Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Soft capsule technology: modified pea starch as a vegetal origin alternative to gelatin in capsule…
Introduction
Gelatin has been used as shell polymer in the manufacture of soft gelatin capsules (softgels) for about the past century. Its rheological and thermal properties offer adequate balance for subsequent process steps including gel…
Distribution of Female and Male First and Last Authorship across Drug Delivery Related Journals with…
First and last authorship are important metrics of productivity and scholarly success for trainees and professors. For 11 drug delivery-related journals in 2021, the percentage of female first (39.5%) and last (25.7%) authorship was…
Unveiling Neusilin® US2’s Prowess: Resolving Oily API Challenges in Contrast to Other Common…
Neusilin® US2 by Fuji Chemical Industries is a synthetic, amorphous form of Magnesium Aluminometasilicate with a neutral pH that can be used in both direct compression and wet granulation of solid dosage forms. Oily APIs affect…
Structural and functional analysis of a new co-processed tableting excipient for food compaction…
Food compacts are convenient to industry and customers and must primarily possess a sufficient strength to withstand packaging processing and customer handling. In contrast to pharmaceutical applications, the choice of excipients is usually…
Oral toxicological study of titanium dioxide nanoparticles with a crystallite diameter of 6 nm in…
Background
Though titanium dioxide (TiO2) is generally considered to have a low impact in the human body, the safety of TiO2 containing nanosized particles (NPs) has attracted attention. We found that the toxicity of silver NPs markedly…
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Advanced multifunctional nano-lipid carrier loaded gel for targeted delivery of 5-flurouracil and…
Non-melanoma skin cancer is one of the most common malignancies reported around the globe. Current treatment therapies fail to meet the desired therapeutic efficacy due to high degree of drug resistance. Thus, there is prominent demand in…
Ocular application of electrospun materials for drug delivery and cellular therapies
The constraints of delivering conventional drugs, biologics and cell-based therapeutics to target ocular sites necessitate the fabrication of novel drug delivery systems to treat diverse ocular diseases. Conventional ocular drug delivery…
Determination of Mucoadhesion of Polyvinyl Alcohol Films to Human Intestinal Tissue
Abstract
The absorption of drugs with narrow absorption windows in the upper small intestine can be improved with a mucoadhesive drug delivery system such as enteric films. To predict the mucoadhesive behaviour in vivo, suitable in vitro…
TPGS Functionalized Carriers: An Emerging Approach for Pulmonary Drug Delivery – Book chapter
Tocophersolan (D-α-tocopheryl polyethylene glycol succinate or TPGS) is a non-ionic surfactant fabricated by esterifying Vitamin E succinate with polyethylene glycol. Owing to its amphipathic nature and unique physicochemical attributes,…
Oral Bioavailability Enhancement of Docetaxel by Preparation of Freeze-Dried Ternary Solid…
Abstract
Purpose
The poor solubility and permeability of docetaxel have limited its oral delivery. The current study was aimed at formulating the ternary solid dispersion of docetaxel for treatment of breast cancer and evaluating its…
Accelerating Topical Drug Development Through Initial Excipient Selection
See the poster presented by Seppic at DDF Summit in Berlin in June 2023:
Introduction
Novel topical drug development will require multiple formulation adjustments from the initial formulation studies to the registration phase .…
Lubrizol Licenses Award-Winning Apisolex™ Excipient to Welton Pharma to Develop a Novel Cancer…
Upwards of 60% of Cancer Drugs Have Solubility Issues, Lubrizol and Welton Aim to Address This Challenge
CLEVELAND, Ohio – June 21, 2023 – The Lubrizol Corporation announces the licensing of its novel excipient polymer technology,…
3D Printing Technology: A New Approach for the Fabrication of Personalized and Customized…
3DP is a computer-aided design with the interesting innovation of prototyping layer-by-layer, creating 3D articles as digital blueprints to accomplish unequaled gracefulness, time protection, and extraordinary assembling ability of…
VITAMIN C – Tableting with LUBRITAB® RBW Lubricant
Vitamin C (ascorbic acid) is a popular supplement available over the counter in dosage forms such as tablets, capsules, sprinkles and gummies. From a formulator’s perspective, it can be challenging since it is poorly compressible and is…
Engineering artesunate-loaded micelles using spray drying for pulmonary drug delivery
Novel d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) micelles containing the anti-cancer drug artesunate (ART) were developed in a dry powder form for inhalation for the treatment of lung cancer. Targeted delivery to the lungs via…
How to Tame Recalcitrant Ingredients like Curcumin
Plant-based functional ingredients behave differently than manufacturers of nutraceuticals and cosmetic products would like. Innovative processes such as double microencapsulation can help them to overcome bioavailability and solubility…
Mucoadhesive 3D printed vaginal ovules to treat endometriosis and fibrotic uterine diseases
Gynaecological health is a neglected field of research that includes conditions such as endometriosis, uterine fibroids, infertility, viral and bacterial infections, and cancers. There is a clinical need to develop dosage forms for…
Control of drug release kinetics from hot-melt extruded drug-loaded polycaprolactone matrices
Sustained local delivery of meloxicam by polymeric structures is desirable for preventing subacute inflammation and biofilm formation following tissue incision or injury. Our previous study demonstrated that meloxicam release from hot-melt…
Parteck® MXP Excipient – Mix. Melt. Perform.
Parteck® MXP Excipient
The hot melt extrusion difference
Poor solubility of APIs is a critical challenge in drug development. One formulation technique to increase solubility and, consequently, improve bioavailability of drugs is hot…
Selective Laser Sintering for printing pharmaceutical dosage forms
Abstract
Three-dimensional (3D) printing has revolutionised the field of pharmaceutical manufacturing due to the unique capabilities to tailor the dosage forms properties and overcome constrains of conventional technologies. There is a…
Colon targeted releases and uptakes of paclitaxel loaded in modified porous starch
Hyaluronic acid can modify porous starch through cross-linking and hydrogen bonding, effectively achieving a paclitaxel entrapment efficiency of ∼92 % and drug loading of ∼23 %. In this study, the pores and intergranular gaps of porous …
Effective nose-to-brain drug delivery using a combination system targeting the olfactory region in…
The nose-to-brain (N2B) pathway has garnered attention because it transports drugs directly into the brain. Although recent studies have suggested the necessity of selective drug administration to the olfactory region for effective N2B drug…
Microneedle array patches for sustained delivery of fluphenazine: A micron scale approach for the…
Schizophrenia is a severe chronic mental illness characterised by impaired emotional and cognitive functioning. To treat this condition, antipsychotics are available in limited dosage forms, mainly oral and injectable formulations. Although…
Risk Mitigation of Nitrosamines Formation in Drug Products: Role of Excipients
1. Introduction
The issue of Nitrosamine impurities in drug and excipient manufacturing has become a significant concern for the pharmaceutical industry and health authorities. In June 2018, the FDA was notified of the presence of…
Integrated continuous melt granulation-based powder-to-tablet line: process investigation and…
In the last decades, continuous manufacturing (CM) has become a research priority in the pharmaceutical industry. However, significantly fewer scientific researches address the investigation of integrated, continuous systems, a field that…
Personalizing oral delivery of nanoformed piroxicam by semi-solid extrusion 3D printing
Semi-solid extrusion (SSE) 3D printing enables flexible designs and dose sizes to be printed on demand and is a suitable tool for fabricating personalized dosage forms. Controlled Expansion of Supercritical Solution (CESS®) is a particle…
Evolution of Nanomedicine Formulations for Targeted Delivery and Controlled Release
Abstract
Nanotechnology research over the past several decades has been aimed primarily at improving the physicochemical properties of small molecules to produce druggable candidates as well as for tumor targeting of cytotoxic molecules.…
Planetary roller melt granulation (PRMG) – A new continuous method for powder processing
Abstract
For the continuous operation of granulation, which is a standard unit operation in powder processing to modify the particle size, the use of twin-screw machines was established as standard method for wet and melt granulation over…
Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye…
Chronic ocular diseases can seriously impact the eyes and could potentially result in blindness or serious vision loss. According to the most recent data from the WHO, there are more than 2 billion visually impaired people in the world.…
Deep Learning-Based Machine Vision System for Use in High-Shear Granulation
Aim
Develop a prototype machine vision system and evaluate feasibility of a deep learning-based image analysis approach for estimation of the state of granulation on the acquired granule bulk surface images.
Introduction
Despite…
Development of a Discriminative Dissolution Method, Using In-Silico Tool for Hydrochlorothiazide and…
Hydrochlorothiazide (HTZ) and Valsartan (VAL) are poorly soluble drugs in BCS classes IV and II. This study aimed to develop a method to assess the dissolution profile of tablets containing HTZ (12.5 mg) and VAL (160 mg) as a fixed-dose…
Chitosan coated niosomes for nose-to-brain delivery of clonazepam: formulation, stability and…
Crossing the Blood Brain Barrier constitutes a challenge in drug administration to the brain. In this context, nose-to-brain delivery is explored as an alternative route in the treatment of central nervous system disorders, and…
Controlled delivery via hot-melt extrusion: A focus on non-biodegradable carriers for non-oral…
Hot-melt extrusion (HME) has an esteemed place in the pharmaceutical industry with significant applications and advancements spreading over 30 years of development. Currently, the choice of matrix excipients is vast, expanding from all…