Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Development, recent advances, and updates in binary, ternary co-amorphous systems, and ternary solid…
Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active pharmaceutical ingredient (API) and small molecule excipients. The properties of these substances make them novel and a very demanding aspect of…
Can Continuous Manufacturing of Topical Semisolids by Hot Melt Extrusion Soon Be a Reality?
For more than five decades, pharmaceutical manufacturers have been relying heavily on batch manufacturing that is a sequential, multistep, laborious, and time-consuming process. However, late advances in manufacturing technologies have…
Book Chapter: Rectal and Vaginal – Practical Pharmaceutics Part 3
An International Guideline for the Preparation, Care and Use of Medicinal Products
See the new book, edited by Paul Le Brun, Sylvie Crauste-Manciet, Irene Krämer, Julian Smith, Herman Woerdenbag:
Description: Practical Pharmaceutics…
Evaluating spray gelation and spray freeze drying as the granulation method to prepare oral tablets…
Amorphous drug nanoplex represents one of the most promising solubility enhancement strategies of poorly-soluble drugs. Solubility enhancement capability of nanoplex hitherto has been demonstrated for nanoplex suspension and…
Beta Caryophyllene-Loaded Nanostructured Lipid Carriers for Topical Management of Skin Disorders:…
This work aimed to overcome the disadvantages of the oral administration of beta-caryophyllene and boost efficiency by developing a nanostructured lipid carrier for topical administration of the drug in skin disorders. The heat…
Dual drug loaded nanostructured lipid carrier for cytotoxic effect against breast cancer-a drug…
Abstract
In the present study nanostructured lipid carrier with a combination of Metformin (MET) and Thymoquinone (THY) was developed, characterized, and was further evaluated for cytotoxic effect on breast cancer cells. The optimized…
Encapsulation of Diosgenin in chitosan nanoparticles with enhanced invitro and invivo anticancer…
The main purpose of this study was to optimise the conditions for synthesizing diosgenin-encapsulated chitosan nanoparticles (DIO@CS NPs) and anticancer activity. Nanoparticles encapsulating diosgenin were synthesized using ionic gelation…
Formulation development with Kollicoat Smartseal: Impact of plasticizers
How can plasticizers impact the functionality of film-coating latex-based dispersion?
When formulating a film coating, plasticizers are often required to increase polymer chain mobility, improve mechanical properties, such as elasticity…
The impact of common pharmaceutical excipients on the gut microbiota
ABSTRACT
Introduction
Increasing attention is being afforded to understanding the bidirectional relationships that exist between oral medications and the gut microbiota, in an attempt to optimize pharmacokinetic performance and…
Nose to brain delivery of radiolabeled chemotherapeutic micelles: Meeting the unmet needs of brain…
The blood brain barrier postures colossal challenges to the CNS delivery of drugs administered via the oral/parenteral route. In conditions like glioblastoma where mean patient survival rate is mere 15months from diagnosis, outwitting the…
Innovative Strategies for Drug Delivery to the Ocular Posterior Segment
Innovative and new drug delivery systems (DDSs) have recently been developed to vehicle treatments and drugs to the ocular posterior segment and the retina. New formulations and technological developments, such as nanotechnology, novel…
Nanomaterial-based ophthalmic drug delivery
The low bioavailability and side effects of conventional drugs for eye disease necessitate the development of efficient drug delivery systems. Accompanying the developments of nanofabrication techniques, nanomaterials have been recognized…
Prediction of dissolution performance of uncoated solid oral dosage forms via optical coherence…
Abstract
Real-time prediction of the dissolution behavior of solid oral dosage forms is an important research topic. Although methods such as Terahertz and Raman can provide measurements that can be linked to the dissolution performance,…
Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional…
Formulating low-solubility or low-permeability drugs is a challenge, particularly with the low administration volumes required in intranasal drug delivery. Nanoemulsions (NE) can solve both issues, but their production and physical…
The processes behind drug loading and release in porous drug delivery systems
Porous materials are ubiquitous and exhibit properties suitable for depositing therapeutic compounds. Drug loading in porous materials can protect the drug, control its release rate, and improve its solubility. However, to achieve such…
New Asahi Kasei Website to Provide Solutions for Your Oral Solid Dose Formulation Needs
Asahi Kasei announces the launch of their new website. The new website should provide a more intuitive and user-friendly experience to the existing and prospective customers.
Over last 50+ years, Asahi Kasei has been leading manufacturer…
Development and pharmacokinetic evaluation of Neusilin® US2-based S-SNEDDS tablets for bosentan:…
The study reported here aimed to develop and optimize the S-SNEDDS tablet of bosentan (BOS) and to investigate its pharmacokinetic and biodistribution properties. The BOS-loaded SNEDDS have been developed and characterized in a previous…
Comparison between polymeric excipients using SeDeM expert system in combination with mathematical…
Based on the quality by design approach, we used the SeDeM expert system to assess seven polymers of different chemical nature and molecular weight for their use in direct compression. Because the SeDeM system fails by not evaluating…
Solving Capping Challenges Using Mannitol As An Excipient Model – See the Webinar on-demand
On June 27 2023 we had an interesting webinar together with the Roquette`s experts Dr. Olaf Häusler and Antoine Billa. The full webinar recording is now available and we invite you to enjoy it now.
You can also get a first impression from…
Solving parenteral solubility challenges in the development of oncology therapeutics
It’s no secret that solubility and bioavailability issues continue to challenge formulators and drug developers. Approximately 60-90% of potential new active pharmaceutical ingredients (APIs) in development pipelines, and more than 40% of…
Lactose in tablets: functionality, critical material attributes, applications, modifications and…
Abstract
Lactose is one of the most widespread excipients used in the pharmaceutical industry. Because of its water solubility and acceptable flowability, lactose is generally added into tablet formulation to improve wettability and…
Inhalable dry powder containing lipid polymer hybrid nanoparticles of Nintedanib esylate: In vitro…
The key objective of this research work was to develop and evaluate dry powder for inhalation containing lipid polymer hybrid nanoparticles (LPHNPs) loaded with Nintedanib esylate (NE) to target deep lung for the treatment of idiopathic…
Development of chitosan-graphene oxide blend nanoparticles for controlled flurbiprofen delivery
The use of natural polymeric nanoparticles (Nps) as drug carriers is a highly promising area of research in the field of drug delivery systems because of their high efficiency. In this study, flurbiprofen (FB) loaded chitosan-graphene oxide…
Chitosan-Based Particulates Carriers for Pulmonary Drug Delivery – Chapter 7
Pulmonary Drug Delivery Systems: Material and Technological Advances
See the new book, edited by Piyush Pradeep Mehta and Vividha Dhapte -Pawar
Description:
Brings new technologies & material advances together in pulmonary…
Formulation Development and Evaluation of Solid Self Microemulsifying Drug Delivery System of…
This study aimed to develop a self-micro emulsifying drug delivery system (SMEDDS) for poorly soluble azelnidipine using Capryol 90 as the oil, Tween 80 as the surfactant, and transcutol-HP as the co-surfactant. A factorial design was used…
In Vitro and In Vivo Characterization of Transdermal Patch Loaded with Nanostructured Lipid Carrier…
The objective of the present research work was to enhance the bioavailability of dolutegravir sodium (anti-HIV drug) by loading the drug into a nanostructured lipid carrier (NLC), fabricated into the patch, and administered through a…
Multifunctional Cyclodextrins Carriers for Pulmonary Drug Delivery: Prospects and Potential
Pulmonary Drug Delivery Systems: Material and Technological Advances
See the new book, edited by Piyush Pradeep Mehta and Vividha Dhapte -Pawar
Description:
Brings new technologies & material advances together in pulmonary…
Advancement of a High-Dose Infant Air-Jet Dry Powder Inhaler (DPI) with Passive Cyclic Loading:…
There is a current medical need for a dry powder aerosol delivery device that can be used to efficiently and consistently administer high dose therapeutics, such as inhaled antibiotics, surfactants and antivirals, to the lungs of infants.…
In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices
The in-situ formation of nanoparticles from polymer-based solid medicines, although previously described, has been overlooked despite its potential to interfere with oral drug bioavailability. Such polymeric pharmaceuticals are becoming…
Rectal Bioavailability of Amoxicillin from Hollow-Type Suppositories: Effect of Chemical Form of…
Rectal drug administration could offer advantages in the delivery of medicines for children by avoiding swallowability issues, improving stability and enabling administration by caregivers. This study aimed to evaluate the rectal…
Enteric-Coated Cysteamine Bitartrate in Cystinosis Patients
Cystinosis is a severe inherited metabolic storage disease caused by the lysosomal accumulation of cystine. Lifelong therapy with the drug cysteamine bitartrate is necessary. Cysteamine cleaves intralysosomal cystine, and thereafter, it can…
Spray Dried Progesterone Formulations for Carrier Free Dry Powder Inhalation
Low oral absorption and extensive first pass metabolism of progesterone is reported for many oral formulations which warrants investigation into other routes of administration. It is the aim of this study to investigate the generation of…
AVICEL® PH LN – A Low Nitrite Microcrystalline Cellulose
Pharma Solutions at IFF provides you access to one of the broadest microcrystalline cellulose (MCC) portfolios in the industry. Backed by decades of innovation, and expertise, Avicel® PH offers a long history of manufacturing the…
Lipid-based particle engineering via spray-drying for targeted delivery of antibiotics to the lung
Pulmonary delivery of antibiotics for the treatment of tuberculosis provides several benefits compared to conventional oral and parenteral administration. API-loaded particles delivered directly to alveolar macrophages, where Mycobacterium…