Use of Poly(vinyl alcohol) in Spray-Dried Dispersions: Enhancing Solubility and Stability of Proteolysis Targeting Chimeras
Abstract
PROTACs, proteolysis targeting chimeras, are bifunctional molecules inducing protein degradation through a unique proximity-based mode of action. While offering several advantages unachievable by classical drugs, PROTACs have unfavorable physicochemical properties that pose challenges in application and formulation. In this study, we show…
STYL’One Nano the revolutionary benchtop R&D tablet press
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Hot Melt Extruded Posaconazole-Based Amorphous Solid Dispersions—The Effect of Different Types of…
Four model polymers, representing (i) amorphous homopolymers (Kollidon K30, K30), (ii) amorphous heteropolymers (Kollidon VA64, KVA), (iii) semi-crystalline homopolymers (Parteck MXP, PXP), and (iv) semi-crystalline heteropolymers…
Pharmaceutical characterization and dissolution behavior of ibuprofen/Soluplus solvent cast films
Purpose: To characterize the physicochemical and dissolution properties of Soluplus®/ibupofen solid
dispersions prepared by solvent casting technique.
Methods: Soluplus® was used as a film-forming agent whereas ibuprofen served as a…
The pipeline for drugs for control and elimination of neglected tropical diseases: 1. Anti-infective…
The World Health Organization ‘Ending the neglect to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021–2030’ outlines the targets for control and elimination of neglected tropical diseases (NTDs). New…
Bioequivalence Dissolution Test Criteria for Formulation Development of High Solubility-Low…
The purpose of the present study was to provide the experimental and theoretical basis of bioequivalence (BE) dissolution test criteria for formulation development of high solubility-low permeability drugs. According to the biowaiver scheme…
Triggered release of antimicrobial peptide from microneedle patches for treatment of wound biofilms
Biofilms pose a great challenge for wound management. Herein, this study describes a near-infrared (NIR) light-responsive microneedle patch for on-demand release of antimicrobial peptide for treatment of wound biofilms. IR780 iodide as a…
A New Challenge for the Old Excipient Calcium Carbonate: To Improve the Dissolution Rate of Poorly…
Calcium carbonate is an excipient traditionally used in solid dosage forms with several functions such as a diluent, a quick dissolution agent, a buffer and an opacifier. Recently, many other challenges have arisen for calcium carbonate…
Development of Robust Tablet Formulations with Enhanced Drug Dissolution Profiles from…
Fibre-based oral drug delivery systems are an attractive approach to addressing low drug solubility, although clear strategies for incorporating such systems into viable dosage forms have not yet been demonstrated. The present study extends…
Design, development, in-vitro and in-vivo evaluation of polylactic acid-based multifunctional…
Impaired healing of diabetic ulcers is one of the major complications of diabetic patients due to high susceptibility to microbial infections, impaired lymphianogenesis, edema, and consequently impairing proper healing. This could even lead…
Development and Stability of a New Formulation of Pentobarbital Suppositories for Paediatric…
Pentobarbital is a drug of choice to limit motion in children during paediatric procedural sedations (PPSs). However, despite the rectal route being preferred for infants and children, no pentobarbital suppositories are marketed, and…
Utilization of experimental design in the formulation and optimization of hyaluronic acid–based…
Numerous problems affect oral health, and intensive research is focused on essential oil–based nanoemulsions that might treat prevent or these problems. Nanoemulsions are delivery systems that enhance the distribution and solubility of…
Overcoming Challenges in Ophthalmic Formulations through Polymer Selection
Ophthalmic drugs are delivered to the eye to treat chronic diseases such as dry eye and acute conditions such as inflammation and infections.
The market for drugs administered to the eye is growing, in large part, due to our aging…
Physiological buffer effects in drug supersaturation – a mechanistic study of hydroxypropyl…
Phosphate buffer is predominantly used instead of the more physiological bicarbonate buffer, as the latter requires a technical solution of adequate gas mixing. Recent pioneering work on how bicarbonate buffer affected drug supersaturation…
3D Printing for Personalised Medicines: Implications for Policy and Practice
The current healthcare dynamic has shifted from one-size-fits-all to patient-centred care, with our increased understanding of pharmacokinetics and pharmacogenomics demanding a switch to more individualised therapies. As the pharmaceutical…
Early Detection and Assessment of Invisible Cracks in Compressed Oral Solid Dosage Forms
In the pharmaceutical manufacturing industry, real-time in situ quality monitoring for detecting defects at an early stage is a desirable ability, especially in high-rate production, to minimize downstream quality-related issues, financial…
Updates on applications of low-viscosity grade Hydroxypropyl methylcellulose in coprocessing for…
Hydroxypropyl methylcellulose (HPMC) is an important polymeric excipient. Its versatility in terms of molecular weights and viscosity grades is the basis for its wide and successful application in the pharmaceutical industry. Low viscosity…
Smart specification setting for dry powder inhalation carriers
The specifications of excipients are important to pharmaceutical manufacturers to ensure that the final product can be manufactured robustly over the entire lifecycle of a drug product. Particle size specifications are key for dry powder…
Vitamin E TPGS-Based Nanomedicine, Nanotheranostics, and Targeted Drug Delivery: Past, Present, and…
It has been seventy years since a water-soluble version of vitamin E called tocophersolan (also known as TPGS) was produced; it was approved by USFDA in 1998 as an inactive ingredient. Drug formulation developers were initially intrigued by…
Inclusion complexation and liposomal encapsulation of an isoniazid hydrazone derivative in…
Tuberculosis, a predominantly pulmonary pathology, is currently the deadliest infection worldwide. Its treatment is based on combination therapy involving selected antimicrobials including Isoniazid. However, physicochemical properties of…
Dasatinib-Loaded Topical Nano-Emulgel for Rheumatoid Arthritis: Formulation Design and Optimization…
The current study aimed to develop a topical emulgel of dasatinib (DTB) for rheumatoid arthritis (RA) treatment to reduce systemic side effects. The quality by design (QbD) approach was employed to optimize DTB-loaded nano-emulgel using a…
Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a…
The direct tailoring of the size, composition, or number of layers belongs to the advantages of 3D printing employment in producing orodispersible films (ODFs) compared to the frequently utilized solvent casting method. This study aimed to…
Lyophilized Nasal Inserts of Atomoxetine HCl Solid Lipid Nanoparticles for Brain Targeting as a…
The study aims to investigate the ability of lyophilized nasal inserts of nanosized atomoxetine HCl solid lipid nanoparticles (ATM-SLNs) to transport atomoxetine (ATM) directly to the brain and overcome the first-pass metabolism. In this…
Development of Mefenamic Acid-Soluplus® amorphous dispersions via hot melt extrusion and in silico…
The objective of this study was to increase the solubility of Mefenamic Acid (MA), a BCS class II drug by formulating amorphous solid dispersions via Hot-Melt Extrusion. The extrudates were prepared at different drug to polymer ratios and…
Selective laser sintering additive manufacturing of dosage forms: Effect of powder formulation and…
Large batches of placebo and drug-loaded solid dosage forms were successfully fabricated using selective laser sintering (SLS) 3D printing in this study. The tablet batches were prepared using either copovidone (N-vinyl-2-pyrrolidone and…
Implementation of Quality by Design (QbD) for Development of Bilayer Tablets
Bilayer tablets offer various drug release profiles for individual drugs incorporated in each layer of a bilayer tablet, which is rarely achievable by conventional tablets. These tablets also help avoid physicochemical incompatibilities…
Evaluating Spray Drying and Co-precipitation as Manufacturing Processes for Amorphous Solid…
Amorphous solid dispersions feature prominently in the approach to mitigate low bioavailability of poorly water-soluble small molecules, particularly in the early development space focusing on toxicity evaluations and clinical studies in…
Predicting pharmaceutical powder flow from microscopy images using deep learning
The powder flowability of active pharmaceutical ingredients and excipients is a key parameter in the manufacturing of solid dosage forms used to inform the choice of tabletting methods. Direct compression is the favoured tabletting method;…
Amorphous Solid Dispersions Layered onto Pellets – An Alternative to Spray Drying?
Spray drying is one of the most frequently used solvent-based processes for manufacturing amorphous solid dispersions (ASDs). However, the resulting fine powders usually require further downstream processing when intended for solid oral…
Cyclodextrin-enabled nepafenac eye drops with improved absorption open a new therapeutic window
Nepafenac is a highly effective NSAID used for treating postoperative ocular inflammation and pain after cataract surgery and its advantage over conventional topical NSAIDs has been proved many times. However, Nevanac® is a suspension eye…
Formation of Dialkyl-N-nitrosamines in Aqueous Solution: An Experimental Validation of a…
The potential for active pharmaceutical intermediates and active ingredients to contain low levels of N-nitrosamines is a topic of continued interest from industry and regulatory authorities, which has led us to generate experimental data…
Formulation of taste-masked orodispersible famotidine tablets by sequential spray drying and direct…
Since famotidine (FA) is prescribed for gastrointestinal diseases orodispersible tablets could contribute to patients’ compliance. Its bitter taste and poor compressibility pose formulation challenges which were addressed in this study.…
Application of biorelevant in vitro assays for the assessment and optimization of ASD-based…
Amorphous solid dispersions (ASD) have been a successful formulation strategy to overcome the poor aqueous solubility of many novel drugs, but the development of pediatric formulations presents a special challenge due to variable…
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement.…
Abstract
Introduction
Mucoadhesive drug delivery systems (MDDS) are specifically designed to interact and bind to the mucosal layer of the epithelium for localized, prolonged, and/or targeted drug delivery. Over the past 4…
Design and Evaluation of Sustained Release Bilayer Tablets of Oxcarbazepine
Objective
The aim of the present study is to modify the release profile of oxcarbazepine by formulating it as a bilayer tablet using direct compression method with dual compression.
Methods
In the bilayer system, the immediate release…