Low drug load, high retention mometasone furoate cream with polyglyceryl − 3 oleate as a chemical enhancer: Formulation development, in vivo and in vitro evaluation and molecular mechanisms
Abstract
The study aimed to create a low loading, high retention, easier to apply O/W mometasone furoate (MF) cream using a chemical enhancer (CE) approach to provide more options for patients with atopic dermatitis (AD) and to investigate molecular mechanisms of its increased release and retention. A Box-Behnken design determined the optimal…
Incorporating QbD Excipient Variability into Pharmaceutical Drug Product Design and Development:…
29. July 2015 By: Joseph Kushner, IV, Ph.D.Senior Principal ScientistDrug Product DesignWorldwide Research & Development Pfizer Inc More
Study of Pharmaceutical Drug-Excipient Interaction by FTIR and Raman Spectroscopy
29. July 2015 By: Ming Huang, Research Investigator IIRobert Wethman, Senior Research ScientistJohn Wasylyk, Principal ScientistBristol-Myers Squibb More…
POTENTIAL USE OF ETHYLENE VINYL ACETATECOPOLYMER EXCIPIENT IN ORAL CONTROLLEDRELEASE APPLICATIONS: A…
28. July 2015 EVA-004_EVAinOralControlledRelease_WP_Gl…
Multiobjective Design Method for the Use Processes of Pharmaceutical Excipients Considering Quality…
28. July 2015 This paper presents a multiobjective design method for determining the optimal setup of excipients use processes, e.g., material reception storage testing and…
Eudragit FS 30D as a potential polymer for use in the technology of preparing matrix tablets contain…
28. July 2015 Eudragit FS 30D as a potential polymer for use in the technology of preparing matrix tablets…
Preparation of polymeric fenofibrate formulations with accelerated drug release: Solvent evaporation…
27. July 2015 Polymeric fenofibrate-loaded films and particles aiming at improved dissolution of this poorly water-soluble drug were prepared by solvent evaporation or…
The Enhanced Inhibitory Effect of Different Antitumor Agentsin Self-Microemulsifying Drug Delivery…
27. July 2015 The Enhanced Inhibitory Effect of Different Antitumor Agentsin Self-Microemulsifying Drug Delivery Systems on Human Cervical Cancer HeLa Cells - Article…
Novel chenodeoxycholic acid–sodium alginate matrix in the microencapsulation of the potential…
27. July 2015 Novel chenodeoxycholic acid–sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. An in vitro study - Abstract Context:…
List of active DMF Type IV as per 2nd quarter 2015 – 25 new since last quarter
27. July 2015 List of active DMF Type IV as per 2nd quarter 2015 The list is an…
Less than a year to risk assess excipients: IPEC Europe develops ‘how to’ guide
24. July 2015 By Gareth MacDonald+, 27-Jul-2015 IPEC Europe has reminded drugmakers they have less than a year to risk assess all excipients used in their products under…
Design for Formulation – Webinar available on Youtube
24. July 2015 In the first "iFormulate Introduces" webinar held on 23rd July 2015, experienced formulator Dr Ian Jolliffe introduces the subject of "Design For Formulation".…
CHARACTERIZATION OF A NOVEL COPROCESSED POWDER OFLENTINUS TUBER REGIUM AND…
24. July 2015 CHARACTERIZATION OF A NOVEL COPROCESSED POWDER OF LENTINUS TUBER REGIUM AND…
2015 IPEC Foundation Award Recipients
23. July 2015
Ralph Shangraw Memorial Award Winner:
Dr. Raj Suryanarayanan, Professor of Pharmaceutics and William and Mildred Peters Endowed Chair, University of Minnesota. Dr. Sury’s goal of research work is to develop a…
Formulation and evaluation of orally disintegrating tablet of ondansetron using natural…
23. July 2015 Formulation and evaluation of orally disintegrating tablet of ondansetron using natural…
smartPearlsTM – novel dermal delivery system for amorphous cosmetic and pharma actives –…
23. July 2015 smartPearlsTM - novel dermal delivery system for amorphous cosmetic and pharma activess…
Effect of Mannitol on Nucleation and Crystal Growth of Amorphous Flavonoids: Implications on the…
22. July 2015 Effect of Mannitol on Nucleation and Crystal Growth of Amorphous Flavonoids: Implications on the Formation of Nanocrystalline Solid Dispersion - Abstract In…
Ilex paraguariensis Pellets from a Spray-Dried Extract: Development, Characterization, and Stability…
22. July 2015 Several studies have shown the potential use of Ilex paraguariensis in developing products with the aim to protect biological systems against oxidative…
A rational approach towards the design of chitosan-based nanoparticles obtained by ionotropic…
22. July 2015 Highlights Nanoparticles of chitosan-sodium tripolyphosphate (CS-TPP) are formed in the dilute and semi dilute regime The degree of coil…
Nano and Microparticulate Chitosan Based System for Formulation of Carvedilol Rapid Melt Tablet …
22. July 2015 Nano and Microparticulate Chitosan Based System for Formulation of Carvedilol Rapid Melt Tablet - Article…
Preparation, Physicochemical and Pharmaceutical Characterization of Chitosan from Catharsius…
22. July 2015 Polypeptide from Catharsius molossus L. is an active ingredient in the treatment of benign prostatic hyperplasia. The residue after extraction is harmful to…
Enteric coated spheres produced by extrusion/spheronization provide effective gastric protection and…
22. July 2015 Enteric coated spheres produced by extrusion/spheronization provide effective gastric protection and efficient release of live therapeutic bacteria - Abstract…
A Quality by Experimental Design Approach to Assess the Effect of Formulation and Process Variables…
22. July 2015
Successful pellet production has been reported in literature with cross-linked poly(vinylpyrrolidone), Polyplasdone® XL-10 and INF-10. In the present study, a quality by experimental design approach was used…
IPEC calls on FDA to establish new review process for novel excipients
22. July 2015 By Zachary Brennan+, 22-Jul-2015 As part of a push to bring more novel excipients to market, IPEC-Americas is calling on the FDA to create a new regulatory…
Focus on eliminating formulation impurities drives introduction of new polysorbate products –…
22. July 2015 Focus on eliminating formulation impurities drives introduction of new polysorbate products…
IPEC-Americas Presents Two Key Excipient Topics at FDA GDUFAMeetingPart I of 2-Part Series – Novel…
22. July 2015 On June 15, 2015, FDA held a public meeting to seek input on the reauthorization of the Generic Drug User Fee Amendments of 2012 (GDUFA). IPEC-Americas…
Formulation, Processing, and Testing of Functionally Coated Multiparticulates Workshop –…
21. July 2015
Formulation, Processing, and Testing of Functionally Coated Multiparticulates Workshop - October 24, 2015 Orlando, Florida
Coated multi-particulates offer many advantages in regards to…
Starter pellets: Materials, manufacturing methods, and applications – Article
20. July 2015 Starter pellets: Materials, manufacturing methods, and applications - Article Starter…
Multipoint Spectroscopy and Stereoscopic Imaging of Pharmaceutical Particles – Thesis Hicham…
20. July 2015 Multipoint Spectroscopy and Stereoscopic Imaging of Pharmaceutical Particles - Thesis Hicham Rifai, Dublin Institute of Technology…
Polyvinyl Alcohol Grafted Polyethylene Glycol Copolymerfor Application in Floating Drug Delivery…
20. July 2015 Polyvinyl Alcohol Grafted Polyethylene Glycol Copolymerfor Application in Floating Drug…
Foamed Polymer Excipients: Novel Way to Deliver Stem Cells, Growth Factors, and Biologics for…
20. July 2015
Celanese Presentation at 2015 CRS Annual Meeting & Exposition July 26-29, 2015 in Edinburgh, Scotland
by Christian Schneider, R&D laboratory manager
Sunday, July 26, 2015 – 1:25 pm to…
FORMULATION AND EVALUATION OF CONTROLLED RELEASE MUCOADHESSIVE MATRIXTABLETS OF LEVAMISOLE: ASSEMENT…
18. July 2015 FORMULATION AND EVALUATION OF CONTROLLED RELEASE MUCOADHESSIVE MATRIX TABLETS OF LEVAMISOLE:…
Microsponges based drug delivery system for augmented gastroparesis therapy: Formulation development…
18. July 2015 Microsponges based drug delivery system for augmented gastroparesis therapy: Formulation…
Solid lipid microparticles: an approach for improving oral bioavailability of aspirin –…
18. July 2015 Solid lipid microparticles: an approach for improving oral bioavailability of aspirin…
Impact of HPMC on the physical properties of spray-congealed PEG microparticles and its swelling…
18. July 2015 Objective: The objective of this investigation was to evaluate the effect of hydroxypropyl methylcellulose (HPMC) as an additive on the physical properties of…