Kolliphor® CS 12 and Kolliphor® CS 20 – emulsifiers by BASF
The science behind emulsifier functionality
Emulsifiers are surface-active substances that reduce the interfacial tension between the oil and water phase of an emulsion. Emulsifiers are adsorbed at the interface, creating a film between the immiscible phases, thus preventing the coalescence of droplets. Due to the amphiphilic structure of an…
Evaluating the effect of glidants on tablet sticking propensity of ketoprofen using powder rheology
Punch sticking has been a leading drawback that has challenged successful tablet manufacturing since its initial conception. Due to the capricious nature of the complication, this can arise during any phase of the development process. Even…
Enhancing the oral drug delivery through hot melt extrusion techniques
Hot melt extrusion has been developed as a fresh technique for taste masking, in recent years. This method provides many aids as compared to traditional methods like avoiding the use of solvents, continuous manufacturing, ease to scale up,…
Polyols Permeability on Caco-2 Cells and Their Effects on Transport of Low-Permeability Drugs
Some pharmaceutical excipients are able to modify intestinal permeability, thus influencing drug absorption and bioavailability. The effect of four polyols (mannitol, maltitol, sorbitol and xylitol) on the permeability of seven active…
Enhanced dissolution rate of nimodipine through β-lactoglobulin based formulation
Amorphous solid dispersions (ASD) have been considered as one of the most effective strategies to increase solubility and dissolution rate of poorly water-soluble drugs. Carriers, in which the poorly water-soluble drug is dispersed,…
A Systematic Overview of Eudragit® Based Copolymer for Smart Healthcare
Eudragit, synthesized by radical polymerization, is used for enteric coating, precise temporal release, and targeting the entire gastrointestinal system. Evonik Healthcare Germany offers different grades of Eudragit. The ratio of…
Formulation and stability study of an oral paediatric phenobarbital 1% solution containing…
Abstract
Objectives
Phenobarbital is a barbiturate, used to treat focal and generalised epilepsy. Since the end of marketing of the oral solution KANEURON in 2017, phenobarbital tablets remain the only available dosage form. Development…
Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
3D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them…
Asahi Kasei completes second plant for Ceolus™ microcrystalline cellulose
Düsseldorf, New York and Tokyo, 15 February 2023 – Asahi Kasei has completed the construction of its second plant for Ceolus™ microcrystalline cellulose (MCC) at its Mizushima Works in Kurashiki, Okayama, Japan, in January 2023. With the…
A novel bedtime pulsatile-release caffeine formula ameliorates sleep inertia symptoms immediately…
Sleep inertia is a disabling state of grogginess and impaired vigilance immediately upon awakening. The adenosine receptor antagonist, caffeine, is widely used to reduce sleep inertia symptoms, yet the initial, most severe impairments are…
Development and implementation of a pneumatic micro-feeder for poorly-flowing solid pharmaceutical…
Consistent powder micro-feeding (< 100 g/h) is a significant challenge in manufacturing solid oral dosage forms. The low dose feeding can well control the content consistency of the dosage forms, which improves drug efficiency and…
Fabrication of Celecoxib PVP Microparticles Stabilized by Gelucire 48/16 via Electrospraying for…
Electrospraying (ES) technology is considered an efficient micro/nanoparticle fabrication technique with controlled dimensions and diverse morphology. Gelurice® 48/16 (GLR) has been employed to stabilize the aqueous dispersion of Celecoxib…
Behaviour of magnesium stearate at particle–particle interfaces: Microdynamic flowability to monitor…
Monitoring magnesium stearate (MgSt) surface coverage remains a challenge in powders. Microdynamic flowability is proposed to better understand the nature of these films and how formulation and process variability affect the final product.…
Engineered Lipid Excellence For Topical Applications – IOI Oleo
Tried & Trusted, Quality & Innovation
With our nature-based excipients you can develop modern pharmaceutical topical formulations that combine functionality, regulatory compliance and a pleasant skin feel. While the advantages of…
Design and Optimization of a Nanoparticulate Pore Former as a Multifunctional Coating Excipient for…
Bioavailability of weakly basic drugs may be disrupted by dramatic pH changes or unexpected pH alterations in the gastrointestinal tract. Conventional organic acids or enteric coating polymers cannot address this problem adequately because…
The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS…
Sprinkle formulations represent an interesting concept of medicinal products aimed at the steadily growing population of patients suffering from swallowing difficulties (dysphagia). In the present work, immediate-release sprinkle MUPS…
Fucoidan in Pharmaceutical Formulations: A Comprehensive Review for Smart Drug Delivery Systems
Fucoidan is a heterogeneous group of polysaccharides isolated from marine organisms, including brown algae and marine invertebrates. The physicochemical characteristics and potential bioactivities of fucoidan have attracted substantial…
What is freeze drying (or lyophilization)?
Freeze drying is cool - literally! It's the only method of drying that doesn't require raising the temperature of a sample and it works by using sublimation. And water only sublimes because it has a triple point. So if you want to…
The Future of Drug Delivery
Drug delivery technologies have been proven to improve treatment outcomes in many ways, including enhancing therapeutic efficacy, reducing toxicity, increasing patient compliance, and enabling entirely new medical treatments. As the…
Multifunctional low temperature-cured PVA/PVP/citric acid-based hydrogel forming microarray patches:…
The characteristics of multifunctional polymeric hydrogel-forming microarray patches based on poly(vinyl alcohol)/poly(vinylpyrrolidone)/citric acid composite crosslinked at 80 °C were investigated. The swelling study showed that this…
Multinational Research Consortium To Advance Nanomedicine Manufacturing
PRESS INFORMATION
Multinational Research Consortium to Advance Nanomedicine Manufacturing
Gattefossé, InProcess-LSP, Knauer, Microfluidics, Skyepharma, and the University of Graz join the RCPE-led European Consortium for Continuous…
The New Excipient BioSustane – The Interview with Eastman
Recently, we did a small interview with Rajendran (Raj) Arunagiri, Global Segment Market Manager from Eastman. The main topic was Eastman’s new excipient BioSustane™ SAIB NF and we asked Raj some key questions to learn more about the…
What is drying?
Drying means the removal of water (or other solvent) from a sample, but why do we do that and how does it work? In this video, Pharma Drama helps you to Get Drying Sorted! We'll explain why we dry materials, how drying methods work, explain…
Poly(caprolactone)/lignin-based 3D-printed dressings loaded with a novel combination of bioactive…
Curcumin (CUR) has been shown to possess significant anti-inflammatory properties and significant wound healing potential. Additionally, lignin (LIG) is a renewable biomacromolecule with well-known antioxidant and antimicrobial properties,…
Efficient Development of Green Emulsifier/Emollient-Based Emulsion Vehicles: From RSM Optimal…
Since natural-origin, sustainable ingredients are preferred by modern consumers, novel emulsifiers and emollients keep entering the market. This study hypothesizes that a combination of in silico, instrumental tools and simplified sensory…
Hybrid Manufacturing of Oral Solid Dosage Forms via Overprinting of Injection-Molded Tablet…
Since 3D printing allows for patient-specific dosage forms, it has become a major focus in pharmaceutical research. However, it is difficult to scale up drug product manufacturing. Injection molding has been used in conjunction with…
Combined DEM and Johanson model for ribbon density prediction in a roller compactor
Abstract
Johanson (1965) developed a one-dimensional model for the stress acting on the powder in between the rolls of a roller compactor. Limited work has been performed regarding estimation of inlet stress; a parameter required for the…
Data-Driven Prediction of the Formation of Co-Amorphous Systems
Co-amorphous systems (COAMS) have raised increasing interest in the pharmaceutical industry, since they combine the increased solubility and/or faster dissolution of amorphous forms with the stability of crystalline forms. However, the…
Numerical Investigation of the Particle Dynamics in a Rotorgranulator Depending on the Properties of…
In the pharmaceutical industry, the coating of particles is a widely used technique to obtain desired surface modifications of the final product, e.g., controlled release of the active agents. The production of round, coated particles is…
Quality Evaluation of Humidified Magnesium Oxide Tablet Formulations with Respect to Disintegration…
In the present study, we conducted a detailed evaluation of the effects of humidification on the quality of five types of commercial magnesium oxide (MgO) tablet formulations. When near-IR spectroscopy was performed, a peak derived from the…
Formulation and evaluation of ocular self-nanoemulsifying drug delivery system of brimonidine…
The aim of the current study was to develop an ocular Self-nanoemulsifying drug delivery system (SNEDDS) loaded with Brimonidine tartrate (BRT) and evaluate its ex-vivo permeability. SNEDDS loaded with BRT were prepared by low energy…
Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery
In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with different types of responsive pore gatekeepers have shown great potential for the formulation of drug delivery systems (DDS) with minimal premature…
Design and Development of Agglomerated Isomalt
The objective of this study was to prepare agglomerated isomalt by using the melt granulation process. This method involved the use of 99.5% of isomalt with the meltable binder glyceryl monostearate in a concentration of 0.5%. Glyceryl…
High-Shear Granulation of Hygroscopic Probiotic-Encapsulated Skim Milk Powder: Effects of…
A fine, hygroscopic, and poorly flowable probiotic powder encapsulating Lactobacillus rhamnosus GG (LGG) was granulated using a high-shear granulation process, wherein a small amount of water (4%, w/w) was used for moisture-activation with…
N-Nitrosamines Impurities in Pharmaceuticals The Abrupt Challenges that Resulted, the Evolving…
In mid-2018, N-nitroso-dimethylamine (NDMA) was unexpectedly detected in a valsartan active pharmaceutical ingredient (API). NDMA, like many other nitrosamines, is mutagenic and a probable human carcinogen. In contrast to many other newly…