Blend uniformity monitoring in a continuous manufacturing mixing process for a low-dosage formulation using a stream sampler and near infrared spectroscopy
Continuous manufacturing has the potential to offer several benefits for the production of oral solid dosage forms, including reduced costs, low-scale equipment, and the application of process analytical technology (PAT) for real-time process control. This study focuses on the implementation of a stream sampler to develop a near infrared (NIR)…
Influence of compression kinetics during tableting of fluidized bed-granulated microorganisms on…
As tablets are convenient to administer to patients, ensure safe dosing and allow cost-effective production on a large scale, they are the favored dosage form for numerous active pharmaceutical ingredients but also for the administration of…
Development of a New Age-Appropriate, Chewable Tablet of Mebendazole 500 mg for Preventive…
The aim of this study was to develop an age-appropriate tablet of mebendazole 500 mg to be used in large donation programs by the World Health Organization (WHO) for preventive chemotherapy of soil-transmitted helminth (STH) infections in…
High resveratrol-loaded microcapsules with trehalose and OSA starch as the wall materials:…
To improve the solubility and stability of resveratrol (Res), Res nanocrystals (Res-ncs) as the capsule core were prepared by wet milling using hydroxypropyl methyl cellulose (HPMCE5), sodium dodecyl sulfate (SDS), and polyvinylpyrrolidone…
Croda announces two new partnerships to drive sustainable delivery systems for the pharmaceutical…
PRESS RELEASE
19 May 2023:
Croda International Plc (Croda) today announced that it has signed two new partnership agreements that will help the pharmaceutical industry move towards a more sustainable supply chain for vaccine…
SmartEx® Plus: a New Co-Processed Excipient for Oral Disintegration Tablets
SmartEx® Plus is an exciting new co-processed excipient that has been developed by Japanese chemical company Shin-Etsu to meet the increased demand for oral disintegration tablets (ODTs), with the added advantage that it offers excellent…
Comparison of scale-up strategies in twin-screw wet granulation
The aim of this study was to compare different scale-up strategies in twin-screw wet granulation and investigate the impact of the selected strategy on granule and tablet properties for a defined formulation. For the scale-up, a granulation…
Optimisation of Pharmaceutical Cocrystal Dissolution Performance through a Synergistic Precipitation…
Abstract
Objectives
Polymeric excipients play an important role in a cocrystal formulation to act as precipitation inhibitors to maximize the potential. Otherwise, a stable form of the parent drug will be recrystallized on the…
3D printing of microencapsulated Lactobacillus rhamnosus for oral delivery
3D Printing is an innovative technology within the pharma and food industries that allows the design and manufacturing of novel delivery systems. Orally safe delivery of probiotics to the gastrointestinal tract faces several challenges…
What is BCS and why it’s quite useful? – Explainer video by Pharma Drama
In this video Pharma Drama aka Prof. Simon Gaisford is going to explain what the BCS is and why it’s quite useful.
See the video and read the full transcript below.
Read the video transcript here:
Welcome to Pharma Drama, the…
Storage and flow of bulk solids
By Greg Mehos, Ph.D., P.E.
About this book
When I became an adjunct professor at the University of Rhode Island, I realized that most books on the subject of bulk solids testing and hopper design were either very terse or rather intense…
Bulk Flow Optimisation of Amorphous Solid Dispersion Excipient Powders through Surface Modification
Particulate amorphous solid dispersions (ASDs) have been recognised for their potential to enhance the performance of various solid dose forms, especially oral bioavailability and macromolecule stability. However, the inherent nature of…
Breakthroughs and bottlenecks of psoriasis therapy: Emerging trends and advances in lipid based…
Psoriasis is a chronic autoimmune skin disease characterised by abnormal epidermal keratinocytes, hyperproliferation, and inflammatory infiltration. The main challenges that make treating psoriasis difficult are the complex aetiology,…
Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery
Nanomedicine is currently focused on the design and development of nanocarriers that enhance drug delivery to the brain to address unmet clinical needs for treating neuropsychiatric disorders and neurological diseases. Polymer and…
Calcium carbonate as a replacement for titanium dioxide in coating: the importance of particle…
Uniform colored and white coatings applied to tablets create a homogeneous appearance across batches, improving aesthetics and patient compliance. Titanium dioxide is used extensively in solid dosage forms for this purpose, serving as an…
Design and Optimization of Quercetin-Loaded Polymeric Eudragit L-100 Nanoparticles for Anti-diabetic…
To design and develop a nanoformulation from isolated quercetin (QT) from the Annona reticulata Linn leaves to enhance therapeutic index, solubility, bioavailability, toxicity mitigation, pharmacological activity improvement, and prevention…
Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the…
In recent years, natural ingredients have gained importance for therapeutic treatment due to their minimal toxicity. However, the delivery of these phytoconstituents poses a challenge to provide better efficacy. Current research reports the…
Comparison of Ceolus™ Grades in Continuous Manufacturing of Tablets using Direct Compression
1. Introduction
The introduction of continuous manufacturing of tablets has been gaining momentum, because it offers reductions in development and manufacturing costs and time and improved reliability of quality assurance.
In this study,…
Numerical simulation of five different screw configurations used during the preparation of hot-melt…
This work developed immediate-release hot melt extruded pellets containing the poorly aqueous soluble drug Indomethacin with five different screw configurations for oral application. Moreover, numerical simulation concerning residence time…
Hot-melt extruded in situ gelling systems (MeltDrops Technology): Formulation development, in silico…
In situ gelling systems (ISGS) can prolong retention time and bioavailability of ophthalmic solutions. The complexity and cost of ISGS avert their industrial scale-up and clinical implementation. In this study, we demonstrate novel…
Control oriented modeling of twin-screw granulation in the ConsiGma-25 production plant
ConsiGmaTM-25 is a continuous production plant integrating a twin-screw granulation, fluid bed drying, granule conditioning, and a tableting unit. The particle size distribution (PSD), active pharmaceutical ingredient (API) content, and…
3D Printing Technology as a Promising Tool to Design Nanomedicine-Based Solid Dosage Forms:…
3D printing technology in medicine is gaining great attention from researchers since the FDA approved the first 3D-printed tablet (Spritam®) on the market. This technique permits the fabrication of various types of dosage forms with…
Development of Orally Administrable Phytochemicals by Nano-Suspension and Nano-Emulsion Techniques
The awareness of the existence in plants of bioactive compounds namely phytochemicals (PHYs), having health properties is progressively expanding. Therefore, their massive introduction in the normal diet, in food supplements, and their use…
Transferrin functionalized nanostructured lipid carriers for targeting Rivastigmine and Resveratrol…
The management of Alzheimer's disease (AD) remains challenging owing to its complex pathophysiology and blood-brain barrier (BBB) restrictions. A rationally designed combination drug multi-target strategy has emerged as a promising approach…
3D printed implantable drug delivery devices for women’s health: Formulation challenges and…
Modern pharmaceutical interventions are shifting from traditional “one-size-fits-all” approaches toward tailored therapies. Following the regulatory approval of Spritam®, the first marketed drug manufactured using three-dimensional printing…
Tablet in Capsule Technology – Overview
Tablets are solid dosage forms containing medicinal substances with or without suitable diluents. They are the most widely preferred form of medication both by pharmaceutical manufacturer as well as physicians and patients. Capsules are…
Self-Nanoemulsifying Drug Delivery System for Enhanced Bioavailability of Madecassic Acid: In vitro…
Purpose: Madecassic acid (MCA) is a natural triterpenoid isolated from centellae herba that has diverse biological effects, such as anti-inflammatory, antioxidant, and anticancer activities. However, the efficacy of MCA is limited by low…
Emulsion-Based Gel Loaded with Ibuprofen and Its Derivatives
The aim of this study was to evaluate the effect of vehicle and chemical modifications of the structure of active compounds on the skin permeation and accumulation of ibuprofen (IBU). As a result, semi-solid formulations in the form of an…
Enhancement of Valsartan Oral Bioavailability by Preparing a Microwave-Irradiated Inclusion Complex…
The purpose of the study is to investigate the influence of sulfobutyl ether β-cyclodextrin (SBE7-β-CD) on the bioavailability of valsartan. Phase solubility investigations showed an AL type curve. The estimated apparent stability constant…
Solid Formulation Development Using Melt-based 3D Printing Technologies – article by Merck
Three-dimensional (3D) printing is a powerful technology that has wide-ranging applications, including many in the pharmaceutical industry. 3D printing offers the potential to produce medications tailored to the needs of patients and dosage…
The History of Electrospinning: Past, Present, and Future Developments
Electrospinning has rapidly progressed over the past few decades as an easy and versatile way to fabricate fibers with diameters ranging from micrometers to tens of nanometers that present unique and intricate morphologies. This has led to…
Long-acting Parenteral Drug Delivery Systems for the Treatment of Chronic Diseases
Abstract
The management of chronic conditions often requires patients to take daily medication for an extended duration. However, the need for daily dosing can lead to nonadherence to the therapy, which can result in the recurrence of the…
A comprehensive overview of dry powder inhalers for pulmonary drug delivery: Challenges, advances,…
Abstract
Dry powder inhaler (DPI) is an attractive dosage form for local and systemic pulmonary drug delivery. However, designing DPIs with adequate physicochemical properties is challenging. The development of novel pulmonary drug…
Oral administration of Huanglian-Houpo herbal nanoemulsion loading multiple phytochemicals for…
How to achieve stable co-delivery of multiple phytochemicals is a common problem. This study focuses on the development, optimization and characterization of Huanglian-HouPo extract nanoemulsion (HLHPEN), with multiple components…
Preformulation screening of lipids using solubility parameter concept in conjunction with…
Abstract
Development of ceftriaxone loaded nanostructured lipid carriers to increase permeability of ceftriaxone across uninflamed meninges after parenteral administration. Lipids were selected by theoretical and experimental techniques…