Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Deep Learning-Based Machine Vision System for In-Line Monitoring of High-Shear Wet Granulation…
Aim
Develop a machine vision system for in-line monitoring of high-shear granulation processes to provide a more reliable and continuous solution for assessing the state of granulation.
Introduction
Granulation is critical for…
Why gene therapies must go virus-free
Gene therapies have made spectacular progress in delivering new cures for previously intractable disease, but they remain the world’s most expensive treatments. Now companies are replacing the virus in gene therapies with new delivery…
Development and in vivo evaluation of nanoemulsions for oral delivery of low molecular weight…
Abstract
Aim
The aim of this study was the development and in vivo evaluation of different types of nanoemulsions for oral delivery of low molecular weight heparin (LMWH).
Methods
Nanoemulsions (NE) were developed consisting of mainly…
Development and evaluation of polymeric mixed micelles prepared using Hot-melt extrusion for…
The poor aqueous solubility is a well-recognized restriction for the clinical application of many drug molecules. Micelles delivery system provides a promising strategy for the solubility enhancement of hydrophobic drugs. This study…
Novel Bioequivalent Tablet of Solifenacin Succinate Prepared Using Direct Compression Technique for…
Abstract
We designed a bioequivalent tablet form of solifenacin succinate (SOL) with an improved storage stability using a direct compression (DC) technique. An optimal direct compressed tablet (DCT) containing an active substance (10 mg),…
Current perspective on the challenges in the development of metformin orally disintegrating tablets…
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by persistent hyperglycaemia with significant morbidity and mortality rates. Currently, metformin is a drug used as first-line therapy during the management of T2DM…
The Effect of Particle Shape on the Compaction of Realistic Non-Spherical Particles—A Multi-Contact…
Abstract
The purpose of this study was to investigate the deformation behavior of non-spherical particles during high-load compaction using the multi-contact discrete element method (MC-DEM). To account for non-spherical particles, the…
Enteric coating of tablets containing an amorphous solid dispersion of an enteric polymer and a…
Recent work has highlighted that amorphous solid dispersions (ASDs) containing delamanid (DLM) and an enteric polymer, hypromellose phthalate (HPMCP), appear to be susceptible to crystallization during immersion in simulated gastric fluids.…
A multi-step machine learning approach for accelerating QbD-based process development of protein…
This study proposes a new material-efficient multi-step machine learning (ML) approach for the development of a design space (DS) for spray drying proteins. Typically, a DS is developed by performing a design of experiments (DoE) with the…
At-line porosity sensing for non-destructive disintegration testing in immediate release tablets
Fully automated at-line terahertz time-domain spectroscopy in transmission mode is used to measure tablet porosity for thousands of immediate release tablets. The measurements are rapid and non-destructive. Both laboratory prepared tablets…
Elucidation of the using condition and working mechanism of tertiary lactose in dry powder…
Tertiary lactose has been shown to improve aerosolization performance of carrier-based dry powder inhalation formulations. The working mechanism of the tertiary lactose, however, is still unclear, even the optimal working condition of the…
Ashland announces Polyplasdone™ Plus multifunctional disintegrant for improved pharmaceutical…
Press Release
Wilmington, Del., June 20, 2023 - Ashland is introducing Polyplasdone™ Plus, a co-processed multifunctional direct compression superdisintegrant containing a glidant and lubricant. Saving time and simplifying development, the…
MCC Spheres Facilitate Precise Dissolution Profile of Controlled Release Formulations
A 100% MCC sphere, Celphere™ has high sphericity and narrow particle size distribution. Also, Celphere™ is less damaged during film coating process because of its high mechanical strength. With regard to comparison with sugar spheres,…
3D printing tablets for high-precision dose titration of caffeine
Through 3D printing (3DP), many parameters of solid oral dosage forms can be customised, allowing for truly personalised medicine in a way that traditional pharmaceutical manufacturing would struggle to achieve. One of the many options for…
Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for…
HIV/AIDS remains a major global public health issue. While antiretroviral therapy is effective at reducing the viral load in the blood, up to 50% of those with HIV suffer from some degree of HIV-associated neurocognitive disorder, due to…
Development of an ethanol-free salbutamol sulfate metered-dose inhaler: Application of molecular…
Abstract
Introduction
More than fifty years after the commercialization of the Ventolin metered-dose inhaler (MDI), its constituent active ingredient, salbutamol sulfate (SS), remains the most prescribed short-acting beta agonist for the…
Regulatory Considerations for Excipients used in Lipid Nanoparticles
Lipid excipients and delivery systems such as lipid nanoparticles (LNPs) are essential for a wide variety of therapeutics including chemotherapy, analgesics, gene therapy, respiratory and ocular applications, anti-fungal applications,…
Self-emulsifying drug delivery systems: A versatile approach to enhance the oral delivery of BCS…
Biopharmaceutical classification systems (BCS) class III drugs belongs to a group of drugs with high solubility in gastrointestinal (GI) fluids and low membrane permeability result in significantly low bioavailability. Self-emulsifying drug…
Binary Polymeric Surfactant Mixtures for the Development of Novel Loteprednol Etabonate Nanomicellar…
The treatment of several ocular inflammatory conditions affecting different areas of the ocular globe involves the administration of topical ophthalmic formulations containing corticosteroids. This research was aimed at evaluating the…
Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and…
Benznidazole, a poorly soluble in water drug, is the first-line medication for the treatment of Chagas disease, but long treatment periods at high dosages cause several adverse effects with insufficient activity in the chronic phase.…
Development of Child-Friendly Lisdexamfetamine Chewable Tablets Using Ion Exchange Resin as a…
Taste masking is critical to improving the compliance of pediatric oral dosage forms. However, it is challenging for extremely bitter lisdexamfetamine dimesylate (LDX) with a long half-life and given in large dose. The present study aims to…
Effect of cyclosporine A – Tempol topical gel for the treatment of alopecia and…
Over the years, extensive research has been carried out to develop new chemical entities for hair loss treatment. Despite these efforts, the newly developed topical and oral treatments have not proven to be curative. Hair loss can result…
Deciphering the Structure-Property Relationship and Antioxidant Mechanisms of Trehalose – An…
Reactive Oxygen Species (ROS) have attracted significant attention among researchers as they play a role in cell death when produced excessively. To address this issue, scientists are actively seeking suitable antioxidants that can…
A prediction system: regulating effect of small-molecule additives on properties of amorphous solid…
Abstract
Amorphous solid dispersions (ASDs) with solubility advantage are suffering from the recrystallization risk and subsequent reduced dissolution triggered by high hygroscopicity of hydrophilic polymers and the supersaturation of ASD…
Transformative Materials for Interfacial Drug Delivery
Abstract
Drug delivery systems (DDS) are designed to temporally and spatially control drug availability and activity. They assist in improving the balance between on-target therapeutic efficacy and off-target toxic side effects. DDS aid in…
A validation of discrete-element model simulations for predicting tablet coating variability
Abstract
Achieving an even coating distribution on tablets during the coating process can be challenging, not to mention the challenges of accurately measuring and quantifying inter-tablet coating variability. Computer simulations…
Pullulan/Poly(vinyl alcohol) Hydrogels Loaded with Calendula officinalis Extract: Design and In…
The therapeutic efficiency of plant extracts has been limited by their poor pharmaceutical availability. Hydrogels have promising potential to be applied as wound dressings due to their high capacity to absorb exudates and their enhanced…
Development of dissolving microneedles for intradermal delivery of the long-acting antiretroviral…
Oral administration and intramuscular (IM) injection are commonly recommended options for human immunodeficiency virus (HIV) treatment. However, poor patient compliance due to daily oral dosing, pain at injection sites and the demand for…
Preparation of mucoadhesive methacrylated chitosan nanoparticles for delivery of ciprofloxacin
Mucoadhesive polymers and their nanoparticles have attracted a lot of attention in pharmaceutical applications, especially transmucosal drug delivery (TDD). Mucoadhesive polysaccharide-based nanoparticles, particularly chitosan, and its…
Three-dimensional (3D) printing of oral dental films (ODFs) using blended Compactcel® polymers…
Abstract
This study aimed to prototype oral dental films (ODFs) loaded with diclofenac sodium (DS) using two different grades of CompactCel® polymers through a semi-solid extrusion (SSE) bioprinter. This three-dimensional (3D) printed ODFs…
MEGGLE USA Inc. appoints Lewis Jackson as new CEO
PRESS RELEASE, 14th June, 2023
MEGGLE USA Inc. a global leader in pharmaceutical excipients, announced the appointment of Lewis Jackson as its new Chief Executive Officer. The experienced business leader will succeed Ruth Leinenbach…
3D screen printing technology enables fabrication of oral drug dosage forms with freely tailorable…
3D printing offers new opportunities to customize oral dosage forms of pharmaceuticals for different patient populations, improving patient safety, care, and compliance. Although several notable 3D print technologies have been developed,…
Zerion Pharma’s Dispersome® technology published in two peer-reviewed papers through partnerships…
PRESS RELEASE
June 8, 2023 (COPENHAGEN, Denmark). Zerion Pharma A/S (“ZERION”) today announces the publication of joint experimental work on its Dispersome® technology in the International Journal of Pharmaceutics and Pharmaceutical…
Design of experiment based formulation optimization of chitosan-coated nano-liposomes of…
The aim of this research was to design and develop chitosan-coated nano-liposomes of progesterone for its safe and effective oral delivery through the vesicular system providing sustained drug release, enhanced drug stability in…