Low drug load, high retention mometasone furoate cream with polyglyceryl − 3 oleate as a chemical enhancer: Formulation development, in vivo and in vitro evaluation and molecular mechanisms
Abstract
The study aimed to create a low loading, high retention, easier to apply O/W mometasone furoate (MF) cream using a chemical enhancer (CE) approach to provide more options for patients with atopic dermatitis (AD) and to investigate molecular mechanisms of its increased release and retention. A Box-Behnken design determined the optimal…
The Effect of Additives on the Behavior of Phase Sensitive In Situ Forming Implants – Abstract
18. July 2015 Phase-sensitive in situ forming implants (ISFI) are a promising platform for the controlled release of therapeutic agents. The simple manufacturing, ease of…
Formulation approaches to pediatric oral drug delivery: benefits and limitations of current…
18. July 2015 Formulation approaches to pediatric oral drug delivery: benefits and limitations of current…
About Tablet Disintegration – Thesis Julian Quodbach, Heinrich-Heine University, Düsseldorf,…
17. July 2015 About Tablet Disintegration - Thesis Julian Quodbach, Heinrich-Heine University…
Designing excipient emulsions to increase nutraceutical bioavailability: emulsifier type influences…
16. July 2015 The influence of emulsifier type on the ability of excipient emulsions to improve the solubility, stability, and bioaccessibility of powdered curcumin was…
Omyapharm FCC, an innovative Mineral excipient for Oral Dispersible Tablets (ODTs)
16. July 2015 Omyapharm FCC, an innovative Mineral excipient for Oral Dispersible Tablets (ODTs)…
The effect of mechanical grinding on the formation, crystalline changes and dissolution behaviour of…
16. July 2015 The effect of mechanical grinding on the formation, crystalline changes and dissolution behaviour of the inclusion complex of telmisartan and β-cyclodextrins - …
Spray drying of nanoparticles to form fast dissolving glipizide – Article
Poor water solubility of pharmaceutical candidates creates a big barrier to development and clinical applications. In this study, glipizide as a poorly water soluble drug was precipitated as nanoparticles and processed by spray drying…
TAYLOR DISPERSION ANALYSIS – AN EMERGINGTECHNIQUE FOR CHARACTERISING PROTEIN STABILITY:I NSULIN AS A…
15. July 2015 TAYLOR DISPERSION ANALYSIS – AN EMERGINGTECHNIQUE FOR CHARACTERISING PROTEIN STABILITY:I NSULIN AS A CASE STUDY - Poster…
Market Size of China Pharmaceutical Excipients is Expected to be RMB54.83 Billion in 2017 Says…
14. June 2015
China has launched more than 500 types of pharmaceutical excipients, far less than 1,500 types of the United States and 3,000 types of Europe. By market size, gelatin capsules, sucrose, starch, film-coated…
A Highly Sensitive Method for the Quantitation of Polysorbate 20 and 80 toStudy the Compatibility…
14. July 2015 A Highly Sensitive Method for the Quantitation of Polysorbate 20 and 80 toStudy the Compatibility between Polysorbates and m-Cresol in the PeptideFormulation -…
Design of pediatric oral formulations with a low proportion of methadone or phenobarbital for the…
14. July 2015 Context: Elaboration of oral liquid formulations is the best alternative when no marketed forms are available for pediatrics. Objective: The development,…
The use of solid lipid nanoparticles for sustained drug release – Abstract
14. July 2015 Novel solid lipid drug delivery systems such as solid lipid nanoparticles (SLN) have attracted wide and increasing attention in recent years. It has been…
Formulation and evaluation of multiparticulate drug delivery systems comprising telmisartan –…
14. July 2015
Telmisartan is poorly soluble in water, and the rate of dissolution, as well as bioavailability, is less. In the present study, an attempt has been made to improve the dissolution of the drug by coating the…
Characterisation of a novel, multifunctional, co-processed excipient and its effect on release…
13. July 2015 Characterisation of a novel, multifunctional, co-processed excipient and its effect on release profile of paracetamol from tablets prepared by direct compressio…
Improving dissolution and oral bioavailability of pranlukast hemihydrate by particle surface…
12. July 2015 Improving dissolution and oral bioavailability of pranlukast hemihydrate by particle surface modification with surfactants and homogenization - Article…
Methods of administering oral formulations and child acceptability – Article
10. July 2015 Children may be unable or unwilling to swallow medicines. In order to avoid or accommodate any such problems, parents may decide to administer medicines other…
Dimethyl silicone dry nanoemulsion inhalations: Formulation study and anti-acute lung injury effect…
10. July 2015 Acute lung injury (ALI) is a severe disease, leading to death if not treated quickly. An emergency medicine is necessary for ALI therapy. Dimethyl silicone…
Study of sodium hyaluronate-based intranasal formulations containing micro- or nanosized meloxicam…
10. July 2015 This article reports on the micro- and nanonization of meloxicam (MEL) with the aim of developing pre-dispersions as intermediates for the design of intranasal…
Carrier-based dry powder inhalation: Impact of carrier modification on capsule filling…
10. July 2015 Carrier-based dry powder inhalation: Impact of carrier modification on capsule filling processability and in vitro aerodynamic performance - Abstract This study…
Designing a biocompatible hydrogel for the delivery of melamine – Abstract
10. July 2015 A new design for nanocomposite hydrogels based on cross-linked chitosan for the delivery of mesalamine is presented. To enhance drug loading in chitosan, the…
7th annual conference on “Formulating Better medicines for Children” in Antwerp,…
09. July 2015
7th annual conference on "Formulating Better medicines for Children" in Antwerp, Belgium, September 16th -17th 2015
The 7th EuPFI conference is the networking platform for all involved in paediatric…
Characterization of Cellulose Derivatives as Pharmaceutical Excipient – Article
09. July 2015 Characterization of Cellulose Derivatives as Pharmaceutical Excipient…
Excipient-related adverse drug reactions: a clinical Approach
08. July 2015
Formulations of the same active pharmaceutical ingredients (API) may contain a variety of inactive pharmaceutical ingredients (IPI) or excipients. Package inserts are important sources of information to…
Synthesis and characterization of thiolated β-cyclodextrin as a novel mucoadhesive excipient for…
06. July 2015 Highlights •Synthesis and characterization of cysteamine conjugated β-cyclodextrin (β-CD-Cys). •Conjugates showed no toxic effects on Caco-2 cells at…
Controlled release of acidic drugs in compendial and physiological hydrogen carbonate buffer from…
06. July 2015 Controlled release of acidic drugs in compendial and physiological hydrogen carbonate buffer from polymer blend-coated oral solid dosage forms - Abstract The…
A Review On: SeDeM Expert System in Formulation Development ofPharmaceutical Forms – Article
06. July 2015 A Review On: SeDeM Expert System in Formulation Development of Pharmaceutical Forms…
The Phosphate Content of Prescription MedicationA New Consideration – Abstract
02. July 2015 Phosphate restriction is needed in most dialysis patients. The package inserts from some medications indicate that phosphate may be part of the excipient…
PRINCIPLES OF TABLET AND CAPSULE FORMULATION – ECEC Course 12-14th October 2015 in London
02. July 2015
Tablets and capsules are the major dosage forms produced by the pharmaceutical industry. The formulation and evaluation of tablets and capsules is therefore an important area for many scientists and…
DESIGN AND DEVELOPMENT OF CONVENTIONAL AND MODIFIED RELEASE ORAL DRUG DELIVERY SYSTEMS – ECEC…
02. July 2015
Three Day Intensive Course for Managers, Scientists and Technicians with the Emphasis on the Principles of Oral Drug Development from Preformulation through to Regulatory Requirements
More…
Ideal Cures Pvt. Ltd.: Ideal Cures Becomes a Trendsetter – Receives EXCiPACT™…
01. July 2015 MUMBAI, India--(BUSINESS WIRE)--IDEAL CURES PVT. LTD. is delighted to announce that it has received third EXCiPACT™ certificate for its manufacturing site…
Colorcon Continues Investment in China – Helping Accelerate Pharmaceutical Formulation Development
HARLEYSVILLE, Pa.--Colorcon officially opened a new technical service laboratory in Beijing, China on June 25, 2015. Located in the Beijing YiZhuang Biomedical Park, this technical centre is in a unique position to work closely with the…
Nanocarriers for photodynamic therapy—rational formulation design and medium-scale manufacture…
30. June 2015 The development and manufacture of novel nanocarriers for drug delivery has proved challenging with regards to scale-up and pharmaceutical quality. …
Influence of humidity on the phase behavior of API/polymer formulations – Abstract
30. June 2015 Amorphous formulations of APIs in polymers tend to absorb water from the atmosphere. This absorption of water can induce API recrystallization, leading to…
Upsalite® can control drug release rate – Newsletter Disruptive Materials
30. June 2015 In a study published today in the Journal of Pharmaceutical Sciences (link), Professor Strømmes group shows, in collaboration with Associate Professor Christel…