Blend uniformity monitoring in a continuous manufacturing mixing process for a low-dosage formulation using a stream sampler and near infrared spectroscopy
Continuous manufacturing has the potential to offer several benefits for the production of oral solid dosage forms, including reduced costs, low-scale equipment, and the application of process analytical technology (PAT) for real-time process control. This study focuses on the implementation of a stream sampler to develop a near infrared (NIR)…
Nano-and Microfabrication Techniques in Drug Delivery – Part 1
Nano-and Microfabrication Techniques in Drug Delivery
See the new book, edited by Dimitrios Lamprou. It brings together technical, clinical, regulatory and industrial perspectives. It provides future prospective and includes the potential…
Optical Coherence Tomography as a novel tool for non-invasive membrane thickness monitoring of…
Abstract
Co-extruded core-membrane formulations have been extensively explored as long-acting subcutaneous implants or vaginal inserts, guaranteeing zero-order release. Although the membrane thickness and homogeneity determine the final…
Influence of talc and hydrogenated castor oil on the dissolution behavior of metformin-loaded…
Multi-unit pellet system (MUPS) is of great interest as it is amenable to customization. MUPS comprises multi-particulates, usually as pellets or spheroids, which can be coated with diffusion barrier coatings. One commonly used diffusion…
Technological Aspects and Evaluation Methods for Polymer Matrices as Dental Drug Carriers
he development of polymer matrices as dental drug carriers takes into account the following technological aspects of the developed formulations: the composition and the technology used to manufacture them, which affect the properties of the…
Soluplus as a solubilizing excipient for poorly water-soluble drugs: Recent advances in formulation…
Since the emergence of Soluplus® (SOL) as a commercial graft copolymer, multiple publications have been issued on its promising potential as a solubilizing excipient that could promote the dissolution rate and bioavailability of several…
Innovation in the Development of Synthetic and Natural Ocular Drug Delivery Systems for Eye Diseases…
Nowadays, ocular drug delivery still remains a challenge, since the conventional dosage forms used for anterior and posterior ocular disease treatments, such as topical, systemic, and intraocular administration methods, present important…
Design, Evaluation and Comparison of Nanostructured Lipid Carriers and Chitosan Nanoparticles as…
There is a serious need of pediatric drug formulations, whose lack causes the frequent use of extemporaneous preparations obtained from adult dosage forms, with consequent safety and quality risks. Oral solutions are the best choice for…
Pre-Processing a Polymer Blend into a Polymer Alloy by KinetiSol Enables Increased Ivacaftor…
This study compares the effects of pre-processing multiple polymers together to form a single-phase polymer alloy prior to amorphous solid dispersion formulation. KinetiSol compounding was used to pre-process a 1:1 (w/w) ratio of…
Role of additives in starch-based edible films and coating: A review with current knowledge
Edible films and coating provide a potentially effective method for preserving fresh food products by reducing moisture loss, regulating respiration rate, improving surface smoothness, and or preventing microbial growth during their…
Cationic nanocapsule suspension as an alternative to the sublingual delivery of nifedipine
Nifedipine (NIFE) is a calcium channel blocker drug used to treat cardiovascular diseases, angina, and hypertension. However, NIFE is photolabile, has a short biological half-life, low aqueous solubility, and undergoes an intense first-pass…
Roquette Cuts Ribbon on $25 Million Pharmaceutical Innovation Center in the United States
PRESS RELEASE
La Madeleine, France, and Philadelphia, USA – April 19, 2023. Roquette, a global leader in plant-based ingredients and a leading provider of pharmaceutical and nutraceutical excipients, today celebrates the grand opening of…
Nanostructured Lipid Carrier–Based Gel for Repurposing Simvastatin in Localized Treatment of Breast…
Simvastatin (SMV) is noticed as a repurposed candidate to be effective against breast cancer (BC). However, poor solubility, dose-limiting toxicities, and side effects are critical hurdles in its use against BC. The above drawbacks…
Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
Poor medication adherence is a pervasive issue with considerable health and socioeconomic consequences. Although the underlying reasons are generally understood, traditional intervention strategies rooted in patient-centric education and…
Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials…
Ocular permeability, intraocular biodistribution of lipid nanocapsule formulation intended for…
Recently, cGMP analogues have been investigated for the treatment of inherited retinal degenerations (IRD) using intravitreal injections. However, higher vitreous elimination rates limit the possibility to treat the retina with small…
Enhanced geranylgeraniol stability and dissolution from self-emulsifying pellets containing the…
The vegetal species sucupira (Pterodon emarginatus Vogel) presents some diterpenes that have anti-inflammatory activities. However, diterpenes are poorly water-soluble compounds. The development of Self-Emulsifying Drug Delivery Systems…
N-nitrosamine Mitigation with Nitrite Scavengers in Oral Pharmaceutical Drug Products
N-nitrosamines are likely human carcinogens. After N-nitrosamine contaminants were detected in pharmaceutical products in 2018, regulatory authorities set a framework for the risk assessment, testing and mitigation of N-nitrosamines in drug…
Taste Detection of Maltooligosaccharides with Varying Degrees of Polymerization
Previous studies have shown that humans can taste maltooligosaccharides but not maltopolysaccharides (MPS; DP of >20) and that their taste detection is independent of the canonical sweet taste receptor. The objectives of this study were…
Advancing non-destructive analysis of 3D printed medicines
Pharmaceutical 3D printing (3DP) has attracted significant interest over the past decade for its ability to produce personalised medicines on demand. However, current quality control (QC) requirements for traditional large-scale…
Preparation of Melatonin Nanoparticles and their Enhancement of Lungs Bioavailability in the…
Background: To develop a first-time-novel polymeric NPs from PLGA and their coating by Chitosan (CS) of Melatonin (MT) for the enhancement of lungs bioavailability by targeting lungs from the nose.
Materials and Methods: The Melatonin…
MEGGLE presents the new DPI product InhaLac® 180 at RDD Europe 2023
Wasserburg, Germany, May, 2023:
Pharmaceutical lactose specialist MEGGLE Excipients will launch its latest inhalable milled lactose grade, InhaLac® 180 at May’s Respiratory Drug Delivery (RDD) in the South of France.
InhaLac® 180 is…
Nanostructured Lipid Carrier Co-Loaded with Docetaxel and Magnetic Nanoparticles: Physicochemical…
Lung cancer is currently the most prevalent cause of cancer mortality due to late diagnosis and lack of curative therapies. Docetaxel (Dtx) is clinically proven as effective, but poor aqueous solubility and non-selective cytotoxicity limit…
3D printing fabrication of Ethylene-Vinyl Acetate (EVA) based intravaginal rings for antifungal…
Vulvovaginal candidiasis is a vaginal infection that affects women of reproductive age. Nowadays, the high administration frequency of conventional antifungal formulations, and recurrences negatively impact patients’ well-being. In this…
Stability of Oral Liquid Dosage Forms in Pediatric Cardiology: A Prerequisite for Patient’s Safety—A…
The development of safe and effective pediatric formulations is essential, especially in therapeutic areas such as pediatric cardiology, where the treatment requires multiple dosing or outpatient care. Although liquid oral dosage forms are…
Entrapment of celecoxib into mesoporous silica particles for tablets with improved dissolution…
The objective of this study was to develop mesoporous silica particles (MSPs) tablet that can entrap large amounts of celecoxib into the mesopores as an amorphous state, exhibiting an enhanced dissolution. Optimal conditions that enable…
Preparation of a ternary amorphous solid dispersion using hot-melt extrusion for obtaining a stable…
In our previous reports, ternary amorphous solid dispersions (ASDs) of probucol (PBC)/polymer/surfactant were prepared by spray-drying and cryo-grinding, and colloidal dispersions of amorphous PBC nanoparticles were obtained by dispersing…
Flowsheet modelling of a powder continuous feeder-mixer system
Abstract
In this study, an integrated flowsheet model of the continuous feeder-mixer system was calibrated, simulated and compared against experimental data. The feeding process was first investigated using two major components (ibuprofen…
The Science of Selecting Excipients for Dermal Self-Emulsifying Drug Delivery Systems
Abstract
Self-emulsification is considered a formulation technique that has proven capacity to improve oral drug delivery of poorly soluble drugs by advancing both solubility and bioavailability. The capacity of these formulations to…
Towards the Continuous Manufacturing of Liquisolid Tablets Containing Simethicone and Loperamide…
Abstract
Continuous manufacturing is becoming the new technological standard in the pharmaceutical industry. In this work, a twin-screw processor was employed for the continuous production of liquisolid tablets containing either…
Cellulose derivatives and natural gums as gelling agents for preparation of emulgel-based dosage…
Incorporation of an emulsion onto a gel base develops a drug delivery system with improved characteristics, known as emulgel, that can envelop both hydrophilic and lipophilic molecules, and therefore increase stability and penetration of…
Tableting of fluidized bed granules containing living microorganisms
Tablets are the favored dosage form for numerous active pharmaceutical ingredients, among others because they are easy to take, ensure safe dosing and allow cost-effective production on a large scale. This dosage form is also frequently…
Comparative analysis of granule properties in continuous granulators
Several contributions in answering granulation challenges including the use of computer simulation and well thought out experimental analyses are being researched. Using a twin screw granulator (TSG) by design of experiments (DoE),…
Predicting pharmaceutical inkjet printing outcomes using machine learning
Inkjet printing has been extensively explored in recent years to produce personalised medicines due to its low cost and versatility. Pharmaceutical applications have ranged from orodispersible films to complex polydrug implants. However,…
Formulation, Characterization, and Taguchi Design Study of Eplerenone Lipid-Based Solid Dispersions…
Eplerenone is a potassium-sparing diuretic of aldosterone antagonist employed to treat chronic heart failure and high blood pressure. Eplerenone is classified as a BSC class II drug since it has poor oral absorption and is difficult to…