Comparison of in vitro screening methods for evaluating the effects of pharmaceutical excipients on membrane permeability
The effects of pharmaceutical excipients on intestinal drug absorption have been highlighted and careful excipient selection is required to develop biologically equivalent formulations. This study aimed to evaluate the effects of excipients on drug permeability and compare the characteristics of in vitro screening methods. Three in vitro models,…
Effect of Common Excipients on the Oral Drug Absorption of Biopharmaceutics Classification System…
31. March 2016
The objective was to assess the impact of larger than conventional amounts of 14 commonly used excipients on Biopharmaceutics Classification System (BCS) class 3 drug absorption in humans. Cimetidine and…
Reply to “On the Effect of Common Excipients on the Oral Absorption of Class 3 Drugs”
31. March 2016 Abstract We previously concluded that 12 common excipients need not be qualitatively the same and quantitatively very similar to reference for…
BCS Class 3 Biowaivers and Transporter Considerations
31. March 2016 Presentation - James E. Polli University of Maryland Background Prior human in vivo studies Recent series of in…
Compatibility of 10 different APIs in SyrSpend SF PH4 oral suspensions
30. March 2016
Objectives: The objective of this study was to evaluate the compatibility of 10 commonly used active pharmaceutical ingredients (APIs) compounded in oral suspensions using a globally available suspending…
The combined effect of wet granulation process parameters and Dried granule moisture content on…
30. March 2016 A pharmaceutical compound was used to study the effect of batch wet granulation process parameters in combination with the residual moisture content remaining…
Health risks related to illegal and on-line sale of drugs and food supplements: results of a survey…
30. March 2016 Health risks related to illegal and on-line sale of drugs and food supplements: results of a survey on marketed products in Italy from 2011 to 2013…
Optimising excipients to improve bioavailability
30. March 2016 Guy Tiene, Director of Strategic Content, That's Nice LLC/Nice Insight, discusses excipient market trends, the use of excipients to improve the poor aqueous…
Formulation and multivariate optimization of microcrystalline cellulose pellets of highly water…
29. March 2016
Formulation and multivariate optimization of microcrystalline cellulose pellets of highly water soluble drug
Microcrystalline Cellulose (MCC) pellets containing highly water soluble compound A was …
DEVELOPMENT OF A MULTI PARTICULATE FORMULATION OF VIABLE BACTERIA FOR ORAL AND VAGINAL DELIVERY
29. March 2016 Nele Poelvoorde, PharmacistThesis submitted to obtain the degree…
Hospitalised neonates in Estonia commonly receive potentially harmful excipients
29. March 2016 Background: Information on the neonatal exposure to excipients is limited. Our aim was to describe the extent of excipient intake by Estonian neonates; to…
8th EuPFI annual conference
29. March 2016
8th EuPFI annualconference
European Paediatric Formulation Initiative (EuPFI) Annual Conference
20th – 22nd September 2016 in Lisbon, Portugal
at Hotel Novotel Lisboa.
This Conference Series…
Effect of the deformability of guest particles on the tensile strength of tablets from interactive…
29. March 2016 In this study, we investigated the influence of deformability of specifically-engineered guest particles on the tensile strength of tablets of interactive…
Extended-release dosage: recent advances and potential in pediatric medicine
29. March 2016 Extended-release formulations can be useful for children who would otherwise need to take medication while at school or during night. Keywords: Drug…
Infacort®, Oral Hydrocortisone Granules with Taste Masking for the Treatment of Neonates and Infants…
29. March 2016
Background: Current treatment for adrenal insufficiency in neonates and infants is unsatisfactory as unlicensed adult formulations are used and the minimum unit dose available is a scored 5mg hydrocortisone…
Wet Granulation Knowledge Brief
28. March 2016
Granulation is the process of joining multiple particles or grains together, typically using a binding agent although mechanical force has been used to bond the particle together as well. This brief will…
Macromolecular excipients exert biological effects via their microbial fermentation absorbable…
27. March 2016 In “The Lives of a Cell”, L. Thomas restated a hitherto prosaic observation as a profound conjecture, i.e, that mitochondria - the…
Injection Molding as a One-Step Process for the Direct Production of Pharmaceutical Dosage Forms…
26. March 2016
The objective of the present study was to develop a one-step process for the production of tablets directly from primary powder by means of injection molding (IM), to create solid-dispersion based tablets.…
Preparation of amorphous drug nanoparticles by high-gravity reactive precipitation technique
26. March 2016 For many water insoluble acidic or alkaline drugs, amorphization and nanonization represent an effective bioavailability enhancement strategy. Cefixime (CFX)…
Essential medicines containing ethanol elevate blood acetaldehyde concentrations in neonates
26. March 2016 Neonates administered ethanol-containing medicines are potentially at risk of dose-dependent injury through exposure to ethanol and its metabolite,…
Drug Delivery Systems Obtained from Silica Based Organic-Inorganic Hybrids
25. March 2016 This is a review of hybrid materials based on silica as an inorganic phase used as drug delivery systems (DDS). Silica based DDS have shown effectivity…
Controlled Release: A New Paradigm with Polyvinyl Acetate Polymer
25. March 2016 Controlled release (CR) has been a subject of continued interest, and the pharma industry is taking a closer look into release profiles of drugs because of…
An Investigative and Explanatory Review on Use of Milk as a Broad-Spectrum Drug Carrier for…
24. March 2016 Objective: The main objective of this review is to investigate the potential role of milk in improvement of bioavailability and patient compliance.…
In silico product design of pharmaceuticals
24. March 2016
The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms. As the number of possible dosage forms may scale towards infinity, their uniqueness require a…
Development of a zero-order sustained-release tablet containing mesalazine and budesonide intended…
24. March 2016 Ulcerative colitis (UC) and Crohn’s disease (CD) are diseases affecting the gastrointestinal tract. Treatment depends on the severity of the disease, site of…
The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems
23. March 2016 A comprehensive study on the dissolution properties of three co-amorphous sulfamerazine/excipient systems, namely sulfamerazine/deoxycholic acid,…
Durio Zibethinus L. (Malvaceae) Seed Gum: Extraction, Characterization, And Evaluation As…
23. March 2016 Durio zibethinus L. (Malvaceae) also known as “Durian” in the Philippines is an evergreen tropical tree found mainly in the regions of Mindanao and Sulu.…
An overview of in situ gelling systems
23. March 2016
Recently controlled and sustained drug delivery has become the new standard in modern pharmaceutical design and a thorough research has been undertaken in achieving much better drug product effectiveness,…
4th Congress on Innovation in Drug Delivery Site-Specific Drug Delivery
23. March 2016
4th Congress on Innovation in Drug Delivery Site-Specific Drug Delivery
25-28 September, 2016
Antibes-Juan-les-Pins, France
The abstract submission deadline is April…
Glycation of polyclonal IgGs: Effect of sugar excipients during stability studies
22. March 2016 A number of intravenous immunoglobulin preparations are stabilized with sugar additives that may lead over time to undesirable glycation reactions especially…
Glucocorticoids and chronotherapy in rheumatoid arthritis
It is evident that the morning symptoms of rheumatoid arthritis (RA) are linked to the circadian abnormal increase in night inflammation, favoured by inadequate cortisol secretion under conditions of active disease. Therefore,…
An industrial perspective on the design and development of medicines for older patients
22. March 2016 An increasing elderly population is leading to a change in the global demographics. This presents a new challenge to society and the pharmaceutical industry.…
Comparison of Conventional and Lignin-Rich Microcrystalline Cellulose
22. March 2016 Three microcrystalline cellulose (MCC) samples were manufactured from bleached and unbleached softwood kraft pulp, and their properties were compared to those…
Quality by Design Approaches to Formulation Robustness—An Antibody Case Study
22. March 2016 Quality by Design Approaches to Formulation Robustness—An Antibody Case Study The International Conference on Harmonization Q8 (R2) includes a…