Use of Poly(vinyl alcohol) in Spray-Dried Dispersions: Enhancing Solubility and Stability of Proteolysis Targeting Chimeras
Abstract
PROTACs, proteolysis targeting chimeras, are bifunctional molecules inducing protein degradation through a unique proximity-based mode of action. While offering several advantages unachievable by classical drugs, PROTACs have unfavorable physicochemical properties that pose challenges in application and formulation. In this study, we show…
Controlled delivery via hot-melt extrusion: A focus on non-biodegradable carriers for non-oral…
Hot-melt extrusion (HME) has an esteemed place in the pharmaceutical industry with significant applications and advancements spreading over 30 years of development. Currently, the choice of matrix excipients is vast, expanding from all…
New and Novel Excipients 2022
The pharmaceutical industry needs innovative, new and novel excipients solutions to support the developments in next generation therapeutics, new manufacturing concepts (eg. continuous manufacturing, 3Dprinting, etc.), drug delivery and API…
Hydroquinone cream-based polymer microneedle roller for the combined treatment of large-area…
Melasma is a common hyperpigmented skin condition that occurs on the face and other areas prone to light exposure, seriously affecting people's quality of life. Microneedle, a new type of transdermal drug delivery device, can significantly…
Recent Advances in Improving the Bioavailability of Hydrophobic/Lipophilic Drugs and Their Delivery…
Formulations based on emulsions for enhancing hydrophobic and lipophilic drug delivery and its bioavailability have attracted a lot of interest. As potential therapeutic agents, they are integrated with inert oils, emulsions, surfactant…
Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro…
Repaglinide (RPG), a monotherapy insulin secretagogue used to treat diabetes mellitus-type II yet, it suffers from poor water solubility and variable bioavailability (∼ 50%) due to hepatic first pass metabolism. In this study, 2FI I-Optimal…
Micro-Scale Vacuum Compression Molding as a Predictive Screening Tool of Protein Integrity for…
Hot-melt extrusion (HME) is used for the production of solid protein formulations mainly for two reasons: increased protein stability in solid state and/or long-term release systems (e.g., protein-loaded implants). However, HME requires…
A Comparison of Spray-drying and Co-precipitation for the Generation of Amorphous Solid Dispersions…
Co-processing of APIs, the practice of creating multi-component APIs directly in chemical processing facilities used to make drug substance, is gaining increased attention with a view to streamlining manufacturing, improving supply chain…
PLGA/Gelatin-based electrospun nanofiber scaffold encapsulating antibacterial and antioxidant…
A full-thickness or hard-to-heal wound pose a significant challenge in clinical feilds. These wounds are very prone to microbial infection, lead to an elevated level of reactive oxygen species, and require a skin regeneration product for…
Ocular Drug Delivery: a Comprehensive Review
The human eye is a sophisticated organ with distinctive anatomy and physiology that hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration is an interest of scientists for many decades. Their difficult…
Dissolvable microneedles for transdermal drug delivery showing skin penetration and modified drug…
Topical therapies for chronic skin diseases suffer from a low patient compliance due to the inconvenient treatment regimens of available products. Dissolvable microneedles (MN) with modified release offer an interesting possibility to…
Enhanced blend uniformity and flowability of low drug loaded fine API blends via dry coating: The…
Although previous research demonstrated improved flowability, packing, fluidization, etc. of individual powders via nanoparticle dry coating, none considered its impact on very low drug loaded blends. Here, fine ibuprofen at 1, 3, and 5 wt%…
Enhancement of itraconazole solubility and release by hot-melt extrusion with Soluplus®
Formulation of poorly water-soluble drugs is a significant challenge in the development of oral solid dosage forms. The objective was to investigate the effect of hot-melt extrusion process and formulation variables on the solid state,…
The Role of Cyclodextrins in COVID-19 Therapy—A Literature Review
Coronavirus disease-19 (COVID-19) emerged in December 2019 and quickly spread, giving rise to a pandemic crisis. Therefore, it triggered tireless efforts to identify the mechanisms of the disease, how to prevent and treat it, and to limit…
The Significance of Tablet Internal Structure on Disintegration and Dissolution of Immediate-Release…
The internal microstructure of a tablet, such as pore geometry and pore volume, impacts the tablet’s disintegration kinetics. Ideally, one could design the microstructure to control dissolution onset and therapeutical performance of…
Skin drug delivery using lipid vesicles: A starting guideline for their development
Lipid vesicles can provide a cost-effective enhancement of skin drug absorption when vesicle production process is optimised. It is an important challenge to design the ideal vesicle, since their properties and features are related, as…
3D-printed EVA-based patches manufactured by direct powder extrusion for personalized transdermal…
In recent years, 3D printing has attracted great interest in the pharmaceutical field as a promising tool for the on-demand manufacturing of patient-centered pharmaceutical forms. Among the existing 3D printing techniques, direct powder…
Engineered Lipid Excellence Quality & Regulatory – IOI Oleo
See the brochure by IOI Oleo Pharma about their Quality & Regulatory:
EXCIPIENTS & ACTIVE PHARMACEUTICAL
INGREDIENTS - MADE IN GERMANY
Founded in 1905, IOI Oleo’s manufacturing site in Witten has been engaged…
Polymeric Systems for the Controlled Release of Flavonoids
Flavonoids are natural compounds that are attracting great interest in the biomedical field thanks to the wide spectrum of their biological properties. Their employment as anticancer, anti-inflammatory, and antidiabetic drugs, as well as…
Intranasal Delivery of a Silymarin Loaded Microemulsion for the Effective Treatment of Parkinson’s…
A mucoadhesive microemulsion of lipophilic silymarin (SLMMME) was developed to treat Parkinson’s disease (PD). Optimization of the SLM microemulsion (ME) was performed using Central Composite Design (CCD). The composition of oil,…
Coatings of Cyclodextrin/Citric-Acid Biopolymer as Drug Delivery Systems: A Review
In the early 2000s, a method for cross-linking cyclodextrins (CDs) with citric acid (CTR) was developed. This method was nontoxic, environmentally friendly, and inexpensive compared to the others previously proposed in the literature. Since…
Transdermal delivery of acemetacin loaded microemulsions: preparation, characterization, in vitro –…
The goal of this study was to see if microemulsions might be used as a transdermal drug delivery system for acemetacin (ACM). Microemulsions containing isopropyl myristate, Tween 80, Transcutol HP, Labrafil M1944 CS, ethanol, and distilled…
Trehalose in Biomedical Cryopreservation–Properties, Mechanisms, Delivery Methods, Applications,…
Cells and tissues are the foundation of translational medicine. At present, one of the main technological obstacles is their preservation for long-term usage while maintaining adequate viability and function. Optimized storage techniques…
Recent advances in long-acting drug delivery systems for anticancer drug
The use of systemic anticancer chemotherapy is intrinsically limited by its toxicity. Whether dealing with small molecules or biopharmaceuticals, after systemic administration, small doses fail to reach effective intratumoral…
Design and bioactivity of Eudragit® encapsulated pH-Sensitive enteric/gastric soluble fluorescent…
Herein, with a view to improving the poor solubility of curcumin and unfavorable optical property of pyrimidine derivatives, the two types of drugs were successfully combined through several simple reactions, and encapsulated with different…
Impact of Formulation design and Lyophilization on the Physicochemical Characteristics of…
Aim
The fundamental purpose of this study was to develop a stable lyophilized finasteride nanosystem (FNS-NS) for topical delivery.
Methods
The FNS-NS was fabricated using an ultrasonication technique. The impact of two…
From Screening to Downstreaming – 4th Seminar on Amorphous Solid Dispersion
See the 4th Seminar on Amorphous Solid Dispersion.
As technology provider in the field of ASD, Shin-Etsu together with the partners Alexanderwerk, Frewitt, PROCEPT and Thermo Fisher Scientific, will share latest insights of ASD development…
Research progress of ophthalmic preparations of immunosuppressants
Immune ophthalmopathy is a collection of autoimmune eye diseases. Immunosuppressants are drugs that can inhibit the body’s immune response. Considering drug side effects such as hepatorenal toxicity and the unique structure of the eye,…
Development and bioequivalence of 3D-printed medication at the point-of-care: bridging the gap…
Personalized medicine is currently hampered by the lack of flexible drug formulations. Especially for pediatric patients, manual compounding of personalized drug formulations by pharmacists is required. 3D printing of medicines, which…
Apisolex™ Polymer – by Lubrizol
Solubility-enhancing polymer for use in bolus injections and IV infusions
Lubrizol Life Science Health’s (LLS Health’s) Apisolex™ GMP, injectable-grade excipient is a safe, polyamino acid-based polymer that enhances the solubility of BSC…
Pediatric Mini-Tablets: Predicting the Hidden Risk of Fill Errors
Compressed mini-tablets in sachets or capsules are an increasingly prevalent oral solid dosage form for pediatric products. While resembling adult tablets, additional care is required to control weight and potency (blend uniformity)…
Downstream processing of amorphous solid dispersions into tablets
Amorphous solid dispersions have gained tremendous attention as a commercially viable solubility enhancement technique for poorly water-soluble drugs. However, poor drug loading associated with poor drug-polymer miscibility is a major…
Nitroso Impurities in Drug Products: An Overview of Risk Assessment, Regulatory Milieu, and Control…
Many nitrosamines have been recognized to be carcinogenic for many decades. Despite the fact that several nitrosamine precursors are frequently used in the manufacturing of pharmaceutical products, their potential presence in pharmaceutical…
Model development and calibration of two-dimensional population balance model for twin-screw wet…
Population balance models (PBMs) have been widely studied for the simulation of continuous twin-screw wet granulation. Due to the limited data availability and computational efforts, one-dimensional PBM is the most popular application to…
Evaluating the effect of glidants on tablet sticking propensity of ketoprofen using powder rheology
Punch sticking has been a leading drawback that has challenged successful tablet manufacturing since its initial conception. Due to the capricious nature of the complication, this can arise during any phase of the development process. Even…