Comparison of in vitro screening methods for evaluating the effects of pharmaceutical excipients on membrane permeability
The effects of pharmaceutical excipients on intestinal drug absorption have been highlighted and careful excipient selection is required to develop biologically equivalent formulations. This study aimed to evaluate the effects of excipients on drug permeability and compare the characteristics of in vitro screening methods. Three in vitro models,…
Current status of selected oral peptide technologies in advanced preclinical development and in…
27. February 2016 The development of oral dosage forms that allows absorption of therapeutic peptides to the systemic circulation is one of the greatest challenges for the…
Extraction Method Plays Critical Role in Antibacterial Activity of Propolis-Loaded Hydrogels
26. February 2016 Extraction Method Plays Critical Role in Antibacterial Activity of Propolis-Loaded Hydrogels Extracted propolis has been used for a long time as a…
Characterization of Supersaturated Danazol Solutions – Impact of Polymers on Solution Properties and…
26. February 2016 Excipients are essential for solubility enhancing formulations. Hence it is important to understand how additives impact key solution properties,…
Improved delivery of poorly soluble compounds using nanoparticle technology: a review
26. February 2016 Although a large number of new drug molecules with varied therapeutic potentials have been discovered in the recent decade, yet most of them are still in…
Formulation, development and characterizationof mucoadhesive lm for treatment of vaginalcandidiasis
25. February 2016 Formulation, development and characterizationof mucoadhesive lm for treatment of vaginalcandidiasis Objective: The objective of the present…
Preparation and characterization of fast dissolving flurbiprofen and esomeprazole solid dispersion…
25. February 2016 We aimed to develop an immediate-release flurbiprofen (FLU) and esomeprazole (ESO) combination formulation with enhanced gastric aqueous solubility and…
STEP Database Updated – 40 Excipients now!
25. February 2016
The STEP stands for Safety and Toxicity of Excipients for Paediatrics. It is a user-designed resource developed by European Paediatric Formulation Initiative (EuPFI) and United States Paediatric…
PVP/corticosteroid microspheres produced by supercritical antisolvent coprecipitation
24. February 2016 Coprecipitation of poorly water soluble drugs with an hydrophilic polymer can enhance the drug dissolution rate and, therefore, its bioavailability. In…
Gums’ based delivery systems: review on cashew gum and its derivatives
24. February 2016 Natural polymers and their derivatives have been widely used in pharmaceutical and food industries. The development of delivery systems using natural…
Application of failure mode and effects analysis in quality by design approach for formulation of…
24. February 2016
Compression coating technique has been used in formulation of chronotherapeutic drug delivery systems with pulsatile carvedilol release with polyethylene oxide as controlling release agent. FMEA, risk…
Application Note: MicroNIR PAT for blend monitoring
24. February 2016 An example of Quality by Design in practice Application Note: MicroNIR PAT for blend monitoringThe aim of Quality by Design (QbD) is to build quality…
Enhanced bioavailability of cinnarizine nanosuspensions by particle size engineering: Optimization…
24. February 2016 Cinnarizine (CIN), a poorly soluble drug with erratic bioavailability due to pH dependent solubility has limited advantage to formulate oral solid…
Gattefossé Foundation – Bulletin Technique 2013
23. February 2016
Galenic Days of Saint-Rémy de Provence
The goal of Galenic Days is to encourage exchange and dialogue between scientists from academic and industrial settings on themes relating to the formulation of…
Development and Evaluation of Fast Dissolving Oral Film of Losartan Potassium
23. February 2016
Fast dissolving oral film of Losartan potassium were prepared and evaluated with an objective to rapid dissolution of drug and absorption which may produce the rapid onset of action in the treatment of…
Drug structural features affect drug delivery from hyperbranched polyesteramide hot melt extrudates
23. February 2016 The aim of this study was firstly to evaluate the utility of Hybrane S1200 as a hot melt extrusion (HME) carrier to prepare instant-release…
Gattefossé Foundation – Bulletin Technique 2014
22. February 2016
Galenic Days of Saint-Rémy de Provence
The goal of Galenic Days is to encourage exchange and dialogue between scientists from academic and industrial settings on themes relating to the formulation of…
Exploring the potential of mannitol as an alternative to lactose in dry powder inhalation
22. February 2016 The principle of carrier-based blends is well established in formulations for dry powder inhalation, as it overcomes problems of micronized…
MHRA concerned about pharma’s preparedness for excipient risk assessments
22. February 2016 By Phil TaylorPhil Taylor, 22-Feb-2016 There are concerns that pharma companies are not fully prepared to meet the new requirements on…
TABLET MANUFACTURINGProcess Training
22. February 2016 TABLET MANUFACTURINGProcess Training MARCH 6 - 9, 2016 - Long Island University, Brooklyn, NY LECTURES & LABORATORY EXERCISES WILL COVER…
Challenges Facing Pharmaceutical Excipients
22. February 2016 The global pharmaceutical excipients market, a multibillion market, is projected to expand at a healthy pace of 6.7 percent annually in the next five years…
Vaccine Excipient & Media Summary
21. February 2016
Vaccine Excipient & Media Summary
Excipients Included in U.S. Vaccines, by Vaccine
This table includes not only vaccine ingredients (e.g., adjuvants and preservatives), but also substances…
Understanding Curing of Ethylcellulose Film Coating and In Vitro In Vivo Performance of Oral Dosage…
21. February 2016 The aim of this study focus on the extended release formulation on two aspects: the quantification and mechanistic research on pharmaceutical coating…
Development and evaluation of Pleurotus tuber-regium-cornstarch composite as a direct…
20. February 2016 Development and evaluation of Pleurotus tuber-regium-cornstarch composite as a direct compressionmultifunctional excipient Aim: The aim was to develop a…
Effect of compression pressure on inhalation grade lactose as carrier for dry powder inhalations
20. February 2016 Introduction: This study focused on the potential effects of compression forces experienced during lactose (InhaLac 70, 120, and 230) storage and transport…
Non Mcc Polymer as a Pelletisation Aid: A Review
20. February 2016
Extrusion spheronization is the widely used method by which the pellets are formulated. Pellets have certain advantages in the development of modified release dosage forms, Because of their regular shape…
Design and Evaluation of Buccal Patch Containing Combination of Hydrochlorothiazide and Lisinopril
19. February 2016
Design and Evaluation of Buccal Patch Containing Combination of Hydrochlorothiazide and Lisinopril
Purpose: The objective of the present study was to formulate and evaluate buccal patches containing…
New Perspectives for Fixed Dose Combinations of Poorly Water-Soluble Compounds: a Case Study with…
18. February 2016 Purpose Aiming to improve the dissolution rate of ezetimibe (EZE) and lovastatin (LOV) in a fixed dose combination (FDC), co-amorphous systems and…
Impact of the digital revolution on the future of pharmaceutical formulation science
18. February 2016 The ongoing digital revolution is no longer limited to the application of apps on the smart phone for daily needs but starts to affect also our…
Formulation and development of ternary hybrid matrix tablets of diltiazem hydrochloride
18. February 2016
Polyethylene oxide (PEO) has been extensively used as an extended-release excipient in matrix tablets due to its extraordinarily safe, stable, soluble, swellable and erodible properties. The present…
Inactive Ingredient Database Issues with ANDAs
18. February 2016 IPEC – FDA OGD Meeting – Inactive Ingredient Database Issues with ANDAs BACKGROUNDER DOCUMENT December 9, 2011…
Product Quality Control of a HME Co-Extrudate Using a Raman Imaging Microscope
18. February 2016 Purpose: Introduction to hot melt co-extrusion for utilization as a drug delivery method. Influence of process parameters on final drug product quality.…
Innovative Fluid Bed Pelletising Technologies
18. February 2016 Innovative Glatt Fluid Bed Pelletising Technologies…
The effect of water activity on granule characteristics and tablet properties produced by moisture…
17. February 2016 This study evaluated the effects of changing the amount of added water for moisture activated dry granulation (MADG) on the resulting granule…
Preparation and evaluation of valsartan by a novel semi-solid self-microemulsifying delivery system…
17. February 2016
The aim of the present study was to develop a novel semi-solid self-microemulsifying drug delivery system (SMEDDS) using Gelucire® 44/14 as oil with strong solid character to improve the oral…