Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Micro-dosing of powders into capsules using a new automated micro-dosing system: effect of powder…
Abstract
Objective
To demonstrate the applicability of a novel micro-dosing system for precisely filling low powder doses (down to a few mg) into capsules along with weighing the filled powder mass accurately.
Methods
Ten…
Establishment of Asahi Kasei Healthcare Headquarters in the United States
PRESS RELEASE
Düsseldorf and New York, 12 July 2023 – Asahi Kasei announced that it is moving the global headquarters for its Healthcare Business to the United States. The Primary Executive Officer for Healthcare and staff will be…
Integrated in vitro – In vivo – In silico studies in the pharmaceutical development of propranolol…
In order to exploit the advantage of drug delivery through the buccal mucosa, mucoadhesive buccal films with propranolol hydrochloride based on polyethylene oxide, hydroxypropyl methylcellulose, and polyvinyl alcohol have been developed.…
Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines
Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines…
Optimization and Evaluation of Lisinopril Mucoadhesive Sustained Release Matrix Pellets: In-Vitro…
Lisinopril (LIS) it is antihypertensive drug, classified as a class III drug with a high water solubility and low permeability. To overcome the low permeability, 32 factorial designs aimed to formulate LIS as a sustained-release (LIS-SR)…
Technical evaluation of precisely manufacturing customized microneedle array patches via inkjet drug…
Dissolvable microneedle array patches offer the possibility to deliver active pharmaceutical ingredients bypassing the gastrointestinal tract by piercing the stratum corneum. Usually, microneedles are produced by micromolding but this often…
Porous Particle Technology: Novel Approaches to Deep Lung Delivery – Chapter 5
Pulmonary Drug Delivery Systems: Material and Technological Advances
See the new book, edited by Piyush Pradeep Mehta and Vividha Dhapte -Pawar
Description:
Brings new technologies & material advances together in pulmonary…
Study of direct compression coverage in view of design space – Ceolus UF grades
1. What is the design space?
The design space (DS) is a multidimensional combination and interaction of input variables (e.g., properties of raw materials) and process parameters that have been proven to ensure the quality of drug…
Attribute transmission and effects of diluents and granulation liquids on granule properties and…
This study aims to examine (i) the effect of diluent types (lactose monohydrate, corn starch, and microcrystalline cellulose) and granulation liquids (20% polyvinylpyrrolidone K30, 65% alcohol, and dispersion containing 40% model drug–…
Rational Design of Topical Semi-Solid Dosage Forms – How Far Are We?
Specific aspects of semi-solid dosage forms for topical application include the nature of the barrier to be overcome, aspects of susceptibility to physical and chemical instability, and a greater influence of sensory perception. Advances in…
Exploring the influence of magnesium stearate content and mixing modality on the rheological…
Since carrier-based dry powder inhalers (DPIs) suffer from inadequate drug deposition in the lung, an increasing number of marketed products have added magnesium stearate (MgSt) to improve the aerosolization, dispersion, and stability…
Understanding the correlations between tablet flow dynamics and coating uniformity in a pan coater:…
Coating uniformity is crucial for pharmaceutical solid dosages to ensure sufficient stability and to program drug release behavior. The present study aims to thoroughly investigate the correlation between the coating uniformity and the…
Effect of batch-to-batch variation of spray dried lactose on the performance of feeders
With the emergence of quality by design (QbD), it becomes imperative to gain understanding of the impact of batch-to-batch variability of raw materials on the performance of processes. Feeding is the first unit of operation in a continuous…
Bioresponsive and multifunctional cyclodextrin-based non-viral nanocomplexes in cancer therapy:…
The interest towards application of nanomaterials in field of cancer therapy is that the drawbacks of conventional therapies including chemoresistance, radio-resistance and lack of specific targeting of tumor cells can be solved by…
Optical Coherence Tomography as a novel tool for non-invasive membrane thickness monitoring of…
Abstract
Co-extruded core-membrane formulations have been extensively explored as long-acting subcutaneous implants or vaginal inserts, guaranteeing zero-order release. Although the membrane thickness and homogeneity determine the final…
Fixed-dose dry powder for inhalation of nintedanib, pirfenidone and mycophenolic acid by thin-film…
Nintedanib and pirfenidone have been approved to treat idiopathic pulmonary fibrosis (IPF) by delaying progression of the disease. Recently, mycophenolic acid has also been used as an additive treatment for IPF. This study aims to produce…
An Intragastric Delivery Device Employing FDM Technology: 3D-Printed Tablet Containing Green…
Mosapride citrate (MC) is a poorly soluble short half-life drug with more pronounced absorption in the stomach. The present study aimed to incorporate MC co-crystals with enhanced solubility into 3D-printed floating tablets. MC co-crystals…
Can the Oral Bioavailability of the Discontinued Prostate Cancer Drug Galeterone Be Improved by…
Galeterone, a novel prostate cancer candidate treatment, was discontinued after a Phase III clinical trial due to lack of efficacy. Galeterone is weakly basic and exhibits low solubility in biorelevant media (i.e., ~ 2 µg/mL in fasted…
Transdermal Delivery of Estradiol Simultaneously Possessing Rapid Release and Sustaine Release…
Dissolving microneedle (DMN) has been researched as a drug delivery technology that improves drug molecule transportation through the skin with little discomfort. However, the sluggish drug absorption, poor skin dissolution, and lengthy…
Acquisition of Solus BioTech expands specialised Pharma business in Asia
PRESS RELEASE
05 July 2023: Croda International Plc (‘Croda’) announced that it has acquired Solus BioTech, a global leader in premium, biotechnology-derived materials, from Solus Advanced Materials. The acquisition provides access to…
Polymeric Microarray Patches for Enhanced Transdermal Delivery of the Poorly Soluble Drug Olanzapine
Transdermal drug delivery is an alternative route of administration that offers avoidance of the associated drawbacks of orally and parenterally administered hydrophobics. However, owing to the extremely specific set of physicochemical…
Nanoparticulate impurities in the pharmaceutical excipient trehalose induce an early immune response
Abstract
Background
Pharmaceutical excipients are an important part of biological products. However, few attempts have been made to distinguish between the risk of inflammation associated with the biological products themselves and that…
Comparing failure tests on pharmaceutical tablets: Interpretation using experimental results and a…
The mechanical strength is an important quality attribute of pharmaceutical tablets. It can be determined using different failure tests like the Brazilian test or the three-point bending test. Nevertheless, literature shows that different…
Effect of process parameters and formulation properties on the lead-lag between in-line NIR tablet…
The use of in-line near-infrared (NIR) measurements for tablet potency monitoring and diversion was studied. First, the optimal sample size for in-line NIR measurements inside the feed chute and the dosing and filling chamber of the tablet…
Comparison of Ceolus™ Grades in Continuous Manufacturing (Wet Granulation) – Continuous…
1. Introduction
Until now, batch manufacturing has been the main mode of pharmaceutical manufacture: raw materials are input and processed in a stage of the process then removed for input and process in the next stage of the sequence.…
Comparison of the Behavior of 3D-Printed Endothelial Cells in Different Bioinks
Biomaterials with characteristics similar to extracellular matrix and with suitable bioprinting properties are essential for vascular tissue engineering. In search for suitable biomaterials, this study investigated the three hydrogels…
Nanoparticle oral absorption and its clinical translational potential
Oral administration of pharmaceuticals is the most preferred route of administration for patients, but it is challenging to effectively deliver active ingredients (APIs) that i) have extremely high or low solubility in intestinal fluids,…
Enhancing the Solubility of Active Pharmaceutical Ingredients Using Hot Melt Extrusion and Polyvinyl…
Solubility of the active pharmaceutical ingredient (API) in an oral formulation is critical for absorption from the gastrointestinal (GI) tract and the intended therapeutic effect. Ensuring that an API has the necessary solubility can be…
2-Hydroxypropyl-β-Cyclodextrin Treatment Induces Modest Immune Activation in Healthy Rhesus Macaques
Experimental simian immunodeficiency virus (SIV) infection of Asian macaques is an excellent model for HIV disease progression and therapeutic development. Recent coformulations of nucleoside analogs and an integrase inhibitor have been…
A Comprehensive Scientific Survey of Excipients Used in Currently Marketed, Therapeutic Biological…
Purpose
The steady development of biotechnology-derived therapeutic biologics over the last few decades has generated drugs that are now standard medical treatments for a range of indications. While the development of protein products…
3D Printing Methods for Pharmaceutical Manufacturing: Opportunities and Challenges: A Review
Abstract:
3D printing, or additive manufacturing, has gained considerable interest due to its versatility regarding design as well as in the large choice of materials. It is a powerful tool in the field of personalized pharmaceutical…
Brain nanotargeted [131I] I-Rolapitant as a model for brain imaging: Intranasal formulation,…
The goal of this study was to create a novel single-photon emission computed tomography (SPECT) probe that would enable the visualization of neurokinin-1 NK1 receptor systems in the brain for the precise diagnosis and follow-up of many…
Kollicoat® Smartseal combines an effective taste-masking functionality with efficient processing
Kollicoat® Smartseal 30 D and Kollicoat® Smartseal 100 P can help formulators tackle challenges when handling bitter active ingredients. It offers superior protection from unpleasant drug taste for minitablets, pellets, particles, and…
3D Printed Flavor-Rich Chewable Pediatric Tablets Fabricated Using Microextrusion for Point of Care…
Abstract
Over the past few years, 3D printing technologies have gained interest in the development of medicinal products for personalized use at the point of care. The printing of drug products offers personalization and flexibility in…