Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
Supersaturating lipid-based solid dispersion of atazanavir provides enhanced solubilization and…
Understanding and controlling the drug solubilization in digestive environment is of great importance in the design of lipid based solid dispersion (LBSD) for oral delivery of poorly aqueous soluble drugs. In the current study we determined…
The Effect of Design and Size of the Fluid-Bed Equipment on the Particle Size-Dependent Trend of…
The focus of the current work is to study and demonstrate the impact of the design, the scale, and settings of fluid-bed coating equipment on the differences in pellet coating thickness, which in case of prolonged-release pellets dictates…
Recent developments in improving the emulsifying properties of chitosan
Chitosan is one of the valuable products obtained from crustacean waste. The unique characteristics of chitosan (antimicrobial, antioxidant, anticancer, and anti-inflammatory) have increased its application in various sectors. Besides…
Scale-up of fluid bed granulation of an active formulation with a scale independent parameter and a…
A practice based approach for the scale-up of fluid bed granulation in the context of drug product development is presented and evaluated in this work in the context of clinical drug product manufacturing development. The approach is based…
Assessment of Tribo-charging and Continuous Feeding Performance of Direct Compression Grades of…
Tribo-charging is often a root cause of mass flow deviations and powder adhesion during continuous feeding. Thus, it may critically impact product quality. In this study, we characterized the volumetric (split- and pre-blend) feeding…
Development of a sorafenib-loaded solid self-nanoemulsifying drug delivery system: Formulation…
Sorafenib, marketed under the brand name Nexavar®, is a multiple tyrosine kinase inhibitor drug that has been actively used in the clinical setting for the treatment of several cancers. However, the low solubility and bioavailability of…
Formulation and Evaluation of a Novel Multiparticulate Drug Delivery System for Poorely Water…
Ziprasidone hydrochloride Monohydrate ZHM, chemically 5- ethyl]-6-chloro-1, 3-dihydroindol-2-one hydrochloride; is an atypical antipsychotic with very poor water solubility and less oral bioavailability. The presented research work is about…
Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
Messenger RNA (mRNA) lipid nanoparticles (LNPs) have emerged at the forefront during the COVID-19 vaccination campaign. Despite their tremendous success, mRNA vaccines currently require storage at deep freeze temperatures which complicates…
Evaluation of In-Die Compression Data for a Deeper Understanding of Altered Excipient Properties…
The thermodynamic analysis of tablet formation includes the thermal and mechanical analysis during compression. The aim of this study was to evaluate alterations of force–displacement data upon temperature rise as an indicator for changed…
TaBlitz™ – Redefining the tablet design process
TaBlitz™ – Redefining and connecting the tablet design process from formulation to manufacturing
The TaBlitz platform is tailored to streamline the pharmaceutical industry's product development and manufacturing processes. This is achieved…
Assessment of glyceride-structured oleogels as an injectable extended-release delivery system of…
This manuscript systematically assesses three different glycerides (tripalmitin, glyceryl monostearate, and a blend of mono-, di- and triesters of palmitic and stearic acids (Geleol™)) as potential gelator structuring agents of medium-chain…
Preparation and Evaluation of Core–Shell Nanofibers Electrospun from PEU and PCL Blends via a…
The core–shell structured nanofibers are routinely fabricated by coaxial solution and single-nozzle emulsion electrospinning of two polymers. Herein, the core–shell structured polymeric nanofibers were electrospun from mixed solutions of…
Start of construction of new U.S. facility for pharmaceutical lipids – Evonik Press Release
Press Release, Health Care, Essen, Germany, March 29, 2023
Facility to secure global supply of functional excipients for RNA medicines
Cooperative agreement with U.S. Government to advance U.S. biopharma industry and ensure pandemic…
Multivariate data analysis to evaluate commonly used compression descriptors
Numerous studies elucidated material behavior based on compression analyses. Especially compressibility, compactibility and tabletability were in the focus of these investigations. In the present study, a comprehensive multivariate data…
MEDELPHARM partners with CMAC on digital medicines manufacturing
News-Release MEDELPHARM S.A.S, March 28th 2023
Beynost, France: – Research-based manufacturer and powder compaction specialists MEDELPHARM S.A.S. is collaborating with the Centre for Continuous Manufacturing and Advanced Crystallization…
Manipulating drug release from 3D printed dual-drug loaded polypills using challenging polymer…
Combining multiple medications in a single dosage form has emerged as an important strategy for treating complex diseases and could help tackle the growing issue of polypharmacy. In this study we investigated the suitability of different…
WHO good manufacturing practices for excipients used in pharmaceutical products – Draft…
The World Health Organization wants to update its guideline on manufacturing pharmaceutical excipients to ensure these products meet the requirements for quality and purity that they purport or are represented to possess.
See the new draft…
Development of Novel pH-Sensitive Eudragit Coated Beads Containing Curcumin-Mesalamine Combination…
This research aims to develop a drug delivery system that effectively treats colitis while administering curcumin/mesalamine by coating alginate/chitosan beads with Eudragit® S-100 to target the colon. Beads were tested to determine their…
Assessing and Predicting Physical Stability of Emulsion-Based Topical Semisolid Products: A Review
The emulsion-based topical semisolid dosage forms present a high degree of complexity due to their microstructures which is apparent from their compositions comprising at least two immiscible liquid phases, often times of high viscosity.…
Recent Progress of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Ocular Drug…
Abstract
Sufficient ocular bioavailability is often considered a challenge by the researchers, due to the complex structure of the eye and its protective physiological mechanisms. In addition, the low viscosity of the eye drops and the…
Clean label pastel colors for film coating – Get one of the limited sample boxes!
The demand for clean label products is not stagnating, it is developing. The trend is continuing to replace artificial ingredients with natural ones (excluding artificial ingredients from back-of-pack).
Our film coating system…
The development of a solid lipid nanoparticle (SLN)-based lacticin 3147 hydrogel for the treatment…
Chronic wounds affect millions of people globally. This number is set to rise with the increasing incidence of antimicrobial-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA), which impair the…
Dissolution Mechanisms of Amorphous Solid Dispersions: A Close Look at the Dissolution Interface
Despite the recent success of amorphous solid dispersions (ASDs) at enabling the delivery of poorly soluble small molecule drugs, ASD-based dosage forms are limited by low drug loading. This is partially due to a sharp decline in drug…
Recent Advancement of Molecular Structure and Biomaterial Function of Chitosan from Marine Organisms…
Chitosan is an innate cationic biological polysaccharide polymer, naturally obtained from chitin deacetylation, that possesses broad-spectrum properties such as antibacterial, biodegradability, biocompatibility, non-toxic,…
Impact of Tablet Size and Shape on the Swallowability in Older Adults
Older adults represent the major target population for oral medications, due to the high prevalence of multimorbidity. To allow for successful pharmacological treatments, patients need to adhere to their medication and, thus,…
Injectable Chitosan-Based Hydrogels for Trans-Cinnamaldehyde Delivery in the Treatment of Diabetic…
Diabetic foot ulcers (DFU) are among the most common complications in diabetic patients and affect 6.8% of people worldwide. Challenges in the management of this disease are decreased blood diffusion, sclerotic tissues, infection, and…
A numerical analysis of the influence of material properties on dry powder coating performance
Dry powder coating is a preferable surface modification technique over the traditional aqueous coating technique due to reduced energy waste and less environmental impact. Despite the benefits of dry powder coating, excessive amount of…
Anomalous Properties of Cyclodextrins and Their Complexes in Aqueous Solutions
Cyclodextrins (CDs) are cyclic oligosaccharides that emerged as industrial excipients in the early 1970s and are currently found in at least 130 marketed pharmaceutical products, in addition to numerous other consumer products. Although CDs…
Enhancement of in-vitro anti-oral cancer activities of silymarin using dispersion of nanostructured…
Silymarin (SME) shows multiple therapeutic actions against several cancers, however, low aqueous solubility and poor bioavailability issues restrict its clinical use. In this study, SME was loaded in nanostructured lipid carriers (NLCs) and…
Oral lyophilizates obtained using aggressive drying conditions: Effect of excipients
Orodispersible drug formulations are a current trend in the pharmaceutical industry, mostly intended for pediatric and geriatric patients. Oral lyophilizates are solid forms, intended either to be placed in the mouth or to be dispersed (or…
Mucoadhesive Oro-Gel–Containing Chitosan Lipidic Nanoparticles for the Management of Oral Squamous…
Abstract
Purpose
The aim of this research work was to develop a mucoadhesive oro-gel–containing resveratrol loaded folate conjugated chitosan-lipidic nanoparticles (RES-FA-LP-NPs) for targeted delivery to oral squamous cell carcinoma…
Quality by Design-Based Development of Solid Self-Emulsifying Drug Delivery System (SEDDS) as a…
For many years, researchers have been making efforts to find a manufacturing technique, as well as a drug delivery system, that will allow for oral delivery of biopharmaceuticals to their target site of action without impairing their…
A two-pronged approach against glioblastoma: Drug repurposing and nanoformulation design for in…
Glioblastoma (GB) is one of the most lethal types of neoplasms. Its biologically aggressive nature and the presence of the blood-brain barrier (BBB) limit the efficacy of standard therapies. Several strategies are currently being developed…
3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and…
Nowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid dispersion. Pharmaceutical 3D printing has great potential in producing amorphous solid oral dosage…