Fabrication of polymeric sorafenib coated chitosan and fucoidan nanoparticles: Investigation of anticancer activity and apoptosis in colorectal cancer cells
The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR) suppresses the growth of tumour cells, the formation…
Tablet ejection: A systematic comparison between force, static friction, and kinetic friction
The magnitude of the frictional forces during the ejection of porous pharmaceutical tablets plays an important role in determining the occurrence of tabletting defects. Here, we perform a systematic comparison between the maximum ejection…
Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation,…
Drug repositioning is a high-priority and feasible strategy in the field of oncology research, where the unmet medical needs are continuously unbalanced. Disulfiram is a potential non-chemotherapeutic, adjuvant anticancer agent. However,…
Formulation and dermal delivery of a new active pharmaceutical ingredient in an in vitro wound model…
The aim of this study was to investigate dermal delivery of the new active pharmaceutical ingredient (API) TOP-N53 into diabetic foot ulcer using an in vitro wound model consisting of pig ear dermis and elucidate the impact of drug…
Analysis of the impact of material properties on tabletability by principal component analysis and…
Principal component analysis (PCA) and partial least squares regression (PLS) were combined in this study to identify key material descriptors determining tabletability in direct compression and roller compaction. An extensive material…
A modified mechanistic approach for predicting ribbon solid fraction at different roller compaction…
Abstract
This research investigates the modeling of the pharmaceutical roller compaction process, focusing on the application of the Johanson model and the impact of varying roll speeds from 1 to 15 RPM on predictive accuracy of ribbon…
Gastrointestinal Permeation Enhancers Beyond Sodium Caprate and SNAC – What is Coming Next?
Abstract
Oral peptide delivery is trending again. Among the possible reasons are the recent approvals of two oral peptide formulations, which represent a huge stride in the field. For the first time, gastrointestinal (GI) permeation…
An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of…
Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate. However, most new chemical entities exhibit poor water solubility, and hence are exempt from…
Advanced optical assessment and modeling of extrusion bioprinting
Abstract
In the context of tissue engineering, biofabrication techniques are employed to process cells in hydrogel-based matrices, known as bioinks, into complex 3D structures. The aim is the production of functional tissue models or even…
Real-time release testing of in vitro dissolution and blend uniformity in a continuous powder…
Abstract
Continuous manufacturing is gaining increasing interest in the pharmaceutical industry, also requiring real-time and non-destructive quality monitoring. Multiple studies have already addressed the possibility of surrogate in…
Predictions of biorelevant solubility change during dispersion and digestion of lipid-based…
Abstract
Computational approaches are increasingly explored in development of drug products, including the development of lipid-based formulations (LBFs), to assess their feasibility for achieving adequate oral absorption at an early…
The development of an innovative method to improve the dissolution performance of rivaroxaban
Abstract
Recent advancements in the formulation of solid dosage forms involving active ingredient-cyclodextrin complexes have garnered considerable attention in pharmaceutical research. While previous studies predominantly focused on…
The influence of milling of ribbons on selected granule quality attributes and carvedilol release…
Abstract
Roller compaction is gaining importance in the pharmaceutical industry. This study evaluates the impact of ribbon milling conditions on properties of granules and compression mixtures and on drug release from hypromellose-based…
A review of hot melt extrusion technology: Advantages, applications, key factors and future…
Abstract
After decades of development, hot melt extrusion (HME) technology has matured as a well-established pharmaceutical methodology. Through the process of extruding both drug and carrier materials in a molten state under specific…
Using Βeta-cyclodextrin and Plasdone K-30 Polymers for Enhancing Drug Solubility by Spray Drying
Abstract
The purpose of this study was to investigate improving solubility using hydrophilic/water-soluble polymers as β-Cyclodextrin and Plasdone K-30 in a solid dispersion formulation of Carvedilol a poorly soluble drug. The…
Nanoliposomes Permeability in a Microfluidic Drug Delivery Platform across a 3D Hydrogel
Abstract
Nanoliposomes are nano-sized vesicles that can be used as drug delivery carriers with the ability to encapsulate both hydrophobic and hydrophilic compounds. Moreover, their lipid compositions facilitate their internalization by…
Inulin-Lipid Core–Shell Microcapsules Target the Gut Microbiota and Mimic the Pharmaceutical Food…
Abstract
The oral delivery of most atypical antipsychotics is severely challenged by their low oral bioavailability and significant food effects that necessitate patient compliance. Lipid formulations are an attractive delivery system…
Nordic Bioproducts Group Receives Pharmaceutical Industry’s EXCiPACT™ Certification for MCC…
Press Release
The Finnish company’s new factory in Lappeenranta has received the prestigious certification after being thoroughly audited by a recognized international entity. Nordic Bioproducts Group’s product offers the perfect solution…
Developing an innovative 3D printing platform for production of personalised medicines in a hospital…
Abstract
Breast cancer is the most frequently diagnosed cancer in women worldwide, and non-adherence to adjuvant hormonotherapy can negatively impact cancer recurrence and relapse. Non-adherence is associated with side effects of…
Formulation and Evaluation of Polysaccharide Microparticles for the Controlled Release of…
Abstract
Propranolol hydrochloride, a non-cardio-selective beta blocker, is used to treat several conditions in children, including hypertension, arrhythmias, hyperthyroidism, hemangiomas, etc. Commercial liquid formulations are available…
Facilitating direct compaction tableting of fine cohesive APIs using dry coated fine excipients:…
The possibility of attaining direct compression (DC) tableting using silica coated fine particle sized excipients was examined for high drug loaded (DL) binary blends of APIs. Three APIs, very-cohesive micronized acetaminophen (mAPAP, 7 …
Systemic delivery of proteins using novel peptides via the sublingual route
Therapeutic proteins often require needle-based injections, which compromise medication adherence especially for those with chronic diseases. Sublingual administration provides a simple and non-invasive alternative. Herein, two novel…
Dual drug-loaded polymeric mixed micelles for ovarian cancer: Approach to enhanced therapeutic…
Chemotherapy resistance remains a significant challenge in treating ovarian cancer effectively. This study addresses this issue by utilizing a dual drug-loaded nanomicelle system comprising albendazole (ABZ) and paclitaxel (PTX),…
Prediction of in-vitro dissolution and tablet hardness from optical porosity measurements
Abstract
Advanced manufacturing technologies such as continuous processing require fast information on the quality of intermediates and products. Process analytical technologies (PAT) to monitor many critical quality attributes (CQAs)…
3D Screen Printing Offers Unprecedented Anticounterfeiting Strategies for Oral Solid Dosage Forms…
Abstract
A threat to human health in developed and, in particular, in developing countries, counterfeit medicines represent the largest identified fraud market worldwide. 3D screen printing (3DSP), an additive manufacturing technology that…
Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia management
Schizophrenia is a psychiatric disorder that results from abnormal levels of neurotransmitters in the brain. Risperidone (RIS) is a common drug prescribed for the treatment of schizophrenia. RIS is a hydrophobic drug that is typically…
Hybrid models to support development of fluid bed granulation processes
Abstract
The hybrid modeling strategy which is based on the integration of mechanistic and data-driven models is proposed and applied on fluidized bed granulation processes. The tight combination of empirical process knowledge by means…
MEDELPHARM Science Lab | Video Series
MEDELPHARM is passionate about designing and manufacturing easy-to-use, fast, reliable equipment for R&D specialists.
For formulation scientists looking for assistance in powder characterization, solid dosage formulation or…
Development of emulgel formulation from Markhamia tomentosa leaf extract: Characterization and in…
Abstract
Objectives:
Skin infections are mild to severe infections often treated with antimicrobial agents. There is an increase in resistance to antimicrobial agents necessitating the search for new medicines. This study developed an…
Synergistic effect of polymers in stabilizing amorphous pretomanid through high drug loaded…
Pretomanid (PTM), an oral antibiotic used in the treatment of adults with pulmonary extensively drug-resistant, nonresponsive multidrug-resistant tuberculosis (MDR-TB). It is a poor glass former, that shows high recrystallization tendency…
Multi-component mixing and demixing model for predictive finite element modelling of pharmaceutical…
A set of numerical methods is described that allows predictive finite element method (FEM) simulations of the compaction of multi-component pharmaceutical powder formulations across the entire range of compositions. An automated…
pH Independent Bi-layer Self-microemulsifying Tablets (SMETs) of Candesartan Cilexetil with…
INTRODUCTION
CANDESARTAN CILEXETIL (CDC)
An angiotensin II receptor antagonist is a prodrug which gets converted to active drug Candersartan during absorption from the gastrointestinal tract.
The conventional CDC tablets have a…
Self-Nano-Emulsifying Drug-Delivery Systems: A Limelight on the Development, Advancements and…
Abstract
Back ground: Orally administered medication solubility is a key concern for the pharmaceutical business; about 35-40% of newly introduced pharmaceuticals have less aqueous solubility, resulting in deprived dissolution and limited…
Quality by design approach for fabrication of extended-release buccal films for xerostomia employing…
The study endeavors the fabrication of extended-release adipic acid (APA) buccal films employing a quality by design (QbD) approach. The films intended for the treatment of xerostomia were developed utilizing hot-melt extrusion technology.…
Formulation and evaluation of floating tablet of esomeprazole by using natural gums
Abstract
Objective: The main objective of the study was to develop and evaluate the gastroretentive floating tablet of esomeprazole magnesium trihydride, which is intended to increase patient compliance, deliver the medication in a…