Low drug load, high retention mometasone furoate cream with polyglyceryl − 3 oleate as a chemical enhancer: Formulation development, in vivo and in vitro evaluation and molecular mechanisms
Abstract
The study aimed to create a low loading, high retention, easier to apply O/W mometasone furoate (MF) cream using a chemical enhancer (CE) approach to provide more options for patients with atopic dermatitis (AD) and to investigate molecular mechanisms of its increased release and retention. A Box-Behnken design determined the optimal…
Managing Excipients for QbD Projects – IPEC Americas Workshop December 11, 2015 in Arlington
27. September 2015
Many aspects of excipient manufacturing (scale, process capability, etc.) can make sampling of them for finished dosage form QbD projects challenging for both pharmaceutical…
Prilling of fatty acids as innovative technology for oral controlled release multiple-unit systems…
27. September 2015 Prilling represents an innovative technology for continuous particle processing and has been intensively used for the production of urea pellets. The…
Melt-in-Mouth Multi-particulate System for the Treatment of ADHD: A Convenient Platform for…
27. September 2015 Generally, pellets obtained from extrusion/spheronization, containing microcrystalline cellulose (MCC), do not disintegrate. An attempt has been made to…
Chitosan and Kappa-Carrageenan Vaginal Acyclovir Formulations for Prevention of Genital Herpes. In…
26. September 2015 marinedrugs-13-05976.pdf…
Improvement of fluvastatin bioavailability by loading on nanostructured lipid carriers –…
26. September 2015 Improvement of fluvastatin bioavailability by loading on nanostructured lipid carriers…
Why are excipients important to neonates?
26. September 2015
Why are excipients important to neonates?
Abstract
Neonates are given many medicines. A significant proportion of these medicines contain excipients. Excipients are used to facilitate the manufacture and…
Combined effects of PEGylation and particle size on uptake of PLGA particles by macrophage cells…
26. September 2015 Combined effects of PEGylation and particle size on uptake of PLGA particles by macrophage…
The role of polymers in oral bioavailability enhancement – A review
26. September 2015 The role of polymers in oral bioavailability enhancement - A review One of the most important obstacles to successful oral drug delivery is the poor…
Elemental Impurities in Pharmaceutical Excipients – Article
24. September 2015 Elemental Impurities in Pharmaceutical Excipients Li, G.,…
Evaluation of carvedilol compatibility with lipid excipients for the development of lipid-based drug…
24. September 2015 Carvedilol (CARV) is a widely used non-selective β-blocker, which has shown low bioavailability after oral administration (20 %) due to its low water…
Furosemide Loaded Silica-Lipid Hybrid Microparticles: FormulationDevelopment, in vitro and ex vivo…
24. September 2015 Furosemide Loaded Silica-Lipid Hybrid Microparticles: Formulation Development, in vitro…
Solid Lipid Nanoparticles and Nanostructured Lipid Carriers:Structure, Preparation and Application…
24. September 2015 Solid Lipid Nanoparticles and Nanostructured Lipid Carriers:Structure, Preparation and…
Continuous twin-screw granulation for enhancing the dissolution of poorly water soluble drug –…
24. September 2015 The article describes the application of a twin-screw granulation process to enhance the dissolution rate of the poorly water soluble drug, ibuprofen…
Oral formulations for paediatrics: palatability studies – Article
Palatability is one of the main (but not exclusive) pharmaceutical attribute of dosage forms which affect patient’s acceptability of an oral medicinal product and it is crucial for compliance to their treatment. The…
Dissolution Highlights from the 2014 AAPS Annual Meeting in San Diego – Article
24. September 2015 Dissolution Highlights from the 2014 AAPS Annual Meeting in San Diego…
MODCOS – A quick look into continuous pharma manufacturing
23. September 2015
Glatt expands its MODCOS line with a further solution of integrated direct compression. The line can integrate up to 3 Mixer and 10 Feeder for powder to tablet direct compression. The Glatt ViewConti System…
Functionalized Calcium Carbonate – Article
23. September 2015 Carolina Diaz-Quijano explains how it performs in tablets, orally disintegrating tablets, and orally disintegrating granules. More…
Background review for the excipient propylene glycol – Draft Report EMA 2014
23. September 2015 Background review for the excipient propylene glycol In the…
Reactive Impurities in Pharmaceutical Excipients and Their Impact on Drug Stability –…
23. September 2015 Reactive Impurities in Pharmaceutical Excipients and Their Impact on Drug Stability…
Research needs in pharmaceutical excipients: implications of a global supply chain –…
23. September 2015 Research needs in pharmaceutical excipients: implications of a global supply chain…
Syloid® XDP silica – New Application Note on Solid delivery of PEG drug solubilizers –…
22. September 2015
Syloid® XDP silica: Carrier for liquid drug solubilizers in solid dosage form.
The solubility of poorly soluble drugs can be increased by using solubilizers such as polyethylene glycols (PEG), Tween 80 etc.…
Site Targeted Press Coated Delivery of Methylprednisolone using Eudragit RS 100 and Chitosan for…
22. September 2015 Inflammatory bowel disease (IBD) is one of the five most prevalent gastrointestinal disease burdens which commonly require lifetime care. Worldwide…
Microcrystalline cellulose-carboxymethyl cellulose sodium as an effective dispersant for drug nano…
22. September 2015 - Drug nanosuspensions were converted into nanocrystals powder via spray drying. - MCCS was used as an alternative dispersant for spray drying of drug…
Hydroxypropylmethyl cellulose films crosslinked with citric acid for control release of nicotine…
22. September 2015 Hydroxypropylmethyl cellulose (HPMC) samples with varying degrees of substitution of methoxy groups (DS), mass molar substitutions of hydroxypropoxy…
Biopharmaceutical Studies on Gastroretentive Oral Dosage Forms for Eradication of Helicobacter…
22. September 2015 Biopharmaceutical Studies on Gastroretentive Oral Dosage Forms for Eradication of Helicobacter pylori - Thesis 2015…
K88 Fimbrial Adhesin Targeting of Microspheres Containing Gentamicin Made with Albumin Glycated with…
22. September 2015 K88 Fimbrial Adhesin Targeting of Microspheres Containing Gentamicin Made with Albumin…
Development of flexible and dispersible oral formulations containing praziquantel for potential…
22. September 2015 Praziquantel (PZQ), an anthelmintic drug used in developing countries for the treatment of schistosome infections, was processed using the fluid bed wet…
Micronized dry binder with superior moisture absorbent properties – News Biogrund
21. September 2015 Micronized dry binder with superior moisture absorbent properties - News Biogrund Moisture absorbent additives are often needed in situations where…
Process Design and Control of a Twin Screw Hot Melt Extrusion for Continuous Pharmaceutical…
21. September 2015 Hot Melt Extrusion (HME) is a well-known process within the plastic and food industries that has been utilized for the past several decades and is…
Excipient variability: Mostly a fuss – Article Tablets & Capsules
21. September 2015
Excipient variability: Mostly a fuss - Article Tablets & Capsules
Excipients do cause batch failures. But we need to ask: How often are they the culprit and can we elucidate what role…
European Commission GMP Guidelines to Take Effect in March
21. September 2015 Drugmakers in the EU have less than seven months to conduct risk assessments of all the excipients they use under good manufacturing practices guidelines…
EMD Millipore Provides Risk-Assessment Information for Raw Materials
19. September 2015 EMD Millipore, the Life Science business of Merck KGaA, introduced expanded documentation and regulatory information for its Emprove portfolio of…
IPEC Federation Publishes Position Paper on Third Party Audit and Certification Programmes
19. September 2015
Problem statement
Pharmaceutical manufacturers are facing increased regulatory demands to ensure that the raw materials used in their medicines - including excipients - are safe, of high-quality, and…
IPEC-Americas Joins Other Industry Associations in Providing Initial Feedback on FDA’s Quality…
19. September 2015 IPEC-Americas Joins Other Industry Associations in Providing Initial Feedback on FDA's Quality Metrics Draft Guidance at Aug. 24 Meeting …