Comparison of in vitro screening methods for evaluating the effects of pharmaceutical excipients on membrane permeability
The effects of pharmaceutical excipients on intestinal drug absorption have been highlighted and careful excipient selection is required to develop biologically equivalent formulations. This study aimed to evaluate the effects of excipients on drug permeability and compare the characteristics of in vitro screening methods. Three in vitro models,…
The Effect of Powder Blend on Drug Release Mechanisms of Hydrophobic Starch Stearate Matrix Tablets
17. February 2016
Free hydroxyl groups of glucose monomer of starch substituted with steroyl group by chemical modification leads to the formation of starch stearate (SS). Modification changes the nature from hydrophilic to…
Ultrasound assisted preparation of novel ibuprofen loaded excipient with improved compression and…
17. February 2016 Context: Most of the active pharmaceutical ingredients (APIs) suffer from a drawback of poor aqeous solubility. In addition to the same, some APIs show…
The effects of arginine glutamate, a promising excipient for protein formulation, on cell viability:…
17. February 2016 The effects of an equimolar mixture of l-arginine and l-glutamate (Arg·Glu) on cell viability and cellular stress using in vitro cell culture systems are…
Carrier-based dry powder formulation for nasal delivery of vaccines utilizing BSA as model drug
17. February 2016 Dry powder formulations for nasal vaccine delivery offer versatile advantages compared to liquid formulations, such as increased storage stability and…
APTES-modified mesoporous silicas as the carriers for poorly water-soluble drug. Modeling of…
17. February 2016 Four mesoporous siliceous materials such as SBA-16, SBA-15, PHTS and MCF functionalized with (3-aminopropyl)triethoxysilane were successfully prepared and…
Polymer-lipid hybrid systems: merging the benefits of polymeric and lipid-based nanocarriers to…
17. February 2016 A number of biobarriers limit efficient oral drug absorption; both polymer-based and lipid-based nanocarriers have demonstrated properties and delivery…
Liquisolid technology applied to pellets I: evaluation of the feasibility and dissolution…
16. February 2016 This study evaluated the feasibility of liquisolid pellets as an innovative drug delivery system to improve the dissolution rate of low solubility drugs,…
Co-Processed κ-Carrageenan-Pectin as Pelletizing Aid for Immediate Release Pellets
16. February 2016 This study investigates the extrusion-spheronization performance of some mixtures of co-processed κ-carrageenan and pectin (as excipient), and sodium…
Marine Origin Polysaccharides in Drug Delivery Systems
16. February 2016 Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The…
Enabling thermal processing of ritonavir–polyvinyl alcohol amorphous solid dispersions by KinetiSol®…
16. February 2016
Polyvinyl alcohol has received little attention as a matrix polymer in amorphous solid dispersions (ASDs) due to its thermal and rheological limitations in extrusion processing and limited…
Review of Disintegrants and the Disintegration Phenomena
16. February 2016 Disintegrant is one of the most important components in a typical tablet dosage form. It is responsible for ensuring the break-up of the tablet matrix…
Processing-induced-transformations (PITs) during direct compression: Impact of tablet composition…
16. February 2016 In the pharmaceutical field, solid-state transitions that may occur during manufacturing of pharmaceuticals are of great importance. The phase transition…
Formulation, Development and Optimization of Fast Dissolving Oral Film of Montelukast Sodium
14. January 2016 Formulation, Development and Optimization of Fast Dissolving Oral Film of Montelukast Sodium …
Formulation and process considerations for the design of sildenafil-loaded polymeric microparticles…
14. January 2016 The current study reports the preparation and characterization of sildenafil-loaded poly(lactide-co-glycolide) (PLGA)-based microparticles (MPs) by means of…
Use of Pseudoboehmite Nanoparticles for Drug Delivery System of Glucantime®
14. January 2016 Recently, the incidence of American Cutaneous Leishmaniasis (ACL) has been grown in Latin America, especially in Brazil, where from 1980 to 2005, 605,062…
Excipient Nanoemulsions for Improving OralBioavailability of Bioactives
14. January 2016 Excipient Nanoemulsions for Improving OralBioavailability of Bioactives Excipient…
Raising the Technological Level:The Scope for API, Excipients, andBiologicals Manufacture in Africa
11. February 2016 Raising the Technological Level:The Scope for API, Excipients, andBiologicals Manufacture in Africa This chapter discusses raising the technological scope…
Aggregated Nanotransfersomal Dry Powder Inhalation of Itraconazole for Pulmonary Drug Delivery
11. February 2016 Purpose: Local therapy is a valuable and strategic approach in the treatment of lung associated diseases and dry powder inhalation (DPI) formulations…
Improved Process Understanding of Fluid Bed Granulation and Coating using Current PAT Solutions
11. February 2016 Industry Workshop at the University of Milan February 26, 2016 More Information & Registration
STEP database – Safety and Toxicity of Excipients for Paediatrics
10. February 2016
The STEP stands for Safety and Toxicity of Excipients for Paediatrics. The STEP database is a user-designed free resource that compiles the safety and toxicity information of excipients that is manually…
Continuous manufacturing of delta mannitol by cospray drying with PVP
10. February 2016 Mannitol is a frequently used diluent in the production of tablets due to its non-hygroscopic character and low drug interaction potential. Although the…
On prilled Nanotubes-in-Microgel Oral Systems for protein delivery
10. February 2016 Newly discovered active macromolecules are highly promising for therapy, but poor bioavailability hinders their oral use. Microencapsulation…
Drug–Excipient Interactions – Article March 2001
09. February 2016 Although considered pharmacologically inert, excipients can initiate, propagate or participate in chemical or physical interactions with drug…
Understanding Drug-Excipient Interactions – Presentation A. Carlin – ExcipientFest 2009
09. February 2016 Excipients are more complex than well-characterized active pharmaceutical ingredients (“APIs”). Often, it is the multi-component nature of the excipient…
Influence of hydrophilic polymers on functional properties and wound healing efficacy of…
09. February 2016 The purpose of this study was to investigate the influence of different hydrophilic polymers on the swelling, bioadhesion and mechanical strength of…
Overview of pharmaceutical excipients used in tablets and capsules
The pharmaceutical industry is ever thirsty to satisfy patient’s therapeutical needs and apart from active ingredients, inactive excipients play a major role in formulation development. Pharmaceutical excipients are substances…
Drug Excipient Interactions
09. February 2016 Unintended physicochemical interaction of an excipient with a drug substance in a dosage form can result in the complexation or binding of the…
Investigation of a suitable in vitro dissolution test for itraconazole-based solid dispersions
08. February 2016 The difficulty to find a relevant in vitro dissolution test to evaluate poorly soluble drugs is a well-known issue. One way to enhance their aqueous…
Analysis of protamine peptides in insulin pharmaceutical formulations by capillary electrophoresis
08. February 2016 Protamines are a group of highly basic peptides which is sometimes added to insulin formulations to prolong the pharmacological action. In this study,…
Tragacanth as an oral peptide and protein delivery carrier: characterization and mucoadhesion
08. February 2016
Biopolymers such as tragacanth, an anionic polysaccharide gum, can be alternative polymeric carrier for physiologically important peptides and proteins. Characterization of tragacanth is thus essential for…
Mucoadhesion: A promising approach in drug delivery system
08. February 2016 Mucoadhesion, the state in which two materials, amongst which one is biological in nature, adhere to each other for extended periods of time with the help…
Webinar: QbD: How can excipient suppliers support you?
08. February 2016 Webinar: QbD: How can excipient suppliers support you? Thursday, March 10, 2016 QbD (Quality by Design) is of growing importance to…
Expanding the Analytical Toolbox for Identity Testing of Pharmaceutical Ingredients: Spectroscopic…
07. February 2016 In the pharmaceutical industry, dextrose is used as an active ingredient in parenteral solutions and as an inactive ingredient (excipient) in tablets…