Comparison of in vitro screening methods for evaluating the effects of pharmaceutical excipients on membrane permeability
The effects of pharmaceutical excipients on intestinal drug absorption have been highlighted and careful excipient selection is required to develop biologically equivalent formulations. This study aimed to evaluate the effects of excipients on drug permeability and compare the characteristics of in vitro screening methods. Three in vitro models,…
‘We are planning to set up shop in the Americas in a very unique way’ – Interview with Kamlesh…
07. March 2016 Ideal Cures has recently announced the opening of its representative office in the US. Dr Kamlesh Oza as the new President – Global Business…
Development of A Taste Masked Oral Suspension of Clindamycin HCl Using Ion exchange Resin Amberlite…
07. March 2016 Purpose: To develop an oral suspension of clindamycin resin complex for the potential use in pediatrics. Conclusion: Clindamycin/Resin complexation has…
US FDA backlog holding up revamp of inactive ingredients database
07. March 2016 The process of sorting out problems with the US FDA's controversial Inactive Ingredients Database (IID) is shaping up to be a huge task, particularly as the…
APGI day: Join Gattefossé and Merck to discuss the “challenges of insoluble APIs”
Overcoming challenges of insoluble APIs in solid oral dosage forms: Formulating with innovative technologies and high performance materials.
Join us at the CNAM in Paris to learn with experts and share knowledge on successful…
Substances considered as not falling within the scope of Regulation (EC) No. 470/20091, with regard…
06. March 2016 Substances considered as not falling within the scope of Regulation (EC) No. 470/20091, with…
Excipients in the label and package leaflet of medicinal products for human use
06. March 2016 Excipients in the label and package leaflet of medicinal products for human use VOLUME 3B - Guidelines Medicinal products for human…
Nano-Crystalline Cellulose as a Novel Tablet Excipient for Improving Solubility and Dissolution of…
05. March 2016 Nano-Crystalline Cellulose as a Novel Tablet Excipient for Improving Solubility and Dissolution of Meloxicam This study explored the effect of…
Formulation of metformin hydrochloride nanoparticles by using spray drying technique and in-vitro…
05. March 2016 The aim of this study was to investigate the combined influence of two independent variables in the preparation of sustained release metformin…
FLOATING MICROSPHERE: A NOVEL GASTRORETENTIVE DOSAGE FORM
05. March 2016 Almost all drugs are rapidly and completely absorbed form gastrointestinal tract. But some drug having problems like first pass metabolism, low…
Solubility parameters of hypromellose acetate succinate and plasticization in dry coating procedures
05. March 2016
Solubility parameters of HPMCAS have not yet been investigated intensively. On this account total and three dimensional solubility parameters of HPMCAS were determined by using different experimental as well…
Preparation and in-vitro evaluation of nifedipine amorphous solid dispersions using mesoporous…
04. March 2016 Preparation and in-vitro evaluation of nifedipine amorphous solid dispersions using mesoporous silica gel The main purpose of this study was to increase…
Increasing Drug Solubility with Solid Dispersions of SilSol 6035 Silica Formulated Into Sublingual…
04. March 2016
Improving the solubility of BCS class 2 drugs is a continuing challenge for the pharmaceutical formulator. Improving solubility could allow for formulations using significantly less active and open the door to new…
Eye on Excipients: A new coprocessed ODT excipient
04. March 2016 Developing orally disintegrating tablets (ODTs) is a worldwide trend, but it’s particularly popular in Japan, where formulators at innovator…
The Future of Excipients,Space Research and the Quest for Better Pharma
03. March 2016 Virginia Wotring Opening Keynote presentation at ExcipientFest Americas 2016 April 25 - 27, 2016 More Information…
Novel naproxen/esomeprazole magnesium compound pellets based on acid-independent mechanism: in vitro…
03. March 2016 The purpose of this study was to develop the novel naproxen/esomeprazole magnesium compound pellets (novel-NAP/EMZ) depending on EMZ acid-independent…
Melt-ExtrudedEudragit® FS-Based Granules for Colonic Drug Delivery
03. March 2016 Melt-ExtrudedEudragit® FS-Based Granules for Colonic Drug Delivery The purpose of this study is to characterize the properties of Eudragit® FS-based granules…
Comparative evaluation of porous silica based carriers for lipids and liquid drug formulations
03. March 2016 Conversion of liquid and semisolid lipids into free flowing powders is an advantageous technique, as the carriers display high surface area, strong adsorption…
Enhancing the Stability of a Famotidine Tablet Formulation through Use of Starch 1500®
03. March 2016 Purpose To evaluate the influence of Starch 1500® partially pregelatinized maize starch on the physical and chemical stability of…
DRUG-EXCIPIENT INTERACTION STUDY FOR APPLE CIDER VINEGAR WITH 20 POTENTIAL EXCIPIENTS USING MODERN…
02. March 2016 Aim: To evaluate possible interaction between apple cider vinegar (ACV) which is the most frequent used active ingredient of diet pills with 20 different…
DESIGN AND EVALUATION OF VERAPAMIL HYDROCHLORIDE CONTROLLED RELEASE HYDROGEL-BASED MATRIX TABLETS
02. March 2016 Aim: The present work was aimed to formulate Verapamil hydrochloride (HCl) an antihypertensive agent as controlled release (CR) matrix tablets using…
Development of pH-sensitive self-nanoemulsifying drug delivery systems for acid-labile lipophilic…
02. March 2016 Oral administration is the most convenient way of all the drug delivery routes. Orally administered bioactive compounds must resist the harsh acidic fluids or…
Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications
02. March 2016 Abstract: In the last decades, the discovery of metabolites from marine resources showing biological activity has increased significantly. Among marine…
DISSOLUTION TESTING – Exploring the Link Between Particle Size & Dissolution Behavior for…
02. March 2016
DISSOLUTION TESTING - Exploring the Link Between Particle Size & Dissolution Behavior for OINDPs
In the development of orally inhaled and nasal products (OINDPs), a primary focus is achieving…
Drug Shortages and Excipient Opportunities: A Parenteral Excipient Market Analysis
01. March 2016 Reports of drug shortages surfaced in news outlets in 2010. By 2011, the number of drug shortages peaked. Of the 251 problem drugs published by the FDA, 183…
EXCiPACT’s excipient certification ambitions extend well beyond Europe
01. March 2016 By Phil Taylor, 01-Mar-2016 Three years since it was set up, excipient certification organisation EXCiPACT is expanding beyond its European heartland to…
SPECIAL FEATURE – Advancements in Drug Delivery Technologies Tackle Solubility &…
01. March 2016
SPECIAL FEATURE - Advancements in Drug Delivery Technologies Tackle Solubility & Bioavailability Challenges
The emerging trends in the combinatorial chemistry and drug design have led to the…
Nanocellulose: Biomedical Nanomaterial Applications
Cellulose is a natural linear biopolymer, which is constituted of an assembly of cellulose nanofibrils in a hierarchical order. Nanocelluloses in particular show great promise as a cost-effective advanced material for…
Piperine containing floating microspheres: an approach for drug targeting to the upper…
29. February 2016 The purpose of this investigation was to prepare and characterize acyclovir loaded floating microspheres by emulsification solvent evaporation method.…
Formulation and characterization of self-nanoemulsifying drug delivery systems containing monoacyl…
29. February 2016
The study investigated the use of monoacyl phosphatidylcholine (MAPC) in self-nanoemulsifying drug delivery system (SNEDDS). A D-optimal design was used to generate two sets of formulations containing…
Formulation and evaluation of metformin HCl floating microspheres
29. February 2016
The purpose of the present investigation was the preparation and evaluation of gastro-retentive floating drug delivery system for anti-diabetic drug metformin hydrochloride that would retain the drug in…
Oral biologics delivery still elusive
29. February 2016 Despite decades of effort, oral delivery of peptide, protein and antibody drugs remains a major pharmaceutical challenge, with only a handful of products…
Solid form changes during drug development: good, bad, and ugly case studies – AAPS open
29. February 2016 The relevance of solid form in drug development has been well established over time. In order to fully understand drug properties, attention has been paid…
A NEW ENHANCED SORBITOL: CALCIUM DIPHOSPHATE COMPOSITE AS A DIRECT COMPRESSION EXCIPIENT: A…
27. February 2016
Objetive: To evaluate and compared the particle and tableting properties of a new sorbitol (SOR) and anhydrous calcium diphosphate (ACD) composite with common excipients used for the preparation of tablets…
Encapsulation of Diclofenac Sodium within Polymer Beads by Silica Species via Vapour-Phase Synthesis
27. February 2016 The present study concerns the preparation of ternary composites via the in situ encapsulation of solid dispersion of diclofenac sodium within the acrylic…