Low drug load, high retention mometasone furoate cream with polyglyceryl − 3 oleate as a chemical enhancer: Formulation development, in vivo and in vitro evaluation and molecular mechanisms
Abstract
The study aimed to create a low loading, high retention, easier to apply O/W mometasone furoate (MF) cream using a chemical enhancer (CE) approach to provide more options for patients with atopic dermatitis (AD) and to investigate molecular mechanisms of its increased release and retention. A Box-Behnken design determined the optimal…
The central role of excipients in drug formulation
Active substances are rarely administered alone. For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment of hypothyroidism, is administered at a very low dosage, ranging from 15 μg to 200 μg.…
Enhancing Nutraceutical Performance Using Excipient Foods: Designing Food Structures and…
07. October 2015 David Julian McClements1,2,*, Liqiang Zou3, Ruojie Zhang3, Laura…
Influence of different types of lactose on powder flow and tablets dissolution – Article
06. October 2015 Influence of different types of lactose on powder flow and tablets dissolution…
Carbon Nanotubes: a viable drug delivery platform for the treatment of cancer – Article
06. October 2015 Carbon Nanotubes: a viable drug delivery platform for the treatment of cancer…
Development and evaluation antitumor activity of PEGylated liposomal doxorubicin on tumor-bearing…
06. October 2015 Minh HPT, Phuong LL, Thanh HN, Anh SH, Thanh TB. Development and…
FORMULATION OF DIRECT COMPRESSED VERAMPAMIL SUSTAINED RELEASE FORMULATION USING OPTIMIZED CO…
06. October 2015 P. Preetha*, A. Srinivasa Rao and C. Y. Priyanka Department of…
Fatty acids for controlled release applications: A comparison between prilling and solid lipid…
06. October 2015 The aim of the present study was to evaluate the solid state characteristics, drug release and stability of fatty acid-based formulations after processing…
Certifying Excipient cGMPs – Interviews
05. October 2015 As EU supplier risk assessment deadlines approach, a number of voluntary third-party auditing and certification options are available. Will more excipient…
DEVELOPMENT OF A RESERVOIR TYPE PROLONGEDRELEASE SYSTEM WITH FELODIPINE VIA SIMPLEX METHODOLOGY
05. October 2015 DEVELOPMENT OF A RESERVOIR TYPE PROLONGED RELEASE SYSTEM WITH FELODIPINE VIA SIMPLEX…
Melt pelletization of alginate: Effects of air pressurization on consolidation and drug release…
Microstructure consolidation of pellets is envisaged to enable a reduction of drug release in early dissolution phase. This study examines the effects of processing air pressure on drug release property of pellets and their mechanistic…
The effect of thermal and chemical modifications of excipients on the compressional properties of…
05. October 2015 The effect of thermal and chemical modifications of excipients on the compressional…
Interest of cyclodextrins in spray-dried microparticles formulation for sustained pulmonary delivery…
05. October 2015 To achieve an efficient lung delivery and efficacy, both active ingredient aerosolisation properties and permeability through the lung need to be optimized.…
Environmental risk assessment for excipients from galenical pharmaceutical production in wastewater…
Highlights
•First formal environmental risk assessment for pharmaceutical excipients.
•Based on material balances of single galenical productions at two sites.
•PEC/PNEC risk ratios for wastewater treatment plants and the…
Self-Emulsifying Drug Delivery Systems (SEDDS) in Pharmaceutical Development
05. October 2015 Beatriz Zanchetta1,2, Marco Vinícius Chaud3 and Maria Helena…
Polymeric drugs: Advances in the development of pharmacologically active polymers – Abstract
05. October 2015 Synthetic polymers play a critical role in pharmaceutical discovery and development. Current research and applications of pharmaceutical polymers are mainly…
Contamination of powders and granules by foreign particles – Mechanical detection and…
05. October 2015 In the production process of a pharmaceutical dosage form there are many sources of foreign particles to be included in the product starting at the…
FORMULATION AND OPTIMIZATION OF SUSTAINED RELEASE MATRIX TABLET OF NIFEDIPINE USING DIFFERENT GRADES…
04. October 2015 FORMULATION AND OPTIMIZATION OF SUSTAINED RELEASE MATRIX TABLET OF NIFEDIPINE USING…
The changes at the USP – Article Chris Moreton
04. October 2015 United States Pharmacopeia-National Formulary R. Christian…
Recent confusion and ongoing actions related to theFDA’s Inactive Ingredient Database (IID) –…
04. October 2015 Recent confusion and ongoing actions related to the FDA’s Inactive Ingredient Database (IID)…
Diffusion and tortuosity in porous functionalised calcium carbonate – Abstract
04. October 2015 Calcium carbonate can be 'functionalized' by use of etching agents such as phosphoric acid to create inter- and intra-particle porosity with a range of…
Nanofiller for the mechanical reinforcement of maltodextrins orodispersible films — Abstract
04. October 2015 Polyvinyl acetate (PVAc) nanoparticles improved the tensile properties of maltodextrin films. Maltodextrin and PVAc are immiscible.…
Interest of cyclodextrins in spray-dried microparticles formulation for sustained pulmonary delivery…
02. October 2015 To achieve an efficient lung delivery and efficacy, both active ingredient aerosolisation properties and permeability through the lung need to be optimized.…
IPEC Insider – Includes Part I of a 2-Part Series: Urgent Issues Related to the Chinese…
01. October 2015 IPEC Insider - Includes Part I of a 2-Part Series: Urgent Issues Related to the Chinese Pharmacopoeia 2015 and more Dec. 1, 2015 is the official…
CPhI experts predict continuous manufacturing for all within 10-years
30. September 2015
Three World-renowned experts – Bikash Chatterjee, President and CSO, Pharmatech Associates; Emil Ciurczak, President at Doramaxx; and Brian Carlin, Director Open Innovation at FMC – look at the…
CPhI Worldwide Reveals Pharma Awards Finalists
30. September 2015
The finalists of the 2015 CPhI Pharma Awards have been revealed.
Best Innovation in Manufacturing Technology, in partnership with Pharmaceutical Technology—Harro Hoefliger, Palladio, and Viavi…
FEASABILITY OF A NEW PROCESS TO PRODUCE FAST DISINTEGRATING PELLETS AS NOVEL MULTIPARTICULATE DOSAGE…
29. September 2015 Novel orally disintegrating system based on multiparticulate form was developed, offering an alternative to encounter major issues in the design of dosage…
Handbook of Polymers for Pharmaceutical Technologies
29. September 2015 Volume 1: Structure and Chemistry Volume 2: Processing and Applications Volume 3: Biodegradable Polymers Volume 4: Bioactive and Compatible…
One-step continuous extrusion process for the manufacturing of solid dispersions – Abstract
29. September 2015 The purpose of this study was to evaluate the performance of synthetic magnesium aluminometasilicate (MAS) as a novel inorganic carrier in hot melt…
Development of dry powder carrier systems for pulmonary application – Poster
29. September 2015 Development of dry powder carrier systems for pulmonary application…
Gelatin – US Pharmacopeial Convention – Notice of Adoption of Harmonized Standard
28. September 2015
Gelatin - US Pharmacopeial Convention - Notice of Adoption of Harmonized Standard
The correction to the harmonized standard for Gelatin has been approved by the Pharmacopeial Discussion Group (PDG) as…
Isomalt US Pharmacopeial Convention – Notice of Adoption of Harmonized Standard
28. September 2015
Isomalt US Pharmacopeial Convention - Notice of Adoption of Harmonized Standard
The new harmonized standard for Isomalt has been approved by the Pharmacopeial Discussion Group (PDG) as described in its PDG…
Magnesium Stearate US Pharmacopeial Convention -Notice of Adoption of Harmonized Standard
28. September 2015
The correction to the harmonized standard for Magnesium Stearate has been approved by the Pharmacopeial Discussion Group (PDG) as described in its PDG sign-off cover sheet. Having reached Stage 6 of the…
Evonik hikes up pharma excipient prices
28. September 2015 Increasing QbD needs and a range of technical service centres have driven up the prices of Evonik’s drug delivery excipient portfolio, the company says.…
Dutch regulatory expresses concern that narrow-spectrum penicillin is no longer available
28. September 2015 Astellas says phasing out is due to unavailability of excipients sodium citrate These products will also be phased out of production in the coming…