Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Effect of process parameters in high shear granulation on characteristics of a novel co-processed…
In this study, insights into the development and optimization of a co-processed excipient based on mesoporous silica are presented. The main advantage of such a material is that it is appropriate for direct tablet compression and has a…
An evaluation of microcrystalline cellulose attributes affecting compaction-induced pellet coat…
Pellet coat damage in multi-unit pellet system (MUPS) tablets has previously been studied and addressed with limited success. The effects of lactose filler material attributes on pellet coat damage have been relatively well-studied but a…
Effects of Phospholipid Structure on the Acoustic Cavitation of Functionalized Mesoporous Silica…
This study investigates the acoustic response of phospholipid-coated, hydrophobically modifed mesoporous silica nanoparticles (PL-HMSNs) for image-guided drug delivery. PL-HMSNs were first stabilized with a PEGylated lipid,…
Putting children first: Understanding caregivers’ and children’s perspectives on the usability of…
A multi-national online survey was developed to obtain feedback on users’ experiences of administration devices for oral and inhaled paediatric medicines. The questionnaire was divided into two identical parts: 1) for caregivers looking…
Poly vinyl pyrrolidone (PVP) based inhaled delivery carriers for olaparib for non-small cell lung…
Non-small cell lung cancer (NSCLC) is ranked first worldwide amongst deadly cancers with poor patient survival rate. While chemotherapy, radiation and surgery are available treatment options, NSCLC tumor cells are known to develop…
Development of an immediate release excipient composition for 3D printing via direct powder…
3D printing offers the possibility to prepare personalized tablets on demand, making it an intriguing technology for hospital pharmacies. For the implementation of 3D-printed tablets into the digital Closed Loop Medication Management…
Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid…
Herbal chemicals with a long history in medicine have attracted a lot of attention. Flavonolignans and flavonoids are considered as two classes of the above-mentioned compounds with different functional groups which exhibit several…
Formulation and Evaluation of Prednisolone Sodium Metazoate-Loaded Mucoadhesive Quatsomal Gel for…
This study aims to formulate a buccal mucoadhesive gel containing prednisolone sodium metazoate-loaded quatsomes for efficient localized therapy of recurrent aphthous ulcers. Quatsomes were prepared using a varied concentration of…
Multifaceted nanolipidic carriers: a modish stratagem accentuating nose-to-brain drug delivery
The exponential growth of nanotechnology has focused on therapeutic pursuits, notably for brain disorders. Nanocarriers have submicron particle sizes, typically around 500 nm. Over the past few years, interest in nanostructured lipid…
Pharmaceutical Continuous Manufacturing: Knowledge Center Debuts to Expand Information Access,…
PRESS RELEASE
Rockville, MD, July 11, 2023 – The U.S. Pharmacopeia (USP) and The National Institute for Pharmaceutical Technology and Education (NIPTE) today announced the official launch of their jointly-developed Continuous…
Formation of N-Nitrosamine Drug Substance Related Impurities in Medicines: A Regulatory Perspective…
Abstract
The detection of N-nitrosamine impurities in medicines and the recent emergence of nitrosamine drug substance related impurities (NDSRIs) has posed a great challenge to manufacturers of drug products and regulators alike. NDSRIs…
Multilayer 3D bioprinting and complex mechanical properties of alginate-gelatin mesostructures
Abstract
In the biomedical field, extrusion-based 3D bioprinting has emerged as a promising technique to fabricate tissue replacements. However, a main challenge is to find suitable bioinks and reproducible procedures that ensure good…
Chitosan-g-estrone Nanoparticles of Palbociclib Vanished Hypoxic Breast Tumor after Targeted…
Abstract
Breast cancer is the leading cause of death among women globally. Approximately 80% of all breast cancers diagnosed are overexpressed with estrogen receptors (ERs). In this study, we have developed an estrone (Egen)-grafted…
Highly Concentrated Emulsions Containing High Loads of Pterostilbene
Abstract
Pterostilbene is a highly researched molecule due to its bioactivity. However, its hydrophobicity limits its application. For this reason, researchers have sought to encapsulate pterostilbene (namely, in oil-in-water emulsion) to…
Investigation of the Kollicoat Smartseal formulation concepts on the taste masking functionality
Did you know that based on the virtual tool BitterPredict, about 40% of random molecules, 66% of clinical and experimental drugs, and almost 77% of natural products are bitter1?
This leads us to concern about the final formulation's…
Development and Characterization of Pentaerythritol-EudragitRS100 Co-processed Excipients as Solid…
Abstract
Atorvastatin (ATV), a lipid-lowering agent, has low oral bioavailability due to its poor water solubility, permeability, and low dissolution rate. Therefore, pentaerythritol-EudragitRS100 co-processed excipients (PECE) were…
Artificial Intelligence in Pharmaceutical Technology and Drug Delivery Design
Abstract
Artificial intelligence (AI) has emerged as a powerful tool that harnesses anthropomorphic knowledge and provides expedited solutions to complex challenges. Remarkable advancements in AI technology and machine learning present a…
AEROSIL® 200 Pharma – well established and ready for tomorrow’s drug production
Continuous manufacturing is one of the greatest trends in the pharmaceutical industry, bringing advantages compared to the traditional batch production:
Quality and cost position of the final medicine is improved…
Modeling the Impact of Excipients Selection on Nitrosamine Formation towards Risk Mitigation
Abstract
Risk control for nitrosamine impurities in drug products is currently a major challenge in the industry. Nitrosamines can form during drug product manufacturing and storage through the reaction of nitrites with amine-containing…
Urethane dimethacrylate-based photopolymerizable resins for stereolithography 3D printing: A…
Abstract
Vat photopolymerisation (VP) three-dimensional printing (3DP) has attracted great attention in many different fields, such as electronics, pharmaceuticals, biomedical devices and tissue engineering. Due to the low availability of…
A Machine Learning Approach to Qualitatively Evaluate Different Granulation Phases by Acoustic…
Wet granulation is a frequent process in the pharmaceutical industry. As a starting point for numerous dosage forms, the quality of the granulation not only affects subsequent production steps but also impacts the quality of the final…
Preformulation Studies of Varenicline for Formulation and Development of a Novel Orally…
Objective:
The major goal of pre-formulation research is to create a drug delivery system that is stable, elegant, safe, and effective by determining the drug's kinetic profile, the formulation's compatibility with various excipients, and…
Tip loaded cyclodextrin-carvedilol complexes microarray patches
Carvedilol, a β-blocker prescribed for chronic heart failure, suffers from poor bioavailability and rapid first pass metabolism when administered orally. Herein, we present the development of tip microarray patches (MAPs) composed of…
Nanocellulose-Based Film-Forming Hydrogels for Improved Outcomes in Atopic Skin
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by impaired skin barrier function. Amongst the various dermal formulations that are being used and/or investigated for AD treatment, one of the advanced approaches…
Not the Usual Suspects: Alternative Surfactants for Biopharmaceuticals
Therapeutically relevant proteins naturally adsorb to interfaces, causing aggregation which in turn potentially leads to numerous adverse consequences such as loss of activity or unwanted immunogenic reactions. Surfactants are ubiquitously…
Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid…
Solid lipid-based formulations (sLBFs) have the potential to increase the oral bioavailability of drugs with poor solubility in water, while counteracting some of the disadvantages of liquid LBFs. The most common experimental set-up to…
Review of industrially recognized polymers and manufacturing processes for amorphous solid…
Evolving therapeutic landscape through combinatorial chemistry and high throughput screening have resulted in an increased number of poorly soluble drugs. Drug delivery strategies quickly adapted to convert these drugs into successful…
Evaluation the Injectability of Injectable Microparticle Delivery Systems on the Basis of Injection…
Background
Subcutaneous injection of biopharmaceutical agents or microparticles is challenging due to issues with low injection efficiency and high residual amounts.
Objective
This study aimed to determine the important factors…
Leveraging the use of in vitro and computational methods to support the development of enabling oral…
Abstract
Due to the strong tendency towards poorly soluble drugs in modern development pipelines, enabling drug formulations such as amorphous solid dispersions, cyclodextrins, co-crystals and lipid-based formulations are frequently…
Raw Materials – Practical Pharmaceutics Part 1
An International Guideline for the Preparation, Care and Use of Medicinal Products
See the new book, edited by Paul Le Brun, Sylvie Crauste-Manciet, Irene Krämer, Julian Smith, Herman Woerdenbag:
Description: Practical Pharmaceutics…
Development and Characterization of Febuxostat Loaded Floating Beads as Gastro-retentive Drug…
Background:
Febuxostat is a BCS class-II drug, used in the treatment of gout. However, because of its lower solubility, a higher and more frequent dose of the drug is required in the treatment.
Objective:
The objective of this research…
A study of microemulsion systems for transdermal delivery of risperidone using penetration enhancers
Abstract
The aim of this study was to develop and characterize microemulsion formulations using penetration enhancers as potential transdermal delivery systems for risperidone. Initially, a simple formulation of risperidone in Propylene…
Oral Solids – Practical Pharmaceutics Part 2
An International Guideline for the Preparation, Care and Use of Medicinal Products
See the new book, edited by Paul Le Brun, Sylvie Crauste-Manciet, Irene Krämer, Julian Smith, Herman Woerdenbag:
Description: Practical Pharmaceutics…
Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of…
Pharmaceutical formulation of oral dosage forms is continuously challenged by the low solubility of new drug candidates. Pickering emulsions, emulsions stabilized with solid particles, are a promising alternative to surfactants for…