Low drug load, high retention mometasone furoate cream with polyglyceryl − 3 oleate as a chemical enhancer: Formulation development, in vivo and in vitro evaluation and molecular mechanisms
Abstract
The study aimed to create a low loading, high retention, easier to apply O/W mometasone furoate (MF) cream using a chemical enhancer (CE) approach to provide more options for patients with atopic dermatitis (AD) and to investigate molecular mechanisms of its increased release and retention. A Box-Behnken design determined the optimal…
Novel doped calcium phosphate-PMMA bone cement composites as levofloxacin delivery systems –…
05. June 2015 Highlights •Novel BC composites with improved mechanical integrity. •Sustained in vitro release of the antibiotic (levofloxacin) from the BC composites…
Interactions and incompatibilities of pharmaceutical excipientswith active pharmaceutical…
05. June 2015 Interactions and incompatibilities of pharmaceutical excipients with active pharmaceutical…
Oral Controlled-Release Solid Dosage Forms, Use of Novel Polymer and Unconventional Polymer Blends…
05. June 2015 Oral Controlled-Release Solid Dosage Forms, Use of Novel Polymer and Unconventional Polymer Blends - Thesis Ali Rebaz (2015), Freie Universität Berlin …
Release adjustment of drug combinations with different drug solubility – Thesis Chaerunisaa …
05. June 2015 Release adjustment of drug combinations with different drug solubility - Thesis Chaerunisaa Anis Yohana (2014) Freie Universität Berlin…
Developing an Orally Inhaled Dry Powder Formulation—A Complex Itinerary and a Technological…
04. June 2015 Developing an Orally Inhaled Dry Powder…
Formulation Study of Chitosan Microparticles Loaded with Lactoferrin – Research Article
04. June 2015
Lactoferrin (LF) is known to show various useful biological features such as antimicrobial, antiviral, antitumor and anti-inflammatory effects. However, orally administered LF undergoes enzymatic degradation…
Cream Formulation Impact on Topical Administration of Engineered Colloidal Nanoparticles –…
04. June 2015 Santini, Benedetta, Ivan Zanoni, Roberta Marzi, Clara Cigni, Marzia…
“Biotherapeutic Immunomodulation as a Countermeasure to Hyperinflammatory Tissue Damage
04. June 2015
"Biotherapeutic Immunomodulation as a Countermeasure to Hyperinflammatory Tissue Damage - A Double-Blind, Phase 1 Human Study of Osteoarthritis, with Surprisin
Presentation and Research Paper presented at the…
Improved Process Understanding and End-Point Determination of High Shear Wet Granulation Process…
03. June 2015 Hua Ma, Senior Development Scientist, GSK Yu-E Zhang, Senior Manager, Ferring Pharmaceuticals Hung Tian, Technical Development Leader,…
US preference for ANSI 363 excipient standards will change, says EXCiPACT
03. June 2015 By Dan Stanton+Dan Stanton, 03-Jun-2015 Multinational excipient-makers will drive US interest in EXCiPACT, the industry-led certification scheme says as a…
ISOCHEM highlights innovative drug delivery model for Tocophersolan TPGS
03. June 2015 Press Release | ISOCHEM S.A.S. JUNE 03, 2015 Vert-Le-Petit, France: A senior scientist for specialist fine chemicals and API manufacturer ISOCHEM has…
CAPSULE TECHNOLOGY – Enteric Capsule Drug Delivery Technology – Achieving Protection Without…
03. June 2015
CAPSULE TECHNOLOGY - Enteric Capsule Dru
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FORMULATION DEVELOPMENT – Overcoming Early Phase Development Challenges & Optimizing…
03. June 2015
FORMULATION DEVELOPMENT - Overcoming Early Phase Development Challenges & Optimizing Formulations With a Minimal Amount of API - Article
FORMULATION DEVELOPMENT - Overcoming Ear
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Excipients: Enhancing the New, Highly Soluble APIs – Article
02. June 2015
Close to 40% of the currently marketed drugs fall into the two low solubility Biopharmaceutical Classification System (BCS) categories; furthermore, if looking at the pipeline of drug entities…
Dissolution and Design Space for an oral pharmaceutical product in tablet form – Abstract
02. June 2015 Kalliopi A Chatzizaharia and Dimitrios T Hatziavramidis Ind. Eng. Chem. Res., Just Accepted Manuscript DOI: 10.1021/ie5050567 Publication Date (Web):…
Evaluating various disintegrants regarding their performance in orally disintegrating tablet…
02. June 2015 82_438_ODT Disintegrant_2014_Reims.pdf…
Evaluating various wet binders to gain lactose based agglomerates applicable for orally…
02. June 2015 81_433_ODT Binder_2014_Reims.pdf…
Bringing an Excipient to Market – Presentation
01. June 2015
Bringing an Excipient to Market
David Schaible - JRS Pharma LP
Excipientfest 2015 San Juan, PR
EF15April28_2_DaveSchaible_JRS.pdf
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Excipient GMP Auditing Workshop Using the NSF/IPEC/ANSI 363 Standard – IPEC June 16-18, 2015
01. June 2015
Excipient GMP Auditing Workshop Using the NSF/IPEC/ANSI 363 Standard - IPEC June 16-18, 2015
Attend this valuable training in Atlanta, GA - June 16-18, 2015
Workshop is led by the IPEC experts…
Particle sizing measurements in pharmaceutical applications: Comparison of in-process methods versus…
01. June 2015 Particle sizing measurements in pharmaceutical applications: Comparison of in-process methods…
IPEC Europe sets its agenda for the next five years
31. May 2015
IPEC Europe's board has responded to member feedback in our recent survey and drawn up a document detailing its priorities over the next five years.
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Cationic, amphiphilic dextran nanomicellar clusters as an excipient for dry powder inhaler…
31. May 2015 Effective delivery of drugs to alveoli in a controlled manner using hydrophobic polymers as carriers has already been reported. Preclinical studies revealed…
Enhanced dissolution and stability of artemisinin by nano-confinement in ordered mesoporous SBA-15…
31. May 2015 Dissolution of poorly water-soluble drug, Artemisinin (ART), was enhanced by encapsulating the drug particles inside pore channels of ordered mesoporous silica,…
APPROACHES TO ACHIEVE ORAL CONTROLLED RELEASE DRUG DELIVERY SYSTEM USING POLYMERS: A RECENT REVIEW…
31. May 2015 The present article contains a brief review on various formulation approaches used in controlled release drug delivery system, the role of polymers in…
Juvenile Animal Testing of Hydroxypropyl-β-Cyclodextrin in Support of Pediatric Drug Development…
31. May 2015 Hydroxypropyl-β-cyclodextrin (HP-β-CD) is being explored as excipient for administration of poorly soluble NCE's in pediatrics. In support of pharmaceutical…
Application of a Mixture Experimental Design in theOptimization of the Formulation of Solid…
31. May 2015 Application of a Mixture Experimental Design in theOptimization of the Formulation of Solid Self-EmulsifyingDrug Delivery Systems Containing Carbamazepine - Ful…
Total Excipient Control (TEC) – IPEC Webinar June 24, 2015
31. May 2015
Key Topics
Excipient Design Controls
Excipient Safety
Excipient Manufacturing Process Control and Distribution
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Trehalose: A Powerful Excipient in the Formulation Toolbox – Product Information
By: Ben Nelson, PhD, and Chris Wilcox
Trehalose is a non-reducing disaccharide consisting of two glucose molecules linked by an α,α–1,1 glycosidic bond. In the pharmaceutical industry, products that benefit from the…
Qualifizierung von Wirk- und Hilfsstoffherstellern – APV Seminar 6.-7. Oktober 2015
28. May 2015
Neue Anforderungen des Kapitel 5 EU-GMP-Leitfaden
06.10. - 07.10.2015 | Mainz, Deutschland
ExcipientFest Americas 2016 Schedule – 25-27 April, 2016
28. May 2015 Workshops Key Note Speakers Educational Sessions - Regulatory, Technical, Sourcing Poster Presentations More…
Quality Risk Assessment for Excipients: An Industry Perspective
27. May 2015
By Patricia Van Arnum posted Tue, May 26, 2015 01:51 PM
The IPEC Federation has issued a position paper on European Union (EU) guidelines for excipients based on quality risk management. Although…
Implementing the ANSI NSF-IPEC 363 Standard on Excipient GMPs Will Help Ensure Compliance with…
27. May 2015 http://multibriefs.com/briefs/ipec/ImplementigtheANSINSFIPECstandardforIPEC_2.pdf…
IPEC Foundation 2015 award applications due by June 11, 2015
27. May 2015
IPEC Foundation 2015 award applications due by June 11, 2015
Shaping the future by energizing research in excipients through education and scholarship.
Award Applications
The deadline for applying for…