Comparison of in vitro screening methods for evaluating the effects of pharmaceutical excipients on membrane permeability
The effects of pharmaceutical excipients on intestinal drug absorption have been highlighted and careful excipient selection is required to develop biologically equivalent formulations. This study aimed to evaluate the effects of excipients on drug permeability and compare the characteristics of in vitro screening methods. Three in vitro models,…
PELLETS AND MICROPELLETS FOR ORAL MULTIPARTICULATE DOSAGE FORMS
03. May 2016 TTC Workshop 20 – 22 SEPTEMBER 2016 in Binzen/Germany More Information & Registration More and more pharmaceutical products…
IPEC e-newsletter – Excipients Insight April 2016
03. May 2016
In this edition of Excipients Insight we are delighted to share details of this year's joint APV/IPEC Europe conference, which once again will provide valuable insights into recent developments in excipient…
Impact of the digital revolution on the future of pharmaceutical formulation science
03. May 2016 The ongoing digital revolution is no longer limited to the application of apps on the smart phone for daily needs but starts to affect also our professional…
Taste-masking properties of solid lipid based micropellets obtained by cold extrusion-spheronization
03. May 2016
Taste-masked properties of micropellets based on hard fat and/or solid lipid mixtures (prepared by solvent-free cold extrusion/spheronization), containing metformin hydrochloride were investigated. An in-line…
High Ester Pectin Based Formulation for Site Specific Delivery of 5-Fluorouracil in to Descending…
03. May 2016 This research has investigated over different parameters and combined the additional anti-cancerous properties of high ester pectin based formulation, which…
Cellulose nanocrystals: A versatile nanoplatform for emerging biomedical applications
02. May 2016 Cellulose nanocrystals (CNCs) are bio-based nanomaterials typically derived from the acid hydrolysis of the most abundant natural polymer, cellulose. These…
Development of a solidified self-microemulsifying drug delivery system (S-SMEDDS) for atorvastatin…
02. May 2016
To improve the dissolution and oral bioavailability (BA) of atorvastatin calcium (ATV), we previously introduced an optimized self-microemulsifying drug delivery system (SMEDDS) using Capmul® MCM…
Polyethylene glycol (PEG): A versatile polymer for pharmaceutical applications
02. May 2016 Introduction: Polyethylene glycol (PEG) is a polymer of choice in drug delivery systems. This USFDA-approved polymer is popular due to its tunable properties…
Macroindentation hardness measurement – Modernization and applications
In this study, we first developed a modernized indentation technique for measuring tablet hardness. This technique is featured by rapid digital image capture, using a calibrated light microscope, and precise area-determination. We…
Mechanisms of transport of polymeric and lipidic nanoparticles across the intestinal barrier
02. May 2016 Unraveling the mechanisms of nanoparticle transport across the intestinal barrier is essential for designing more efficient nanoparticles for oral…
Using Supercritical Fluid Technology (SFT) in Preparation of Tacrolimus Solid Dispersions
02. May 2016 Tacrolimus is an immunosuppressant agent that suffers from poor and variable bioavailability. This can be related to limited solubility and dissolution. The…
Evaluation of excipients for enhanced thermal stabilization of a human type 5 adenoviral vector…
01. May 2016
We have produced a thermally stable recombinant human type 5 adenoviral vector (AdHu5) through spray drying with three excipient formulations (l-leucine, lactose/trehalose and mannitol/dextran). Spray drying leads to…
Superabsorbent hydrogels via graft polymerization of acrylic acid from chitosan-cellulose hybrid and…
01. May 2016 Superabsorbent polymers fabricated via grafting polymerization of acrylic acid from chitosan (CTS) yields materials that suffer from poor mechanical strength.…
Evaluation of the ability of powdered milk to produce minitablets containing paracetamol for the…
01. May 2016 The work aims at evaluating the usefulness of powdered milk as a drug matrix for the production of minitablets specifically designed for children. Mixtures…
TASTE MASKED ORODISPERSIBLE TABLETS: A HIGHLY PATIENT COMPLAINT DOSAGE FORM
01. May 2016 Objective: Tablet is still most popular conventional dosage forms existing today, but the drawback of solid dosage forms is the difficulty in…
IPEC Foundation Graduate Student Winners….Where are they now?
29. April 2016 Spotlight on Award Winners; Amit Wani and Qi “Tony” Zu…
Advancing Powder Compaction Analysis with the New Gamlen D Series
29. April 2016
Gamlen Tableting’s new flagship D series dynamic powder compaction analyzers feature dwell time control. Supplied with new “in-die” and “out-of-die” compaction analysis software, D series…
Orally Disintegrating Tablets – enhancing ease of use and patient compliance
29. April 2016 Orally disintegrating tablets (ODT), are an innovative solid oral dosage form that is becoming more and more important in the pharmaceutical market, both for…
Pharmaceutical Manufacturing in the 21st Century-From Batch to Continuous Manufacturing-An FDA…
29. April 2016
Webcast Wednesday, 15th June 2016 | 9AM EST
More Information and free Registration
Product Substitution as a Way Forward in Avoiding Potentially Harmful Excipients in Neonates
28. April 2016
Our objectives were to explore the possibility of avoiding neonatal exposure to potentially harmful excipients of interest (EOI)—parabens, polysorbate 80, propylene glycol, benzoates, saccharin sodium,…
Use of к-Carrageenan, Chitosan and Carbopol® 974P in Extruded and Spheronized Pellets That are…
28. April 2016 The search for excipients to replace microcrystalline cellulose (MCC) in the production of pellets by extrusion-spheronization in cases of drug…
Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in…
28. April 2016
Abstract: The aim of this study was to formulate probiotics-loaded pellets in a tablet form to improve storage stability, acid tolerability, and in vivo intestinal protective effect. Bacteria-loaded pellets…
ICH Q3D practical implementation challenges – a dual perspective -Manufacturer and excipient…
28. April 2016
Presentation by Dr Andrew Teasdale AstraZeneca
IPEC Europe Excipients Forum - Making Pharmaceutics 2016
Link to pharm tech article (March 2015)
IPEC Elemental Impurities Lette & Template (incl.…
Drug loaded and ethylcellulose coated mesoporous silica for controlled drug release prepared using a…
28. April 2016 The goal of this study was to test the feasibility to load non-ordered, non-spherical mesoporous silica with the model drug paracetamol, and subsequently coat…
IPEC – Elemental Impurities Webinar
28. April 2016 IPEC - Elemental Impurities Webinar ICH Q3D Guideline for Elemental Impurities will be effective June 2016. Learn from the excipient…
Development and characterization of fast-dissolving tablet formulations of glyburide based on solid…
26. April 2016 The aim of this work was to develop effective fast-dissolving tablet formulations of glyburide, endowed with improved dissolution and technological…
Improving Dry Powder Inhaler Performance by Surface Roughening of Lactose Carrier Particles
26. April 2016 This study investigated the impact of macro-scale carrier surface roughness on the performance of dry powder inhaler (DPI) formulations. Methods…
Flow and compaction properties of hypromellose: new directly compressible versus the established…
26. April 2016
Context: Information about flow and compaction properties of hypromellose (HPMC) polymers is essential for technologists who are facing challenges regarding poor flow and compaction while developing new…
A Holistic Multi Evidence Approach to Study the Fragmentation Behaviour of Crystalline Mannitol
26. April 2016 Mannitol is an essential excipient employed in orally disintegrating tablets due to its high palatability. However its fundamental disadvantage is its…
Evidence-Based Nanoscopic and Molecular Framework for Excipient Functionality in Compressed Orally…
26. April 2016 The work investigates the adhesive/cohesive molecular and physical interactions together with nanoscopic features of commonly used orally disintegrating…
Application of the Design of Experiments in Optimization of Drug Layering of Pellets with an Insight…
25. April 2016 This study consists of two experimental designs. Within the first one, suitable technique for application of model drug onto inactive pellets was evaluated…
AMORPHOUS SOLID DISPERSIONS OF BCS CLASS II DRUGS: A RATIONAL APPROACH TO SOLVENT AND POLYMER…
25. April 2016 Miniaturised solvent casting (MSC) has been developed as a method for screening the stability of amorphous solid dispersions (ASD) of BCS class II drugs. The…
A study on the effect of the polymeric additive HPMC on morphology and polymorphism of…
25. April 2016 In the present study, the effect of Hydroxy Propyl Methyl Cellulose (HPMC) on the crystallization of ortho-aminobenzoic acid (OABA) was investigated by seeded…
Drug Formulation, Solubility & Bioavailability Summit
25. April 2016 Drug Formulation, Solubility & Bioavailability Summit May 30-31, 2016 Novotel Barcelona City Barcelona, Spain More Information…