Blend uniformity monitoring in a continuous manufacturing mixing process for a low-dosage formulation using a stream sampler and near infrared spectroscopy
Continuous manufacturing has the potential to offer several benefits for the production of oral solid dosage forms, including reduced costs, low-scale equipment, and the application of process analytical technology (PAT) for real-time process control. This study focuses on the implementation of a stream sampler to develop a near infrared (NIR)…
Multilayer Films Based on Chitosan/Pectin Polyelectrolyte Complexes as Novel Platforms for Buccal…
Buccal films are recognized as easily applicable, microbiologically stable drug dosage forms with good retentivity at the mucosa intended for the therapy of oromucosal conditions, especially infectious diseases. Multilayer films composed of…
Long-acting PLGA microspheres: advances in excipient and product analysis toward improved product…
Abstract
Poly(lactic-co-glycolic acid) (PLGA) microspheres are a sustained-release drug delivery system with several successful commercial products used for the treatment of a variety of diseases. By utilizing PLGA polymers with different…
Microbiota-sensitive drug delivery systems based on natural polysaccharides for colon targeting
Colon targeting is an ongoing challenge, particularly for the oral administration of biological drugs or local treatment of inflammatory bowel disease (IBD). In both cases, drugs are known to be sensitive to the harsh conditions of the…
SEPISMART™ SR – Time to release your creativity
See the new Seppic product SEPISMART™ SR in use cases with Vitamin C and caffein delivery:
INTESTINAL ABSORPTION - a critical step
1. At physiological pH, vitamin C is mainly found in its ionized form, named ascorbate (Asc) and to…
Preparation of sustained-release tablets using a solventless-mixing tablet coating technique:…
The aim of this study was to produce sustained-release tablets by V-shaped blending of polymer and tablets without using solvents or heating, and we investigated the design of polymer particles with high coating performance by modifying the…
A smart solution for Biopharmaceutical Development – by Hayashibara
TREHALOSE SG JP, USP-NF, Ph. Eur., CP
High-purity and low endotoxin injectable grade trehalose
TREHALOSE SG is an injectable grade pharmaceutical excipient and is monographed as being low endotoxin and high purity. It is supplied as…
Gelucire® 44/14 – Self-emulsifying excipient for solubility and oral bioavailability…
Product description
Gelucire® 44/14 is a non-ionic water dispersible surfactant recommended for use in lipid-based formulations to increase the aqueous solubility and oral bioavailability of poorly water soluble drugs.
A multi-component…
Predicting Residence Time and Melt Temperature in Pharmaceutical Hot Melt Extrusion
Hot-melt extrusion is increasingly applied in the pharmaceutical area as a continuous processing technology, used to design custom products by co-processing drugs together with functional excipients. In this context, the residence time and…
Residence Time Distribution-Based Smith Predictor: an Advanced Feedback Control for Dead…
Purpose
In continuous manufacturing (CM), the material traceability and process dynamics can be investigated by residence time distribution (RTD). Many of the unit operations used in the pharma industry were characterized by dead…
Analyzing the interparticle batch homogeneity of natural hot-melt coatings
Abstract
The hot-melt coating process is widely used in the food and pharmaceutical industries. Its purpose of use is very diverse and includes, among other things, changing the functional properties of the particle surfaces, forming a…
Effect of the Freezing Step on Primary Drying Experiments and Simulation of Lyophilization Processes
Lyophilization is a widely used preservation method for thermosensitive products. It consists of three process steps: freezing, primary and secondary drying. One of the major drawbacks is the long processing time. The main optimization…
Nano-and Microfabrication Techniques in Drug Delivery – Insights Part 3
Nano-and Microfabrication Techniques in Drug Delivery
See the new book, edited by Dimitrios Lamprou. It brings together technical, clinical, regulatory and industrial perspectives. It provides future prospective and includes the potential…
Recent advances in edible coating of food products and its legislations: A review
Abstract
Food products are highly perishable in nature which undergoes quick quality deterioration. In this note, the kind of packaging decides the active preservation of food qualities. Especially, edible coating plays a significant role…
Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during…
The sticking of active pharmaceutical ingredient (API) to the surfaces of compaction tooling, frequently referred to as punch sticking, causes costly downtime or product failures in commercial tablet manufacturing. Magnesium stearate (MgSt)…
Neutralisation of SARS-CoV-2 by monoclonal antibody through dual targeting powder formulation
Neutralising monoclonal antibody (mAb) is an important weapon in our arsenal for combating respiratory viral infections. However, the effectiveness of neutralising mAb has been impeded by the rapid emergence of mutant variants. Early…
Risk-based contamination control strategy of manufacturing non-sterile pharmaceutical products
Introduction and aim
Contamination is one of the biggest risks to patients’ health and the quality of pharmaceutical products. According to the new version of Annex 1: Manufacture for sterile medicine products, manufacturers of…
Improving API Solubility Using Hot Melt Extrusion Formulation With Polyvinyl Alcohol
Poor solubility of active pharmaceutical ingredients (APIs) is a critical challenge in drug development. There are many avenues to improving API solubility including promoting API dissolution, API processing, and formulation approaches. One…
Evaluating the Effect of Microcrystalline Cellulose Variations on Tablet Quality of Natural Plant…
Microcrystalline cellulose (MCC) of different grades from different manufacturers differ in particulate and powder properties significantly. The choice of MCC is important to the development of a tablet formulation with satisfactory…
Novel Applications of Hot Melt Extrusion Technology
Hot melt extrusion (HME) technology was introduced to pharmaceuticals in the 1970s for manufacturing and product development. Since then, there were several developments in HME technology to utilize it effectively for the manufacturing of…
Experimental Design of D-α-tocopherol polyethylene glycol 1000 succinate Stabilized Bile Salt Based…
Nowadays, conventional anticancer therapy suffers many pitfalls, including drastic side effects and limited therapeutic efficacy resulting from diminished oral bioavailability. So, in an attempt to enhance their poor solubility and oral…
Mechanism of Insoluble Aggregate Formation in a Reconstituted Solution of Spray-Dried Protein Powder
Abstract
Background
Spray-drying is considered a promising alternative drying method to lyophilization (freeze-drying) for therapeutic proteins. Particle counts in reconstituted solutions of dried solid dosage forms of biologic drug…
MEGGLE’s sieved, milled and micronized alpha-lactose monyhydrate for dry powder inhalation: InhaLac®
MEGGLE is a pioneer in co-processing technologies that allow simple, robust formulation development and manufacture. Through co-processing, MEGGLE developed highly functional excipients possessing unique qualities for directly compressible…
Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for…
HIV/AIDS remains a major global public health issue. While antiretroviral therapy is effective at reducing the viral load in the blood, up to 50% of those with HIV suffer from some degree of HIV-associated neurocognitive disorder, due to…
Chemical Analysis and Molecular Modelling of Cyclodextrin-Formulated Propofol and Its Sodium Salt to…
Propofol is a widely used general anesthetic in clinical practice, but its use is limited by its water-insoluble nature and associated pharmacokinetic and pharmacodynamic limitations. Therefore, researchers have been searching for…
Influence of Solid Oral Dosage Form Characteristics on Swallowability, Visual Perception, and…
Abstract
Swallowability, visual perception, and any handling to be conducted prior to use are all influence factors on the acceptability of an oral dosage form by the patient. Knowing the dosage form preferences of older adults, as the…
Nano-and Microfabrication Techniques in Drug Delivery – Part 2
Nano-and Microfabrication Techniques in Drug Delivery
See the new book, edited by Dimitrios Lamprou. It brings together technical, clinical, regulatory and industrial perspectives. It provides future prospective and includes the potential…
Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly…
A drug’s aqueous solubility is defined as the ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market. According to some estimates, up to 40% of commercialized products…
The Passive Diffusion Improvement of Vitamin B12 Intestinal Absorption by Gelucire that fit for…
Vitamin B12 (VB12) is a vital micronutrient to maintain the normal state of the hematopoietic system. It must be obtained from the diet since the human body cannot synthesize it. Moreover, the absorption of VB12 needs to be mediated by…
A review on co-processed excipients used in direct compression of tablet dosage form
Co-processed excipients may enhance functionality and reduce drawbacks of traditional excipients for the manufacture of tablets on a commercial scale. The following study aimed to characterize a range of co-processed excipients that may…
Corroborating various material-sparing techniques with hot melt extrusion for the preparation of…
Amorphous solid dispersions (ASD) are one of the most adopted technologies for improving the solubility of novel molecules. Formulation of ASDs using solvent free methods such as hot melt extrusion (HME) has been in the spotlight…
Long-Acting Injectable Aqueous Suspensions—Summary From an AAPS Workshop
Through many years of clinical application of long-acting injectables, there is clear proof that this type of formulation does not just provide the patient with convenience, but more importantly a more effective treatment of the medication…
Development of Doxazosin mesylate liquisolid system for improved manufacturing processability and…
In the present research, an attempt was made to optimize the blends of different carriers Neusilin US2, Avicel PH101, and Fujicalin SG by individually blending with each of coating materials Aerosil 200 and Syloid 244 FP that were proposed…
Achillea wilhelmsii–Incorporated Chitosan@Eudragit Nanoparticles Intended for Enhanced Ulcerative…
Achillea wilhelmsii (A. wilhelmsii) contains several therapeutic phytochemicals, proposing a protective effect on inflammatory responses in autoimmune diseases such as ulcerative colitis (UC). However, its activities against UC encounter…
Comparison of 5-ASA layered or matrix pellets coated with a combination of ethylcellulose and…
The aim of this study was to evaluate and optimize the combination of time and pH-dependent polymers as a single coating for the design of the colon-specific drug delivery system of 5-aminosalicylic acid (5-ASA) pellets. 5-ASA matrix…