Compounds and Implications for…
07. June 2016 Purpose Currently, the FDA allows biowaivers for Class I (high solubility and high permeability) and Class III (high solubility and low permeability)…
Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients
07. June 2016 Purpose To investigate if drug solubility in pharmaceutical excipients used in lipid based formulations (LBFs) can be predicted from physicochemical…
Pediatric Dispersible Tablets: a Modular Approach for Rapid Prototyping
07. June 2016 Purpose The design of pediatric formulations is challenging. Solid dosage forms for children have to meet the needs of different ages, e.g. high number of…
Compatibility studies of hydrocortisone with excipients using thermogravimetric analysis supported…
06. June 2016 Application of thermogravimetry (TG) alone to study compatibility/incompatibility of active pharmaceutical ingredients (APIs) with excipients yields to…
Successful management of allergy to the insulin excipient metacresol in a child with type 1…
06. June 2016 Introduction: Insulin allergy to human insulin preparations during the treatment of diabetes is suggested to occur at rates ranging from <1.0% to 2.4%.…
Unveiling the compatibility of eugenol with formulation excipients by systematic drug-excipient…
06. June 2016 Background: The drug-excipient compatibility studies were carried out with the possible excipients viz. Tween 80, Carbopol 940, chitosan, sodium alginate, and…
The Molecular Chaperone α-Crystallin as an Excipient in an Insulin Formulation – Research…
06. June 2016 Purpose To investigate insulin fibrillation under accelerated stress conditions in the presence of a novel excipient, the molecular chaperone…
Identification of Protein-Excipient Interaction Hotspots Using Computational Approaches
05. June 2016 Protein formulation development relies on the selection of excipients that inhibit protein-protein interactions preventing aggregation. Empirical strategies…
CRS Annual Meeting & Exposition July 17-20 in Seattle
05. June 2016 CRS Annual Meeting & Exposition July 17-20 in Seattle Information & Registration…
Surface tension examination of variousliquid oral, nasal, and ophthalmic dosage forms
05. June 2016 Surface tension examination of variousliquid oral, nasal, and ophthalmic dosage forms Surface tension at the surface-to-air interface is a physico-chemical…
An accurate and precise representation of drug ingredients
05. June 2016 Background: In previous work, we built the Drug Ontology (DrOn) to support comparative effectiveness research use cases. Here, we have updated our…
The effect of mechanical strain on properties of lubricated tablets compacted at different pressures
04. June 2016 A full factorial design of experiments was used to study the effect of blend shear strain on the compaction process, relative density and strength of…
Assessment of distribution of pellets in tablets by non-destructive microfocus X-ray imaging and…
04. June 2016 In this study, potassium chloride (KCl) containing matrix pellets were compressed into tablets using powder or pellet form of partially spray dried lactose as…
Randomized Controlled Trial of Talactoferrin Oral Solution in Preterm Infants
04. June 2016 Objective To evaluate the safety and explore the efficacy of recombinant human lactoferrin (talactoferrin ) to reduce infection. Study design We…
Natural polysaccharides platforms for oral controlled release of ketoprofen lysine salt
04. June 2016 Context Ketoprofen lysinate (KL) is one of the most widely used non-steroidal anti-inflammatory drugs in the symptomatic treatment of some chronic…
Excipients: Manufacturers Look to Co-Processing as a Way of Improving Functionality
04. June 2016
The global excipients market should reach nearly $6.9 billion by 2020 from approximately $6.3 billion in 2015, according to a new report from BCC Research, LLC. Growth in the demand for pharmaceuticals and…
CFDA Releases the Name List of Excipients Available for Health Food Filing (the First Batch) for…
04. June 2016 On 17 February 2016, CFDA released the Health Food Raw Materials Directory (the first batch) –Nutrition Supplement Raw Materials Directory. In…
Formulation and In-Vitro Evaluation of Controlled Porosity Osmotic Pump Release Tablets of…
02. June 2016 Formulation and In-Vitro Evaluation of Controlled Porosity Osmotic Pump Release Tablets of Nifedipine In this study, osmotically controlled drug…