Comparison of in vitro screening methods for evaluating the effects of pharmaceutical excipients on membrane permeability
The effects of pharmaceutical excipients on intestinal drug absorption have been highlighted and careful excipient selection is required to develop biologically equivalent formulations. This study aimed to evaluate the effects of excipients on drug permeability and compare the characteristics of in vitro screening methods. Three in vitro models,…
13C solid-state NMR analysis of the most common pharmaceutical excipients used in solid drug…
Excipients used in the solid drug formulations differ in their NMR relaxation and 13C cross-polarization (CP) kinetics parameters. Therefore, experimental parameters like contact time of cross-polarization and repetition time have a major…
Chitosan-tripolyphosphate nanoparticles: Optimization of formulation parameters for improving…
22. January 2016 At a novel pH value of the polymeric solution (6.2), variable chitosan (Cs) and sodium tripolyphosphate (TPP) concentrations and mass ratios were optimized…
Predicting flow behavior of pharmaceutical blends using shear cell methodology: A quality by design…
22. January 2016 The purpose of this study is to develop a model for predicting the flow properties of a four-component powder mixture. More
Taste Masking Technologies: An Overview and RecentUpdates
21. January 2016 Taste Masking Technologies: An Overview and RecentUpdates Taste Masking Technologies: An…
Smart strategies for sustained release tablets: Compritol® 888 ATO
21. January 2016 gattefosse-smart-strategies-for-sr-table…
“Design Space” Determination of a Paracetamol Fluid Bed Granulation Using Design of Experiments
20. January 2016
This study was performed to increase understanding of a paracetamol fluid bed granulation process and to identify the
critical process parameters in a laboratory scale granulation process. The screening of the process…
IPEC Insider – Impure thoughts
20. January 2016 In the pharmaceutical world, the application of a definition developed for one purpose to other areas frequently has unintended consequences, resulting in…
Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement
20. January 2016 Jagadevappa Patil*VT’s Shivajirao S Jondhle College of Pharmacy,…
Oscillatory Shear Rheology in Examining the Drug-Polymer Interactions Relevant in Hot Melt Extrusion
20. January 2016 The flow properties of drug-polymer mixtures have a significant influence on their processability when using techniques such as hot melt extrusion (HME).…
Polysaccharide-based micro/nanocarriers for oral colon-targeted drug delivery
20. January 2016 Oral colon-targeted drug delivery has attracted many researchers because of its distinct advantages of increasing the bioavailability of the drug at the…
POWTECH 2016 – Trade Fair for Processing, Analysis, and Handling of Powder and Bulk Solids
19. January 2016 The highlight for international experts from 19 - 21 April 2016 in the exhibition center Nuremberg More Information…
Formulation and Evaluation of Acyclovir Orodispersible Tablets Using Sublimation Method
19. January 2016 Formulation and Evaluation of Acyclovir Orodispersible Tablets UsingSublimation Method…
A study of a novel coprocessed dry binder composed of α-lactose monohydrate, microcrystalline…
19. January 2016 This paper deals with a study of the novel coprocessed dry binder Combilac®, which contains 70% of α-lactose monohydrate, 20% of microcrystalline cellulose…
Synthesis and characterisation of mucoadhesive thiolated polyallylamine
19. January 2016 The thiolation of polyallylamine (PAAm) for use in mucoadhesive drug delivery has been achieved. PAAm was reacted with different ratios of Traut's reagent,…
Great expectations in new excipients
19. January 2016 As pharma deals with patent cliffs, reduced healthcare spending and increasingly stringent regulations, drug development has become more challenging. New…
“Detection and mechanical removal of foreign particles in pharmaceutical powders”…
18. January 2016
January 29, 2016 at 12.15 in
Restaurant Safran-Zunft, Gerbergasse 11, 4001 Basel
Insight to drug delivery aspects for colorectal cancer
18. January 2016 World J Gastroenterol 2016 January 14; 22(2): 582-599ISSN…
Effects of the granule composition on the compaction behavior of deformable dry granules
18. January 2016 Calibration of the Drucker Prager Cap (DPC) model parameters provides a means for a deeper understanding of the impact of granule composition on the…
Investigation on release of highly water soluble drug from matrix-coated pellets prepared by…
18. January 2016 The objective was to formulate itopride HCl (ITP) extended release matrix-coated pellets by extrusion–spheronization and to investigate the influence of…
Formulation and characterisation of novel films for buccal mucosa drug delivery for paediatric…
18. January 2016 Khan, Sajjad (2015) Formulation and characterisation of novel…
Colorcon, Inc. Acquires Paulaur Corporation’s Pharmaceutical Sugar Spheres Business
18. January 2016 HARLEYSVILLE, Pa.--(BUSINESS WIRE)--Colorcon, Inc. today announces the acquisition of the Pharmaceutical Sugar Spheres product line from Paulaur…
FORMULATION AND EVALUATION OF LANSOPRAZOLE DELAYED RELEASE PELLETS
18. January 2016 S. Ramu*, P. Chandra Gopal Reddy, D. Srinivasa Rao and G.…
Recent developments in micro- and nanofabrication techniques for the preparation of amorphous…
17. January 2016 Nano- and microfabrication techniques have been widely explored in the textile, polymer and biomedical arenas, although more recently these systems have…
Chronotherapeutic Drug Delivery Systems
17. January 2016 Shanmugan and Bandameedi, J Drug Metab Toxicol 2015,…
Co-extrusion as a processing technique to manufacture a dual sustained release fixed-dose…
17. January 2016 This study aimed to design a fixed-dose combination dosage form which provides a sustained release profile for both the freely water-soluble metformin HCl…
Development and characterization of mucoadhesive buccal Patches forcontrolled delivery of…
15. January 2016 Development and characterization of mucoadhesive buccal Patches for controlled delivery of…
Next generation of buccadhesive excipient: preactivated carboxymethyl cellulose
15. January 2016 Aim Assessment of preactivated carboxymethyl cellulose as potential excipient for buccal drug delivery. Methods Firstly, carboxymethyl cellulose…
Incorporation of acetaminophen as an active pharmaceutical ingredient into porous lactose
15. January 2016 A new formulation method for solid dosage forms with drug loadings from 0.65 ± 0.03% to 39 ± 1% (w/w) of acetaminophen (APAP) as a model drug has been…
Ashland U.S. Site receives EXCiPACT GMP Certification
Brussels, 12th January, 2016
EXCiPACT asbl is delighted to announce that Ashland Specialty Ingredients ISP Chemicals LLC has recently been awarded an EXCiPACT™ Certificate from SGS ICS France, one of EXCIPACT’s internationally-recognised…
Microcrystalline Cellulose Market by Application – Trends & Forecasts to 2020
13. January 2016
Microcrystalline Cellulose Market by Application - Trends & Forecasts to 2020
Microcrystalline cellulose (MCC) is partially depolymerized alpha cellulose obtained from purified pulp, which is derived…
Micropellet-loaded rods with dose-independent sustained release properties for individual dosing via…
13. January 2016 Individual dosing of medicines is relevant for paediatrics, geriatrics and personalised medicine. The Solid Dosage Pen (SDP) allows for individual dosing by…
A trial for the design and optimization of pH-sensitive microparticles for intestinal delivery of…
13. January 2016 The aim of this study was to formulate a microparticulate delivery system to deliver cinnarizine (CIN) directly to its site of absorption to overcome its…
Investigation into the Effect of Ethylcellulose Viscosity Variation on the Drug Release of…
13. January 2016 Ethylcellulose is one of the most commonly used polymers to develop reservoir type extended release multiparticulate dosage forms. For multiparticulate…
Investigation and Evaluation of an in Situ Interpolymer Complex of Carbopol with…
12. January 2016 Carbopol (CP) is a biocompatible bioadhesive polymer used as a matrix for gastroretentive (GR) tablets, however, its rapid hydration shortens its…