Comparison of in vitro screening methods for evaluating the effects of pharmaceutical excipients on membrane permeability
The effects of pharmaceutical excipients on intestinal drug absorption have been highlighted and careful excipient selection is required to develop biologically equivalent formulations. This study aimed to evaluate the effects of excipients on drug permeability and compare the characteristics of in vitro screening methods. Three in vitro models,…
Formulation and In-Vitro Evaluation of Controlled Porosity Osmotic Pump Release Tablets of…
02. June 2016 Formulation and In-Vitro Evaluation of Controlled Porosity Osmotic Pump Release Tablets of Nifedipine In this study, osmotically controlled drug…
Influence of mannitol concentration on the physicochemical, mechanical and pharmaceutical properties…
02. June 2016 Mannitol is a pharmaceutical excipient that is receiving increased popularity in solid dosage forms. The aim of this study was to provide comparative…
Facilitating Gastrointestinal Solubilisation and Enhanced Oral Absorption of SN38 Using a…
02. June 2016 SN38 (7-ethyl-10-hydroxycamptothecin) is a highly potent anti-cancer compound. However, it is poorly soluble in pharmaceutically acceptable excipients, thus…
Molecular insights into the formation of drug-monoacyl phosphatidylcholine solid dispersions for…
02. June 2016 Phospholipid-based formulations provide a key technology to formulate poorly water-soluble drugs. A recent interest has been in using phospholipids with a high…
New Multi-Particle Systems for Colon-Targeted Meloxicam
31. May 2016
Meloxicam (MLX) is a non-steroidal anti-inflammatory drug (NSAIDs) from the Oxicam family. This group of NSAIDs has been highly used in the treatment of rheumatoid arthritis and post-operative…
Design, characterization and in vitro evaluation of HPMC K100 M CR loaded Fexofenadine HCl…
31. May 2016 The aim of the current study was to formulate Fexofenadine hydrochloride loaded sustained release microspheres using HPMC K100 M CR, a release retardant…
Screening of formulation parameters for stabilizing recombinant human serum albumin (rHSA) in liquid…
31. May 2016 In the present study, the stabilizing effect of excipients present in recombinant Human Serum Albumin (rHSA) solutions are studied using rheological analysis.…
Nanomilling of Drugs for Bioavailability Enhancement: A Holistic Formulation-Process Perspective
29. May 2016 Abstract: Preparation of drug nanoparticles via wet media milling (nanomilling) is a very versatile drug delivery platform and is suitable for oral, injectable,…
Stabilizing Agents for Drug Nanocrystals: Effect on Bioavailability
29. May 2016 Abstract: Drug nanocrystals are a versatile option for drug delivery purposes, and while the number of poorly soluble drug materials is all the time…
Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy
29. May 2016 Smoking cessation is of current topical interest due to the significant negative health and economic impact in many countries. This study aimed to develop…
DEVICE CHALLENGE Q&A: System for Dosing and Dispensing Multiparticulate Formulations of…
29. May 2016 DEVICE CHALLENGE Q&A: System for Dosing and Dispensing Multiparticulate Formulations of Pediatric Drugs…
Considerations and recommendations on traditional and non-traditional uses of excipients in oral…
29. May 2016
Abstract
Excipients represent diverse classes of molecules, small molecules or macromolecules, with versatile structures within a given class and are from natural, semi-synthetic and synthetic sources. They…
Effects of Cooling Rate in Microscale and Pilot Scale Freeze-Drying – Variations in Excipient…
28. May 2016 Microscale freeze-drying makes rapid process cycles possible for early-stage formulation development. To investigate the effects of equipment scale and cooling…
Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear…
28. May 2016 Dry eye disease (DED) has been reported to afflict 7–33% of the population, thereby reducing their quality of life. For normal vision, continuous…
Preparation and evaluation of diclofenac sodium orally disintegrating tablets
28. May 2016 Orally disintegrating tablets (ODTs) are dosage forms which disintegrate in mouth within seconds without need of water. This type of quality in dosage form can…
EVALUATION OF THE SUSPENDING PROPERTIES OF SHEA TREE GUM
27. May 2016 Objective: Shea gum is found large quantities in the northern part of Ghana. Its use in the pharmaceutical industry has been limited by lack of research into…
Pharmaceutical Excipients: Properties, Functionality, and Applications in Research and Industry
27. May 2016 This book provides an overview of excipients, their functionalities in pharmaceutical dosage forms, regulation, and selection for pharmaceutical products…
Effervescent tablets: a safe and practical delivery system for drug administration
26. May 2016 Effervescence is defined as the evolution of gas bubbles from a liquid as a result of a chemical reaction. For medicinal use, effervescent tablets have specific…
Formulation and In Vitro Evaluation of Piroxicam Loaded Alginate Microspheres (Colon Specific) Using…
25. May 2016 Abstract: The main aim of the present work was to develop colon specific piroxicam loaded alginate microspheres intended for the treatment of rheumatoid…
The effect of excipients on the stability and aerosol performanceof salmon calcitonin dry powder…
25. May 2016 NARGES POURSINA ALIREZA VATANARA* MOHAMMAD REZA ROUINI KAMBIZ…
Cytotoxicity of Different Excipients on RPMI 2650 Human Nasal Epithelial Cells
25. May 2016 Cytotoxicity of Different Excipients on RPMI 2650 Human Nasal Epithelial Cells Abstract: The nasal route receives a great deal of attention as a…
Why Chitosan? From properties to perspective of mucosal drug delivery
24. May 2016 Non-parenteral drug delivery routes primarily remove the local pain at the injection site. The drugs administered through the oral route encounter the process…
Design, Evaluation and Characterization ofRapidly Dissolving Oral Strips of MetoprololSuccinate
24. May 2016 The present investigation is an attempt to design and evaluate rapidly dissolving oral strips of metoprolol succinate, an anti-hypertensive agent. Rapidly…
Design of controlled release PLGA microspheres for hydrophobic fenretinide
24. May 2016 Fenretinide, a chemotherapeutic agent for cancer, is water-insoluble and has a very low oral bioavailability. Hence, the objective was to deliver it as an…
Study of the effect of formulation variables on the characteristicsof combination tablets containing…
24. May 2016 To evaluate the influence of different variables on tablet formulations containing enalapril maleate and indapamide as active substances, two separate…
Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes
24. May 2016 Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes Patients tend to prevent hypoglycemia by excessive…
Effect of polymer type and drug dose on the in vitro and in vivo behavior of amorphous solid…
24. May 2016 This study investigated the non-sink in vitro dissolution behavior and in vivo performance in rats of celecoxib (CCX) amorphous solid dispersions with polyvinyl…
Emergence of 3D Printed Dosage Forms: Opportunities and Challenges
24. May 2016 The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare.…
Hot-melt extruded filaments based on pharmaceutical grade polymers for 3D printing by Fused…
24. May 2016 Fused deposition modeling (FDM) is a 3D printing technique based on the deposition of successive layers of thermoplastic materials following their…
BA’EMEK ADVANCED TECHNOLOGIES LTD RECEIVES EXCiPACT GMP CERTIFICATION AS PHARMACEUTICAL EXCIPIENT…
24. May 2016
EXCiPACT asbl is delighted to announce that Ba’Emek Advanced Technologies Ltd has recently been awarded an EXCiPACT Certificate from AJA Europe, one of EXCIPACT’s internationally-recognised Certification Bodies.…
Colorcon Asia Private Limited receives EXCiPACT certificate
19. May 2016 20160519 EXC_Newsrelease_Colorcon Asia P…
Improving dissolution kinetics of pharmaceuticals by fluidized bed impregnation of active…
19. May 2016 Investigational drugs are increasingly becoming less soluble in aqueous media thus presenting real challenges during development. Previous work has successfully…
Formulation and evaluation of Deflazacort liquisolid tablets
19. May 2016
In the present investigation, liquisolid compact technique is investigated as a tool for enhancement of dissolution of poorly water-soluble drug, Deflazacort. Deflazacort liquisolid tablets were…