Comparison of in vitro screening methods for evaluating the effects of pharmaceutical excipients on membrane permeability
The effects of pharmaceutical excipients on intestinal drug absorption have been highlighted and careful excipient selection is required to develop biologically equivalent formulations. This study aimed to evaluate the effects of excipients on drug permeability and compare the characteristics of in vitro screening methods. Three in vitro models,…
Mucoadhesive polymers: Synthesis and in vitro characterization of thiolated poly(vinyl alcohol)
14. March 2016 The aim of this study was to synthesize thiolated poly(vinyl alcohol) (PVA) and to evaluate its mucoadhesive properties. Thiourea and 3-mercaptopropionic acid…
Dispersibility of lactose fines as compared to API in dry powders for inhalation
14. March 2016 This work investigates the dispersion performance of fine lactose particles as function of processing time, and compares it to the API, using Beclomethasone…
Contrasting the crospovidones functionality as excipients for direct compression
14 March 2016
Specific values of technological properties of excipients allow the establishment of numerical parameters to de ne and compare their functionality. This study investigates the functionality of Polyplasdones XL…
APS Excipients – selection, control, application and suitability
14. March 2016 Burleigh Court, Loughborough Monday 23rd and Tuesday 24th May 2016 More Information & Registration…
l-Leucine as an excipient against moisture on in vitro aerosolization performances of highly…
13. March 2016 l-Leucine (LL) has been widely used to enhance the dispersion performance of powders for inhalation. LL can also protect powders against moisture, but this…
Harmful excipients in medicines for neonates in Spain
13. March 2016
Background Neonates may respond differently from adults to drug components. Hence, ingredients that seem safe in adults may not be safe in this age group. Objective To describe the content of harmful…
Novel tablet formulation of amorphous indomethacin using wet granulation with a high-speed mixer…
13. March 2016
Solid dispersion techniques are useful for improving the dissolution of poorly water-soluble drugs. This study aimed to produce and evaluate solid dispersion tablets improving the solubility and…
Controlled Release of Multiple Therapeutics from Silicone Hydrogel Contact Lenses
13. March 2016
Purpose: The majority of contact lens wearers experience a significant level of ocular discomfort associated with lens wear, often within hours of wear, related to dry lenses, inflammation, protein adhesion…
Evonik launches new formulation technology for the development of alcohol resistant drug products
12. March 2016
Evonik has developed a formulation technology, which offers a novel approach to developing alcohol resistant oral drug products with delayed or sustained release profiles. EUDRATEC™ ADD delivers a solution to…
The effect of surfactants on the dissolution behavior of amorphous formulations
12. March 2016 The optimal design of oral amorphous formulations benefits from the use of excipients to maintain drug supersaturation and thus ensure adequate absorption…
INFLUENCE OF INTERFACIAL AND BULK PROPERTIES OF CELLULOSE ETHERS ON LIPOLYSIS OF OIL-IN-WATER…
12. March 2016
Cellulose ethers are usually used as secondary emulsifiers. Different types of commercial hydroxypropylmethylcellulose (HPMC) have been used here as the main emulsifier of oil-in-water emulsions to probe…
FORMULATION DEVELOPMENT AND STATISTICAL OPTIMIZATION OF IVABRADINE HYDROCHLORIDE FLOATING PULSATILE…
12. March 2016
Formulation Developement and Statistical Optimization of Ivabradine Hydrochloride Floating Pulsatile Pellets by Fluidized Bed Coating Technique
Objective: The objective of the current work was to…
Evaluation of a Process Relevant Method for Determining the Robustness of Sugar Spheres as a Drug…
12. March 2016 The mechanical strength, particle size and sphericity of starting sugar spheres for drug layering and subsequent functional coating applications are…
MPEG–PCL copolymeric nanoparticles in drug delivery systems
11. March 2016 Abstract: Methoxypoly(ethylene glycol) Poly(caprolactone) (mPEG–PCL) copolymers are important synthetic biomedical materials with amphiphilicity,…
Oral delivery of diabetes peptides – Comparing standard formulations incorporating functional…
11. March 2016 While some orally delivered diabetes peptides are moving to late development with standard formulations incorporating functional excipients, the demonstration…
Industry consortium aims to take the pain out of ICH Q3D compliance
10. March 2016 With the first deadline for the ICH Q3D guideline on elemental impurities just a few weeks away, pharma companies are still facing some uncertainty about how…
Preparation and Evaluation of Sustained Release Tablets of Cefixime Trihydrate using Natural…
10. March 2016
ABSTRACT
Six batches of formulated sustained release matrix tablets of Cefixime Trihydrate were prepared by using different polymers like Tamarind Gum, Carnauba wax, HPMC, MCC, PVP K30 by wet granulation…
Gastro-resistant multiparticles for mesalazine colonic delivery
10. March 2016 Gastro-resistant multiparticles for mesalazine colonic delivery Purpose: To develop gastro-resistant multiparticles systems for mesalazine colon delivery…
Design and evaluation of an innovative floating and bioadhesive multiparticulate drug delivery…
09. March 2016 In this study a gastric-retentive delivery system was prepared by a novel method which is reported here for the first time. An innovative floating and…
Lubricants in Pharmaceutical Solid Dosage Forms
Lubrication plays a key role in successful manufacturing of pharmaceutical solid dosage forms; lubricants are essential ingredients in robust formulations to achieve this. Although many failures in pharmaceutical manufacturing…
EFFECT OF MAGNESIUM STEARATE ON A PHARMACEUTICAL BLEND USING THERMAL EFFUSIVITY
09. March 2016 Powders are blended together to produce pharmaceutical products and the consistency of those powders is critical to the quality of the product. Typically a…
The Story of Magnesium Stearate as a Powder and a Tablet Lubricant
09. March 2016
The Story of Magnesium Stearate as a Powder and a Tablet Lubricant
Presented by Doug Lugge
Director, API Development and Engineering Mallinckrodt
at Excipientfest Americas 2013…
Pediatric and PK: Where is the challenge?
09. March 2016
Pediatric and PK: Where is the challenge?
Children are not small adults! This phrase has been used by many when referring to use of medications in pediatric patients. It is well recognized that pediatric…
Stearic acid crystals stabilization in aqueous polymeric dispersions
09. March 2016 In wet granulation processes, coatings or binders generally consist of mixtures of various raw materials that confer or enhance specific properties to the…
EMERGING TRENDS IN COMPRESSION COATED TABLET DOSAGE FORMS: A REVIEW
09. March 2016 EMERGING TRENDS IN COMPRESSION COATED TABLET DOSAGE FORMS: A REVIEW ABSTRACT: Tablets are widely used and most preferred dosage form because of its ease…
Lactose Free, Direct Compression Formulation Used to Produce Loratadine (10 mg) Tablets
09. March 2016 Lactose Free, Direct Compression Formulation Used to Produce Loratadine (10 mg) Tablets Loratadine is a popular over-the-counter, non…
S-protected thiolated hydroxyethyl cellulose (HEC): novel mucoadhesive excipient with improved…
08. March 2016
The aim of this study was the design of novel S-protected thiolated hydroxyethyl cellulose (HEC) and the assessment of its mucoadhesive properties and biodegradability compared to the corresponding unmodified…
Mucoadhesive polymers in the treatment of dry X syndrome
08. March 2016 Mucoadhesive polymers are an essential tool in the treatment of diseases where dry mucosal surfaces are involved. In this review, we focus on the application…
A Novel Scale Up Model for Prediction of Pharmaceutical Film Coating Process Parameters
08. March 2016 In the pharmaceutical tablet film coating process, we clarified that a difference in exhaust air relative humidity can be used to detect differences in…
Formulation and evaluation of atenolol floating bioadhesive system using optimized polymer blends
08. March 2016 Introduction: Oral sustained release gastro retentive dosage forms offer several advantages for drugs having absorption from the upper…
Roquette Freres receives EXCiPACT certification
08. March 2016
Roquette Freres' plant in Lestrem, France, has earned EXCiPACT certification for Good Manufacturing Practice (GMP) from SGS France, one of EXCIPACT’s internationally-recognised certification bodies. The…
76th FIP World Congress of Pharmacy and Pharmaceutical Sciences 2016
07. March 2016 28 August 2016- 01 September 2016 Buenos Aires, Argentina More Information
American Association of Pharmaceutical Scientists (AAPS)
07. March 2016 14 November 2016- 17 November 2016 Denver Convention Center, Denver, Colorado, United States More Information
Excipient Quality and Selection
07. March 2016 Choosing the right excipient manufacturer can help ensure the use of quality excipients. How does one define quality as applied to excipients? If we pose…