Low drug load, high retention mometasone furoate cream with polyglyceryl − 3 oleate as a chemical enhancer: Formulation development, in vivo and in vitro evaluation and molecular mechanisms
Abstract
The study aimed to create a low loading, high retention, easier to apply O/W mometasone furoate (MF) cream using a chemical enhancer (CE) approach to provide more options for patients with atopic dermatitis (AD) and to investigate molecular mechanisms of its increased release and retention. A Box-Behnken design determined the optimal…
Elemental Impurities – IPEC Americas Webinar – September 9, 2015
13. August 2015
Get the Latest on the ICH Q3D Guideline for Elemental Impurities!
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Characterisation of a novel, multifunctional, co-processed excipient and its effect on release…
11. August 2015 Characterisation of a novel, multifunctional, co-processed excipient and its effect on…
PROCESS FOR PRODUCING COMPOSITIONS RICH IN CRYSTALS OF MANNITOL IN DELTA FORM, COMPOSITIONS AND…
11. August 2015 A process for producing a composition which is particularly rich in D-mannitol, the latter being present in the form of crystals having a volume average…
Powder, capsule and device: An imperative ménage à trois for respirable dry powders – Abstract
11. August 2015 The development of inhaled products to treat or to prevent lung infection is a very active research field in drug delivery. The pulmonary route is extremely…
Formulation, in vitro Characterization and Stability Studies of Fast Dispersing Tablets of…
11. August 2015 Formulation, in vitro Characterization and Stability Studies of Fast Dispersing Tablets of…
2nd Annual Oral Drug FormulationInnovations Summit – September 29-30, 2015 –…
11. August 2015 2nd Annual Oral Drug FormulationInnovations Summit - September 29-30, 2015 - Philadelphia, PA Information & Registration…
Evaluation of Acetaminophen Particle Size and Crystal Morphology onTaste-Masking Performance from…
11. August 2015 Raxit Y. Mehta, Charles R. Cunningham and Ali R. Rajabi-Siahboomi…
Numerical evaluation of the capping tendency of microcrystalline cellulose tablets during a…
11. August 2015 Capping is one of the major problems that occur during the tabletting process in the pharmaceutical industry. This study provided an effective method for…
Novel method of the surface modification of the microcrystalline cellulose powder with poly(isobutyl…
11. August 2015 Novel method of the surface modification of the microcrystalline cellulose powder with poly(isobutyl vinyl ether) using mechanochemical polymerization - Abstrac…
Towards a rational basis for selection of excipients: Excipient Efficiency for controlled release…
08. August 2015 There are many factors influencing the drug release behaviour from a pharmaceutical formulation as the particle size of the drug and excipient, porosity of…
Studies on Preparation and Characterization of Carboxymethyl high Amylose Starch: As a Novel…
08. August 2015 Studies on Preparation and Characterization of Carboxymethyl high Amylose Starch: As a Novel Polymeric Carrier in Oral Controlled Drug Delivery - Abstract The…
Preformulation studies and optimization of sodium alginate based floating drug delivery system for…
08. August 2015 The aim of this study was to design a local, floating, mucoadhesive drug delivery system containing metronidazole for Helicobacter…
Enhancing the water dispersibility of paclitaxel by complexation with hydrophobic peptides –…
08. August 2015 Highlights Hydrophobic peptides with high molecular weights (Pep-A) enhanced the water dispersibility of paclitaxel (Ptx). The complex between…
Why Sugar Is Added to Food: Food Science 101 – Full Article
08. August 2015 Why Sugar Is Added to Food: Food Science 101 Goldfein, K. R. and…
Long-term amorphous drug stability predictions using easily calculated, predicted and measured…
08. August 2015 Purpose: To develop a predictive model of the amorphous stability of drugs with particular relevance for poorly water-soluble compounds. Methods: 25…
EUDRAGIT® AWARD 2015
07. August 2015 Release your creativity! As a company at the forefront of innovation, our focus has always been on polymer research and application development. For this…
Controlled Release of Diclofenac by a New System Based on a Cellulosic Substrate and Calcium…
06. August 2015 Controlled Release of Diclofenac by a New System Based on a Cellulosic Substrate and Calcium…
Preferential Interactions and the Effect of Protein PEGylation – Article
06. August 2015 Louise Stenstrup Holm , Peter W. Thulstrup, Marina R. Kasimova,…
Solid State Compatibility Studies of Miconazole Using Thermal and Spectroscopic Methods –…
06. August 2015
Drug excipient physicochemical characterization is a systematic approach towards design of therapeutically active and stable dosage forms. The rapid advancements in novel drug delivery systems have led to an…
Current Practices inSolid Dosage Form Processing Seminar by Glatt Air Techniques – September…
06. August 2015 Current Practices inSolid Dosage Form Processing Seminar by Glatt Air Techniques - September 22-24, 2015 at Sheraton Mahwah Hotel, New Jersey…
Effect of Reprocessing and Excipient Characteristics on Ibuprofen Tablet Properties – Article
Purpose: To determine excipient and ibuprofen: excipient mixture sensitivity to reprocessing produced by either direct compression or wet granulation.
Methods: The effect of excipient type, technology and reprocessing on flow,…
Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review
The ICH quality vision introduced the concept of quality by design (QbD), which requires a greater understanding of the raw material attributes, of process parameters, of their variability and their interactions. Microcrystalline cellulose…
IPEC-Americas Publishes Position Paper on“Accelerated Stability”
05. August 2015 Accelerated_Stability_Position_Paper.pdf…
Novel Oral Delivery Systems – Articles ONdrugDELIVERY July 2015
05. August 2015
Introduction: Optimising Drug Delivery - the Challenges & Opportunities
Mr Patrick Crowley and Professor Luigi G Martini
ARTICLE PDF
Review: Oral Peptide Delivery - Technology Landscape…
Guidelines of 19 March 2015 on the formalised risk assessment for ascertaining the appropriate good…
05. August 2015 Was is the current impact on excipient manufacturers and users on these guidelines? Guidelines Related article
Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen…
03. August 2015 This study investigates the effects of a variety of coating materials on the flowability and dissolution of dry-coated cohesive ibuprofen powders, with the…
Can ‘extrafine’ dry powder aerosols improve lung deposition? Abstract
03. August 2015 There is increasing interest in the use of so-called ‘extrafine’ aerosols to target the small airways in the management of asthma and COPD. Using previously…
FLOATING MICROSPHERES: A NOVEL APPROACH IN DRUG DELIVERY SYSTEM – Article
03. August 2015 FLOATING MICROSPHERES: A NOVEL APPROACH IN DRUG DELIVERY SYSTEM…
Fuji’s Speciality Excipients: Neusilin – Video
A Unique Form of Amorphous Magnesium Aluminometasilicate
Neusilin® US2 is a fine ultra light granule of magnesium aluminometasilicate and is widely accepted as a multifuntional excipient that improves the quality of…
Correlation of Structural and Macroscopic Properties of Starches with Their Tabletability Using the…
31. July 2015 The effects of PURE-DENT® and SPRESS® starch properties on their compression behavior was characterized using “SM2” approach (structural properties,…
Product Robustness: A Comprehensive Product Quality Strategy – AAPS
30. July 2015
A key challenge of manufacturing is variability. Variability is caused by many operational and human factors including human error, environment, wear and tear, variability in raw materials and…
Fourth Symposium on Phospholipids in Pharmaceutical Research – 21-22 September 2015 in…
29. July 2015 Fourth Symposium on Phospholipids in Pharmaceutical Research - 21-22 September 2015 in Heidelberg…
Formulation and evaluation of cefuroxim loaded submicron particles for ophthalmic delivery –…
29. July 2015 Chitosan gelatin particles could be the ideal candidate for intraocular drug delivery due to their desirable properties. Double crosslinking in double emulsion…