Use of Poly(vinyl alcohol) in Spray-Dried Dispersions: Enhancing Solubility and Stability of Proteolysis Targeting Chimeras
Abstract
PROTACs, proteolysis targeting chimeras, are bifunctional molecules inducing protein degradation through a unique proximity-based mode of action. While offering several advantages unachievable by classical drugs, PROTACs have unfavorable physicochemical properties that pose challenges in application and formulation. In this study, we show…
Effect of Process Parameters, Protectants and Carrier Materials on the Survival of Yeast Cells…
The administration of living microorganisms is of special interest, with regard to probiotic microorganisms providing health benefits to the patient. Effective dosage forms require the preservation of microbial viability until…
Effect of co-processed excipient type on properties of orodispersible tablets containing captopril,…
An important feature of orodispersible tablets (ODTs) is the convenient administration of the drugs, in some cases, faster onset of action, stability maintenance, and dose precision. This work focused on the preparation of ODTs containing…
Lipid-core nanoparticles: Classification, preparation methods, routes of administration and recent…
Nanotechnological drug delivery platforms represent a new paradigm for cancer therapeutics as they improve the pharmacokinetic profile and distribution of chemotherapeutic agents over conventional formulations. Among nanoparticles,…
Preparation and Evaluation of a Dosage Form for Individualized Administration of Lyophilized…
Probiotics have been used in human and veterinary medicine to increase resistance to pathogens and provide protection against external impacts for many years. Pathogens are often transmitted to humans through animal product consumption.…
Nanosystems for Brain Targeting of Antipsychotic Drugs: An Update on the Most Promising Nanocarriers…
Orally administered antipsychotic drugs are the first-line treatment for psychotic disorders, such as schizophrenia and bipolar disorder. Nevertheless, adverse drug reactions jeopardize clinical outcomes, resulting in patient…
Machine learning in additive manufacturing & Microfluidics for smarter and safer drug delivery…
A new technological passage has emerged in the pharmaceutical field, concerning the management, application, and transfer of knowledge from humans to machines, as well as the implementation of advanced manufacturing and product optimisation…
Formulation and Evaluation of Xanthan Gum Microspheres for the Sustained Release of Metformin…
This work aimed to formulate xanthan gum microspheres for the encapsulation of metformin hydrochloride, according to the process of ionotropic gelation. The obtained microparticles, based on various fractions of xanthan gum (0.5–1.25), were…
Evonik opens new facility for pharmaceutical lipids at site in Hanau, Germany
PRESS RELEASE
Essen, Germany, March 8, 2023
New GMP facility for clinical and small-scale commercial pharmaceutical lipids
Supports all types of custom and proprietary lipids
Reinforces Evonik’s position as integrated…
Formulation and Characterization of Buccal Films Containing Valsartan with Additional Support from…
The present study was aimed to the development and characterization of valsartan-containing buccal films with an introduction to a novel technique of image analysis. Visual inspection of the film provided a wealth of information that was…
Unlock the Potential of Poorly Soluble Drugs with Apisolex™ Technology
Don’t let poor solubility affect your innovative drug projects
Approximately 60% of potential active pharmaceutical ingredients (APIs) under development, and more than 40% of those in reformulation, are poorly water soluble1.…
Technological advances and challenges for exploring attribute transmission in tablet development by…
High shear wet granulation and tableting (HSWG-T) are complex pharmaceutical processes, which makes tablet quality be influenced by many variables including raw material attributes, process variables, and intermediate granule properties. To…
Mucoadhesion matters – by Lubrizol
And so does your choice of mucoadhesive polymer.
Choose Carbopol® polymers and Noveon® polycarbophil.
Mucoadhesion is a type of bioadhesion in which two materials, at least one of which is mucosal, are held together for extended periods…
Compaction Behavior of Co-Amorphous Systems
Co-amorphous systems have been shown to be a promising strategy to address the poor water solubility of many drug candidates. However, little is known about the effect of downstream processing-induced stress on these systems. The aim of…
SIPERNAT®, ZEOFREE® and AEROSIL® for Spray Drying Operations – Technical information by Evonik
Introduction
Spray drying is a common process to isolate solid products from emulsions, dispersions or solutions.
A wide range of products are produced by spray drying:
Food products
(e.g., tomato powder, soup mixes,…
3D printed infliximab suppositories for rectal biologic delivery
Infliximab is a monoclonal antibody that plays an important role in the management and treatment of chronic inflammatory bowel diseases (IBD). Due to its macromolecular structure, its delivery through the oral route is challenging, limiting…
Development of a Liposomal Gel for Prolonged Ophthalmic Soluble Drug Delivery
Liposome, as a drug delivery vehicle, entraps drugs, releases them sustainably, and modifies release patterns. This entrapment has diminished exposure of the drug to the eye medium, which could minimize adverse effects. In this…
Solid-in-oil nanodispersion as a novel topical transdermal delivery to enhance stability and skin…
l-ascorbic acid （Vitamin C, VC）is the most abundant antioxidant in human skin. But its poor penetration into the skin and unstability limit the application. The aim of the study was to promote the topical skin permeation and retention of…
Hydrogel-forming microarray patch mediated transdermal delivery of tetracycline hydrochloride
Antibiotic resistance is one of the most serious health problems today and is expected to worsen in the coming decades. It has been suggested that antibiotic administration routes that bypass the human gut could potentially tackle this…
Oligonucleotide Formulations Prepared by High-Speed Electrospinning: Maximizing Loading and…
The aim of this study was to develop antisense oligonucleotide tablet formulations using high-speed electrospinning. Hydroxypropyl-beta-cyclodextrin (HPβCD) was used as a stabilizer and as an electrospinning matrix. In order to optimize the…
Novel Collagen-Polyphenols-Loaded Silica Composites for Topical Application
Lesions can affect skin functions and cause a simple issue, such as dehydration, or more challenging complications, such as bacterial infections. The purpose of this study was to design composites for topical application that can prevent…
Polymer- and Lipid-Based Nanocarriers for Ocular Drug Delivery: Current Status and Future…
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of over 43 million blindness. However, efficient drug delivery to treat ocular diseases, particularly intraocular disorders, remains a huge…
Enteric coating of drug loaded aerogel particles in a wurster fluidized bed and its effect on…
Ibuprofen loaded and unloaded alginate aerogel particles were successfully coated with methacrylic acid-ethyl acrylate copolymer in a Wurster fluidized bed. Pores of both aerogels were well-preserved during the coating process. Effects of…
Nitrosamine Impurities: Latest USP Tool Further Aids Understanding and Control
USP has launched the newest tool in their suite of solutions to address the evolving nitrosamines crisis: the Nitrosamines Analytical Hub, a public, web-based repository of downloadable analytical procedures to test for nitrosamine…
Electrospun nanofibres in drug delivery: advances in controlled release strategies
Emerging drug-delivery systems demand a controlled or programmable or sustained release of drug molecules to improve therapeutic efficacy and patient compliance. Such systems have been heavily investigated as they offer safe, accurate, and…
Continuous Manufacturing of Drug Substances and Drug Products – FDA announces guidance for…
FDA issued the ICH final guidance, Q13 Continuous Manufacturing of Drug Substances and Drug Products in March 2023. The document represents, according to FDA, a proactive step the FDA is taking to facilitate the pharmaceutical industry’s…
An investigation into solubility and dissolution improvement of alectinib hydrochloride as a…
Poorly water-soluble drugs belonging to BCS Class II and IV present a big challenge to formulators owing to their limited solubility and bioavailability. Alectinib hydrochloride (ALB), a BCS IV molecule, shows very low solubility resulting…
3D Printing Technologies in Personalized Medicine, Nanomedicines, and Biopharmaceuticals
3D printing technologies enable medicine customization adapted to patients’ needs. There are several 3D printing techniques available, but majority of dosage forms and medical devices are printed using nozzle-based extrusion, laser-writing…
Alternative Excipients for Protein Stabilization in Protein Therapeutics: Overcoming the Limitations…
Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been the most widely used excipients for the stabilization of protein therapeutics for years. In recent decades, however, there have been numerous…
Anionic and Ampholytic High-Amylose Starch Derivatives as Excipients for Pharmaceutical and…
Many chemical modifications of starch are realized in organic (mostly methanol) phase, allowing high degrees of substitution (DS). Some of these materials are used as disintegrants. To expand the usage of starch derivative biopolymers as…
Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics
Three-dimensional printing (3DP) technology enables an important improvement in the design of new drug delivery systems, such as gastroretentive floating tablets. These systems show a better temporal and spatial control of the drug release…
Flowability, binding and release property of “self-lubricating” microcrystalline cellulose
Microcrystalline cellulose (MCC) has been widely used as an excipient in tablets. Silicified microcrystalline cellulose (SMCC) has more application than MCC by using silicon dioxide (SiO2) as a lubricant. However, findings show that the…
World Asthma Day 2024
World Asthma Day takes place every year on the first Tuesday of May and will be held for the 27th time in 2024. The day was initiated as a global initiative led by the Global Initiative for Asthma (GINA) in collaboration with health care…
Recent Progress of Lipid Nanoparticles-Based Lipophilic Drug Delivery: Focus on Surface…
Numerous drugs have emerged to treat various diseases, such as COVID-19, cancer, and protect human health. Approximately 40% of them are lipophilic and are used for treating diseases through various delivery routes, including skin…
AEROPERL® 300 Pharma – Improving the dissolution of poorly soluble APIs
AEROPERL® 300 Pharma colloidal silicon dioxide: Our solution to the solubility challenge
Active pharmaceutical ingredients (APIs) by Evonik in oral dosage forms need to dissolve before they can be absorbed in the intestine to enter…