Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Micro array patch assisted transdermal delivery of high dose, ibuprofen sodium using…
Current study reports the combined technique of microneedle array patches and thermoresponsive gels. Microneedles array patch mediated in situ skin depots were evaluated for sustain drug delivery using sodium alginate/Poly…
Breaking the ocular barrier through nano-lipid carriers to treat intraocular diseases
Abstract
The human eye is a special organ. Its defense mechanisms protect it from invading microbes and harmful molecules. Treatment of different eye diseases often shows poor results due to the presence of these barriers. Nano lipid…
Evaluation of the Effects of Storage Conditions on Spray-Dried siRNA-LNPs Before and after…
In an ideal world, pharmaceutical drugs would have infinite shelf life, no susceptibility to degradation, chemical reactions or loss of efficacy. In reality, these processes occur, however, making it desirable to extend a drugs’ shelf life.…
Florite® R as a model for incorporation of essential oils as active substances into a solid dosage…
Application of essential oils in modern medicine has a limited use due to its specific physico-chemical properties which can make them extremely unsuitable for the formulation of stable pharmaceutical forms. The aim of this study was to…
Redispersible 3D printed nanomedicines: An original application of the semisolid extrusion technique
Abstract
Semisolid extrusion is a layer-by-layer 3D printing technique that produces objects from gels or pastes. This process can be carried out at room temperature, without using a light source, and has been explored in pharmaceutics in…
A starch-based implant as a controlled drug release system: Non-invasive in vivo characterization…
Solid implants are parenteral depot systems that can provide a controlled release of drugs in the desired body area over a few days to months. Finding an alternative for the two most commonly used polymers in the production of parenteral…
Conceptual stabilizer selection for nanomilling based on dispersibility parameters
The choice of stabilizers to prevent particle agglomeration during nanomilling is an elaborate process which is often based on empirical rules and experience. Usually, extensive screening studies are required to find an appropriate…
Omega-3 fatty acid-based self-microemulsifying drug delivery system (SMEDDS) of pioglitazone:…
Pioglitazone (PGL) is an effective insulin sensitizer, however, side effects such as accumulation of subcutaneous fat, edema, and weight gain as well as poor oral bioavailability limit its therapeutic potential for oral delivery. Recent…
Optimising excipient properties to prevent aggregation in biopharmaceutical formulations
Excipients are included within protein biotherapeutic solution formulations to improve colloidal and conformational stability, but are generally not designed for the specific purpose of preventing aggregation and improving cryoprotection in…
Chitosan-coated nanostructured lipid carriers for effective brain delivery of Tanshinone IIA in…
Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder associated with increased oxidative stress, the underlying vital process contributing to cell death. Tanshinone IIA (TAN) is a phytomedicine with a…
Effects of Additives on the Physical Stability and Dissolution of Polymeric Amorphous Solid…
Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the solubility of poorly water-soluble drugs. However, achieving both physical stability and dissolution performance in an ASD prepared with a single polymer can…
Continuous Direct Compression of a High-dose Drug Evaluation of Process and Quality Attributes
Summary
Continuous production has now been adopted even in the pharmaceutical industry and is indispensable in current product developments. This study focuses on the process of continuous direct compression, with the aim of guaranteeing…
The relationship between molecular-structural properties and functional-related characteristics of…
Croscarmellose sodium (CCS)is a superdisintegrant used in the formulation of pharmaceutical tablets. As with most other pharmaceutical ingredients, CCS is produced by various manufacturers. Our previous work has shown that products of…
Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System
Skin diseases are among the most prevalent non-fatal conditions worldwide. The transdermal drug delivery system (TDDS) has emerged as a promising approach for treating skin diseases, owing to its numerous advantages such as high…
Drug delivery systems for thyroid disease treatment: A mini review on current therapies and…
Thyroid hormones play an important role in many metabolic processes in the human body. However, these processes can often be disrupted by an over or underactivity of the thyroid gland which, if undiagnosed or untreated, can result in…
Challenges and strategies for ocular posterior diseases therapy via non-invasive advanced drug…
Posterior segment diseases, such as age-related macular degeneration (AMD) and diabetic retinopathy (DR) are vital factor that seriously threatens human vision health and quality of life, the treatment of which poses a great challenge to…
Wet granulation of co-amorphous indomethacin systems
The feasibility of co-amorphous systems to be wet granulated together with microcrystalline cellulose (MCC) was investigated. Solid state and molecular interactions were analysed for various co-amorphous drug-amino acid formulations of …
QbD Design, Formulation, Optimization and Evaluation of Trans-Tympanic Reverse Gelatination Gel of…
Traditional otic drug delivery methods lack controlled release capabilities, making reverse gelatination gels a promising alternative. Reverse gelatination gels are colloidal systems that transition from a sol to a gel phase at the target…
Comparative Evaluation of the Powder and Tableting Properties of Regular and Direct Compression…
Hypromellose, a widely used polymer in the pharmaceutical industry, is available in several grades, depending on the percentage of substitution of the methoxyl and hydroxypropyl groups and molecular weight, and in various functional forms…
Development of Fluoride-Loaded Chitosan Microparticles for Controlled Drug Delivery: A Comparative…
Purpose
The oral administration of drugs is usually the most convenient, economical, and preferred route for patients. Chitosan is a natural polymer that is biocompatible and possesses good mucoadhesion properties and has been proposed for…
Simulation of roller compaction by combination of a compaction simulator and oscillating mill – A…
This study investigates the feasibility of a compaction simulator and oscillating mill to mimic a roller compactor as a material sparing approach for process development. Microcrystalline cellulose and dicalcium phosphate dihydrate were…
Inhalation powder development without carrier: How to engineer ultra-flying microparticles?
Particle engineering technologies have led to the commercialization of new inhaled powders like PulmoSolTM or PulmoSphereTM. Such platforms are produced by spray drying, a well-known process popular for its versatility, thanks to…
Long-acting microneedle formulations
The minimally-invasive and painless nature of microneedle (MN) application has enabled the technology to obviate many issues with injectable drug delivery. MNs not only administer therapeutics directly into the dermal and ocular space, but…
Investigation on nozzle zone agglomeration during spray drying using response surface methodology
During spray drying, dry powder is circulated into the nozzle zone to force collisions, inducing agglomeration. This study systematically determined the effect of fine powder mass flowrate (varying from 7.1 ± 1.2–15.9 ± 0.5 kg∙h−1), drying…
Mitigating Nitrosamine Risks in Drug Products: Fuji Chemical Offers a Low-Risk Solution with…
See the latest issue of Fuji Chemical Industries Technical Newsletter: It presents Fujicalin®, a low-risk solution for mitigating nitrosamine risks in drug products.
Mitigating Nitrosamine Risks in Drug Products: Fuji Chemical Offers a…
Enteric protection followed by rapid drug release in the upper small intestine or colon
AN ADVANCED PORTFOLIO FOR PRECISE TARGETING AND RAPID DRUG RELEASE
Many oral products require enteric protection followed by rapid, homogeneous drug release to enable precise targeting within either the proximal region of the…
The battle of lipid-based nanocarriers against blood-brain barrier: a critical review
Central nervous system integrity is the state of brain functioning across sensory, cognitive, emotional-social behaviors, and motor domains, allowing a person to realise his full potential. Thus, brain disorders seriously affect patients’…
Recent advances in microwave-assisted nanocarrier based drug delivery system: Trends and…
Microwave irradiation technology has a lot of applications in the field of food processing, organic synthesis, pharmaceuticals, and biomedical therapy. The basic mechanisms observed in microwave-assisted syntheses are dipolar polarization…
Screening and optimization of supercritical fluid process for the preparation of albendazole solid…
Solid dispersion (SD) technology has been proved to be one of the most successful techniques to enhance aqueous solubility of poorly-water soluble drugs. Supercritical fluid (SCF) using carbon dioxide (CO2) became attractive due to its own…
Biosafety of mesoporous silica nanoparticles; towards clinical translation
Mesoporous silica nanoparticles (MSNs) have attracted the attention of chemists, who have developed numerous systems for the encapsulation of a plethora of molecules, allowing the use of mesoporous silica nanoparticles for biomedical…
Developing a robust in vitro release method for a polymeric nanoparticle: Challenges and learnings
Nanomedicines have emerged as a promising approach for targeted therapeutic delivery and specifically as a beneficial alternative to conventional cancer therapies as they can deliver higher concentrations of chemotherapeutic agents at the…
Nanostructured Lipid Carriers to Enhance the Bioavailability and Solubility of Ranolazine:…
Chronic stable angina pectoris is the primary indication for ranolazine (RZ), an anti-anginal drug. The drug has an anti-ischemic action that is unaffected by either blood pressure or heart rate. Due to the first-pass effect, the drug has a…
In-line particle size measurement during granule fluidization using convolutional neural…
This paper presents a machine learning-based image analysis method to monitor the particle size distribution of fluidized granules. The key components of the direct imaging system are a rigid fiber-optic endoscope, a light source and a…
Development of Bedaquiline Loaded SNEDDS Using Quality by Design (QbD) Approach to Improve…
Background:
The ever-growing emergence of antibiotic resistance associated with tuberculosis (TB) has become a global challenge. In 2012, USFDA has given expedited approval to bedaquiline (BDQ), as a new treatment for drug-resistant TB in…