Low drug load, high retention mometasone furoate cream with polyglyceryl − 3 oleate as a chemical enhancer: Formulation development, in vivo and in vitro evaluation and molecular mechanisms
Abstract
The study aimed to create a low loading, high retention, easier to apply O/W mometasone furoate (MF) cream using a chemical enhancer (CE) approach to provide more options for patients with atopic dermatitis (AD) and to investigate molecular mechanisms of its increased release and retention. A Box-Behnken design determined the optimal…
FORMULATION DEVELOPMENT – A QbD Approach to Develop Extended Release Softgels
31. March 2015
Soft gelatin capsules (softgels) continue to be the oral solid dosage form preferred by consumers.1 Understandably, as they are easy to swallow and digest, effectively mask unpleasant tastes and smells, and have a pleasing…
Co-Processed Chitin-Mannitol as a New Excipient for Oro-Dispersible Tablets
30. March 2015 Mar. Drugs 2015, 13(4), 1739-1764; doi:10.3390/md13041739…
Zein-based films and their usage for controlled delivery: Origin, classes and current landscape
30. March 2015 Received 5 December 2014, Revised 24 March 2015, Accepted 25 March 2015, Available online 27 March 2015…
The effects of improper mixing and preferential wetting of active and excipient ingredients on…
30. March 2015 Elsevier - Powder Technology - Available online 21 March 2015 This work focuses on the content non-homogeneity in granules across size classes in a high…
Capsugel invests in vegetarian capsules citing demand for lower moisture content and API…
27. March 2015 By Gareth MacDonald+, 26-Mar-2015 Capsugel will invest $25m (€22m) to expand production of vegetarian-friendly drug and food supplement capsules.…
Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate,…
27. March 2015 A New Era in Novel Drug Delivery for Pediatrics and Geriatrics J Drug Deliv. 2015; 2015: 640529. Published online 2015 Feb…
Formulation and in vitro evaluation of ketoprofen fast-dissolving tablets.
27. March 2015 Pharm Dev Technol. 2015 Mar 23:1-8. Comoglu T1, Inal O, Yaacoub HB. rugs exhibiting satisfactory absorption from the oral mucosa or…
The latest developments in drug excipients: Exclusive online event
26. March 2015 By Staff ReporterStaff Reporter, 25-Mar-2015Want the latest market information, and scientific insights in the pharmaceutical excipients market? Then join us…
GMP for excipients: new EU rules on raw materials, packaging, tracking
25. March 2015 By Fiona Barry +Fiona BARRY, 25-Mar-2015The European Commission has published guidelines on GMP excipients after a two-year consultation.…
Fundamental aspects of solid dispersion technology for poorly soluble drugs
24. March 2015 Yanbin Huanga, Wei-Guo Daib, doi:10.1016/j.apsb.2013.11.001Open…
Optimization of a PGSS process for a fenofibrate lipid-based solid dispersion formulation
23. March 2015 The aim of this study was to develop a formulation containing fenofibrate and Gelucire® 50/13 (Gattefossé, France) in order to improve the oral…
Vaccine Excipient & Media SummaryExcipients Included in U.S. Vaccines, by Vaccine
23. March 2015
Vaccine Excipient & Media SummaryExcipients Included in U.S. Vaccines, by Vaccine
Vaccine Excipient Table 2
excipient-table-2.pdf
Adobe Acrobat Document 147.2 KB
Download…
FORMULATION AND EVALUATION OF METFORMIN ORODISPERSIBLE TABLETS
22. March 2015 S. Madhavi*1, GNV RamaRaju2, B. John Kalyan2, G. Kamesh3 Indo American J of Pharm Sci 2015;2(2):567-572…
The “New Polyethylene Glycol Dilemma”: Polyethylene Glycol Impurities and Their Paradox Role in mAb…
22. March 2015 Christian Hildebrandt1,*, Lea Joos1, Rainer Saedler2 and Gerhard Winter1 Article first published online: 21…
Solvent-Free Melting Techniques for the Preparation of Lipid-Based Solid Oral Formulations
21. March 2015 Karin Becker - Sharareh Salar-Behzadi -Andreas Zimmer Pharmaceutical Research, Mar 2015 Lipid excipients are applied for numerous purposes such as…
Chitin and Chitosan as Direct Compression Excipients in Pharmaceutical Applications
20. March 2015 Adnan A. Badwan *, Iyad Rashid, Mahmoud M.H. Al Omari and Fouad H. Darras Research and Innovation Center (RIC), The Jordanian Pharmaceutical Manufacturing…
Oral bioavailability and pharmacodynamic activity of hesperetin nanocrystals generated using a novel…
19. March 2015 Ganesh Shete , Yogesh B. Pawar , Kaushik Thanki , Sanyog Jain , and Arvind K Bansal Mol. Pharmaceutics, Just Accepted Manuscript DOI: 10.1021/mp5008647…
The Development of Direct Extrusion-Injection Moulded Zein Matrices as Novel Oral Controlled Drug…
19. March 2015 Purpose To evaluate the potential of zein as a sole excipient for controlled release formulations prepared by hot melt Extrusion.…
EVA Foamed Excipient: Novel Way to Deliver Stem Cells, Growth Factors and Biologics for Controlled…
17. March 2015 Controlled release delivery of therapeutic agents for creating a microenvironment to prevent recurrence of brain tumors following resection is of interest...…
PQRI/USP Workshop on Elemental Impurity Requirements in aGlobal Environment – Next Steps?
17. March 2015 PQRI/USP Workshop on Elemental Impurity Requirements in aGlobal Environment – Next Steps? March 31 – April 1, 2015 - USP Meeting Center Rockville, Maryland…
TTC Workshop – Functional Film Coating 19 – 21 May 2015
17. March 2015
This workshop is conceived as a supplement to our theoretical film-coating workshop, in order to explain and demonstrate potential effects on the desired functional film-coating quality, caused by…
Nisso Announces Completion of NISSO HPC (Hydroxypropyl Cellulose) Production Capacity Expansion
17. March 2015
Nisso has completed production capacity expansion for NISSO HPC to respond to growth in worldwide demand. This supports growth of the the unique excipient NISSO HPC SSL-SFP, which can solve tablet…
ExcipientFest 2015 Presentations – April 28-29, 2015 in Puerto Rico
16. March 2015
“Solving the bioavailability challenge: The key success factor of pharmaceutical formulations”
MIchelle Quinn - EMD Millipore
“FDA Office of Pharmaceutical Quality Inactive Ingredient Database…
ExcipientFest Workshops – April 27, 2015 in Puerto Rico
16. March 2015
ExcipientFest Workshops - April 27, 2015 in Puerto Rico
Overview of Select IPEC Guides through the Eyes of the New ANSI/NSF/IPEC 363 Standard Workshop Leader: Mr. Dale Carter (IPEC Americas)
Abstract:This…
Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using…
15. March 2015 Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector Kodai Murayama 1,* , Daitaro Ishikawa…
Upcoming EXCiPACT US Training Courses
15. March 2015
The course is ideal for pharmaceutical excipient suppliers looking to implement and be certified using the EXCiPACT™ Scheme, using either the EXCiPACT™ GMP and/or GDP Standards with ISO 9001, or the new…
IPEC – Excipient GMP Auditor Workshop Oct. 20-22, 2015
13. March 2015
IPEC - Excipient GMP Auditor Workshop Oct. 20-22, 2015
IPEC-Americas Heaquarters3138 10th Street N., Suite 300Arlingtopn, VA 22201
http://ipecamericas.org
Excipients Exacerbate Confusion in NY Attorney General’s Flawed Supplement Testing
13. March 2015
The New York Attorney General unnecessarily alarmed many consumers when he announced that traces of DNA from other plants were found in several herbal supplements sold by major retailers ..
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Continuous Manufacturing of Solid Oral Drug Products: It’s Time for Change – AAPS Blog
12. March 2015
Continuous Manufacturing of Solid Oral Drug Products: It’s Time for Change - AAPS Blog
Do you foresee any Impact on the excipient (industry)?
National Standard for Excipient Good Manufacturing Practices Published by NSF International
12. March 2015
Consensus-based standard incorporates multiple regulatory and industry requirements into a single rigorous standard for the manufacturing and distribution of pharmaceutical excipients
ANN ARBOR,…
Docusate Sodium
12. March 2015 A Pharmaceutical Grade Excipient Docusate sodium is a pharmaceutical grade surfactant, making it an efficient emulsifier, wetting, dispersing and…
Supporting BTD for Solid Oral Dosage Forms – AAPS Blog
11. March 2015
Supporting BTD for Solid Oral Dosage Forms - AAPS Blog
Over the past 10-15 years, a tremendous amount of effort has been placed in developing high potency, oncology-based drug products in numerous…
Consideration of Critical Material Attributes in Hypromellose BasedHydrophilic Matrices Comprising…
11. March 2015 Consideration of Critical Material Attributes in Hypromellose BasedHydrophilic Matrices Comprising Drugs of Various Solubility - Colorcon CRS 2013 Abstract…
Colorcon adds Opadry amb II to portfolio
10. March 2015 US coating specialist Colorcon claims to have made a significant advancement in protection for pharmaceutical products sensitive to environmental moisture…