Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Tioconazole-Loaded Transethosomal Gel Using Box–Behnken Design for Topical Applications: In Vitro,…
Tioconazole (TCZ) is a broad-spectrum fungicidal BCS class II drug with reported activity against Candida albicans, dermatophytes, and certain Staphylococci bacteria. We report the use of TCZ-loaded transethosomes (TEs) to overcome the…
Propolis‑loaded nanostructured lipid carriers halt breast cancer progression through miRNA‑223…
Abstract
The most frequent malignant tumor in women is breast cancer, and its incidence has been rising every year. Propolis has been used for its antibacterial, antifungal, and anti-inflammatory properties. The present study aimed to…
The role of Eudragit® as a component of hydrogel formulations for medical devices
Over the last decade, significant progress has been made in developing hydrogels as medical devices. By physically cross-linking pharmaceutically approved polymers into three-dimensional matrices, we can ensure their biocompatibility and…
Silicified Microcrystalline Cellulose, Modern Co-Processed Excipient For Low Dose Solid Dosage Forms
ABSTRACT
Low dose 75 mg aspirin tablets are widely used for adults in arthritis, rheumatic fever, pain and to reduce uric acid
excretion. Low dose formulation are manufactured by wet granulation method, which is time consuming and…
Development of Osthole-Loaded Microemulsions as a Prospective Ocular Delivery System for the…
Osthole (OST), a natural coumarin compound, has shown a significant inhibitory effect on corneal neovascularization (CNV). But, its effect on treating CNV is restricted by its water insolubility. To overcome this limitation, an OST-loaded…
Formulation And Characterization Of Provesicular Based Drug Delivery System For Effective…
Oral intake of Itraconazole (ITZ) causes severe side effects in the gastrointestinal tract and has low bioavailability ~55%. Owing to these disadvantages, Transdermal drug delivery system (TDDS) of such antifungal agents can overcome such…
Design and development of donepezil hydrochloride loaded nanostructured lipid carriers for efficient…
Objective
The primary objective of this study was to develop nanostructured lipid carriers of donepezil hydrochloride (DNZ HCl) for effective management of Alzheimer’s disease (AD).
Significance
Intranasal administration of DNZ…
CPHI Barcelona 2023 – with a focus on excipients
This year CPHI Europe opens its doors in Barcelona at Fira Barcelona Gran Via.
From 24th to 26th October you can have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack,
P-MEC, FDF, ICSE and BioProduction will be…
The Use of a Closed Feed Frame for the Development of Near-Infrared Spectroscopic Calibration Model…
Purpose
This study evaluates the use of the closed feed frame as a material sparing approach to develop near-infrared (NIR) spectroscopic calibration models for monitoring blend uniformity. The effect of shear induced by recirculation on…
Chitosan in Oral Drug Delivery Formulations: A Review
Abstract
Nanoformulations have become increasingly useful as drug delivery technologies in recent decades. As therapeutics, oral administration is the most common delivery method, although it is not always the most effective route because…
Additive Manufacturing in Pharmaceuticals – Part 3
Additive Manufacturing in Pharmaceuticals
See the new book, edited by Dr. Subham Banerjee, Ph.D., Associate Professor in the Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Guwahati,…
Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of…
Abstract
Nanoparticles have numerous applications as drug carriers in drug delivery. The aim of the study was to produce tamoxifen nanoparticles with a defined size and higher encapsulation for efficient tissue uptake with controlled drug…
Effect of Moisture Content of Excipient (Microcrystalline Cellulose)
Abstract
Quality of pharmaceutical product is very important because pharmaceuticals drugs should be safe and therapeutically active formulation performance should be consistent and predictable. Final product quality depends on all…
Development and Optimization of a Novel Lozenge Containing a Metronidazole-Peppermint Oil-Tranexamic…
In-depth studies on essential oil–based nanoemulsions (NEs) have centered on a variety of oral health issues. NEs improve the delivery of nonpolar active agents to sites and thereby boost the dissolution and distribution of the agents.…
Formulation and Development of Flurbiprofen Colon-Specific Eudragit Coated Matrix Tablets: Use of a…
The rationale for the current investigation is to study the crude banana peel (CBP) powder efficiency as a novel natural time-dependent polymer along with a pH-sensitive polymer to develop flurbiprofen colon-specific tablets. The direct…
The versatile capabilities of galenIQ™
Introduction
Imagine an excipient that not only adds sweetness but can also act as a filler-binder which can be used for a wide range of dosage forms. An excipient that combines versatile capabilities like excellent compressibility, high…
Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery…
Three-dimensional printing by fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) is a point of convergence of research efforts directed toward the development of personalized dosage forms. In addition to the customization…
Influence of beta-cyclodextrin on the phase transition in carbamazepine polymorphs
Introduction
Carbamazepin (CBZ), a widespread used antiepileptic drug, branded as Tegretol, firstly was launched in form of Active Pharmaceutical Ingredient (API) as a commercially available polymorphic form III. Additionally,…
Investigating the Impact of Co-processed Excipients on the Formulation of Bromhexine Hydrochloride…
Abstract
Purpose
Orodispersible tablets (orally disintegrating tablets, ODTs) have been used in pharmacotherapy for over 20 years since they overcome the problems with swallowing solid dosage forms. The successful formula manufactured by…
Leveraging a multivariate approach towards enhanced development of direct compression extended…
Extended release formulations play a crucial role in the pharmaceutical industry by maintaining steady plasma levels, reducing side effects, and improving therapeutic efficiency and compliance. One commonly used method to develop extended…
Safety of Surfactant Excipients in Oral Drug Formulations
Abstract
Surfactants are a diverse group of compounds that share the capacity to adsorb at the boundary between distinct phases of matter. They are used as pharmaceutical excipients, food additives, emulsifiers in cosmetics, and as…
Uncovering advances in final end-user applications, user acceptability, quality assurance, and…
The increasing demand for innovative drugs and personalized treatment is radically changing the pharmaceutical industry, where significant efforts in research and development (R&D) are taking place. Three-dimensional (3D) printing…
Meeting Contemporary Challenges: Development of Nanomaterials for Veterinary Medicine
Abstract
In recent decades, nanotechnology has been rapidly advancing in various fields of human activity, including veterinary medicine. The review presents up-to-date information on recent advancements in nanotechnology in the field and…
Effect of Different Types of Wood Pulp on Hydrolysis Reaction Time and Degree of Polymerization of…
Abstract
Different types of wood pulps are used to manufacture microcrystalline cellulose. Percentage of alpha cellulose depends on type of wood pulp. Both wood pulp soft and hard wood pulp are usually used to manufacturing…
Nanocarriers mediated delivery of methotrexate is instrumental in treating auto-immune diseases and…
Methotrexate (MTX) is used extensively in cancer chemotherapy and for the management of various autoimmune disorders such as rheumatoid arthritis and psoriasis. The well reported mechanism of action of MTX is to obstruct the…
Fenofibrate loaded nanofibers based thermo-responsive gel for ocular delivery: Formulation…
This research work is to develop nanofiber loaded in -situ gel for the delivery of fenofibrate to the posterior ocular site. Fenofibrate had showed its efficacy in neovascular ocular diseases under clinical studies but its low aqueous…
Cannabidiol safety considerations: Development of a potential acceptable daily intake value and…
Consumer use of hemp-derived products continues to rise, underscoring the need to establish evidence-based safety guidance. The present study sought to develop recommendations for oral upper intake limits of cannabidiol (CBD) isolate.…
A Review On Novel Excipients
ABSTRACT
The field of pharmaceutical formulation is constantly evolving, driven by the need for improved drug delivery systems and enhanced therapeutic outcomes. One critical aspect of this evolution is the development and utilization of…
Design and development of lipid modified arginine based self-nanoemulsifying drug delivery systems…
Cefixime (CEF) has numerous potential applications in the treatment of bacterial infections. However, due to its decreased cellular internalization, poor aqueous solubility, rapid intestinal hepatic metabolism, its clinical efficacy is…
Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo…
Abstract
Purpose
Amorphous solid dispersions (ASD) for nasal delivery offer the opportunity to increase drug release performance, while using polymers with mucoadhesive properties. The aim of the present study was to apply this…
A quality by design framework for developing nanocrystal bioenabling formulations
The present study aims to outline a rational framework for the design and development of a 1.0% (w/v) hydrocortisone nanocrystal-based formulation, resorting to a simple, efficient, and scalable nanonization methodology, based on the…
Xanthan and gum acacia modified olive oil based nanoemulsion as a controlled delivery vehicle for…
In this study, olive oil nanoemulsion modified with xanthan gum and gum acacia was explored as a potential controlled topical delivery vehicle. Oil-in-water nanoemulsion formulated with optimized composition of olive oil, tween 80, and…
Preparation, Characterization and Stability Study of Eugenol-Loaded Eudragit RS100 Nanocapsules for…
Eugenol is a phenolic compound with numerous biological activities. It is widely used in dentistry to treat toothache and pulpitis. In particular, eugenol may be used for tooth whitening procedures to minimize dental sensitivity in…
Additive Manufacturing in Pharmaceuticals – Part 2
Additive Manufacturing in Pharmaceuticals
See the new book, edited by Dr. Subham Banerjee, Ph.D., Associate Professor in the Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Guwahati,…