Low drug load, high retention mometasone furoate cream with polyglyceryl − 3 oleate as a chemical enhancer: Formulation development, in vivo and in vitro evaluation and molecular mechanisms
Abstract
The study aimed to create a low loading, high retention, easier to apply O/W mometasone furoate (MF) cream using a chemical enhancer (CE) approach to provide more options for patients with atopic dermatitis (AD) and to investigate molecular mechanisms of its increased release and retention. A Box-Behnken design determined the optimal…
Why are excipients important to neonates? – Abstract
10. September 2015 Neonates are given many medicines. A significant proportion of these medicines contain excipients. Excipients are used to facilitate the manufacture and…
Nanocrystals: From raw material to the final formulated oral dosage form – A review.
10. September 2015 Many new developed drug actives are poorly soluble, therefore the need to increase the solubility of these actives arises. Nanosuspensions are fast and…
Preparation and Characterization of Microcrystalline Cellulose (MCC) by Acid Hydrolysis Using…
09. September 2015 The microcrystalline cellulose (MCC) was extracted by microwave assisted from cotton wool. The effects of sulfuric acid concentration, time and…
Structure, morphology and mechanical behaviour of novel bio-based polyurethane composites with…
09. September 2015 The aim of this work was to obtain bio-based polyurethane composites using biocomponents such as, bio-glycol, modified natural oil-based polyol, and…
Lubrizol buys Particle Sciences to build in device and formulations contracting space
09. September 2015
Lubrizol buys Particle Sciences to build in device and formulations contracting space
By Gareth MacDonald+, 09-Sep-2015
Berkshire Hathaway-owned Lubrizol has bought drug formulation and…
Feasibility of highly branched cyclic dextrin as an excipient matrix in dry powder inhalers –…
09. September 2015 We investigated the feasibility of highly branched cyclic dextrin (HBCD) as an excipient matrix in dry powder inhalers (DPIs). The fine particles of HBCD…
HPMC capsules: Current status and future prospects – Flashback 2010 Article
09. September 2015 HPMC capsules: Current status and future prospects…
A new HPMC capsule for optimum formulation of pharmaceutical dosage forms – Info Article…
09. September 2015 A new HPMC capsule for optimum formulation of pharmaceutical dosage forms - Info Article & White Paper A powerful alternative for pharmaceutical dosage…
IPEC-Americas Representatives Continue Discussions with FDA IID Working Group, Respond to Issues…
07. September 2015 Discussions with FDA IID Working Group Representatives from IPEC-Americas recently met with FDA's Office of Generic Drugs (OGD) Inactive Ingredient…
Towards a rational basis for selection of excipients: Excipient Efficiency for controlled release…
07. September 2015 There are many factors influencing the drug release behaviour from a pharmaceutical formulation as the particle size of the drug and excipient, porosity…
Pharmacokinetic evaluation of ibuprofen controlled release matrixtablets using hydrophilic Eudragit®…
06. September 2015 Pharmacokinetic evaluation of ibuprofen controlled release matrix tablets using…
Advanced Qualification of Pharmaceutical Excipient Suppliers by Multiple Analytics and Multivariate…
06. September 2015 Pharmaceutical excipients have different functions within a drug formulation, consequently they can influence the manufacturability and/or performance of…
Structural investigation of spherical hollow excipient Mannit Q by X-ray microtomography –…
06. September 2015 The structure of Mannit Q particles, an excipient made by spray-drying a d-mannitol solution, and Mannit Q tablets were investigated by synchrotron X-ray…
Mechanism of generation of drug nanocrystals in celecoxib: mannitol nanocrystalline solid dispersion…
06. September 2015 Objective of this work was to understand the mechanism of formation of celecoxib nanocrystals in celecoxib: mannitol nanocrystalline solid dispersion…
Control-release microcapsule of famotidine loaded biomimetic synthesized mesoporous silica…
06. September 2015 Highlights • Biomimetic synthesized mesoporous silica nanoparticles (B-MSNs) were used as carrier. • Famotidine (FMT) loaded B-MSN exhibited a…
Prediction of Powder Flow Performance using a Multi-component Granular Bond Number
01. September 2015 The flow function coefficients (ffc) of pharmaceutical materials were evaluated. •…
Formulation Design of Dry Powders for Inhalation
01. September 2015 Drugs for inhalation are no longer exclusively highly crystalline small molecules. They may also be amorphoussmall molecules, peptides, antibodies, and myriad…
A New Low Melting-Point Polymorph of Fenofibrate Prepared via Talc Induced Heterogeneous Nucleation
30. August 2015 This study describes a heterogeneous crystallization method by adding talc to obtain a new fenofibratepolymorph, form III. This work highlights the importance of…
In silico and in vitro methods to optimize the performance of experimental gastroretentive floating…
30. August 2015 Development of floating drug delivery systems (FDDS) is challenging. To facilitate this task, an evaluationmethod was proposed, which allows for a combined…
Mathematical approach for understanding deagglomeration behaviour of drug powder in formulations…
29. August 2015 Deagglomeration of cohesive particles in combination with coarse carrier is a key requirement for inhaled formulations. The aim of the project was to…
Formulation of a modified-release pregabalin tablet using hot-melt coating with glyceryl behenate
29. August 2015 A modified-release (MR) tablet of the anti-anxiety drug pregabalin (PRE) was prepared by hot-melt coating PRE with glyceryl behenate (GB) as a release…
Phospholipid-based solid drug formulations for oral bioavailability
24. August 2015 Low bioavailability nowadays often represents a challenge in oral dosage form development. Solid formulationscomposed of drug and phospholipid (PL), which, upon…
Formulation Design of Dry Powders for Inhalation – Abstract
22. August 2015 Drugs for inhalation are no longer exclusively highly crystalline small molecules. They may also be amorphous small molecules, peptides, antibodies, and…
The Effect of Excipients on the Permeability of BCS Class III Compounds and Implications for…
22. August 2015 Purpose Currently, the FDA allows biowaivers for Class I (high solubility and high permeability) and Class III (high solubility and low permeability)…
Polycaprolactone/maltodextrin nanocarrier for intracellular drug delivery: formulation, uptake…
19. August 2015 Prostate cancer (PCa) disease progression is associated with significant changes in intracellular and extracellular proteins, intracellular signaling…
Formulation Strategy for the Delivery of Cyclosporine A: Comparison of Two Polymeric Nanospheres…
19. August 2015 A wide range of nanoparticles has been explored for the delivery of highly hydrophobic drugs, but very few publications provide comparative data of the…
Stabilization Challenges and Formulation Strategies Associated with Oral Biologic Drug Delivery…
18. August 2015 Delivery of proteins to mucosal tissues of GI tract typically utilize formulations which protect against proteolysis and target the mucosal tissues. Using…
Extemporaneous sotalol hydrochloride oral solutions for use in paediatric cardiology: formulation…
15. August 2015 Objectives Sotalol hydrochloride (SOT) is an antiarrhythmic β-blocker which is highly effective for the treatment of supraventricular tachycardia in…
Excipient manufacturers raise concerns over stability testing
14. August 2015 Manufacturers of excipients are being sent inappropriate requests for stability data by some regulators and pharma companies, threatening to disrupt the…
Dissolution Testing and Specification Criteria for Immediate-Release Solid Oral Dosage Forms…
14. August 2015 Dissolution Testing and Specification Criteria for Immediate-Release Solid Oral Dosage Forms…
The Physico-Technical Properties of a Multicomponent Lentinus tuber regium Based Co-processed…
13. August 2015 The Physico-Technical Properties of a Multicomponent Lentinus tuber regium Based Co-processed…
Development and characterization of a novel standardized propolis dry extract obtained by factorial…
13. August 2015
Besides the known propolis biological activities, widely reported in many scientific studies, new findings in animal models have opened new fields for propolis application. Recently, there has…
How can you survive excipient regulatory changes – Webinar by Dow Corning – September…
13. August 2015 Key Learning Objectives - Learn how to make sure your excipients are regulatory compliant - Learn how to stay up-to-date on new…