Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Sustained Release of Salicylic Acid from Ethyl Cellulose Microspheres Fabricated Using…
Delivery of drugs using micro-sized particles is an efficient tool. Using ethyl cellulose (EC) as a polymer and the quasi-emulsion solvent diffusion (QESD) method paves the way for the utilization of a cost-effective polymer and an…
Fabrication and optimization of itraconazole-loaded zein-based nanoparticles in coated capsules as a…
Itraconazole (ITZ), a broad-spectrum antifungal drug, was formulated into colon-targeting system aiming to treat opportunistic colonic fungal infections that commonly infect chronic inflammatory bowel diseases (IBD) patients due to…
Solid implantable devices for sustained drug delivery
Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug administration routes. Oral and injectable drug administration are the most common routes for drug delivery providing peaks of drug concentrations…
Comprehensive powder flow characterization with reduced testing
Powder flow is a critical attribute of pharmaceutical blends to ensure tablet weight uniformity and production of tablets with consistent and reproducible properties. This study aims at characterizing different powder blends with a number…
Polyvinyl alcohol: Revival of a long lost polymer
Introduction
With target-oriented drug discovery and an increasing focus on specialized medicines, the manufacturing of final drug products is becoming more and more complex. The processing and formulation of active pharmaceutical…
Critical Excipients in Topical and Parenteral Dermatological Formulations: Novel Analytical…
Background & Introduction
Excipients play a crucial role in efficacy, safety and quality of medicinal products. In topical dermatological formulations, often complex excipients of natural or semi-synthetic origin with broad…
Moisture Behavior of Pharmaceutical Powder during the Tableting Process
Abstract
The moisture content of pharmaceutical powder is a key parameter contributing to tablet sticking during the tableting process. This study investigates powder moisture behavior during the compaction phase of the tableting process.…
Process and formulation parameters influencing the survival of Saccharomyces cerevisiae during spray…
Abstract
Probiotic microorganisms provide health benefits to the patient when administered in a viable form and in sufficient doses. To ensure this, dry dosage forms are preferred, with tablets in particular being favored due to several…
Formulation of Intranasal Mucoadhesive Thermotriggered In Situ Gel Containing Mirtazapine as an…
The purpose of the present work was to develop nanoemulsion-based formulations of mirtazapine for intranasal delivery using a spray actuator to target the brain for treating depression. Research on the solubility of medications in different…
Pharmaceutical evaluation of Levofloxacin orally disintegrating tablet formulation using low…
We evaluated the pharmaceutical properties of levofloxacin (LV) in the form of an orally disintegrating tablet (LVODT) to find a new usefulness of low frequency (LF) Raman spectroscopy. LVODT contained dispersed granules with diameters in…
New insights on the effects of blend composition on the biodegradation and permeability of…
Abstract
Inulin has been applied in Inulin-Eudragit RS (Inu-ERS) coatings as the component responsible for degradation by human microbiota. However, studies on how bacterial enzymes can degrade polysaccharides like inulin imbedded in water…
Better performance with Pharma MMC – by Disruptive Pharma
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Better performance with Pharma MMC amorphous drug formulations offerings
Give existing products extended life and improved performance.
Facilitate novel drug development with one formulation from…
A step forward on the in vitro and in vivo assessment of a novel nanomedicine against melanoma
Abstract
Melanoma is the most aggressive form of skin cancer, with increasing incidence and mortality rates. To overcome current treatment limitations, a hybrid molecule (HM) combining a triazene and a sulfur L-tyrosine analogue, was…
Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and…
Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly deliver therapeutics to the site of skin lesions, resulting in increased therapeutic efficacy while having minimum side effects. MNs are used to…
Ultra-High-Resolution Optical Coherence Tomography for the investigation of thin multilayered…
Optical Coherence Tomography (OCT) has recently gained attention as a promising technology for in-line monitoring of pharmaceutical film-coating processes for (single-layered) tablet coatings and end-point detection with commercial systems.…
In vitro-in vivo relationship for amorphous solid dispersions using a double membrane…
The use of amorphous solid dispersions (ASDs) is one commonly applied formulation strategy to improve the oral bioavailability of poorly water-soluble drugs by overcoming dissolution rate and/or solubility limitations. While bioavailability…
Characterization and Validation of a New 3D Printing Ink for Reducing Therapeutic Gap in Pediatrics…
Abstract
3D printing technology can be used to develop individualized medicines in hospitals and pharmacies, allowing a high degree of personalization and the possibility to adjust the dose of the API based on the quantity of material…
Real-time in-line prediction of drug loading and release rate in the coating process of diclofenac…
Abstract
The preparation of diclofenac sodium spheres by fluidized bed is a common production mode for the pharmaceutical preparations at present, but the critical material attributes in the production process is mostly analyzed off-line,…
Natural product-based excipients for topical green formulations
Abstract
The industry has been paying more attention to the quality of excipients since they play a fundamental role in the efficacy, safety, and acceptability of pharmaceutical products. However, in the case of topical products synthetic…
On the Influence of Raw Material Attributes on Process Behaviour and Product Quality in a Continuous…
Continuous manufacturing of oral solids is a complex process in which critical material attributes (CMAs), formulation and critical process parameters (CPPs) play a fundamental role. However, assessing their effect on the intermediate and…
Dual-Drug-Loaded Topical Delivery of Photodynamically Active Lipid-Based Formulation for Combination…
Topical administration of anti-cancer drugs along with photodynamically active molecules is a non-invasive approach, which stands to be a promising modality for treating aggressive cutaneous melanomas with the added advantage of high…
PLGA – A versatile copolymer for design and development of nanoparticles for drug delivery
Introduction
Poly (lactic-co-glycolic acid) or PLGA, a highly hydrophobic copolymer comprised of lactic acid and glycolic acid, has been approved in many drug products and medical devices.1 Over the years since the first approved in 1997,…
Oral insulin delivery: Barriers, strategies, and formulation approaches: A comprehensive review
Diabetes Mellitus is characterized by a hyperglycemic condition which can either be caused by the destruction of the beta cells or by the resistance developed against insulin in the cells. Insulin is a peptide hormone that regulates the…
How to ensure a successful tablet coating formulation development by using polyvinyl alcohol and…
Purpose
Recent ban of titanium dioxide (TiO2; E171) for the use in food and nutritional supplements (European Commission). The regulation includes a commitment to review the necessity of titanium dioxide as a white colorant in…
The impact of material chemistry and morphology on attrition behavior of excipients during high…
Particle breakage by attrition is unavoidable in some unit operations and can lead to uncontrolled behavior of materials during processing. The aim of this study is to clarify the impact of material properties on attrition behavior. For the…
A state-of-the-art review on solid lipid nanoparticles as a nanovaccines delivery system
In the design of vaccine generation, significant attempts have been made to produce novel vaccines and, as well, to increase the effectiveness of available vaccines versus particular diseases. Over the past few years, with nanovaccines,…
Croda Breaks Ground On New Manufacturing Facility For Pharmaceutical Excipients In Lamar,…
(CLINTON COUNTY, PA) – Croda, Inc., the company that uses smart science to create high-performance ingredients and solutions that improve lives, broke ground on 9 May 2023, its newest manufacturing facility in Lamar, Clinton County,…
Solving capping challenges using mannitol as an excipient model
Pharma Excipients & Roquette present the new webinar:
Solving capping challenges using mannitol as an excipient model
Date & Time:
Jun 27, 2023 03:00 PM CET, 9:00 AM EST
Register here
Description:
During…
A case study on distributed manufacturing of 3D printed medicines
Pharmaceutical 3D printing (3DP) is one of the emerging enabling technologies of personalised medicines as it affords the ability to fabricate highly versatile dosage forms. In the past 2 years, national medicines regulatory authorities…
Exploiting common ion addition to accelerate zolpidem hemitartrate release from Eudragit EPO…
The current study aimed at optimizing a previously developed non-clinical formulation for use in zolpidem deprescribing. The formulation under investigation consists of extruded zolpidem hemitartrate (30% w/w) and Eudragit EPO (70% w/w)…
Thiolated α-cyclodextrin: The likely smallest drug carrier providing enhanced cellular uptake and…
This study aimed to evaluate the effect of thiolated α-cyclodextrin (α-CD-SH) on the cellular uptake of its payload.
For this purpose, α-CD was thiolated using phosphorous pentasulfide. Thiolated α-CD was characterized by FT-IR and 1H NMR…
A Data-Driven Approach to Predicting Tablet Properties after Accelerated Test Using Raw Material…
The purpose of this study was to develop a model for predicting tablet properties after an accelerated test and to determine whether molecular descriptors affect tablet properties. Tablets were prepared using 81 types of active…
Tablet coating in lab-scale drum coaters: Combining DEM simulations and spray experiments to predict…
In pharmaceutical industry the coating of granulates or tablets is an essential production step, which is often realised in a rotating drum moving the tablet bed and a number of spray nozzles installed above this bed. The nozzles atomise…
Revolutionizing pediatric HIV therapy: The latest breakthroughs in drug delivery techniques
Human Immunodeficiency Virus (HIV) is the root cause of acquired immunodeficiency syndrome (AIDS), which destroys the body's immune cells, thereby rendering the body unable to fight any infections. It is a sexually transmitted disease (STD)…