Low drug load, high retention mometasone furoate cream with polyglyceryl − 3 oleate as a chemical enhancer: Formulation development, in vivo and in vitro evaluation and molecular mechanisms
Abstract
The study aimed to create a low loading, high retention, easier to apply O/W mometasone furoate (MF) cream using a chemical enhancer (CE) approach to provide more options for patients with atopic dermatitis (AD) and to investigate molecular mechanisms of its increased release and retention. A Box-Behnken design determined the optimal…
Technically Unavoidable Particles (TUPs) an IPEC Excipient Webinar – May 6, 2015,…
04. May 2015
This webinar will review the issues surrounding technically unavoidable particles and the role of the new TUPP guide in supporting a risk-based approach for evaluating visible particles in…
Atomization and Spray Drying: Applied and Practical Approach – June 25-26 2015 in Barcelona
04. May 2015
Key areas covered include the various atomization methods, atomizer design, factors affecting operation, flow in atomizers, drop size, spray angle and other spray characteristics, atomizer…
FORMULATION AND OPTIMIZATION OF SUSTAINED RELEASE FLOATING MATRIX TABLETS OF SALBUTAMOL SULPHATE…
03. May 2015 Oral salbutamol sulphate has site-specific absorption in the stomach and upper part of the small intestine. Its bioavailability is about 40% due to several…
Monitoring Fluid-Bed Granulation and Milling Processes In-Line with Real-Time Imaging
03. May 2015 By P.J. CullenPharmaceutical TechnologyVolume 39, Issue 3Submitted:…
2nd Annual Controlled & Modified Drug Release Congress – May 13-14, 2015 in Philadelphia
03. May 2015 2nd Annual Controlled & Modified Drug Release Congress - May 13-14, 2015 in Philadelphia Based on the success of 2014’s inaugural event,…
Drug Delivery Strategy: Advanced Mechanisms & Product Design Congress – May 13-14, 2015…
03. May 2015 Drug Delivery Strategy: Advanced Mechanisms & Product Design Congress - May 13-14, 2015 in Philadelphia Event Description Drug delivery…
CPhI India
02. May 2015 Mix with the world of Pharma, products, people & solutions 1 - 3 December 2015, Bombay Convention and Exhibition Centre, Mumbai, India…
TTC Workshop – Fluidized Bed: Maintenance & Troubleshooting 7 – 9 July 2015
02. May 2015
TTC Workshop - Fluidized Bed: Maintenance & Troubleshooting 7 - 9 July 2015
Considering the trend towards prolonged operation time of production lines (up to 24 hours), breakdowns become…
TTC Workshop – Continuous Granulation 22 – 24 September 2015
02. May 2015
Fluidized bed technology has been widely accepted by the food, feed, fine chemical and pharmaceutical industries as an appropriate and very versatile method for drying, granulation,…
TTC Workshop – Tablet Coating 6 – 8 October 2015
02. May 2015
On the one hand, increasing international competition is forcing companies to restructure business to improve their yields, efficiency, market share and, if possible, profit.
On the other…
Mesoporous Silica Gel as a Formulation Aid for Moisture Sensitive Drugs and Excipients –…
02. May 2015 Over the years, interaction of water with actives and inactive pharmaceutical materials remained thrust area for the formulation scientists to ensure production…
IPEC Excipient GMP Auditor Workshop – June 16-18, 2015
02. May 2015
IPEC Excipient GMP Auditor Workshop - June 16-18, 2015
Cumberland Center II - 3100 Cumberland Blvd. - Atlanta GA 30339
APV/IPEC Europe Excipient Conference – September 23-24, 2015
02. May 2015
APV/IPEC Europe Excipient Conference 2015 - 23-24th September 2015, Barcelona
IPEC Europe and APV are delighted to invite you once again to our annual conference on pharmaceutical…
New Standards for Excipient GMPs Analyzing the Impact of NSF/IPEC/ANSI 363-2014
30. April 2015
New Standards for Excipient GMPs Analyzing the Impact of NSF/IPEC/ANSI 363-2014
Maxine Fritz — Executive Vice President of Pharma Biotech Consulting at NSF Health Sciences
FDANEWS Webinar…
Influence of the Component Excipients on the Quality and Functionality of a Transdermal Film…
30. April 2015 The influence of formulation variables, i.e., a hydrophilic polymer (Methocel® E15) and a film-forming polymer (Eudragit® RL 100 and Eudragit® RS 100), on the…
Bioinspired silica as drug delivery systems and their biocompatibility
30. April 2015 Silica nanoparticles have been shown to have great potential as drug delivery systems (DDS), however, their fabrication often involves harsh chemicals and…
How to Implement QbD in Generics – Interview with Inna Ben-Anat
30. April 2015 http://qbdworks.com/qbd-in-generics-inna-ben-anat/
Formulation and evaluation of gastroretentive floating drug delivery system of dipyridamole.
29. April 2015 A multiple-unit floating alginate bead drug delivery system with prolonged stomach retention time was developed in this study. The floating alginate beads…
Cytec Showcasing How Docusate Products Can Improve APIs’ Solubility at ExcipientFest 2015
28. April 2015 http://www.cytec.com/company/news/press-release/cytec-showcasing-how-docusate-products-can-improve-apis’-solubility
USP’s Newly Elected 2015–2020 Council of Experts Announced
28. April 2015
Rockville, Md., April 27, 2015 — A newly elected Council of Experts of the United States Pharmacopeial Convention (USP) will be responsible for establishing quality standards for medicines,…
The Granule Porosity Controls the Loss of Compactibility for Both Dry- and Wet-Processed Cellulose…
28. April 2015 Josefina Nordström* and Göran Alderborn Article first published online: 14 APR 2015 DOI: 10.1002/jps.24439 © 2015 Wiley Periodicals, Inc. and the…
Study of the Preparation of Amorphous Itraconazole Formulations
28. April 2015 Schematic representation of the effect of excipients in the stability to recrystallize amorphous pure glassy itraconazole when redispersing it in water.…
Optimization and evaluation of bioactive drug-loaded polymeric nanoparticles for drug delivery
28. April 2015 The premise of the present study was to suitably select or modify the constitution of the polymer matrix to achieve significantly high entrapment of…
Novel oral formulation approach for poorly water-soluble drug using lipocalin-type prostaglandin D…
27. April 2015 Eur J Pharm Sci. 2015 Apr 20. pii: S0928-0987(15)00155-4. doi: 10.1016/j.ejps.2015.04.012. Lipocalin-type prostaglandin D synthase (L-PGDS), a…
Quality by Design for Excipients – a Checklist for Suppliers and Users
27. April 2015
29/04/2015 09:35 - 09:55 - IPEC Europe, Room C
Liz Meehan
Principal Scientist in Material Attributes and Product Performance - Astra Zeneca
TCC TB – Novel excipient for direct compression
24. April 2015 Released by Jungbunzlauer April 23, 2015 TCC TB is a tricalcium citrate tetrahydrate designed to function as a direct compression excipient. See…
EU Commission published guidelines for risk assessment to ascertain GMP for excipients
24. April 2015 On march 21st 2015 the EU published new guidelines on the formalized risk assessment for ascertaining the appropriate good manufacturing practice for…
Excipient-related adverse drug reactions : a clinical approach : review article
24. April 2015
Formulations of the same active pharmaceutical ingredients (API) may contain a variety of inactive pharmaceutical ingredients (IPI) or excipients. Package inserts are important sources of…
List of US FDA DMF Type IV as per 1st quarter 2015
23. April 2015 List of US FDA DMF Type IV as per 1st quarter 2015 List of active DMF Type IV as per 1st…
Geriatric Population across the Globe to Boost the Oral Solid Dosage Forms (OSDF) and Pharma…
23. April 2015 The global oral solid dosage forms and pharma excipients market is forecasted to register a positive growth, growing at a CAGR of 6.3% during the period…
IPEC-Americas Publishes Position Paper on FDA Inactive Ingredient Database
23. April 2015
Issues related to inaccurate and incomplete information on excipients referenced in the U.S. FDA Inactive Ingredient Database (IID) and FDA policies and guidance related to the review of inactive…
Nanoparticle formulation of ormeloxifene for pancreatic cancer.
22. April 2015 Biomaterials. 2015 Jun;53:731-43. doi: 10.1016/j.biomaterials.2015.02.082. Epub 2015 Mar 26. Pancreatic cancer is the fourth most prevalent cancer with…
The effect of excipients on the stability and phase transition rate of xylazine hydrochloride and…
22. April 2015 Highlights • IR spectroscopy showed absence of chemical interaction between excipients and drug. • In thermal analysis physical interaction between…