Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Effect of Compaction Pressure on the Enzymatic Activity of Pancreatin in Directly Compressible…
Tableting of biomolecules is a challenging formulation phase due to their sensitivity to various process parameters, such as compression pressure, process dynamics, or the temperature generated. In the present study, pancreatin was…
Moisture protection strategies and challenges for solid oral dosages
Protecting moisture sensitive substances from environmental moisture is one of the biggest challenges in the pharmaceutical and nutritional supplements industry. Coating the tablet core with a suitable film coating therefore plays an…
3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering
Abstract
Selective laser sintering (SLS) has drawn attention for the fabrication of three-dimensional oral dosage forms due to the plurality of drug formulations that can be processed. The aim of this work was to employ SLS with a CO2 …
Quercetin and Morin dual drug loaded nanostructured lipid carriers: formulation and in vitro…
The aim of the study was to prepare nanostructured lipid carriers (NLCs) co-encapsulated with Quercetin and Morin and to compare the cytotoxicity of the NLCs with individual drugs as well as with their combination form. The Quercetin and…
Development of Simvastatin-Loaded Particles Using Spray Drying Method for Ex Tempore Preparation of…
In this work, a spray drying method was developed to produce drug/polymer (simvastatin/polycaprolactone) microparticles that have the potential to be used as a pre-formulation for ex tempore preparation of 2D printing cartridges. An…
Impact of Hypromellose acetate succinate and Soluplus® on the performance of β-carotene solid…
Solid dispersions (SDs) possess the potential to enhance the bioavailability of insoluble active pharmaceutical ingredients (APIs) by effectively converting them into amorphous state. However, SDs have a tendency to recrystallize unless…
Live Biotherapeutics: importance of formulation and lyophilization parametersand an example of a…
In recent years, probiotics have expanded from their traditional classification as “health promoting food” to the development of live biotherapeutic products (LBP). Traditional probiotics are marketed as food/dietary supplements while LBPs…
Innovative Design of Targeted Nanoparticles: Polymer–Drug Conjugates for Enhanced Cancer Therapy
Abstract
Polymer–drug conjugates (PDCs) have shown great promise in enhancing the efficacy and safety of cancer therapy. These conjugates combine the advantageous properties of both polymers and drugs, leading to improved pharmacokinetics,…
Design, formulation, and evaluation of risperidone mucoadhensive buccal patches
Objectives: To construct and optimize Risperidone (RIS) mucoadhesive buccal films for systemic distribution as an alternate route. To make buccal patches of Risperidone utilizing natural polymers such sodium alginate (SA), Hydroxypropyl…
Recent Research Advances on Oral Colon-Specific Delivery System of Nature Bioactive Components: A…
Oral colon-specific delivery system (OCDS) is a targeted approach that aims to directly deliver bioactive compounds directly to the colon following oral administration, thereby enhancing the colonic release of bioactive substances and…
The Guide to Formulating Oral Extended-Release Tablets
Extended-release tablets, also known as sustained-release, controlled-release, or time-release tablets, have become increasingly important in the healthcare sector due to their ability to maintain consistent drug levels in the body over a…
Influence of Manufacturing Process on the Microstructure, Stability, and Sensorial Properties of a…
The manufacturing process for ointments typically involves a series of heating, cooling, and mixing steps. Precise control of the level of mixing through homogenization and the cooling rate, as well as temperature at different stages, is…
Quality-by-Design-Based Development of Rivaroxaban-Loaded Liquisolid Compact Tablets with Improved…
Rivaroxaban (RXN) finds use in the management of pulmonary embolism and deep vein thrombosis. Its poor solubility (5–7 µg/mL) and P-gp-mediated efflux from intestinal lining limits the oral application of RXN. This work assessed the impact…
Continuous Manufacturing of Solvent-Free Cyclodextrin Inclusion Complexes for Enhanced Drug…
Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot-melt extrusion (HME) for forming cyclodextrin inclusion…
Co-delivery of exemestane and thymoquinone via nanostructured lipid carriers for efficient breast…
Owing to the poor therapeutic outcomes with a single chemotherapeutic agent, the co-delivery of agents for achieving high efficacy in managing breast cancer has been gaining a lot of interest lately. The objective of the present study was…
Evaluation of In-Die Compression Data for a Deeper Understanding of Altered Excipient Properties…
The thermodynamic analysis of tablet formation includes the thermal and mechanical analysis during compression. The aim of this study was to evaluate alterations of force–displacement data upon temperature rise as an indicator for changed…
A Potential Breakthrough in the Enhancement of Glimepiride Solubility and Dissolution Rate by Binary…
Abstract
Purpose
Glimepiride, an anti-diabetic and third-generation sulfonylurea drug belonging to class II BCS (Biopharmaceutical Classification System) type, is characterized by its low solubility and high permeability. In order to…
Comparison of Hydroxypropyl Methylcellulose and Alginate Gel Films with Meloxicam as Fast…
Abstract
The aim of the study was the preparation and comparison of two types of orodispersible gel films (ODF) by the solvent casting method. Natural polymers: sodium alginate (ALG) or hydroxypropyl methylcellulose (HPMC) were used as the…
Cyclodextrin: A prospective nanocarrier for the delivery of antibacterial agents against bacteria…
Abstract
Supramolecular chemistry introduces us to the macrocyclic host cyclodextrin, which has a hydrophobic cavity. The hydrophobic cavity has a higher affinity for hydrophobic guest molecules and forms host-guest complexation with…
Loratadine oral bioavailability enhancement via solid dispersion loaded oro-dispersible films:…
Loratadine (LRD) belongs to second-generation tricyclic H1 antihistamine class, known for its non-sedating properties in allergic reactions. H1 antihistamines avoid and block the responses to allergens or histamine in nose and…
Formulation Design and characterization of Antifungal Emulgel for Topical Delivery
Emulgel is the latest generation in novel drug transport device used for manage launch of emulsion and gel for the reason of topical use. The steadiness of emulsion is increased, while it is integrated into gel. Miconazole is an antifungal…
Optimization of ultra-sonicated homogenization conditions of fish oil emulsions to improve…
This study aimed to improve the quality characteristics of fish oil microcapsules from monolayer and multilayer emulsions by optimizing the ultra-sonicated homogenization conditions to obtain a stable source of omega-3 fatty acids to add in…
The shelf life of ASDs: 2. Predicting the shelf life at storage conditions
Amorphous solid dispersions (ASDs) are a widely used formulation technology for poorly water-soluble active pharmaceutical ingredients (API). Depending on the API-polymer combination and API load in the ASD, the amorphous API might be…
Positive Preclinical Results Unveiled for DPH001
August 23, 2023, Disruptive Pharma Announcement by Peter Åsberg
We're delighted to share positive results from our recent preclinical study for DPH001. With our innovative MMC technology, researchers at Disruptive Pharma AB have…
3D-printed dosage forms for oral administration: a review
Oral administration is the most commonly used form of treatment due to its advantages, including high patient compliance, convenient administration, and minimal preparation required. However, the traditional preparation process of oral…
Polymeric micelles for cutaneous delivery of the hedgehog pathway inhibitor TAK-441: formulation…
TAK-441 is a potent inhibitor of the hedgehog pathway (IC50 4.4 nM) developed for the treatment of basal cell carcinoma that is active against the vismodegib-resistant Smoothened receptor D473H mutant. The objective of this study was to…
Microneedle array-based electrochemical sensor functionalized with SWCNTs for the highly sensitive…
Illicit drug consumption constitutes a great concern worldwide due to its increased spread and abuse, and the negative consequences exerted on society. For instance, 3,4-methylenedioxymethamphetamine (MDMA), a synthetic amphetamine-type…
Evaluation of tricalcium citrate as a direct compressible diluent using the SeDeM Expert Diagram…
ABSTRACT
Oral administration of medicine is one of the most common delivery routes still in use today. Various dosage forms are administered via the oral route including tablets, capsules, syrups, solutions and emulsions. Tablets…
Manufacturing pharmaceutical mini-tablets for pediatric patients using drop-on-demand printing
Abstract
The pharmaceutical industry has traditionally manufactured medicines in a limited range of dose strengths, with an emphasis on addressing the needs of the largest patient subgroups. This has disadvantaged smaller patient subsets,…
3D powder bed tablet printing: From a R&D printer to a scalable GMP printer
Powder bed-based 3D printing has been used to produce pharmaceutical tablets mainly under laboratory conditions. To advance the technology for commercial use, laboratory's proof of principles should be translated to and validated under…
Advanced process automation of a pharmaceutical continuous wet granulation line: Perspectives on the…
Abstract
Pharmaceutical continuous manufacturing provides the appropriate tools (e.g. the understanding of process dynamics and appropriate and adaptable control strategy) in order to deal with Quality-by-Design expectations and even to…
Recent advances in chitosan-based materials; The synthesis, modifications and biomedical…
The attention to polymer-based biomaterials, for instance, chitosan and its derivatives, as well as the techniques for using them in numerous scientific domains, is continuously rising. Chitosan is a decomposable naturally occurring…
Effect of Material Properties and Variability of Mannitol on Tablet Formulation Development
Abstract
Purpose
Using a high level of mannitol as a diluent in oral formulations can potentially result in tablet defects (e.g., chipping, cracking) during compression. This work aims to scrutinize the linkage between the mechanical…
Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and…
Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery systems complementing conventional pharmacology has been widely acknowledged. Among these nanomaterials, lipid-based nanoparticles (LNPs) have shown…