Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Evaluation of solubilizing potential of functional poly(jasmine lactone) micelles for hydrophobic…
Achieving high solubilization capacity with the aid of polymeric micelles (PM) is still a major challenge. To address this shortcoming, novel poly(jasmine lactone) (PJL)-based PM were developed and compared with Soluplus® and poly(lactide)…
Mechanically promoted lipid-based filaments via composition tuning for extrusion-based 3D-printing
Abstract
Lipid excipients are favorable materials in pharmaceutical formulations owing to their natural, biodegradable, low-toxic and solubility/permeability enhancing properties. The application of these materials with advanced…
Intraoral Drug Delivery: Highly Thiolated κ-Carrageenan as Mucoadhesive Excipient
Aim: This study aims to design a novel thiolated κ-carrageenan (κ-CA-SH) and evaluate its potential as an excipient for the design of mucoadhesive drug delivery systems.
Methods: Native κ-carrageenan (κ-CA) was thiolated with phosphorous…
Virodex™: exploring our innovative solution to the Triton™ X-100 ban
Triton™ X-100 is a widely used non-ionic surfactant and emulsifier, with a range of applications including viral inactivation, cell lysis and protein solubilisation. Triton™ X-100 belongs to the substance group Phenol ethoxylates which are…
MicroCoat™: A Breakthrough in Oral Multiparticulate Formulation Development
Oral multiparticulate systems are often the ‘go to’ solution for flexible dosing, especially in cases where a degree of functionality, such as taste masking or modified release, is required from the formulation. One of the preferred methods…
Impact of Raman Mapping Area and Intra-Tablet Homogeneity on the Accuracy of Sustained-Release…
This exploratory study investigated the minimum required Raman mapping area for predicting sustained-release tablet dissolution profiles based on intra-tablet homogeneity. The aim was to minimize scanning time while achieving reliable…
Protein corona formation on lipidic nanocapsules: Influence of the interfacial PEG repartition
The parameters currently used for characterization of nanoparticles, such as size and zeta potential, were not able to reflect the performance of a nanocarrier in the biological environment. Therefore, more thorough in vitro …
In Vitro and In Vivo Evaluation of Composite Oral Fast Disintegrating Film: An Innovative Strategy…
Here, we evaluate the feasibility of co-loading plain ranitidine hydrochloride (RHCl) and microencapsulated flurbiprofen (FBP) in a Lycoat® RS780-based oral fast disintegrating film (ODF). These films were developed by the solvent casting…
Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems
Rosacea is a multifactorial chronic inflammatory dermatosis characterized by flushing, nontransient erythema, papules and pustules, telangiectasia, and phymatous alterations accompanied by itching, burning, or stinging, the pathophysiology…
Factors That Influence Sustained Release from Hot-Melt Extrudates
Hot-melt extrusion is a well-established tool in the pharmaceutical industry, mostly implemented to increase the solubility of poorly soluble drugs. A less frequent application of this technique is to obtain formulations with extended…
Sodium lauryl sulfate as lubricant in tablets formulations: is it worth?
Lubricants are excipients used in tablet formulations to reduce friction and adhesion forces within the die or on the punches surface during the manufacturing process. Despite these excipients are always required for the tablets production,…
Polymeric microsponges: an emerging prospect in topical delivery of therapeutic agents
Skin disorders have an important psychosocial impact on the life of the affected patient. Skin disorders are usually treated by using topical drug delivery systems like creams and gels. These conventional topical drug delivery systems…
Lipid-based formulations: A promising approach for poorly soluble drug delivery via the intestinal…
Abstract
Lipid-based formulation (LBF) has attracted more and more attention as it can significantly improve the efficiency of oral delivery of poorly soluble drugs by exploiting the specific absorption pathway of lipids in the…
Design and Evaluation of Hydrophobic Ion Paired Insulin Loaded Self Micro-Emulsifying Drug Delivery…
Despite several novel and innovative approaches, clinical translation of oral insulin delivery into commercially viable treatment is still challenging due to its poor absorption and rapid degradation in GIT. Thus, an insulin-SDS hydrophobic…
Liquid for Fused Deposition Modeling Technique (L-FDM)—A Revolution in Application Chemicals to 3D…
This article presents a novel 3D printing technique called L-FDM (liquid for fused deposition modeling), which is based on the deposition of molten thermoplastic material. The new method allows for the direct introduction of chemicals and…
Formulating with Self-Emulsifying Cream Bases: Kolliphor® CSL
Kolliphor® CSL (cetostearyl alcohol, sodium lauryl sulfate, and sodium cetostearyl sulfate) by BASF is an emulsifier and structuring agent combination product that is suitable for O/W (oil-in-water) formulations.
Its strategically…
The R&D landscape for infectious disease vaccines
Vaccines have a tremendous impact on public health, and their importance has been emphasized by the COVID-19 pandemic. Here, we provide an overview of the current state of research and development (R&D) on prophylactic vaccine…
Strategy of eudragit coated curcumin nanoparticles delivery system: Release and cell imaging studies…
Abstract
Curcumin has a broad-spectrum anti-tumor effect and has no toxic side effects. However, the unique diketone structure of curcumin will undergo diketo-enol tautomerism under different acid-base conditions, resulting in its…
Dynamic investigation of maltodextrins surface properties by environmental atomic force microscopy
Abstract
For the first time on food powders, environmental Atomic Force Microscopy (AFM) was used to probe single particle surface properties in real time by variating relative humidity (RH) and temperature. Low, intermediate, and high…
Development of Lipid Polymer Hybrid Drug Delivery Systems Prepared by Hot-Melt Extrusion
This study sought to develop polymer-lipid hybrid solid dispersions containing the poorly soluble drug lopinavir (LPV) by hot-melt extrusion (HME). Hence, the lipid and polymeric adjuvants were selected based on miscibility and…
Selection of Silica Type and Amount for Flowability Enhancements via Dry Coating: Contact Mechanics…
Abstract
Purpose
To investigate the effect of dry coating the amount and type of silica on powder flowability enhancement using a comprehensive set of 19 pharmaceutical powders having different sizes, surface roughness, morphology, and…
Virodex™ – For viral inactivation and cell lysis applications for bioprocessing
Are you utilising viral inactivation and cell lysis techniques in your bioprocessing applications?We’re introducing our new range of detergents specifically designed to support the key steps in your biomanufacturing processes.
The…
Electrospinning of pullulan-based orodispersible films containing sildenafil
Feasibility of electrospinning in the manufacturing of sildenafil-containing orodispersible films (ODFs) intended to enhance oxygenation and to reduce pulmonary arterial pressure in pediatric patients was evaluated. Given the targeted…
Development of a time-dependent oral colon delivery system of anaerobic Odoribacter splanchnicus for…
Odoribacter (O.) splanchnicus is an anaerobic member of the human intestinal microbiota. Its decrease in abundance has been associated with inflammatory bowel disease (IBD), non-alcoholic fatty liver, and cystic fibrosis. Considering the…
Electrospun composite nanofibers for treating infectious esophagitis
The electrospinning technique enables the convenient fabrication of non-woven fibrous materials with excellent properties such as fine diameters, a large surface area per unit mass, high porosity, high gas permeability, and small pore…
Colour of Medicines and Children’s Acceptability? A Systematic Literature Review of Children’s…
The colour of a product plays an important role in consumer experiences, and in the context of pharmaceutical products, this could potentially affect a patient’s expectations, behaviours, and adherence. Several studies have been conducted…
Nitrosamine Impurities and NDSRIs
A. FDA Issues notice on “Identification, Assessment, and Control of Nitrosamine Drug Substance-Related Impurities (NDSRIs) and requests comments”.
While the FDA’s investigation of the presence of nitrosamine impurities in drug products…
Improvement of the solubility and anticancer activity of 6,8-dibromochrysin by encapsulation into…
Abstract
Background
6,8-dibromochrysin (BrCN), a halogenated chrysin, possesses a profound bioactivity against dengue and Zika viruses and various types of cancer. However, the pharmaceutical applications of BrCN are limited by its poor…
Quality by design (QbD) approach to develop fast-dissolving tablets using melt-dispersion paired…
Developing amorphous solid dispersions with good flow properties is always challenging for formulation scientists to convert into tablets. Hence, the present study investigates the impact of the combination of melt-dispersion and…
Active ingredient vs excipient debate for nanomedicines
Nanomedicines are complex drugs where components that have typically been regarded as excipients may now be considered part of the active ingredient. The distinction between the active ingredient and excipients for nanomedicines has…
Enhanced Oral Bioavailability of Rivaroxaban-Loaded Microspheres by Optimizing the Polymer and…
This study aimed to develop microspheres using water-soluble carriers and surfactants to improve the solubility, dissolution, and oral bioavailability of rivaroxaban (RXB). RXB-loaded microspheres with optimal carrier…
Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed…
The aim of this study is to investigate the influence of polymer chemistry on the properties of oral dosage forms produced using selective laser sintering (SLS). The dosage forms were printed using different grades of polyvinyl alcohol or…
The Nitrosamine “Saga”: Lessons Learned from Five Years of Scrutiny
Abstract
The onset of the N-nitrosamine (NA) saga in 2018 was chiefly related to certain small dialkyl N-nitrosamines originating from the synthesis of the active pharmaceutical ingredient (API). However, the subsequent comprehensive…
Roquette signs agreement to acquire Qualicaps and reinforce its global position in the…
Roquette signs agreement to acquire Qualicaps and reinforce its global position in the pharmaceutical industry