Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Formulation development, optimization, in vivo antidiabetic effect and acute toxicity of directly…
The aim of the present study was to design and optimize the oral tablet formulation of Merremia tridentata extract (MSE) with maximum therapeutic effect and acceptable tablet parameters to aid in diabetes treatment using the response…
New study: BENEO’s galenIQ™ proves suitable for powder feeding in continuous manufacturing
Press Release
New study: BENEO’s galenIQ™ proves suitable for powder feeding in continuous manufacturing
Mannheim (Germany), March 2023 – A recently published comparative scientific study demonstrates that BENEO’s agglomerated…
Design and characterization of dexamethasone loaded microsponges for the management of ulcerative…
Ulcerative colitis is an inflammatory condition with ulcerations throughout the colon. The existing remedies have some limitations such as drug inactivation, poor absorption, and adverse reactions. The present study aimed to design novel…
Assessment of blend uniformity in a stream sampler device using Raman spectroscopy
This study describes the first implementation of Raman spectrometer in a stream sampler for the in-line monitoring of low drug concentration in poor flowability powder blends. Raman spectra were continuously acquired as the powder blends…
Box–Behnken Design of Experiments of Polycaprolactone Nanoparticles Loaded with Irinotecan…
Background: The Box–Behnken design of experiments (BBD) is a statistical modelling technique that allows the determination of the significant factors in developing nanoparticles (NPs) using a limited number of runs. It also allows the…
PVP solid dispersions containing Poloxamer 407 or TPGS for the improvement of ursolic acid release
Solid dispersions (SDs) of ursolic acid (UA) were developed using polyvinylpyrrolidone K30 (PVP K30) in combination with non-ionic surfactants, such as D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) or poloxamer 407 (P407) with…
Development and Characterization of Chitosan-Based-Spray-Dried Solid Dispersions of Apigenin: 3D…
This study aimed to develop chitosan-based apigenin spray dried solid dispersion using 1:1,1:1.5,1:2 w/w ratios. The results of process yield and drug assay were found to be (87.5%, 94.2%, and 95.86%), (95.2 ±1.34%), (99.5 ±0.85%), and…
Encapsulation of Morin in Lipid Core/PLGA Shell Nanoparticles Significantly Enhances its…
Morin (3,5,7,2′,4′-pentahydroxyflavone; MR) is a bioactive plant polyphenol whose therapeutic efficacy is hindered by its poor biopharmaceutical properties. The purpose of this study was to develop a nanoparticle (NP) formulation to enhance…
Formulation Development, Optimization, and Characterization of Entrectinib-Loaded Supersaturable…
Entrectinib is a novel potent anticancer drug with poor aqueous solubility. A supersaturable self-nanoemulsifying drug delivery system of entrectinib is developed using a super saturation promoter. The components of the isotropic mixture of…
F-MELT: The Cost-Effective Solution For Producing High-Quality Orally Disintegrating Tablets (ODTs)
See the sixth issue of Fuji Chemical Industries Technical Newsletter:
Directly compressible excipient system for fast-Disintegrating oral tablets*,
F-MELT® formulations are designed with a focus on three important characteristics of…
Intranasal Insulin Delivery: Microparticle Formulations Consisting of Aloe vera Polysaccharides for…
Aloe vera gel and whole leaf materials, as well as polysaccharides, precipitated from the gel, have previously been shown to enhance macromolecular drug delivery across epithelial tissues. This study investigated the effectiveness of…
Preparation and evaluation of ciprofloxacin solid dispersion tablets developed from stearic acid,…
Ciprofloxacin is a fluoroquinolone antibiotic with a broad spectrum of activity used for the treatment of various bacterial infections and is characterized by poor aqueous solubility and low permeability. The aim of this study is to…
Development of Clinically Optimized Sitagliptin and Dapagliflozin Complex Tablets: Pre-Formulation,…
The purpose of this study is to derive an optimal drug release formulation with human clinical bioequivalence in developing a sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixed-dose combination (FDC) tablet as a…
Development and Characterization of the Floating Beads Containing the BCS Class II Drug Lumafentrine…
Floating Drug delivery systems are designed to prolong the gastric residence time after oral administration. Gastroretentive systems can remain in the gastric region for several hours and significantly prolong the gastric residence of the…
High-Speed Tableting of High Drug-Loaded Tablets Prepared from Fluid-Bed Granulated Isoniazid
The aim of this feasibility study was to investigate the possibility of producing industrial-scale relevant, robust, high drug-loaded (90.9%, w/w) 100 mg dose immediate-release tablets of isoniazid and simultaneously meet the biowaiver…
Foundation models for generalist medical artificial intelligence
The exceptionally rapid development of highly flexible, reusable artificial intelligence (AI) models is likely to usher in newfound capabilities in medicine. We propose a new paradigm for medical AI, which we refer to as generalist medical…
Hyaluronic acid modified oral drug delivery system with mucoadhesiveness and macrophage-targeting…
Based on the biocompatibility and macrophage targeting of natural polysaccharides, combined with the physiological and pathological characteristics of the gastrointestinal tract and colonic mucosa of ulcerative colitis (UC), we prepare…
Modeling die filling under gravity for different scales of rotary tablet presses
For tableting, die filling is an important process step as it directly influences the tablet weight and its variation, which is connected to the drug dose. However, the impact of process parameters and materials properties is not…
Use of a Platform Formulation Technology to De-Risk Solid-State Variation in Drug Development
Active pharmaceutical ingredients (APIs) can exist in multiple crystal forms, known as polymorphs, that are chemically identical. Polymorphs of an API can appear over the course of development and lead to deviations across batches…
Impact of matrices composition and processes on β-galactosidase encapsulation
Advances in existing drying techniques are essential for upgrading large scale industries. Enzymes are often degraded by drying processes. Spray drying (SD) has detrimental effects on bioactive molecules at high temperatures. Freeze-drying…
Considering inelasticity in the real-time monitoring of particle size for twin-screw granulation via…
A recently developed process analytical technology (PAT) using artificial intelligence to form the framework of its model, combining frequency-domain acoustic emissions (AE) and elastic impact mechanics to accurately predict complex …
Surface Solid Dispersion Review
Oral route is mostly preferred route for administering drugs to patient. But due to the poor solubility many drug has limited used in oral administration. Enhancement of water solubility of poor water soluble drug is a main target in a…
Formulation and Evaluation of Solid-Self Micro Emulsifying Drug Delivery System (S-SMEDDS) of…
The aim of this study was to create a solid-self-micro emulsifying drug delivery system (S-SMEDDS) to improve the oral bioavailability of Agomelatine, which is weakly water soluble. Agomelatine, an antidepressant medication, is rapidly…
In Vitro and In Vivo Characterization of the Transdermal Gel Formulation of Desloratadine for…
Chronic use of antihistamines can induce abnormalities in lipid absorption with potential excessive accumulation of lipids in the mesentery that can lead to the development of obesity and a metabolic syndrome. The focus of the present work…
The Current States, Challenges, Ongoing Efforts, and Future Perspectives of Pharmaceutical…
A major hurdle in pediatric formulation development is the lack of safety and toxicity data on some of the commonly used excipients. While the maximum oral safe dose for several kinds of excipients is known in the adult population, the…
Viscoelastic Behavior of Supercooled and Glassy ASDs at Humid Conditions Can Be Predicted
Amorphous solid dispersions (ASDs) are commonly used to increase the dissolution rate of poorly soluble active pharmaceutical ingredients (APIs). Unfortunately, most ASDs are thermodynamically unstable and, even though kinetically…
Unraveling the pharmaceutical and clinical relevance of the influence of syringic acid loaded…
Natural medicines are promising platforms for competent topical treatment modalities benefiting the cosmetic implementation and proffering solutions to the current remedies. Therefore, the objective of this study was to formulate syringic…
Impact of Different Saccharides on the In-Process Stability of a Protein Drug During Evaporative…
Objectives
Solid biopharmaceutical products can circumvent lower temperature storage and transport and increase remote access with lower carbon emissions and energy consumption. Saccharides are known stabilizers in a solid protein produced…
Development, characterization and in vitro cytotoxicity of kaempferol-loaded nanostructured lipid…
Glioblastoma multiforme is the most common and most aggressive human brain cancer. GBM treatment is still a challenge because many drugs are not able to cross the blood-brain barrier, in addition to the increasing resistance to currently…
Synergistic Encapsulation of Paclitaxel and Sorafenib by Methoxy Poly(Ethylene…
Ovarian cancer has a high mortality rate due to difficult detection at an early stage. It is necessary to develop a novel anticancer treatment that demonstrates improved efficacy while reducing toxicity. Here, using the freeze-drying…
Inclusion Complex of Ibuprofen-β-Cyclodextrin Incorporated in Gel for Mucosal Delivery: Optimization…
β-Cyclodextrin/ibuprofen inclusion complex was synthesized by freeze-drying method and characterized for phase solubility profiles, infrared spectra, thermal analysis, and X-ray powder diffractograms. The inclusion complex with HP-β-CD, as…
Microneedle-assisted transdermal delivery of nanoparticles: Recent insights and prospects
Transdermal delivery of drugs offers an interesting alternative for the administration of molecules that present certain troubles when delivered by the oral route. It can produce systemic effects or perform a local action when the…
Enhanced multi-component model to consider the lubricant effect on compressibility and…
Modeling of structural and mechanical tablet properties consisting of multiple components, based on a minimum of experimental data is of high interest, in order to minimize time- and cost-intensive experimental trials in the development of…
Overcoming Excipient Risks and Challenges for Parenteral Formulations – Merck article
ATTRIBUTES OF EXCIPIENTS FOR HIGH-RISK FORMULATIONS
Excipients play an important role in parenteral formulations, which are high-risk given their route of administration. They protect, support, and enhance stability and bioavailability,…