Low drug load, high retention mometasone furoate cream with polyglyceryl − 3 oleate as a chemical enhancer: Formulation development, in vivo and in vitro evaluation and molecular mechanisms
Abstract
The study aimed to create a low loading, high retention, easier to apply O/W mometasone furoate (MF) cream using a chemical enhancer (CE) approach to provide more options for patients with atopic dermatitis (AD) and to investigate molecular mechanisms of its increased release and retention. A Box-Behnken design determined the optimal…
INTRODUCTION TO THE FORMULATION AND STABILISATION OF PROTEIN AND PEPTIDE DRUGS – ECEC Course…
30. June 2015
Two-Day Short Course with the Emphasis on Formulation and Dosage Form Design Strategies, Mechanisms of Degradation and Excipient Choices Holiday Inn Hotel, Oxford Circus, London, UK…
Latest Advances in the Stabilisation and Formulation of Protein and Peptide Drugs – ECEC…
30. June 2015
Two-Day Intensive Course with the Emphasis on Formulation and Dosage Form Design Strategies, Analytical Methods and Excipient Choices Holiday Inn Hotel, Oxford Circus, London, UK9th
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MIT researchers create polymer nanoparticle for cancer drug delivery
29. June 2015 Chemists at MIT have created a triple warhead against cancer. They believe theirs is the first example a polymer nanoparticle which…
Studying the impact of modified saccharides on the molecular dynamics and crystallization tendencies…
29. June 2015 Molecular dynamics of pure nifedipine and its solid dispersions with modified carbohydrates as well as the crystallization kinetics of API (active…
IPEC-Americas Inactive Ingredient Proposals for Consideration during GDUFA Negotiations –…
29. June 2015 IPEC-Americas Inactive Ingredient Proposals for Consideration during GDUFA Negotiations…
New Formulation of Sustained Release Naloxone Can Reverse Opioid Induced Constipation Without…
28. June 2015 An international double-blind randomized placebo controlled study evaluated the safety and efficacy of four doses of a new sustained release naloxone capsule…
Development of a novel approach to enhance the solubility of ftibamzone formulation – Article
28. June 2015 Development of a novel approach to enhance the solubility of ftibamzone formulation…
Enniatin-containing solutions for oromucosal use: Quality-by-design ex-vivo transmucosal risk…
28. June 2015 Fusafungine, a mixture of the cyclic hexadepsipeptides enniatins, is currently on the market for the treatment of upper respiratory tract diseases because of…
Comparing the Effect of Tampering on the Oral Pharmacokinetic Profiles of Two Extended-Release…
28. June 2015 Comparing the Effect of Tampering on the Oral Pharmacokinetic Profiles of Two Extended-Release Oxycodone Formulations with Abuse-Deterrent Properties - Abstract…
The Effect of Formulation Excipients and Thermal Treatment onthe Release Properties of Lisinopril…
27. June 2015 The Effect of Formulation Excipients and Thermal Treatment on the Release Properties of…
Orally Disintegrating Tablets: A Short Review – Article
26. June 2015 Orally Disintegrating Tablets: A Short Review This article…
Formulation optimization of mouth dissolving tablets of Meloxicam using mixed hydrotropic…
25. June 2015 Formulation optimization of mouth dissolving tablets of Meloxicam using mixed hydrotropic…
Preparation of protein-loaded PLGA-PVP blend nanoparticles by nanoprecipitation method: entrapment,…
25. June 2015 Preparation of protein-loaded PLGA-PVP blend nanoparticles by nanoprecipitation method: entrapment, Initial burst and drug release kinetic studies - Article…
Drug Products with Nanomaterials: A Regulatory Prospective – AAPS Blog
25. June 2015
Drug Products with Nanomaterials: A Regulatory Prospective - AAPS Blog
Nanotechnology is an emerging technology that can be used in a broad array of Food and Drug Administration (FDA)-regulated…
Formulation development, in vitro and in vivo evaluation of microemulsion-based gel loaded with…
25. June 2015 This study was initiated with the intention to deliver low aqueous soluble ketoprofen to enhance its solubility by developing microemulsion system as a…
Formulation of nanoemulsion: a comparison between phase inversion composition method and…
25. June 2015 There is lot of confusion in the literatures regarding the method of production of nanoemulsion. According to some authors, only the methods using high energy…
Liposome-based Formulation for Intracellular Delivery of Functional Proteins – Abstract
25. June 2015 The intracellular delivery of biologically active protein represents an important emerging strategy for both fundamental and therapeutic applications. Here, we…
Application of Film-Casting Technique to Investigate Drug–Polymer Miscibility in Solid Dispersion…
24. June 2015 Determination of drug–polymer miscibility is critical for successful development of solid dispersions. This report details a practical method to predict…
Novel aspects for the analysis and optimisation of amorphous formulations – Thesis
24. June 2015 Formulating drugs in the amorphous form is an attractive and promising strategy to overcome the poorly water soluble challenge commonly encountered in the…
PBP World Meeting – 04th – 6th April 2016 in Glasgow
24. June 2015
The World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology is a high class scientific congress with the accompanying exhibition ResearchPharm.
Meet us at…
Questions and answers on sodium in the context of the revision of the guideline on ‘Excipients in…
24. June 2015 WC500188513.pdf Adobe…
β-Cyclodextrins as a Solubilization Tool for Insoluble APIs – Whitepaper Roquette
24. June 2015
To find the right solubilization tool for poorly soluble active ingredients is a big challenge.
Want to know how to increase the aqueous solubility of your API and its physico-chemical…
Porous Tablets As Carriers For Liquid Formulations – Patent Application 2015
23. June 2015 A novel tablet product that in an easy, flexible and reproducible manner can be loaded with a relatively high amount of a pharmaceutically acceptable liquid…
IPEC Americas: 3 Workshops Focused on Risk Assessment – November 10-12, 2015 / Arlington,…
23. June 2015
IPEC Americas: 3 Workshops Focused on Risk Assessment - November 10-12, 2015 / Arlington, Virginia
Did you know that ELEVEN sections of the new NSF/IPEC/ANSI 363-2014 standard require risk…
Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite® – Abstract
In vitro drug release from well-defined particle-size fractions of the mesoporous magnesium carbonate material Upsalite(®) was investigated in detail using ibuprofen, a biopharmaceutics classification system class II drug, as the model…
New nanotech excipient makes for better delayed-release drugs say researchers – News Article
22. June 2015 By Gareth MacDonald+, 22-Jun-2015 Swedish scientists who developed the solubility enhancing nanotech excipient Upsalite say it can also be used to…
Exploring the potential of porous silicas as a carrier system for dissolution rate enhancement of…
22. June 2016
Abstract
Malaria is a parasitic and vector determined blood-conceived infectious disease transmitted through infected mosquitoes. Anti-malarial drug resistance is a major health problem, which hinders the…
Beyond Traditional Tablet Disintegration Testing – Article
21. June 2015 "New insights for immediate release formulations and new opportunities for PAT measurement techniques" More Download related Article: …
Formulation of Novel Layered Sodium Carboxymethylcellulose Film Wound Dressings with Ibuprofen for…
21. June 2015 Abstract Effective assessment and management of wound pain can facilitate both improvements in healing rates and overall quality of life. From a…
Formulation optimization of galantamine hydrobromide loaded gel drug reservoirs in transdermal patch…
21. June 2015 Galantamine hydrobromide (GH) is an effective drug for Alzheimer's disease. It is currently delivered via the oral route, and this might cause nausea,…
Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from…
20. June 2015 The effect of incorporating the lipidic medium-chain triglyceride (MCT) into polymeric film-forming systems (FFS) for topical drug delivery has been…
Preparation and Characterization of Novel Drug-Inserted-Montmorillonite Chitosan Carriers for Ocular…
20. June 2015 Preparation and Characterization of Novel Drug-Inserted-Montmorillonite Chitosan Carriers for Ocular Drug Delivery - Article…
Effect of thermal and chemical modifications on the mechanical and release properties of paracetamol…
20. June 2015 Effect of thermal and chemical modifications on the mechanical and release properties of…
Formulation and In Vitro, In Vivo Evaluationof Effervescent Floating Sustained-ReleaseImatinib…
19. June 2015 Formulation and In Vitro, In Vivo Evaluationof Effervescent Floating Sustained-ReleaseImatinib Mesylate Tablet - Article…