Blend uniformity monitoring in a continuous manufacturing mixing process for a low-dosage formulation using a stream sampler and near infrared spectroscopy
Continuous manufacturing has the potential to offer several benefits for the production of oral solid dosage forms, including reduced costs, low-scale equipment, and the application of process analytical technology (PAT) for real-time process control. This study focuses on the implementation of a stream sampler to develop a near infrared (NIR)…
Overcoming Excipient Risks and Challenges for Parenteral Formulations – Merck article
ATTRIBUTES OF EXCIPIENTS FOR HIGH-RISK FORMULATIONS
Excipients play an important role in parenteral formulations, which are high-risk given their route of administration. They protect, support, and enhance stability and bioavailability,…
Study of the feeding performance of mesoporous silica in a loss-in-weight feeder
Accurate and reliable continuous feeding is essential for the continuous manufacturing of solid-dose pharmaceuticals to ensure the reproducible composition of the final product. Consistent feeding of cohesive powders is challenging and…
The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials
A model of the compaction process that has come into increasing use with the pharmaceutical industry is the Drucker-Prager Cap model (DPC). It has long been used in conjunction with the finite element methods to simulate the density and…
Machine learning approaches to the prediction of powder flow behaviour of pharmaceutical materials…
Understanding powder flow in the pharmaceutical industry facilitates the development of robust production routes and effective manufacturing processes. In pharmaceutical manufacturing, machine learning (ML) models have the potential to…
A double-layered gastric floating tablet for zero-order controlled release of dihydromyricetin:…
Dihydromyricetin (DHM) is an important natural flavonoid. However, most of DHM preparations have shown shortcomings such as low drug loading, poor drug stability, and/or large fluctuations in blood concentration. This study aimed to develop…
Instantaneous Topical Drug Quantification using a 3D Printed Microfluidic Device and Coherent Raman…
Cutaneous drug concentration quantification after topical application remains an active, yet challenging research area for topical drug development. Macroscale approaches quantify cutaneous pharmacokinetics 30 minutes to hours after…
Prediction of subcutaneous drug absorption – Characterization of subcutaneous interstitial…
Unlike orally administered drugs, the absorption profile of subcutaneously injectable drugs in humans is difficult to predict from preclinical studies. Since the subcutaneous interstitial fluid (ISF) is the first fluid interacting with the…
Polymer coated polymeric microneedles for intravitreal delivery of dexamethasone
The polymer coated polymeric (PCP) microneedles (MNs) is a novel approach for controlled delivery of drugs (without allowing release of the excipients) to the target site. PCP MNs was explored as an approach to deliver the drug…
Impact of material properties and process parameters on tablet quality in a continuous direct…
The current paper shows how excipient properties impact the process parameters and the final tablet properties in a fully integrated continuous direct compression line. Blend properties of low-dose (1% w/w) and high-dose (40% w/w) …
Implementation of a fully integrated CM direct compression and coating process at a commercial…
This is the second of two articles detailing the continuous manufacturing (CM) development and implementation activities for an marketed product which have been realized in novel, qualified equipment, using validated control strategy…
Twin-screw continuous mixing: Effect of mixing elements and processing parameters on properties of…
Twin-screw continuous mixing was used to prepare aerosol powders containing 1% budesonide, 0.3% magnesium stearate, and 98.7% α-lactose monohydrate. The effect of mixing configuration was studied using three screw profiles containing either…
Study of diminutive granules as feed powders for manufacturability of high drug load minitablets
The maximal amount of drug contained in a minitablet is limited. To reduce the total number of minitablets in a single dose, high drug load minitablets can be prepared from high drug load feed powders by various pharmaceutical processing…
A ready-to-use dry powder formulation based on protamine nanocarriers for pulmonary drug delivery
The use of oral antibiotic therapy for the treatment of respiratory diseases such as tuberculosis has promoted the appearance of side effects as well as resistance to these treatments. The low solubility, high metabolism, and degradation of…
A High Throughput Approach of Selecting Excipients for Solubility Enhancement of BCS Class II Active…
Scientists have been faced with the challenge of selecting the right solubilizing excipients for solubility enhancement of poorly water-soluble active pharmaceutical ingredients for decades. In this investigation, the purpose was to ease…
Maintaining supersaturation generation and protein integrity of amorphous curcumin-albumin nanoplex…
Amorphous curcumin-albumin nanoplex (size ≈ 100 nm, 55 wt% curcumin content) is a highly promising nanoscale delivery system of curcumin attributed to its high curcumin's payload and kinetic solubility. Its storage stability, however, has…
Development of Imeglimin Electrospun Nanofibers as a Potential Buccal Antidiabetic Therapeutic…
The prevalence of type 2 diabetes (T2D) has been growing worldwide; hence, safe and effective antidiabetics are critically warranted. Recently, imeglimin, a novel tetrahydrotriazene compound, has been approved for use in T2D patients in…
3D Printed Pharmaceutical Systems for Personalized Treatment in Metabolic Syndrome
The current healthcare system is widely based on the concept of “one size fit for all”, which emphasizes treating a disease by prescribing the same drug to all patients with equivalent doses and dosing frequency. This medical treatment…
Progress in research of process intensification of spouted beds: A comprehensive review
The development of intensification technology for spouted beds has become a current research focus, and an effective way to improve the efficiency of spouted beds is to reform their structure. Although numerous studies have been conducted…
Texture analysis – a versatile tool for pharmaceutical evaluation of solid oral dosage forms
In the past few decades, texture analysis (TA) has gained importance as a valuable method for the characterization of solid oral dosage forms. As a result, an increasing number of scientific publications describe the textural methods that…
Statistical Investigation of Rotary Fluidized Bed Agglomeration Process with Tangential Spray and…
A statistical design of experiments for a rotary fluidized bed agglomeration process is performed to improve both the knowledge of the process and the influence of the process parameters. Agglomerates of a pharmaceutical formulation are…
A dynamic model of tablet film coating processes for control system design
Aqueous film coating is a common and important step in the production of most pharmaceutical tablets. Controlling this process is beneficial to maintain stable and optimal operation and the use of a model capable of describing its main…
Electrospun HPMC/PEO-blend orodispersible films: how slight batch differences affect the crucial…
Orodispersible films comprise a promising dosage form with a wide range of advantages compared to conventional formulations. The electrospinning process can significantly enhance the relevant characteristics of orodispersible films, e.g.,…
How Should We Think About Pharmaceutical Excipients in Clinical Pharmacy Education?
ABSTRACT
Background: As the pharmaceutical industry shifts to a patient-oriented approach, pharmaceutical education has fairly garnered increasing attention from educators, so that the teaching course centered on pharmaceutical excipients…
Cannabinoid-Based Ocular Therapies and Formulations
The interest in the pharmacological applications of cannabinoids is largely increasing in a wide range of medical areas. Recently, research on its potential role in eye conditions, many of which are chronic and/or disabling and in need of…
A review on the colours, flavours and shapes used in paediatric 3D printed oral solid dosage forms
Abstract
Objectives
This review aims at gleaning the currently available research reports that relate to 3D printlets for paediatric patients, and especially the excipients used to produce various colours, flavours, shapes and sizes.…
Formulation and in vitro Evaluation of Taste-Masked Orodispersible Tablets of Levocetirizine…
Abstract
The main aim was to formulate and evaluate and optimize taste- masked orodispersible tablets of Levocetirizine Dihydrochloride, a drug used in Allergic Rhinitis was prepared by direct compression method. The study involved…
Exploring the potential of quercetin/aspirin-loaded chitosan nanoparticles coated with Eudragit L100…
Growing evidence suggests quercetin and aspirin may have anticancer properties, notably in the case of colorectal cancer. The goal of this study was to create Pluronic F127 and polyethylene glycol 4000 solid dispersion-loaded chitosan…
Discrimination of β-cyclodextrin/hazelnut (Corylus avellana L.) oil/flavonoid glycoside and…
The goal of the study was the discrimination of β-cyclodextrin (β-CD)/hazelnut (Corylus avellana L.) oil/antioxidant ternary complexes through Fourier-transform infrared spectroscopy coupled with principal component analysis (FTIR–PCA).…
Development of Transdermal Oleogel Containing Olmesartan Medoxomil: Statistical Optimization and…
Olmesartan medoxomil (OLM) is a first-line antihypertensive drug with low oral bioavailability (28.6%). This study aimed to develop oleogel formulations to decrease OLM side effects and boost its therapeutic efficacy and bioavailability.…
Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles
Recently, there has been increasing interest in developing biocompatible inhalable nanoparticle formulations, as they have enormous potential for treating and diagnosing lung disease. In this respect, here, we have studied superparamagnetic…
Chitosan-Based Nanoparticles with Optimized Parameters for Targeted Delivery of a Specific…
Chitosan is a positively charged polysaccharide obtained through chitin deacetylation. It belongs to a group of biodegradable, bioavailable, and non-toxic materials of natural origin; thus, it is a promising matrix for creating delivery…
Development, QbD based optimization and in vitro characterization of Diacerein loaded nanostructured…
Abstract
Objective
DCN is a chondro-protective agent which displays inadequate oral bioavailability along with gastrointestinal side effects. It is a choice of drug for treatment of osteoarthritis. Therefore, the objective of this study…
Spray drying and nano spray drying as manufacturing methods of drug-loaded polymeric particles
In this review, benefits and drawbacks of the process of spray drying and nano spray drying with regard to the manufacturing of polymeric particles for pharmaceutical applications are discussed. Spray drying has been used for many years in…
Effect of different seed crystals on the supersaturation state of ritonavir tablets prepared by…
Hot-melt extrusion (HME) is a technology increasingly common for the commercial production of pharmaceutical amorphous solid dispersions (ASDs), especially for poorly water-soluble active pharmaceutical ingredients (APIs). However,…